10 research outputs found
Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease
- Author
- A Abbate
- A Abhyankar
- A Adams
- A Agafina
- A Akyea-Djamson
- A Alan
- A Alfieri
- A Alfrey
- A Alvarisqueta
- A Amos
- A Anadiotis
- A Anneveldt
- A Antolick
- A Arthur
- A Aslam
- Abaci F
- Abdullakutty J
- Abhaichand R
- Abib E Jr
- Aboufakher R
- Abrantes J
- Abreu M
- Abulencia K
- Acampora D
- Acampora M
- Accini Mendoza Jl
- Aceto L
- Acevedo B
- Acevedo L
- Acheatel R
- Actis Mv
- Adams M
- Adjic Nc
- Affaki Gs
- Agarwal Dk
- Aggarwal Rk
- Agosta Gf
- Aguilar M
- Aguilar M
- Ahire N
- Ahmad I
- Ahmed Sh
- Ahn Y
- Aish B
- Aiub F
- Aiub J
- Ajax K
- Ajioka M
- Akai Y
- Akatova E
- Akrap B
- Al Joundi T
- Al-Khalili F
- Albisu J
- Alcalde Jm
- Alcide P
- Alfonso T
- Allen J
- Alllison Dc
- Almaliky T
- Amerena J
- Andersen K
- Andor M
- Angelova I
- Angiolillo D
- Anita S
- Anker Sd
- Antalik L
- Antonicelli R
- Aparicio Cv
- Apel T
- Apostolovic S
- Ara M
- Aragorn L
- Arango Jl
- Araujo Fonseca M
- Ardissino D
- Arenas Leon Jl
- Arevalo S
- Argiolas G
- Arif I
- Armas E
- Aron G
- Arora S
- Asafu-Adjaye N
- Ashcom T
- Ashford M
- Ashino K
- Asim Oktay Ao
- Assarsson E
- Ata B
- Ather N
- Atieh M
- Aull L
- Avalos V
- Avdonina N
- Awasthi Ak
- Axthelm C
- Ayala M
- Ayasse D
- Ayasse M
- Azizad M
- Azize Gm
- B Becker
- Baar M
- Babu R
- Backer T
- Badea C
- Baden M
- Baehl S
- Baek C
- Baeumer A
- Bagi Es
- Bai A
- Bailey K
- Bailey S
- Bair S
- Baker A
- Baker C
- Bakhai A
- Bakker H
- Baksi A
- Baldin Mg
- Bali Hk
- Ballantyne C
- Ballmajo M
- Balode A
- Balukova E
- Bang Sa
- Banker D
- Banker K
- Baquero A
- Barbarash Ol
- Barbato E
- Barbosa E
- Barnett S
- Baron S
- Barreto M
- Barroso A
- Barroso W
- Bartkowiak A
- Bartosh L
- Bartuseviciene S
- Bashir K
- Baszak J
- Bata Ir
- Bayram E
- Beall K
- Beaudry M
- Beauregard La
- Beckett L
- Belejchak P
- Belle Isle J
- Belohlavek J
- Bendelow T
- Bender D
- Benedetti G
- Benjamin S
- Benton J
- Berdoff R
- Berger V
- Bergeron P
- Bergholtz T
- Bergler-Klein J
- Berk M
- Berli Ma
- Bernstein M
- Berra Fc
- Berti S
- Berulfsen A
- Bevilacqua Mt
- Bhadade S
- Bilazarian S
- Bilodeau N
- Binder A
- Binns Y
- Birdane A
- Bisne V
- Bitzer V
- Blagdon M
- Blahey M
- Blankenberg S
- Blazsek Z
- Bloch S
- Blom Kb
- Bluemel J
- Blumberg C
- Blumenthal R
- Bocanera M
- Bodanese L
- Boffetti P
- Bohra P
- Bohula E
- Boivin Mc
- Bolduc H
- Boley K
- Bolognesi Mg
- Bolsmann C
- Boman K
- Bonner J
- Borrayo Na
- Boström På
- Botelho R
- Botta C
- Boudreaux R
- Boulanger K
- Bourgeois S
- Bouvy C
- Bowen L
- Boyarkin M
- Bradley A
- Brady L
- Bramlet D
- Brath H
- Braun P
- Bredlau C
- Brickman T
- Briggs S
- Briké C
- Brodmann M
- Brons S
- Brousalis L
- Brouwer M
- Brown C
- Brown N
- Brown S
- Buchannan C
- Budaj A
- Budassi N
- Budkova J
- Bugan V
- Buhlman S
- Bulashova O
- Bunschoten P
- Burke W
- Burley T
- Burova N
- Burris H
- Burton C
- Burton J
- Burton M
- Burtt D
- Busak L
- Busic N
- Byars W
- Bøen Rh
- C Clavier-Firmin
- C Conradie
- C Contzen
- C Cotes
- C Covert
- C Cuneo
- Caballero-Valiente B
- Cabau Jr
- Calabrese A
- Campanale Eg
- Candusso R
- Cantor W
- CANTOS Trial Group. Krum H
- Capova L
- Carabajal T
- Carr K
- Carrillo J
- Caruso G
- Casala J
- Caso P
- Casoinic F
- Castillo J
- Castillo T
- Cech V
- Cei L
- Cendali G
- Cepinskiene L
- Cerda L
- Cermak O
- Chachalis G
- Chaggar S
- Chambers J
- Chamblee T
- Chang K
- Chang Kc
- Chang Wh
- Charlier F
- Charmarthi B
- Chattin W
- Chauhan D
- Chauhan H
- Chaussé I
- Chavada J
- Chaverra I
- Chaware G
- Chee L
- Chella S
- Chen Cp
- Chen J
- Chen Mh
- Chen Y
- Chen Yc
- Chen Zc
- Cheng Jj
- Cheng S
- Cheng Sm
- Cherlin R
- Cheung D
- Chhabra A
- Chintala P
- Chiodi L
- Choi Aj
- Chou S
- Chouinard G
- Christensen L
- Christenson S
- Chung A
- Churina S
- Cifkova R
- Ciglenecki N
- Cioffi A
- Cislowski D
- Cleveland T
- Clocotan M
- Cmrecnjak J
- Colfer H
- Colhoun H
- Collier D
- Collins R
