253 research outputs found

    A new method to estimate the lifetime of long-life product categories

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    Increased recycling and reuse rates are a central part of the objectives laid out by the COP21. Nonetheless, the practical implementation of what has been called the circular economy, as well as its true potential are not easily established. This is because the impact and implementation time scales of any intervention depend on knowing the lifetime of products, which is frequently unknown. This is particularly true in construction, responsible for 39% of worldwide emissions, 11% of which are embodied. Most MFA models will simply assume a range of plausible life expectancies when bottom-up data is lacking (e.g. for buildings). In this work, we propose a novel method of identification using the high quality but highly aggregated trade data available, and use it to establish a “mortality curve” for buildings and other long-lasting products. This identification method is intended to provide more reliable inputs to existing MFA models. It is widely applicable due to the general availability of the underlying data. Using it on UK trade data, we identify product classes at 1 year for packaging/home scrap, one around 10 years for vehicles/equipment, and around 50 years for construction. The identification approach was then validated using classical approaches using bottom up data for vehicles

    Fission yeast Pcp1 links polo kinase-mediated mitotic entry to γ-tubulin-dependent spindle formation

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    The centrosomal pericentrin-related proteins play pivotal roles in various aspects of cell division; however their underlying mechanisms remain largely elusive. Here we show that fission-yeast pericentrin-like Pcp1 regulates multiple functions of the spindle pole body (SPB) through recruiting two critical factors, the γ-tubulin complex (γ-TuC) and polo kinase (Plo1). We isolated two pcp1 mutants (pcp1-15 and pcp1-18) that display similar abnormal spindles, but with remarkably different molecular defects. Both mutants exhibit defective monopolar spindle microtubules that emanate from the mother SPB. However, while pcp1-15 fails to localise the γ-TuC to the mitotic SPB, pcp1-18 is specifically defective in recruiting Plo1. Consistently Pcp1 forms a complex with both γ-TuC and Plo1 in the cell. pcp1-18 is further defective in the mitotic-specific reorganisation of the nuclear envelope (NE), leading to impairment of SPB insertion into the NE. Moreover pcp1-18, but not pcp1-15, is rescued by overproducing nuclear pore components or advancing mitotic onset. The central role for Pcp1 in orchestrating these processes provides mechanistic insight into how the centrosome regulates multiple cellular pathways

    Integrand reduction of one-loop scattering amplitudes through Laurent series expansion

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    We present a semi-analytic method for the integrand reduction of one-loop amplitudes, based on the systematic application of the Laurent expansions to the integrand-decomposition. In the asymptotic limit, the coefficients of the master integrals are the solutions of a diagonal system of equations, properly corrected by counterterms whose parametric form is konwn a priori. The Laurent expansion of the integrand is implemented through polynomial division. The extension of the integrand-reduction to the case of numerators with rank larger than the number of propagators is discussed as well.Comment: v2: Published version: references and two appendices added. v3: Eq.(6.11) corrected, Appendix B updated accordingl

    Scaling Patterns for QCD Jets

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    Jet emission at hadron colliders follows simple scaling patterns. Based on perturbative QCD we derive Poisson and staircase scaling for final state as well as initial state radiation. Parton density effects enhance staircase scaling at low multiplicities. We propose experimental tests of our theoretical findings in Z+jets and QCD gap jets production based on minor additions to current LHC analyses.Comment: 36 pages, 16 figure

    On the Integrand-Reduction Method for Two-Loop Scattering Amplitudes

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    We propose a first implementation of the integrand-reduction method for two-loop scattering amplitudes. We show that the residues of the amplitudes on multi-particle cuts are polynomials in the irreducible scalar products involving the loop momenta, and that the reduction of the amplitudes in terms of master integrals can be realized through polynomial fitting of the integrand, without any apriori knowledge of the integral basis. We discuss how the polynomial shapes of the residues determine the basis of master integrals appearing in the final result. We present a four-dimensional constructive algorithm that we apply to planar and non-planar contributions to the 4- and 5-point MHV amplitudes in N=4 SYM. The technique hereby discussed extends the well-established analogous method holding for one-loop amplitudes, and can be considered a preliminary study towards the systematic reduction at the integrand-level of two-loop amplitudes in any gauge theory, suitable for their automated semianalytic evaluation.Comment: 26 pages, 11 figure

    Meta-analysis of diffusion tensor imaging studies shows altered fractional anisotropy occurring in distinct brain areas in association with depression

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    Fractional anisotropy anomalies occurring in the white matter tracts in the brains of depressed patients may reflect microstructural changes underlying the pathophysiology of this disorder. We conducted a meta-analysis of fractional anisotropy abnormalities occurring in major depressive disorder using voxel-based diffusion tensor imaging studies. Using the Embase, PubMed and Google Scholar databases, 89 relevant data sets were identified, of which 7 (including 188 patients with major depressive disorder and 221 healthy controls) met our inclusion criteria. Authors were contacted to retrieve any additional data required. Coordinates were extracted from clusters of significant white matter fractional anisotropy differences between patients and controls. Relevant demographic, clinical and methodological variables were extracted from each study or obtained directly from authors. The meta-analysis was carried out using Signed Differential Mapping. Patients with depression showed decreased white matter fractional anisotropy values in the superior longitudinal fasciculus and increased fractional anisotropy values in the fronto-occipital fasciculus compared to controls. Using quartile and jackknife sensitivity analysis, we found that reduced fractional anisotropy in the left superior longitudinal fasciculus was very stable, with increases in the right fronto-occipital fasciculus driven by just one study. In conclusion, our meta-analysis revealed a significant reduction in fractional anisotropy values in the left superior longitudinal fasciculus, which may ultimately play an important role in the pathology of depression
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