A simulational and theoretical study of the spherical electrical double layer for a size-asymmetric electrolyte: the case of big coions

Monte Carlo simulations of a spherical macroion, surrounded by a size-asymmetric electrolyte in the primitive model, were performed. We considered 1:1 and 2:2 salts with a size ratio of 2 (i.e., with coions twice the size of counterions), for several surface charge densities of the macrosphere. The radial distribution functions, electrostatic potential at the Helmholtz surfaces, and integrated charge are reported. We compare these simulational data with original results obtained from the Ornstein-Zernike integral equation, supplemented by the hypernetted chain/hypernetted chain (HNC/HNC) and hypernetted chain/mean spherical approximation (HNC/MSA) closures, and with the corresponding calculations using the modified Gouy-Chapman and unequal-radius modified Gouy-Chapman theories. The HNC/HNC and HNC/MSA integral equations formalisms show good concordance with Monte Carlo "experiments", whereas the notable limitations of point-ion approaches are evidenced. Most importantly, the simulations confirm our previous theoretical predictions of the non-dominance of the counterions in the size-asymmetric spherical electrical double layer [J. Chem. Phys. 123, 034703 (2005)], the appearance of anomalous curvatures at the outer Helmholtz plane and the enhancement of charge reversal and screening at high colloidal surface charge densities due to the ionic size asymmetry.Comment: 11 pages, 7 figure

Aseptic meningitis in a patient taking etanercept for rheumatoid arthritis: a case report

Background \ud We report a case of a 53 year old lady recently commenced on etanercept, an anti-TNF (tumour necrosis factor) therapy for rheumatoid arthritis presenting with \ud confusion, pyrexia and an erythematous rash. \ud \ud Case presentation \ud A lumbar puncture was highly suggestive of bacterial meningitis, but CSF cultures produced no growth, and polymerase chain reactions (PCR) for all previously reported bacterial, fungal and viral causes of meningitis were negative. \ud \ud Conclusions \ud This case report describes aseptic meningitis as a previously unreported complication of etanercept therapy, and serves as a reminder of the rare but potentially lifethreatening risk of serious infections in patients taking anti-TNF therapy for a variety of conditions

Programa de tasas retributivas en colombia: una evaluación del diseño de fiscalización y su cumplimiento en el caso de corpochivor.

Este trabajo presenta una revisión del diseño de fiscalización contemplado en el programa de Tasas Retributivas en Colombia (PTRC) y una evaluación del desempeño en términos de cumplimiento de fuentes pertenecientes a la Corporación Autónoma Regional del Chivor (CORPOCHIVOR). El análisis sugiere que las Corporaciones Autónomas Regionales (CAR) deben elaborar sus propias estrategias de fiscalización, acordes con las limitaciones en personal y recursos. Pese a esto, en la mayoría de ellas no se cuenta con el apoyo de sanciones con suficiente poder disuasivo para inducir adecuados niveles de cumplimiento y contención de costos de fiscalización. El cobro coactivo se presenta como único instrumento legal para inducir el cumplimiento en el pago de tasas retributivas. Adicionalmente, nuestro análisis del caso de CORPOCHIVOR indica para el periodo analizado que el incumplimiento promedio en el pago de la tasa alcanza 40% de las fuentes. El incumplimiento se agudiza en fuentes de carácter privado, fuentes pertenecientes al sector porcícola y fuentes auditadas mediante visitas de funcionarios

A newly described strain of Eimeria arloingi (strain A) belongs to the phylogenetic group of ruminant-infecting pathogenic species, which replicate in host endothelial cells in vivo

Coccidiosis caused by Eimeria species is an important disease worldwide, particularly in ruminants and poultry. Eimeria infection can result in significant economic losses due to costs associated with treatment and slower growth rates, or even with mortality of heavily infected individuals. In goat production, a growing industry due to increasing demand for caprine products worldwide, coccidiosis is caused by several Eimeria species with E. arloingi and E. ninakohlyakimovae the most pathogenic. The aims of this study were genetic characterization of a newly isolated European E. arloingi strain (A) and determination of phylogenetic relationships with Eimeria species from other ruminants. Therefore, a DNA sequence of E. arloingi strain (A) containing 2290 consensus nucleotides (the majority of 18S rDNA, complete ITS-1 and 5.8S sequences, and the partial ITS-2) was amplified and phylogenetic relationship determined with the most similar sequences available on GenBank. The phylogenetic tree presented a branch constituted by bovine Eimeria species plus E. arloingi, and another one exclusively populated by ovine Eimeria species. Moreover, E. arloingi, E. bovis and E. zuernii, which all replicate in host intestinal endothelial cells of the lacteals, were found within the same cluster. This study gives new insights into the evolutionary phylogenetic relationships of this newly described caprine Eimeria strain and confirmed its close relationship to other highly pathogenic ruminant Eimeria species characterized by macromeront formation in host endothelial cells of the central lymph capillaries of the small intestine

