Paraoxonase and Arylesterase Activities, Lipid Profile, and Oxidative Damage in Experimental Ischemic Colitis Model

Objective. In the present study, since PON1 is known as an HDL-associated antioxidant enzyme that inhibits the oxidative modification of LDL and oxidative stress plays a role in the pathogenesis of mesenteric ischemia, we investigated the changes in PON1 activity and lipid profile in an experimental ischemic colitis model. Methods. Forty male Wistar albino rats were divided into two groups: the control group (N = 15) and the experimental group (N = 25). All animals were anesthetized with ether and ketamine anesthesia to undergo a midline laparotomy. Ischemic colitis was induced by marginal vessel ligation in the splenic flexura (devascularization process). A sham laparotomy was performed in the control group. All animals were sacrificed on the seventh postoperative day. Oxidative stress marker (malonyldialdehyde, MDA), lipid profile, and paraoxonase (PON-1) and arylesterase activities were determined. Histopathological evaluation was done under light microscopy, after sectioning and staining with hematoxyline and eosin. Statistical analysis was conducted using Student's t-test and Mann-Whitney U test, and P 0.05).Conclusions. PON1 and arylesterase play an important role in the pathophysiology of ischemic colitis

Implantable vascular access port-associated bloodstream infection caused by rhizobium radiobacter: A case report

Rhizobium radiobacter is an uncommon opportunistic pathogen present in soil. It has been particularly associated with indwelling intravascular devices in immunocompromised patients. Reported herein is a case of R. radiobacter bloodstream infection associated with an implantable vascular access port, which was easily controlled with antimicrobial treatment and did not require removal of the intravascular device, in a child diagnosed with acute lymphoblastic leukemia. Also included is a review of the pertinent literature regarding the clinical presentation and management of R. radiobacter infections in the childhood period

Change of Laboratory Findings of Acute Epstein-Barr Virus Infection According to Age Groups Akut Epstein-Barr Enfeksiyonunun Yaş Gruplarına Göre Laboratuvar Bulgularının Değişimi

Objective: The aim of this study was to investigate the clinical and laboratory findings of patients diagnosed with acute Epstein-Barr virus (EBV) infection according to age groups. Material and Methods: Patients diagnosed with acute EBV infection were enrolled in this cross-sectional study. Results: Totally, 894 patients diagnosed as acute EBV infection were included in the study. Of them, 540 (60.5%) patients were males (male/fe-male=1.52). Median age of the patients was four years (57 days-18 years). Seropositivity rate increased statistically as age increased (47.9%, 73.8% and 87.2%, respectively). Seventy patients were admitted with clinical presentation of IM with a median age of seven years (3 years-18 years). Serum median hemoglobin, leukocyte, thrombocyte, mean platelet values were statistically signficifantly different according to age groups (for all p15 years old of age (29.3%, 17.1% and 7.7%, respectively, p15 years old of age [304 (49.4%), 204 (33.2%), 107 (17.4%), respectively, p= 0.04]. Conclusion: EBV infection causes different laboratory findings and clinical presentations according to age groups

The value of inflammatorymarkers and biochemicalparameters in assessment of severityof acute pancreatitis

AMAÇ : Akut pankreatit hala önemli bir patolojidir. Bu çalışmamızda akut pankreatit nedeni ile tedavi ettiğimiz hastalarda ciddi pankreatit gelişimine gösterebilecek inflamatuar markırlar ve bio- kimyasal parametreler retrospektif olarak ince- lendi. GEREÇ VE YÖNTEM : Mayıs 2011 ile Ekim 2011 tarihleri arsında akut pankreatit tanısı alan 52 hasta retrospektif olarak incelendi. Hastalar BTciddiyet indeksine göre hafif ve ciddi pankreatit olarak 2 gruba ayrıldı . Hastaların yaş,cinsiyet, Laboratuar ve görüntüleme yöntemlerinin sonuçları, ,hastanede yatış süreleri, morbidite ve mortalite sonuçları toplandı. Sonuçlar SPSS 17 istatstik programında değerlendirildi. BULGULAR: Retrospektif olarak incelenen52 hastanın 39u kadın ve 13ü erkekti. Hastaların yaş ortalaması 56.817.2 (19-97 arası) idi. Hastaların 30u hafif (BTindeksi A-B- C), 22si ciddi (BTindeksi D-E) olarak sınıflandırıldı. CRPdeğerleri ciddi pankreatit grubunda daha yüksek olmasına rağmen istatistiksel olarak anlamlı değildi. Ağır pankreatit grubunda Lökosit sayısı ve serum glukoz değerleri hafif pankreatit grubuna göre istatistiksel olarak anlamlı derecede yüksek olarak bulundu. ( p 0.006 ve p 0.009). SONUÇLAR: Bu çalışma ciddi pankreatitli hasta grubunda lökosit sayımı ve kan şeker düzeylerinin hafif pankreatitli hastalara göre anlamlı olarak yüksek seyrettiğini göstermiştir. Bu laboratuar testleri pankreatitli hastaların prognozunu balirlemede yardımcı olabilir.OBJECTİVE : Acute pancreatitis is still an important pathology. In this study, we analyzed retros- pectively the predictive value of inflammatory markers and biochemical parameters for developement of severe pancreatitis. METHODS: Fifty-two patients with diagnosis of acute pancreatitis were retrospectively studied in between May 2011 to October 2011.The patients were separated in two groups according to CTseverity indexs as mild and severe pancreatitis. Data about patients age,gender, laboratory and imaging results ,duration of hospitalization, morbidity and mortality rates were collected. The statistical analysis was performed with SPSS 17 program. RESULTS: There were 39 women and 13 men patients. The median age was 56.8±17.2 (Ran- ge:19-97). There were 30 mild and 22 severe pancreatitis. Although CRPvalue was higher in severe pancreatitis it was not statistically meaningful. The leucocyte count and gluco- se level were statistically higher in severe pancreatitis group (p value0.006 and p value0.009 respectively) CONCLUSION : This study demonstrated that leucocyte cound and glucose level can be predictive laboratory tests for severe pancreatitis

Primary Nasal Tuberculosis in A 10-Year-Old Girl

Nasal tuberculosis is a rare clinical entity which mainly presents in elderly people. Nasal tuberculosis has always been considered to be secondary to tuberculosis of the lungs, and in rare instances it is a primary infection, usually when mycobacteria are inhaled. We describe the case of a 10-year-old girl who was successfully treated for primary nasal tuberculosis. This patient is one of the very few children who have been reported to have primary nasal tuberculosis.PubMedWoSScopu

Kluyvera ascorbata infections in children: a case series

Kluyvera is a relatively newly described member of the Enterobacteriaceae family that rarely causes infections in humans. In the pediatric population, it is described in association with clinically significant infections ranging from urinary tract infections to sepsis with multiorgan failure. Our aim is to determine the clinical significance of K. ascorbata infections in the pediatric population at our institution. We retrospectively analyzed clinical microbiology data as from 2006 and identified four clinically significant isolates in this period. The isolates were from four cases who presented with sepsis, bacteremia associated with central venous catheter, pyelonephritis and intraabdominal collection. The ages of these patients ranged between seven months to 17 years. All patients received prompt antimicrobial treatment on the basis of susceptibility testing and good clinical response was obtained in all patients. Successful treatment options include third-generation cephalosporins, aminoglycosides, betalactams with beta-lactamase inhibitors and carbapenems. Clinicians should be aware of the spectrum of disease and increasing clinical importance associated with this pathogen