- Coloma G
- Colquhoun D
- Colvin T
- Coman S
- Commerford P
- Commerford P
- Conrado Y
- Cools F
- Cornel Jh
- Corona V
- Coronel J
- Cosgrove N
- Cosgrove S
- Cosmi F
- Costa Amorim R
- Coufalova Z
- Covell W
- Cox B
- Cox R
- Craig W
- Crandall L
- Crawford G
- Crea F
- Crepps K
- Crocamo A
- Cromer M
- Cruz H
- Cruz H
- Cruz M
- Csala L
- Cucher F
- Cuentas I
- Cuervo A
- Curiac D
- Cymerman K
- Cyprian R
- Czerski T
- D'Amours Dg
- D Dash
- D Dattani
- D Denham
- D Desai
- D Desalle
- D Digangi
- D Dunn
- Da Costa F
- Da Silva A
- Da Silva D Jr
- Da Silva O Jr
- Dahlen G
- Dalseg Am
- Damron M
- Danik J
- Davalos C
- Dave B
- Dave K
- Davidsson K
- Davies M
- Davies N
- Davis B
- Davis M
- Dawkins-Hughes S
- Dawood Sy
- Dayer M
- De Boer P
- De Caterina R
- De Jong C
- De Knijf K
- De Krumbach L
- De Los Milagros Had M
- De Los Rios M
- De Rosa S
- De Vos A
- De Wolf L
- Dean J
- Debnam S
- Decsi K
- Decsi Kl
- Dedek V
- Dedkova S
- Defosse C
- Degennaro N
- Dehning M
- Dela Llana A
- Delfonso F
- Delforge M
- Delgadillo T
- Dellasa M
- Dellborg M
- Dellorso M
- Demidova M
- Den Hartog F
- Denecke C
- Dengler T
- Dermitzakis A
- Deslongchamps F
- Dessalvi Cc
- Destro M
- Dettmer M
- Devasia T
- Deweerdt N
- Dhanak R
- Dhawan M
- Di Biase M
- Diago M
- Diaz M
- Dicken T
- Dickstein K
- Diederich C
- Diederich M
- Diehl R
- Diller P
- Dimattia M
- Dimitrov G
- Diodati J
- Dobariya H
- Dobilas V
- Dodds G
- Doesborg L
- Doggett J
- Dognini Gp
- Doi M
- Dokupilova A
- Dommerholt R
- Donahue K
- Donath M
- Donaubauer T
- Dong X
- Dormidontova G
- Dorogova I
- Dos Santos A
- Dos Santos F
- Dos Santos P
- Doughty A
- Doughty L
- Dovgalevskiy Y
- Dovgolis S
- Dragutksy B
- Dreese M
- Drost I
- Drouin K
- Duchesne L
- Duckert A
- Duda N
- Dudarev M
- Dudhatra N
- Duff J
- Duhan S
- Dunhurst F
- Dussan Ma
- Dutka C
- Dwenger E
- Dzupina A
- Dékány Jn
- E Eleuteri
- E Englmann
- Earl J
- East C
- Eaton C
- Eaves W
- Ebeling K
- Ebrahim I
- Eccleston D
- Echeverria L
- Eder F
- Edgerton L
- Edillo C
- Edwards J
- Edwards T
- Eichinger G
- Einhorn D
- Eki Y
- El Hachem M
- El Hafi S
- Ellenbroek D
- Ellis M
- Emil B
- Endo T
- Engelen W
- Erhard M
- Erickson B
- Ervin W
- Eskridge L
- Espinosa V
- Everett Bm
- F Fedele
- F Fonseca
- F Fucci
- Facello A
- Facello M
- Faghih M
- Fail P
- Falcon D
- Fang C
- Fang Cy
- Farias E
- Fattal P
- Fawson A
- Feitosa G
- Felario Junior Ga
- Felix L
- Feng Y
- Feng Z
- Ferdinand K
- Ferkl R
- Fernandez Aa
- Ferrari V
- Ferrario M
- Ferraz R
- Ferreira Dos Santos T
- Ferreira-Jardim A
- Fien E
- Filardi Pp
- Filho P
- Fintel D
- Firek C
- Fischer Sm
- Fisher J
- Fitilev S
- Fitz-Patrick D
- Fitzpatrick L
- Flaksa I
- Flather M
- Flezar M
- Fliesser-Goerzer E
- Flores E
- Flores E
- Flores Gs
- Flores H
- Floro T
- Foerster A
- Folkeringa Rj
- Fonseca A
- Fontaine S
- Forgon T
- Forgosh L
- Forker A
- Forster T
- Foster M
- Foucauld J
- Fowler V
- Fox B
- Franco M
- Francoeur L
- Frandsen B
- Frandsen B
- Frankenstein L
- Fratczak M
- Freitas E
- French J
- Frivold G
- Fruchter G
- Fu G
- Fucak E
- Fuchs R
- Fucili A
- Fukuike C
- Fullerton D
- Fulop P
- Fulop T
- Fulwani M
- Furch G
- Furuseth B
- G Gacioch
- G Gosselin
- Gabito A
- Gabor M
- Gabriel J
- Gabrielli D
- Gaeb-Strasas B
- Gamba C
- Ganau A
- Gapon L
- Garas S
- Garcia Duran R
- Garcia Pinna J
- Garcia Rinaldi R
- Garcia F
- Garcia N
- Garcia-Fragoso V
- Garcia-Portela M
- Garner K
- Gazizianova V
- Gelb R
- Genest J
- Genova D
- George F
- Germann H
- Gersh B
- Gervais B
- Ghali J
- Ghondale N
- Ghosh N
- Ghosh S
- Giese C
- Gilbert J
- Gilley J
- Gits F
- Glancy R
- Glenny J
- Glover J
- Glynn Rj
- Godoy Sanchez M
- Goette A
- Goff R
- Goffinet C
- Gohel P
- Goldberg N
- Gomez Sanchez J
- Gonsorcik J
- Gonzales D
- Gonzales V
- Gonzalez E
- Gordeev I
- Gorges R
- Gospodinov K
- Gotcheva N
- Goudev A
- Gould R
- Govindaraj D
- Goyal B
- Goyal S
- Grabeau R
- Grable M
- Graham J
- Graham Ja
- Graif J
- Gralow J
