Is open source software the New Lex Mercatoria?

The first generation of academic scholarship on the Internet proclaimed that its transnational nature rendered it inherently unregulable by conventional governments. Instead, the Internet would be governed by rules and customs developed by members of the online community itself. Although most of these early Internet theorists remained somewhat vague about the mechanism through which such norms and structures might arise, some suggested that they might emerge through international standard setting organizations or the system for resolving domain name disputes. As a model for how such system might emerge, they pointed to the lex mercatoria, which is generally characterized as a set of uniform legal principles developed during medieval times on behalf of traveling merchants that was based on the customs and practices of international trade, enforced by special merchant courts, and independent of local governments and their laws. Other scholars expressed skepticism about the Internet’s supposed unregulability. Indeed, such claims would ultimately be contradicted by events such as the United States’ unilateral efforts to block the creation of the .xxx domain on the Internet, the influence of governments and large corporations over international standard setting organizations, as well as China’s success in restricting the online activity of its citizens. These failures have done little to dampen the desire for a conceptual foundation for Internet self-governance. Interestingly, Internet guru Lawrence Lessig has suggested that more widespread use of open source software may increase the Internet’s ability to resist governmental control. This Article explores potential implications of that observation by examining whether more widespread use of open source software might provide the basis for the type of bottom-up ordering associated with the lex mercatoria. Part I offers an overview of open source software. Part II describes both the ancient and modern versions of the lex mercatoria and outlines some of the central debates about those institutions. Part III examines whether open source software can provide a decentralized mechanism for unifying the online commercial environment that is independent of national governments and international organizations in the manner that the proponents of the lex mercatoria envision. Perhaps unsurprisingly, a system of self-governance based on open source runs afoul of the same questions of spontaneity, universality, and autonomy that surround the lex mercatoria. Other scholars expressed skepticism about the Internet’s supposed unregulability. Indeed, such claims would ultimately be contradicted by events such as the United States’ unilateral efforts to block the creation

Proton decay of high-lying states in odd nuclei

In the framework of the quasiparticle-phonon model, we study the non-statistical proton decay of excited states in odd nuclei towards low-lying collective states. Partial cross sections and branching ratios for the proton decay of the high angular momentum states in $^{41}$Sc, $^{59}$Cu and $^{91}$Nb %{\it excited by means of the ($^{7}$Li,$^{6}$He) reaction} are evaluated. The calculated branching ratios predict strong direct proton decays to the low-lying vibrational states in $^{41}$Sc and $^{91}$Nb. A general agreement with existing experimental data is found.Comment: 12 pages, 2 figures, Latex, accepted for publication in Nucl. Phys.

FIH-1, a novel interactor of mindbomb, functions as an essential anti-angiogenic factor during zebrafish vascular development

Objective: It has been shown that Mindbomb (Mib), an E3 Ubiquitin ligase, is an essential modulator of Notch signaling during development. However, its effects on vascular development remain largely unknown

ZnO/Mg0.2Zn0.8O coaxial nanorod heterostructures for high-performance electronic nanodevice applications

We report on fabrication and electrical characteristics of field effect transistors (FETs) based on ZnO/Mg0.2Zn0.8O coaxial nanorod heterostructures. As compared to bare ZnO nanorod FETs, coaxial nanorod heterostructure FETs exhibited the enhanced mobility (similar to 110 cm(2)/V s), superior subthreshold swing (similar to 200 mV/decade), and negligibly small hysteresis to demonstrate very stable operation of high-performance nanorod FETs. In situ surface passivation and carrier confinement effects provided by heteroepitaxially grown Mg0.2Zn0.8O shell layer are presumably responsible for the highly enhanced device performance.open111825sciescopu

Observation of coherent backscattering of light by cold atoms

Coherent backscattering (CBS) of light waves by a random medium is a signature of interference effects in multiple scattering. This effect has been studied in many systems ranging from white paint to biological tissues. Recently, we have observed CBS from a sample of laser-cooled atoms, a scattering medium with interesting new properties. In this paper we discuss various effects, which have to be taken into account for a quantitative study of coherent backscattering of light by cold atoms.Comment: 25 pages LaTex2e, 17 figures, submitted to J. Opt. B: Quant. Semicl. Op