Simplified Self-Consistent Theory of Colloid Dynamics

One of the main elements of the self-consistent generalized Langevin equation (SCGLE) theory of colloid dynamics [Phys. Rev. E {\bf 62}, 3382 (2000); ibid {\bf 72}, 031107 (2005)] is the introduction of exact short-time moment conditions in its formulation. The need to previously calculate these exact short-time properties constitutes a practical barrier for its application. In this note we report that a simplified version of this theory, in which this short-time information is eliminated, leads to the same results in the intermediate and long-time regimes. Deviations are only observed at short times, and are not qualitatively or quantitatively important. This is illustrated by comparing the two versions of the theory for representative model systems.Comment: 1 text archive, 3 figure

Theranostic applications of phage display to control leishmaniasis: Selection of biomarkers for serodiagnostics, vaccination, and immunotherapy

© 2015, Sociedade Brasileira de Medicina Tropical. All rights reserved. Phage display is a high-throughput subtractive proteomic technology used for the generation and screening of large peptide and antibody libraries. It is based on the selection of phage-fused surface-exposed peptides that recognize specific ligands and demonstrate desired functionality for diagnostic and therapeutic purposes. Phage display has provided unmatched tools for controlling viral, bacterial, fungal, and parasitic infections, and allowed identification of new therapeutic targets to treat cancer, metabolic diseases, and other chronic conditions. This review presents recent advancements in serodiagnostics and prevention of leishmaniasis -an important tropical parasitic disease- achieved using phage display for the identification of novel antigens with improved sensitivity and specificity. Our focus is on theranostics of visceral leishmaniasis with the aim to develop biomarker candidates exhibiting both diagnostic and therapeutic potential to fight this important, yet neglected, tropical disease.Peer Reviewe

Sorghum, an alternative cereal for gluten-free product.

There is a growing demand for health foods, indicated by the number of searches including the terms celiac disease and gluten free products. Most information is designed not only for celiac and gluten intolerant patients, but by others interested in obtaining additional health benefits from foods. Sorghum has been recently recognized as a cereal with functional properties, able to improve human health, but still of low direct human consumption. This review aims to illustrate the publication trends relating to sorghum for gluten free products and celiac disease. The scientific literature available in databases from the last twenty years was used. We perceived the need for further sensorial studies in order to understand the consumer expectations of gluten free products, considering the large varieties of colored sorghum grains that could be used to prepare different gluten free products. Keywords: Meta-analysis; Antioxidant capacity; Sensorial analysis; Gluten free products.Review Article

Boost operators in Coulomb-gauge QCD: the pion form factor and Fock expansions in phi radiative decays

In this article we rederive the Boost operators in Coulomb-Gauge Yang-Mills theory employing the path-integral formalism and write down the complete operators for QCD. We immediately apply them to note that what are usually called the pion square, quartic... charge radii, defined from derivatives of the pion form factor at zero squared momentum transfer, are completely blurred out by relativistic and interaction corrections, so that it is not clear at all how to interpret these quantities in terms of the pion charge distribution. The form factor therefore measures matrix elements of powers of the QCD boost and Moeller operators, weighted by the charge density in the target's rest frame. In addition we remark that the decomposition of the eta' wavefunction in quarkonium, gluonium, ... components attempted by the KLOE collaboration combining data from phi radiative decays, requires corrections due to the velocity of the final state meson recoiling against a photon. This will be especially important if such decompositions are to be attempted with data from J/psi decays.Comment: 14 pages, 4 figure

Stray dogs inside and outside of official markets of Villa El Salvador district in Lima, Peru

El objetivo del estudio fue estimar la población de canes vagabundos en el interior y exterior de 21 mercados formales del distrito de Villa el Salvador, Lima, Perú. Se elaboró una ficha epidemiológica y se registró el número de canes por mercado, características de los canes (sexo, tamaño, número de hembras lactantes, alteraciones de su condición física o salud) y su proximidad a puestos de expendio de alimentos. Se contabilizaron 518 y 568 canes en el interior y exterior de los mercados, respectivamente (24.6 ± 4.9 y 27.1 ± 7.7 canes por mercado, respectivamente). Los resultados muestran la necesidad de aplicar las normas correspondientes que regulan la presencia de canes vagabundos en los mercados a fin de prevenir potenciales problemas que pudieran afectar la salud pública.The aim of the study was to estimate the population of stray dogs inside and outside 21 official markets of the district of Villa El Salvador, Lima, Peru. An epidemiological form was developed and the number and characteristics of dogs per market (sex, size, number of lactating females, welfare status), and their proximity to selling food stalls were registered. The total population of stray dogs was 518 and 568 inside and outside respectively (24.6 ± 4.9 y 27.1 ± 7.7 dogs per market respectively). The results showed the need to apply the relevant rules governing the presence of stray dogs in the markets to prevent potential problems that could affect public health

Kad pogledam svijet - Zbornik radova Međunarodne studije, Vol. I., 2000.

Zbornik radova Međunarodne studije, Vol. I., 2000. Hrvatska udruga za međunarodne studije, Zagreb i Golden Marketing, Zagreb