- Gravellone M
- Gravenhorst-Muenter U
- Green E
- Greener R
- Greenway F
- Grieshaber V
- Griffin S
- Grigaraviciene I
- Grigorova V
- Gros C
- Grosse A
- Grover A
- Grundtvig M
- Gudipati Rvc
- Guerrero A
- Guillinta P
- Gundala Ak
- Gupta A
- Gupta A
- Gupta M
- Gupta V
- Gutmann J
- Guzman I
- Guzman P
- Gwyn M
- Gyorgyova E
- H Haldane
- H Hansen
- H Haught
- H Hill
- Haase F
- Haege R
- Haenel T
- Hage F
- Hageman T
- Hagemann D
- Hagenow A
- Hagiwara Y
- Haidar A
- Haider K
- Hakas J
- Haldis T
- Hall C
- Hall L
- Hall S
- Halliwell Tc
- Halpern S
- Hamer Bjb
- Hamud-Socoro A
- Han B
- Han S
- Hanak P
- Hanefeld M
- Hangyal T
- Hansson A
- Hanustiakova A
- Hao Y
- Hardas S
- Hardee L
- Harrell W
- Harrington A
- Harris B
- Hartleib M
- Hartwell J
- Hasan F
- Hasbani E
- Hasegawa K
- Hattler B
- Haughton G
- Haynes E
- Haywood A
- He Y
- He Z
- Heaney L
- Hecht J
- Heeren G
- Hegedus V
- Heider J
- Heisters J
- Henley L
- Hennig D
- Henriksson A
- Hermans K
- Hernandez E
- Hernandez I
- Hernandez M
- Hernández N
- Herrman Jp
- Herzog W
- Hess E
- Hettwer Magedanz E
- Hickey L
- Hiden C
- Hielscher S
- Higuchi T
- Higuchi Y
- Hilkert R
- Hilton T
- Himpel-Boenninghoff A
- Hinderaker P
- Hioki M
- Hirayama A
- Hiroma J
- Ho Cj
- Hodnett P
- Hoffman M
- Hofsoey K
- Hogan C
- Hollanders G
- Holmes Z
- Holoubek D
- Holscher A
- Hominal M
- Homza M
- Hong T
- Hong T
- Hoogslag Pam
- Horackova K
- Horak A
- Hornig M
- Horvat P
- Hosokawa S
- Hotchkiss D
- Houra M
- Hristova K
- Hsieh Ic
- Huang A
- Huang P
- Huang Ph
- Humbert J
- Hurtig U
- Hutchens E
- Huynh T
- Hwang Jj
- Hwang Jj
- Hyun K
- Härstedt N
- Høivik Ho
- I Ilic
- I Ivanov
- Iachini K
- Iannopollo G
- Ibarra J
- Ibarra M
- Ibañez J
- Iby M
- Ichisawa M
- Igbokidi O
- Iijima T
- Ilahi T
- Ilic S
- Ilsley M
- Imbrognio M
- Imre Bs
- Inada T
- Inagaki M
- Indolfi C
- Infusino F
- Invitti C
- Ipp E
- Isaza D
- Istratoaie O
- Istvan Kp
- Iteld B
- Ito K
- Ivan P
- Iveta H
- Izmozherova N
- J Jiang
- J Johnson
- J Johnston
- J Jose
- Jacques G
- Jafri A
- Jafry B
- Jagtap P
- Jaguszewska G
- Jain A
- Jansen M
- Jardula M
- Jayasinghe R
- Jefferson D
- Jenkins R
- Jensen Ed
- Jeric M
- Jerzewski A
- Jeserich M
- Jia Z
- Jiang T
- Jiang X
- Jimenez D
- Jirvankar P
- Johansen Bb
- Johansen E
- Johansson K
- Johnson E
- Jones S
- Jonsson Je
- Joosten C
- Joshi U
- Julien Ve
- JuliĂŁo K
- Jure D
- Jure H
- Jutrisa N
- K Kaigawa
- K Katahira
- K Kiroglu
- K Kordic
- K Kostov
- Kabakchieva Vm
- Kaczmarek N
- Kafarakis P
- Kaiserova L
- Kajihara S
- Kala P
- Kaldara E
- Kalina A
- Kalkman C
- Kam J
- Kamensky G
- Kamiya H
- Kamiya J
- Kan G
- Kaneno Y
- Kanitz S
- Kapp I
- Kara Yd
- Karakai H
- Karel I
- Karpuram M
- Karsai Xz
- Kastelein Jjp
- Kataoka M
- Katona A
- Katova T
- Kaur H
- Kawahara M
- Kawai M
- Kawasaki T
- Kawka-Urbanek T
- Kazanskay E
- Ke Y
- Keba E
- Keenan S
- Kelehan S
- Kellnerova I
- Kelly R
- Kelt T
- Kendall T
- Kereiakes D
- Khan A
- Khan M
- Khan R
- Khan S
- Khariouzov A
- Khirmanov V
- Khromtsova O
- Kick J
- Kiefer R
- Kietselaer B
- Kim B
- Kim Ks
- Kim M
- Kimmel M
- King A
- King T
- Kirkland S
- Kiss Rg
- Kissel S
- Kitchens D
- Klamm M
- Klein C
- Klein P
- Klemsdal To
- Kleve R
- Klugherz B
- Knight J
- Knutsson A
- Koba M
- Kobalava Z
- Kodem Dr
- Koeitti P
- Koenig W
- Kojima E
- Kok M
- Koldas N
- Koleckar P
- Kolikova V
- Kolleroy C
- Kolokathis F
- Komati S
- Komura Y
- Kondagunta V
- Konradi A
- Kooiman E
- Kopaczewski J
- Kopczyńska M
- Korban E
- Koren M
- Kormann A
- Korte M
- Korth-Wiemann B
- Kose V
- Kosmacheva E
- Kostakou P
- Kostis J
- Kotek L
- Kouz Sm
- Kovacic D
- Kovacs A
- Kozak M
- Kozlova S
- Krapivsky A
- Kreckova M
- Kreutter F
- Krupciakova B
- Krupicka J
- Kuenzler J
- Kulibaba E
- Kulkarni L
- Kullal P
- Kultursay H
- Kumar Ks
- Kumbla M
- Kuntzsch A
- Kuo Jy
- Kuramochi T
- Kuruma T
- Kusnick B
- Kuzin A
- Kyo E
- L Levinson
- L Lim
- L Link
- L Liu
- Laane E
- Labovitz R
- Lachance P
- Lai Wt
