APPROCCIO CLINICO E RIABILITATIVO AL PAZIENTE PROTESIZZATO D'ARTO INFERIORE

Nella chirurgia sostitutiva protesica, ripercorrendo le tappe riabilitative e analizzandone le modalità e le tecniche, si evince che è possibile permettere al paziente il riapprendimento della corretta deambulazione con la riorganizzazione di tutte le fasi e della gestualità corrente per il reinserimento efficace nel contesto sociale di appartenenza. Oltre che dal punto di vista puramente motorio, il soggetto deve essere seguito anche sotto l’aspetto della psicomotricità e nel rispetto di importanti esigenze psicologiche. Viene sorretto, incoraggiato, ma soprattutto responsabilizzato sul fatto che per la ripresa completa si rende indispensabile la sua partecipazione attiva e la costanza dell’impegno. I riflessi pratici di una guarigione efficace e completa sono quindi estremamente proficui per il soggetto, il quale avverte in sé la capacità di ottemperare all’impegno del proprio recupero; seppur con stati d’ansia che insidiano il suo equilibrio, egli tenderà a proiettarsi nel suo futuro che quindi non apparirà denso di incognite. Non vi sarà commiserazione né emarginazione, ma voglia di vivere in una società che, anche se disumanizza i rapporti fra le differenti fasce di età, offre interessi e spazi per quanti sappiano organizzare la propria esistenza senza frustrazioni, remore e tentennamenti. La riabilitazione del protesizzato è un processo complesso perché non riguarda solamente il recupero della funzionalità della singola articolazione ma è rivolto a un riaddestramento globale del soggetto a una nuova modalità di vita relazionale. Il programma riabilitativo, quindi, deve essere personalizzato sul singolo e deve proporsi obiettivi differenti in base alle condizioni generali (anche cognitive). È necessario rendere possibile il raggiungimento di un livello di autosufficienza e autonomia motoria tale da permettere il ritorno alle normali attività di vita quotidiana

Video Smoothing of Aggregates of Streams with Bandwidth Constraints

Compressed variable bit rate (VBR) video transmission is acquiring a growing importance in the telecommunication world. High data rate variability of compressed video over multiple time scales makes an efficient bandwidth resource utilization difficult to obtain. One of the approaches developed to face this problem are smoothing techniques. Various smoothing algorithms that exploit client buffers have been proposed, thus reducing the peak rate and high rate variability by efficiently scheduling the video data to be transmitted over the network. The novel smoothing algorithm proposed in this paper, which represents a significant improvements over the existing methods, performs data scheduling both for a single stream and for stream aggregations, by taking into account available bandwidth constraints. It modifies, whenever possible, the smoothing schedule in such a way as to eliminate frame losses due to available bandwidth limitations. This technique can be applied to any smoothing algorithm already present in literature and can be usefully exploited to minimize losses in multiplexed stream scenarios, like Terrestrial Digital Video Broadcasting (DVB-T), where a specific known available bandwidth must be shared by several multimedia flows. The developed algorithm has been exploited for smoothing stored video, although it can also be quite easily adapted for real time smoothing. The obtained numerical results, compared with the MVBA, another smoothing algorithm that is already presented and discussed in literature, show the effectiveness of the proposed algorithm, in terms of lost video frames, for different multiplexed scenarios

Gambling at the time of COVID-19: results from interviews in an Italian sample of gamblers

© 2022 The Author(s). Published by Elsevier Ltd on behalf of International Society for the Study of Emerging Drugs. https://creativecommons.org/licenses/by/4.0/The coronavirus pandemic affected the life of those suffering from addic- tive behaviors often confined to prolonged periods of self-isolation. To explore the variation of symptoms related to gambling, 46 outpatients of the mental health services in the Trento Province were invited to take part in a phone interview at the start of the national lockdown. Although only 2.17% increased gambling activity during this period, half of the sample (50.00%) experienced irritability, mood fluctuation (43.48%) and anxiety (39.13%). Follow-up studies should assess modifications in their behaviors that occurred after the reopening of gambling venues.Peer reviewedFinal Published versio

Dose-escalated pelvic radiotherapy for prostate cancer in definitive or postoperative setting

Purpose Given the absence of standardized planning approach for clinically node-positive (cN1) prostate cancer (PCa), we collected data about the use of prophylactic pelvic irradiation and nodal boost. The aim of the present series is to retrospectively assess clinical outcomes after this approach to compare different multimodal treatment strategies in this scenario. Methods Data from clinical records of patients affected by cN1 PCa and treated in six different Italian institutes with prophylactic pelvic irradiation and boost on pathologic pelvic lymph nodes detected with CT, MRI or choline PET/CT were retrospectively reviewed and collected. Clinical outcomes in terms of overall survival (OS) and biochemical relapse-free survival (b-RFS) were explored. The correlation between outcomes and baseline features (International Society of Urological Pathology-ISUP pattern, total dose to positive pelvic nodes 60 Gy, sequential or simultaneous integrated boost (SIB) administration and definitive vs postoperative treatment) was explored. Results ISUP pattern < 2 was a significant predictor of improved b-RFS (HR = 0.3, 95% CI 0.1220-0.7647, P = 0.0113), while total dose < 60 Gy to positive pelvic nodes was associated with worse b-RFS (HR = 3.59, 95% CI 1.3245-9.741, P = 0.01). Conversely, treatment setting (postoperative vs definitive) and treatment delivery technique (SIB vs sequential boost) were not associated with significant differences in terms of b-RFS (HR = 0.85, 95% CI 0.338-2.169, P = 0.743, and HR = 2.39, 95% CI 0.93-6.111, P = 0.067, respectively). Conclusion Results from the current analysis are in keeping with data from literature showing that pelvic irradiation and boost on positive nodes are effective approaches. Upfront surgical approach was not associated with better clinical outcomes