Modulation doping in ZnO nanorods for electrical nanodevice applications

We introduce a modulation-doping method to control electrical characteristics of ZnO nanorods. Compared with a conventional homogeneous doping method, the modulation-doping method generates localized doping layers along the circumference in ZnO nanorods, useful for many device applications. Here, we investigated electrical, structural, and optical characteristics of Ga-doped ZnO nanorods with the dopant modulation layers. Electrical conductivity of ZnO nanorods was controlled by changing either dopant mole fraction or the number of modulation-doped layers. Furthermore, the modulation-doped nanorod field effect transistors exhibited precisely controlled conductance in the order of magnitude without degradation of electron mobility. The effects of the doping on structural and optical characteristics of the nanorods are also discussed.open112126sciescopu

Attention deficit hyperactivity symptoms predict problematic mobile phone use

Attention-deficit-hyperactivity disorder (ADHD) is the most commonly diagnosed childhood disorder characterised by inattention, hyperactivity/impulsivity, or both. Some of the key traits of ADHD have previously been linked to addictive and problematic behaviours. The aim of the present study was to examine the relationship between problematic mobile phone use, smartphone addiction risk and ADHD symptoms in an adult population. A sample of 273 healthy adult volunteers completed the Adult ADHD Self-Report Scale (ASRS), the Mobile Phone Problem Usage Scale (MPPUS), and the Smartphone Addiction Scale (SAS). A significant positive correlation was found between the ASRS and both scales. More specifically, inattention symptoms and age predicted smartphone addiction risk and problematic mobile phone use. Our results suggest that there is a positive relationship between ADHD traits and problematic mobile phone use. In particular, younger adults with higher level of inattention symptoms could be at higher risk of developing smartphone addiction. The implication of our findings for theoretical frameworks of problematic mobile phone use and clinical practice are discussed

Adaptive transaction scheduling for transactional memory systems

Transactional memory systems are expected to enable parallel programming at lower programming complexity, while delivering improved performance over traditional lock-based systems. Nonetheless, there are certain situations where transactional memory systems could actually perform worse. Transactional memory systems can outperform locks only when the executing workloads contain sufficient parallelism. When the workload lacks inherent parallelism, launching excessive transactions can adversely degrade performance. These situations will actually become dominant in future workloads when large-scale transactions are frequently executed. In this thesis, we propose a new paradigm called adaptive transaction scheduling to address this issue. Based on the parallelism feedback from applications, our adaptive transaction scheduler dynamically dispatches and controls the number of concurrently executing transactions. In our case study, we show that our low-cost mechanism not only guarantees that hardware transactional memory systems perform no worse than a single global lock, but also significantly improves performance for both hardware and software transactional memory systems.M.S.Committee Chair: Lee, Hsien-Hsin; Committee Member: Blough, Douglas; Committee Member: Yalamanchili, Sudhaka

Evidence for Two Modes of Synergistic Induction of Apoptosis by Mapatumumab and Oxaliplatin in Combination with Hyperthermia in Human Colon Cancer Cells

Colorectal cancer is the third leading cause of cancer-related mortality in the world-- the main cause of death from colorectal cancer is hepatic metastases, which can be treated with isolated hepatic perfusion (IHP). Searching for the most clinically relevant approaches for treating colorectal metastatic disease by isolated hepatic perfusion (IHP), we developed the application of oxaliplatin concomitantly with hyperthermia and humanized death receptor 4 (DR4) antibody mapatumumab (Mapa), and investigated the molecular mechanisms of this multimodality treatment in human colon cancer cell lines CX-1 and HCT116 as well as human colon cancer stem cells Tu-12, Tu-21 and Tu-22. We showed here, in this study, that the synergistic effect of the multimodality treatment-induced apoptosis was caspase dependent and activated death signaling via both the extrinsic apoptotic pathway and the intrinsic pathway. Death signaling was activated by c-Jun N-terminal kinase (JNK) signaling which led to Bcl-xL phosphorylation at serine 62, decreasing the anti-apoptotic activity of Bcl-xL, which contributed to the intrinsic pathway. The downregulation of cellular FLICE inhibitory protein long isoform (c-FLIPL) in the extrinsic pathway was accomplished through ubiquitination at lysine residue (K) 195 and protein synthesis inhibition. Overexpression of c-FLIPL mutant (K195R) and Bcl-xL mutant (S62A) completely abrogated the synergistic effect. The successful outcome of this study supports the application of multimodality strategy to patients with colorectal hepatic metastases who fail to respond to standard chemoradiotherapy that predominantly targets the mitochondrial apoptotic pathway. © 2013 Song et al