Firenze in guerra 1940-1944 : Catalogo della mostra storico-documentaria (Palazzo Medici Riccardi, ottobre 2014-gennaio 2015)

The volume reproduces the documentary path of the exhibition Florence in the war 1940-1944 promoted by the Historical Institute of the Resistance in Tuscany on the occasion of the 70th anniversary of the Resistance and Liberation. Introductory contributions illustrate the work in progress who accompanied the exhibition project and intend to guide the reader through a series of historiographical questions at the center of the exhibition: the centrality of the 1940-1943 phase, which has hitherto remained in the background, the economic transformations, the knots of consent and social control, the characters of the German occupation, the role of the Church and the complex plot of the Florentine Resistance. The aim of the research was to closely investigate the impact of the war on the population of a large urban area, trying to highlight its specificity and connections with the national framework.Il volume riproduce il percorso documentario della mostra Firenze in guerra 1940-1944 promossa dall’Istituto Storico della Resistenza in Toscana in occasione del 70\ub0 anniversario della Resistenza e della Liberazione. I contributi introduttivi illustrano il work in progress che ha accompagnato il progetto espositivo e intendono guidare il lettore attraverso una serie di questioni storiografiche al centro della mostra: la centralit\ue0 della fase 1940-1943, finora rimasta sullo sfondo, le trasformazioni economiche, i nodi del consenso e del controllo sociale, i caratteri dell’occupazione tedesca, il ruolo della Chiesa e la complessa trama della Resistenza fiorentina. Obiettivo della ricerca \ue8 stato quello di indagare da vicino l’impatto della guerra sulla popolazione di una grande area urbana, provando a evidenziarne specificit\ue0 e connessioni con la cornice nazionale

Identification of IQCH as a calmodulin-associated protein required for sperm motility in humans

Summary: Sperm fertilization ability mainly relies on proper sperm progression through the female genital tract and capacitation, which involves phosphorylation signaling pathways triggered by calcium and bicarbonate. We performed exome sequencing of an infertile asthenozoospermic patient and identified truncating variants in MAP7D3, encoding a microtubule-associated protein, and IQCH, encoding a protein of unknown function with enzymatic and signaling features. We demonstrate the deleterious impact of both variants on sperm transcripts and proteins from the patient. We show that, in vitro, patient spermatozoa could not induce the phosphorylation cascades associated with capacitation. We also provide evidence for IQCH association with calmodulin, a well-established calcium-binding protein that regulates the calmodulin kinase. Notably, we describe IQCH spatial distribution around the sperm axoneme, supporting its function within flagella. Overall, our work highlights the cumulative pathological impact of gene mutations and identifies IQCH as a key protein required for sperm motility and capacitation