- Lail J
- Lainscak M
- Lake J
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- Lamance J
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- Landers B
- Landolfi A
- Landzberg J
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- Lazov P
- Ledger G
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- Leggewie S
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- Leimbach W
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- Lembo G
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- Lennard M
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- Levine D
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- Liberato Nl
- Libov I
- Lierse T
- Ligueros M
- Lillo J
- Lima F
- Limaye Ap
- Lin T
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- Lindner C
- Liniado G
- Lino E
- Lipchenko A
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- Liviu C
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- Lohkare M
- Lok Dja
- Long C
- Longaker R
- Lopes R
- Lopez P
- Lorch G
- Lorenc Z
- Lorenzatti A
- Lousberg A
- Lozhkina N
- Lu Z
- Luciardi H
- Lucksinger G
- Luecke-Uzar M
- Luedemann J
- Lukac J
- Lundqvist M
- Lupkovics G
- Luquez H
- Luz Serrano H
- Lv Y
- Lynd S
- Lysek R
- Lönnberg I
- M Malek
- M Mallagray
- M Mandati
- M Mandviwala
- M Marsters
- M Mays
- M Mcdonald
- M Medvegy
- M Meinrich
- M Mikus
- M Milanova
- M Moustafa
- Ma C
- Ma G
- Maboyi S
- Macdonald J
- Macfadyen Jg
- Machova V
- Madder R
- Maehara G
- Maffei L
- Magness K
- Maheshwari A
- Maheux K
- Maia L
- Majercak I
- Majul C
- Makedonska Jj
- Makhe B
- Makotoko E
- Malchikova S
- Maletz L
- Malhotra S
- Malhotra V
- Malik J
- Mancikova I
- Mandic L
- Manenti E
- Manfreda S
- Manga P
- Mani Ck
- Mani H
- Manne S
- Manning B
- Mannucci E
- Manolis A
- Manolis Aj
- Manov E
- Mantas I
- Manuel J
- Manukov D
- Manukov I
- Manyari D
- Manzur F
- Marcela Wenetz Lm
- Marchelletta N
- Marchi Al
- Marcinkeviciene J
- Marcun R
- Marengo Garcia De Carvalho L
- Marinaro S
- Marino P
- Mariottoni B
- Maron B
- Marschke T
- Marshall L
- Martin E
- Martin L
- Martinez E
- Martinez J
- Maruzzo S
- Marziali A
- Masarikova L
- Massaccesi R
- Mathew A
- Matyasek I
- Mauersberger K
- Maus O
- Mavromatis K
- Maximov D
- Mayer T
- Maynard R
- Mays B
- Mazutavicius R
- Mbulaiteye A
- Mcalister R
- Mccoy C
- Mccrary D Jr
- Mccullough-O'Brien H
- Mcgill J
- Mcgrew F
- Mcintosh C
- Mckenzie A
- Mckenzie C
- Mckibbin A
- Mclaurin B
- Mclellan Ba
- Mcmahon G
- Mcneil D
- Mcneill R
- Mcpherson C
- Medina F
- Megalou A
- Mehrle A
- Mehta A
- Mehta S
- Meijlis P
- Meissner A
- Mejia I
- Melbie K
- Mellberg L
- Melliza T
- Mendoza N
- Mendoza Y
- Mercuro G
- Merkely B
- Messina T
- Mestdagh I
- Meyer R
- Michalaros Y
- Michalska A
- Michaud N
- Michel K
- Mickel C
- Micko K
- Mihaly N
- Mikdadi G
- Mikusova T
- Milicic D
- Militaru C
- Miliuniene R
- Milkas A
- Miller A
- Miller C
- Miller G
- Miller R
- Miller W
- Minescu B
- Minocha G
- Mitchell J
- Mittal A
- Miyamoto T
- Moats Djr
- Modi R
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- Westberg Jc
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- Wohnlich T
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- Yakushin S
- Yamada T
- Yamaguchi E
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- Yamamoto T
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- Yang Cc
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- Yang P
- Yao Z
- Yaoqing H
- Yarows S
- Yasuoka S
- Yasutake M
- Yigit Z
- Yilmaz Mb
- Yim Kh
- Yim S
- Yokoyama M
- Yong H
- Yoshida M
- Yoshimoto E
- Yossen M
- Young A
- Younis L
- Youssef G
- Yuan Z
- Yunoki C
- Yupanqui H
- Z Zhai
- Z Zilahi
- Zadionchenko V
- Zadra R
- Zagozen P
- Zaidman C
- Zalazar L
- Zaman A
- Zangroniz P
- Zarate J
- Zareczky P
- Zarifis I
- Zdrenghea D
- Zebrack J
- Zena N
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- Zhang W
- Zhang Y
- Zhao R
- Zhou H
- Zidova M
- Zielinski M
- Zieve F
- Zineldine A.