Involvement of GTA protein NC2β in Neuroblastoma pathogenesis suggests that it physiologically participates in the regulation of cell proliferation

<p>Abstract</p> <p>Background</p> <p>The General Transcription Apparatus (GTA) comprises more than one hundred proteins, including RNA Polymerases, GTFs, TAFs, Mediator, and cofactors such as heterodimeric NC2. This complexity contrasts with the simple mechanical role that these proteins are believed to perform and suggests a still uncharacterized participation to important biological functions, such as the control of cell proliferation.</p> <p>Results</p> <p>To verify our hypothesis, we analyzed the involvement in Neuroblastoma (NB) pathogenesis of GTA genes localized at 1p, one of NB critical regions: through RT-PCR of fifty eight NB biopsies, we demonstrated the statistically significant reduction of the mRNA for NC2β (localized at 1p22.1) in 74% of samples (p = 0.0039). Transcripts from TAF13 and TAF12 (mapping at 1p13.3 and 1p35.3, respectively) were also reduced, whereas we didn't detect any quantitative alteration of the mRNAs from GTF2B and NC2α (localized at 1p22-p21 and 11q13.3, respectively). We confirmed these data by comparing tumour and constitutional DNA: most NB samples with diminished levels of NC2β mRNA had also genomic deletions at the corresponding locus.</p> <p>Conclusion</p> <p>Our data show that NC2β is specifically involved in NB pathogenesis and may be considered a new NB biomarker: accordingly, we suggest that NC2β, and possibly other GTA members, are physiologically involved in the control of cell proliferation. Finally, our studies unearth complex selective mechanisms within NB cells.</p

Head–neck melanoma: Clinical, histopathological and prognostic features of an Italian multicentric study

factor. As regards the scalp, some studies indicate a particularly aggressive biological behaviour for this anatomical localisation. Objectives: In this multicentric study, data regarding head–neck melanoma (HNM) have been revised. Methods: The design of the study included two main phases. In this retrospective study, data regarding HNM have been collected and analysed. Results: In summary, our data suggest that the posterior neck is the area most affected by thicker melanomas. Cheeks and neck melanoma are associated with reduced disease‐free years of life and overall survival compared with all other sites of HNM. Conclusions: This study provides useful information in defining the clinical features of HNM, thus improving diagnosis and treatment strategies

Head–neck melanoma: Clinical, histopathological and prognostic features of an Italian multicentric study

BackgroundPrimitive location of melanoma could be a relevant prognostic factor. As regards the scalp, some studies indicate a particularly aggressive biological behaviour for this anatomical localisation.ObjectivesIn this multicentric study, data regarding head-neck melanoma (HNM) have been revised.MethodsThe design of the study included two main phases. In this retrospective study, data regarding HNM have been collected and analysed.ResultsIn summary, our data suggest that the posterior neck is the area most affected by thicker melanomas. Cheeks and neck melanoma are associated with reduced disease-free years of life and overall survival compared with all other sites of HNM.ConclusionsThis study provides useful information in defining the clinical features of HNM, thus improving diagnosis and treatment strategies.Primitive location of melanoma could be a relevant prognostic factor. In this multicentric study, data regarding head-neck melanoma (HNM) have been revised.Our data suggest that posterior neck is the area most affected by thicker melanomas. Cheeks and neck melanoma are associated with reduced disease-free years of life and overall survival compared with all other sites of HNM.This study provides useful information in defining the clinical features of HNM, thus improving diagnosis and treatment strategies. imag

Preliminary Assessment of Radiolysis for the Cooling Water System in the Rotating Target of {SORGENTINA}-{RF}

The SORGENTINA-RF project aims at developing a 14 MeV fusion neutron source featuring an emission rate in the order of 5-7 x 10(13) s(-1). The plant relies on a metallic water-cooled rotating target and a deuterium (50%) and tritium (50%) ion beam. Beyond the main focus of medical radioisotope production, the source may represent a multi-purpose neutron facility by implementing a series of neutron-based techniques. Among the different engineering and technological issues to be addressed, the production of incondensable gases and corrosion product into the rotating target deserves a dedicated investigation. In this study, a preliminary analysis is carried out, considering the general layout of the target and the present choice of the target material