- Zirlik A
- Zucchetti C
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2017
- Field of study
Background: Experimental and clinical data suggest that reducing inflammation without affecting lipid levels may reduce the risk of cardiovascular disease. Yet, the inflammatory hypothesis of atherothrombosis has remained unproved. Methods: We conducted a randomized, double-blind trial of canakinumab, a therapeutic monoclonal antibody targeting interleukin-1β, involving 10,061 patients with previous myocardial infarction and a high-sensitivity C-reactive protein level of 2 mg or more per liter. The trial compared three doses of canakinumab (50 mg, 150 mg, and 300 mg, administered subcutaneously every 3 months) with placebo. The primary efficacy end point was nonfatal myocardial infarction, nonfatal stroke, or cardiovascular death. RESULTS: At 48 months, the median reduction from baseline in the high-sensitivity C-reactive protein level was 26 percentage points greater in the group that received the 50-mg dose of canakinumab, 37 percentage points greater in the 150-mg group, and 41 percentage points greater in the 300-mg group than in the placebo group. Canakinumab did not reduce lipid levels from baseline. At a median follow-up of 3.7 years, the incidence rate for the primary end point was 4.50 events per 100 person-years in the placebo group, 4.11 events per 100 person-years in the 50-mg group, 3.86 events per 100 person-years in the 150-mg group, and 3.90 events per 100 person-years in the 300-mg group. The hazard ratios as compared with placebo were as follows: in the 50-mg group, 0.93 (95% confidence interval [CI], 0.80 to 1.07; P = 0.30); in the 150-mg group, 0.85 (95% CI, 0.74 to 0.98; P = 0.021); and in the 300-mg group, 0.86 (95% CI, 0.75 to 0.99; P = 0.031). The 150-mg dose, but not the other doses, met the prespecified multiplicity-adjusted threshold for statistical significance for the primary end point and the secondary end point that additionally included hospitalization for unstable angina that led to urgent revascularization (hazard ratio vs. placebo, 0.83; 95% CI, 0.73 to 0.95; P = 0.005). Canakinumab was associated with a higher incidence of fatal infection than was placebo. There was no significant difference in all-cause mortality (hazard ratio for all canakinumab doses vs. placebo, 0.94; 95% CI, 0.83 to 1.06; P = 0.31). Conclusions: Antiinflammatory therapy targeting the interleukin-1β innate immunity pathway with canakinumab at a dose of 150 mg every 3 months led to a significantly lower rate of recurrent cardiovascular events than placebo, independent of lipid-level lowering. (Funded by Novartis; CANTOS ClinicalTrials.gov number, NCT01327846.
Structural diversity and defensive properties of diterpenoid alkaloids
- Author
- A Ameri
- A González-Coloma
- A González-Coloma
- A González-Coloma
- A González-Coloma
- A Ulubelen
- Azucena González-Coloma
- C De Inés
- CA Heinz
- CA Mullin
- CF Kukel
- DJ Hardick
- FN Dzhakhangirov
- G Fuente De la
- G Palmer
- IA Bessonova
- J Friese
- JR Bloomquist
- JR Sanes
- KE Panter
- KR Jennings
- L Li
- L Li
- M Atta-ur-Rahman
- M Reina
- M Wink
- MatĂas Reina
- P Dobelis
- P González
- P González
- PB Schiff
- R Nauen
- RW Cohen
- U Seitz
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
A patient-preference cohort study of office versus inpatient uterine polyp treatment for abnormal uterine bleeding.
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2016
- Field of study
Uterine polyps can cause abnormal bleeding in women. Conventional practise is to remove them under general anaesthesia but advances in technology have made it possible to perform polypectomy in the office setting. We conducted a patient-preference study to explore women's preferences for treatment setting and to evaluate the effectiveness and treatment experience of women undergoing uterine polypectomy. Three hundred ninety-nine women with abnormal uterine bleeding who were found to have uterine polyps at diagnostic hysteroscopy were recruited. Office polypectomies were performed in office hysteroscopy clinics, and inpatient procedures were undertaken in operating theatres. Three hundred twenty-four of 399 (81Â %) expressed a preference for office treatment. There was no difference found between office treatment and inpatient treatment in terms of alleviating abnormal uterine bleeding as assessed by patients and in improving disease-specific quality of life. Acceptability was lower and patient pain scores were significantly higher in the office group. When offered a choice of treatment setting for uterine polypectomy, patients have a preference for office over inpatient treatment. Ambulatory gynaecology services should be available within healthcare systems to meet patient demand
Recombinant Antibodies for Ectopic Expression
- Author
- A Bradbury
- A Bradbury
- A Bradbury
- A Crameri
- A Heinrichs
- A Nissim
- A Tramontano
- AD Griffiths
- AS Kang
- AS Perelson
- BA Watkins
- C Chothia
- C Chothia
- C Hamers-Casterman
- C Krebber
- C Milstein
- C Ostermeier
- CF Barbas
- CF Barbas
- D Desplancq
- D Neri
- D Neri
- DC Merz
- DM Crothers
- EA Kabat
- EA Kabat
- EL Davies
- ES Ward
- F Ruberti
- GP Smith
- H Field
- H Gram
- H Orum
- HM Griffin
- HR Hoogenboom
- HR Hoogenboom
- HR Hoogenboom
- I Stengele
- IA Wilson
- IM Tomlinson
- J Buchner
- J Davies
- J Davies
- J Kruif
- J Mccafferty
- J Thompson
- JB Edwards
- JD Marks
- JD Marks
- JD Marks
- JD Marks
- JJ Trill
- JW Larrick
- JW Larrick
- K Takkinen
- KR Tindall
- L Persic
- L Persic
- L Sastry
- M Bauer
- M Duenas
- M Hofnung
- M Ohlin
- MA Frohman
- MA Walls
- MJ Campbell
- MJ Coloma
- MS Neuberger
- NM Low
- NN Anand
- O Perisic
- P Bross
- P Holliger
- P Pack
- R Orlandi
- R Schier
- R Schier
- RE Bird
- RE Bird
- RE Hawkins
- RM Maccallum
- RS Ames
- S Cabilly
- SD Breitling
- SJ Deng
- SL Zebedee
- ST Jones
- T Clackson
- V Chaudhary
- WP Stemmer
- WP Yang
- X Cai
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/1997
- Field of study
Management of patients with antiphospholipid antibodies: what to do in laboratory scenarios that do not fit the guidelines
- Author
- Abdel-Wahab N
- Abisror N
- Alijotas-Reig J
- Alijotas-Reig J
- Alijotas-Reig J
- Alijotas-Reig J
- Amory CF
- Cervera R
- Coloma Bazán E
- Conti F
- Criado-GarcĂa J
- Da Silva FF
- Devreese KM
- Diz-Kucukkaya R
- Erkan D
- Galli M
- Girón-González JA
- Gkrouzman E
- Hindilerden F
- Khawaja M
- Levine SR
- Li X
- Lo HW
- Martinez-Berriotxoa A
- Medina G
- Mekinian A
- Mekinian A
- Merrill JT
- Misasi R
- Ofer-Shiber S
- Pignatelli P
- Pregnolato F
- Radin M
- Rahman A
- Ramires De JesĂşs G
- Riancho-Zarrabeitia L
- Rodziewicz M
- Sciascia S
- Sciascia S
- Skeith L
- Stojanovich L
- Sugiura-Ogasawara M
- Tan BE
- Uthman I
- Volkov I
- Xourgia E
- Yelnik CM
- Zen M
- Publication venue
- 'Informa UK Limited'
- Publication date
- Field of study
Genetically Engineered Antitumor Monoclonal Antibodies
- Author
- A Renda
- A Skerra
- A Skerra
- A Thor
- A Thor
- AF Lobuglio
- AF Lobuglio
- AH Horwitz
- AJ Caton
- AM Guisti
- AS Kang
- AY Liu
- AY Liu
- AY Liu
- B Delaloye
- BA Brown
- BG Sahagan
- BL Daugherty
- BM Mueller
- BM Mueller
- C Cheadle
- C. Queen
- CB Beidler
- CF Barbas
- D Colcher
- D Colcher
- D Colcher
- D Colcher
- D Colcher
- D Givol
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- D Picard
- D Rice
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- DE Milenic
- DJ Jeske
- DL Shawler
- DM Zaller
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- E Barker
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- ES Ward
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- MD Baker
- MG Gallo
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- RJ Leatherbarrow
- RP Junghans
- S Cabilly
- S Junker
- S Matsushita
- S Menard
- S Oikawa
- S Tonegawa
- SD Gillies
- SD Gillies
- SD Gillies
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- SL Morrison
- SL Morrison
- SL Zebedee
- T Clackson
- T Doetschman
- T Gerster
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- UH Weidle
- VG Johnson
- VK Chaudhary
- VK Chaudhary
- VT Oi
- VT Oi
- W Zimmerman
- WD Huse
- Y Nishimura
- Z Steplewski
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/1995
- Field of study
Insect ryanodine receptors: molecular targets for novel pest control chemicals
- Author
- A Gonzalez-Coloma
- A Herrmann-Frank
- A Seo
- A Sonnleitner
- A Verkhratsky
- AE MacKenzie
- AL Waterhouse
- AP Timerman
- AR Marks
- BP Pepper
- CF Perez
- CH George
- D Cordova
- Daniel Cordova
- David B. Sattelle
- DJ Jenden
- DL Bennett
- DL Clapper
- DM Balshaw
- DM Bers
- E Lehmberg
- E Puente
- EF Rogers
- F Fusi
- F Zhao
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- FC Riddoch
- G Giannini
- G Kuwajima
- G Meissner
- G Meissner
- G Thiene
- GG Du
- GP Lahm
- H Matsuda
- H Oyamada
- H Takeshima
- H Takeshima
- I Zimanyi
- II Serysheva
- IN Pessah
- IN Pessah
- J Nakai
- J Seok
- J Suko
- JA Copello
- JA Copello
- JJ MacKrill
- JJ Zhang
- K Otsu
- K Paul-Pletzer
- K Tsubata
- KA Quane
- L Ottini
- L Xu
- L Xu
- M Fill
- M Hohenegger
- M Radermacher
- M Schmitt
- M Tohnishi
- M Yano
- MJ Berridge
- MJ Berridge
- MJ Berridge
- MW Ledbetter
- N Bai
- N Hadad
- N Tiso
- O Vazquez-Martinez
- PB Allen
- PR Jeffries
- R Coronado
- R Nauen
- R Sitsapesan
- RE Heal
- S Currie
- S Hamilton
- SE Lehnart
- SO Marx
- SO Marx
- T Hall
- T Masaki
- T Masaki
- T Murayama
- Timothy R. Cheek
- TS Scott-Ward
- U Ebbinghaus-Kintscher
- U Ebbinghaus-Kintscher
- V Sorrentino
- X Xu
- XH Wehrens
- Y Ogawa
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
A review on recent research results on bio-effects of plant essential oils against major Coleopteran insect pests
- Author
- Abbas-Azimi R
- Abbasipour H
- Abd El-Galeil SA
- Amirmohammadi F
- Arabi F
- Asawalam EF
- Asgar Ebadollahi
- Athanassiou CG
- Ayvaz A
- Bachrouch O
- Bakkali F
- Bassole IHN
- Batooli H
- Bekele J
- Ben Jemâa JM
- Benelli G
- Benhalima H
- Benzi V
- Bertoli A
- Bertuzzi G
- Betancur RJ
- Betancur-Galvis L
- Bittner ML
- Brito JP
- Burt S
- Caballero-Gallardo K
- Chaubey MK
- Chaubey MK
- Chowdhury JU
- Chu SS
- Chu SS
- Chu SS
- Chu SS
- Chu SS
- Cosimi S
- De-Oliveira AC
- Denloye AA
- Descamps LR
- Dieumou FE
- Dubey NK
- Ebadollahi A
- Ebadollahi A
- Ebadollahi A
- Ebadollahi A
- Ebadollahi A
- Ebadollahi A
- El Nagar TFK
- Enan EE
- Fang R
- Fazolin M
- Franca SM
- Garcia M
- Garcìa M
- Ghannadi A
- Ghosh A
- Gonzalez-Coloma A
- Hagstrum DW
- Handa SS
- Hargreaves K
- Hart PH
- Hedjal-Chehheb M
- Heydarzade A
- Ilboudo Z
- Isikber AA
- Islam R
- Isman MB
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- Jalal Jalali Sendi
- Kamal GM
- Kamaraj C
- Karemu CK
- Kerdchoechuen O
- Ketoh GK
- Khadria A
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- Khani A
- Kim J
- Kim SI
- Knio KM
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- Kordali S
- Kotan R
- Koul O
- Lahlou M
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- Lancelle HG
- Laznik Z
- Lee BH
- Li WQ
- Liang Y
- Lima RK
- Liu CH
- Liu CH
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- Liu ZL
- Liu ZL
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- Liu ZL
- Lopez MD
- Maciel MV
- Maedeh M
- Mahmoudvand M
- Mauchline AL
- Mossi AJ
- Murray AP
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- Negahban M
- Negahban M
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- Pickett AJ
- Pimentel MAG
- Qin W
- Rali T
- Rasouli I
- Rattan RS
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- Romeilah RM
- Rozman V
- Sahaf BZ
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- Semnani KM
- Senthilkumar A
- Senthilnathan S
- Shukla P
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- Stefanazzi N
- Suthisut D
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- Taghizadeh-Sarikolaei A
- Taghizadeh-Saroukolai A
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- Zhang JS
- Ziaee M
- Zoubiri S
- Publication venue
- 'Informa UK Limited'
- Publication date
- Field of study
Monoclonal antibody therapy
- Author
- A Armstrong
- A Aviles
- A Bernard
- A Chachoua
- A Chan
- A Chaudhry
- A Cohen
- A Conconi
- A Cortelezzi
- A Demiden
- A Diaz
- A Forero
- A Hekman
- A Hjelm Skog
- A Katzenwadel
- A Khorana
- A Lipton
- A Mittelman
- A Mittelman
- A Morabito
- A Mountain
- A Osterborg
- A Ribas
- A Sandler
- A Seidman
- A Younes
- A Ziada
- AA Noujaim
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- AD Jensen
- AD Seidman
- AF LoBuglio
- AF LoBuglio
- AL Schecter
- AL Yu
- AM Jubb
- AM Scott
- AM Scott
- AM Scott
- AM Scott
- AM Scott
- AN Houghton
- AR Tan
- AS Goustin
- AT Chan
- AU Buzdar
- AU Buzdar
- AV Maker
- AV Maker
- AW Tolcher
- AX Zhu
- AY Liu
- AY Liu
- B Baslund
- B Bodey
- B Burtness
- B Coiffier
- B Coiffier
- B Escudier
- B Klein
- B Leyland-Jones
- B Ramaswamy
- B Vincenzi
- BA Brown
- BA Diamond
- BA Lindstrom
- BC Ekstrand
- BH Kushner
- BI Eisenberg
- BI Rini
- BI Rini
- BJ Giantonio
- BJ Giantonio
- BJ Scallon
- BP Avner
- BP Coudert
- BR Straatsma
- BS Choi
- C Bokemeyer
- C Buske
- C Delbaldo
- C Emmanouilides
- C Kollmannsberger
- C Kosmos
- C Nabhan
- C Pinto
- C Thieblemont
- C Wiseman
- CA White
- CD Thienelt
- CF Molthoff
- CG Lee
- CG Willett
- CH Crane
- CH Thompson
- CJ Punt
- CL Vogel
- CM Wendtner
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- D Brooks
- D Cunningham
- D Herlyn
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- D Huhn
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- E Barker
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- E Feldman
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- F Boue
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- YH Chen
- YH Kim
- YJ Chua
- YS Kim
- Z Steplewski
- Z Varga
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2009
- Field of study
Molecular Variants Characterization in Protein Therapeutics Development
- Author
- A Agarwal
- A Amoresano
- A Beck
- A Beck
- A Blank
- A Bond
- A Clements
- A Combes
- A Krezel
- A McAuley
- A Noguchi
- A Okumura
- AB Joshi
- AB Joshi
- AC Lazar
- AF Labrijn
- AG Ferrige
- AH Merry
- AH Que
- AJ Alexander
- AJ Cordoba
- AK Mandal
- AL Burlingame
- AM Salzano
- AM Sinclair
- AR Karala
- B Aguirre
- B Domon
- B Gesslbauer
- B Herbert
- B Kuster
- B Saul
- B Schmidt
- B Yan
- BA Budnik
- BA Garcia
- BA Garcia
- BN Violand
- BR Branchini
- BS Kendrick
- BT Chait
- BT Chait
- C Chumsae
- C Chumsae
- C Legros
- C Sottani
- C Temporini
- C Trachsel
- CA Scorer
- CD Calvano
- CE Voorter
- CF Goochee
- CG Cupples
- CI Murray
- CK Riener
- CL Gatlin
- CM Ryan
- CS Barnes
- CT Yuen
- D Bilusich
- D Chelius
- D Chelius
- D Guo
- D Piszkiewicz
- D Ren
- D Ren
- D Ren
- D Volke
- D Wen
- DB Volkin
- DD Banks
- DE McNulty
- DF Clark
- DJ Harvey
- DJ Harvey
- DJ Harvey
- DJ Janecki
- DM Carlson
- DM Sheeley
- DR Muller
- DS Dalpathado
- DS Rehder
- DT Liu
- E Canova-Davis
- E Delorme
- E Gimenez
- E Mirgorodskaya
- EA Padlan
- EB Kramer
- EM Yoo
- EQ Lawson
- ER Lacy
- ES Witze
- EV Petrotchenko
- EY Chi
- F Marcus
- F Torta
- FA Gala
- G Bogosian
- G Gaza-Bulseco
- G Jones
- G Mack
- G Walsh
- GD Pipes
- GE Reid
- GI Tous
- GM Edelman
- GM Neumann
- GR Kleemann
- GR Moura
- H Aono
- H Dorai
- H Geyer
- H Ito
- H Iwasaki
- H Lis
- H Liu
- H Liu
- H Liu
- H Liu
- H Schellekens
- H Stockinger
- H Yamaguchi
- H Yang
- H Zhang
- H Zhang
- HI Kim
- HJ Andreazza
- HS Gadgil
- HS Gadgil
- HS Lu
- HST Dorai
- I Apostol
- I Mahmood
- IH Yuk
- IR Correia
- J Jebanathirajah
- J Langridge
- J Ling
- J Parker
- J Parker
- J Qi
- J Schuurman
- J Schuurman
- J Wu
- J Wypych
- J Yang
- J Zhao
- JC Aon
- JD Fowler
- JE Syka
- JJ Gerschler
- JJ Gorman
- JL Stephenson Jr
- JR Engen
- JR Knowles
- JS Lebkowski
- JS Philo
- JS Philo
- JS Philo
- JT Watson
- JW Bloom
- K Beebe
- K Deguchi
- K Gupta
- K Hakansson
- K Hakansson
- K Hashimoto
- K Ko
- K Polec Pawlak
- K Sparbier
- K Tanaka
- K Yamaguchi
- KA Johnson
- KF Geoghegan
- KF Medzihradszky
- KG Huwiler
- KJ Morrow Jr
- Kolfschoten M Neut van der
- KR Anumula
- L Huang
- L Jia
- L Krasny
- L Runkel
- L Wang
- L Yu
- LJ Brady
- M Adamczyk
- M Butler
- M Eng
- M Guo
- M Haniu
- M Karas
- M Kleinova
- M Kvaratskhelia
- M Le
- M Liu
- M Masuda
- M Mormann
- M Nili
- M Oh-eda
- M Trexler-Schmidt
- M Wan
- M Wuhrer
- M Wuhrer
- M Wuhrer
- M Zhang
- MA Ritchie
- MA Smith
- MA Wouters
- MD Jones
- MF Bean
- MI Catalina
- MJ Coloma
- MJ Huddleston
- MJ Thies
- MM Siegel
- MV Trivedi
- N Buren Van
- N Imai
- N Kawasaki
- N Nagano
- N Sethuraman
- N Siuti
- N Viseux
- N Viseux
- NE Robinson
- NL Kelleher
- NM Karabacak
- NM Reynolds
- O Mozziconacci
- O Mozziconacci
- O Palacios
- ON Jensen
- P Du
- P Giron
- P Hossler
- P Liu
- P Pristatsky
- P Umana
- PE Rao
- Pierre Stallforth
- PJ Hogg
- PJ Hogg
- PM Gehrig
- Q Shu
- R Apweiler
- R Jefferis
- R Jefferis
- R Malhotra
- R Mhatre
- R Tyler-Cross
- RA Laine
- RA Zubarev
- RA Zubarev
- RA Zubarev
- RAKNA Zubarev
- RAKNA Zubarev
- RB Kirkpatrick
- RC Aalberse
- RC Aalberse
- RF Rosenberger
- RG Keck
- RG Werner
- RH Fillingame
- RJ Harris
- RJ Harris
- RJ Rose
- RJ Sola
- RL Shields
- RR Seipert
- RS Zee
- RW Nelson
- RW Nielsen
- S Amon
- S Cao
- S Catak
- S Choi
- S Gu
- S Iyer
- S Kalkhof
- S Kamoda
- S Krapp
- S Perez-Rafael
- S Sinha
- S Sinha
- SA Brooks
- SA Carr
- SA Carr
- SA Svarovsky
- SD Patterson
- SG Bell
- SH Chen
- SK Singh
- SK Wright
- SL Cohen
- SL Cook
- SL Wu
- SL Wu
- SL Wu
- SR Brych
- SS Thakur
- T Arakawa
- T Ashton
- T Azuma
- T Dingermann
- T Fischer
- T Geiger
- T Kibe
- T Lee
- T Martinez
- T Rispens
- T Rispens
- T Rispens
- T Xiang
- TA Kunkel
- TD Wood
- TJ Dayhuff
- TL Calderone
- TM Dillon
- TM Dillon
- TM Dillon
- TP Wallis
- TS Raju
- TS Raju
- TY Yen
- TY Yen
- U Bahr
- U Bahr
- V Katta
- V Nene
- V Schnaible
- VA Mikhailov
- VN Reinhold
- VP Bhavanandan
- W Feng
- W Jiskoot
- W Maret
- W Maret
- W Maret
- W Maret
- W Maret
- W Morelle
- W Morelle
- W Morelle
- W Zhang
- W Zhang
- WE Gall
- WE Gall
- WR Alley Jr
- WR Gray
- X Su
- XC Yu
- XN Chen
- Y Fukuyama
- Y Huang
- Y Kaneko
- Y Mimura
- Y Wada
- Y Wada
- Y Wang
- Y Yang
- Y Young
- Y Zhang
- YD Liu
- YM Fung
- Z Pan Zhang
- Z Wang
- Z Zhang
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study