171 research outputs found
Electron Bernstein waves emission in the TJ-II Stellarator
Taking advantage of the electron Bernstein waves heating (EBWH) system of the
TJ-II stellarator, an electron Bernstein emission (EBE) diagnostic was
installed. Its purpose is to investigate the B-X-O radiation properties in the
zone where optimum theoretical EBW coupling is predicted. An internal movable
mirror shared by both systems allows us to collect the EBE radiation along the
same line of sight that is used for EBW heating. The theoretical EBE has been
calculated for different orientations of the internal mirror using the TRUBA
code as ray tracer. A comparison with experimental data obtained in NBI
discharges is carried out. The results provide a valuable information regarding
the experimental O-X mode conversion window expected in the EBW heating
experiments. Furthermore, the characterization of the radiation polarization
shows evidence of the underlying B-X-O conversion process.Comment: 21 pages, 14 figure
Mahogunin Ring Finger 1 Is Required for Genomic Stability and Modulates the Malignant Phenotype of Melanoma Cells.
The mouse mahoganoid mutation abrogating Mahogunin Ring Finger-1 (MGRN1) E3 ubiquitin ligase expression causes hyperpigmentation, congenital heart defects and neurodegeneration. To study the pathophysiology of MGRN1 loss, we compared Mgrn1-knockout melanocytes with genetically matched controls and melan-md1 (mahoganoid) melanocytes. MGRN1 knockout induced a more differentiated and adherent phenotype, decreased motility, increased the percentage of cells in the S phase of the cell cycle and promoted genomic instability, as shown by stronger γH2AX labelling, increased burden of DNA breaks and higher abundance of aneuploid cells. Lack of MGRN1 expression decreased the ability of melanocytes to cope with DNA breaks generated by oxidizing agents or hydroxyurea-induced replicative stress, suggesting a contribution of genomic instability to the mahoganoid phenotype. MGRN1 knockout in B16-F10 melanoma cells also augmented pigmentation, increased cell adhesion to collagen, impaired 2D and 3D motility and caused genomic instability. Tumors formed by Mgrn1-KO B16-F10 cells had lower mitotic indices, fewer Ki67-positive cells and showed a trend towards smaller size. In short-term lung colonization assays Mgrn1-KO cells showed impaired colonization potential. Moreover, lower expression of MGRN1 is significantly associated with better survival of human melanoma patients. Therefore, MGRN1 might be an important phenotypic determinant of melanoma cells
Space-times admitting a three-dimensional conformal group
Perfect fluid space-times admitting a three-dimensional Lie group of
conformal motions containing a two-dimensional Abelian Lie subgroup of
isometries are studied. Demanding that the conformal Killing vector be proper
(i.e., not homothetic nor Killing), all such space-times are classified
according to the structure of their corresponding three-dimensional conformal
Lie group and the nature of their corresponding orbits (that are assumed to be
non-null). Each metric is then explicitly displayed in coordinates adapted to
the symmetry vectors. Attention is then restricted to the diagonal case, and
exact perfect fluid solutions are obtained in both the cases in which the fluid
four-velocity is tangential or orthogonal to the conformal orbits, as well as
in the more general "tilting" case.Comment: Latex 34 page
Clinical study of cervicogenic headache
The cervicogenic headache was studied to get a deeper insight into the pathogenetic mechanisms, and clinical
presentation forms. Material and Methods. Eleven female patients, ranging from 34 to 81 years-old, with cervicogenic headaches, were studied and correlated with NMR images of the cervical spine. Results. Intense neck pain irradiated to parietal, occipital, temporal regions, and shoulders were correlated with NMR images of the degenerated cervical spine. Also, lumbar spine pathology, osteoporosis, gallstones, and cholecystitis were found. The following associated neurological, neurobehavioral, and metabolic diseases comorbidities were observed, such as blood hypertension, diabetes,
obesity, hypothyroidism, partial epilepsy, tremor, familial stress, memory, sleep disorders, and dizziness. Also, we found mixed cervicogenic headaches and migraines in 50% of cases studied. Conclusion. The headache and the associated images of cervical pathology have been clinically interpreted as cardinal signs of cervicogenic headache. A mixed cervicogenic mixed type was observed
G_2 Perfect-Fluid Cosmologies with a proper conformal Killing vector
We study the Einstein field equations for spacetimes admitting a maximal
two-dimensional abelian group of isometries acting orthogonally transitively on
spacelike surfaces and, in addition, with at least one conformal Killing
vector. The three-dimensional conformal group is restricted to the case when
the two-dimensional abelian isometry subalgebra is an ideal and it is also
assumed to act on non-null hypersurfaces (both, spacelike and timelike cases
are studied). We consider both, diagonal and non-diagonal metrics and find all
the perfect-fluid solutions under these assumptions (except those already
known). We find four families of solutions, each one containing arbitrary
parameters for which no differential equations remain to be integrated. We
write the line-elements in a simplified form and perform a detailed study for
each of these solutions, giving the kinematical quantities of the fluid
velocity vector, the energy-density and pressure, values of the parameters for
which the energy conditions are fulfilled everywhere, the Petrov type, the
singularities in the spacetimes and the Friedmann-Lemaitre-Robertson-Walker
metrics contained in each family.Comment: Latex, no figure
Zonal flows and long-distance correlations during the formation of the edge shear layer in the TJ-II stellarator
A theoretical interpretation is given for the observed long-distance
correlations in potential fluctuations in TJ-II. The value of the correlation
increases above the critical point of the transition for the emergence of the
plasma edge shear flow layer. Mean (i.e. surface averaged, zero-frequency)
sheared flows cannot account for the experimental results. A model consisting
of four envelope equations for the fluctuation level, the mean flow shear, the
zonal flow amplitude shear, and the averaged pressure gradient is proposed. It
is shown that the presence of zonal flows is essential to reproduce the main
features of the experimental observations.Comment: 19 pages, 7 figure
Asymptotic Behaviour of Inhomogeneous String Cosmologies
The asymptotic behaviour at late times of inhomogeneous axion-dilaton
cosmologies is investigated. The space-times considered here admit two abelian
space-like Killing vectors. These space-times evolve towards an anisotropic
universe containing gravitational radiation. Furthermore, a peeling-off
behaviour of the Weyl tensor and the antisymmetric tensor field strength is
found. The relation to the pre-big-bang scenario is briefly discussed.Comment: 15 pages, Late
Micro-computed tomography and histology to explore internal morphology in decapod larvae
Traditionally, the internal morphology of crustacean larvae has been studied using destructive
techniques such as dissection and microscopy. The present study combines advances in microcomputed
tomography (micro-CT) and histology to study the internal morphology of decapod larvae,
using the common spider crab (Maja brachydactyla Balss, 1922) as a model and resolving the individual
limitations of these techniques. The synergy of micro-CT and histology allows the organs to be easily
identified, revealing simultaneously the gross morphology (shape, size, and location) and histological
organization (tissue arrangement and cell identification). Micro-CT shows mainly the exoskeleton,
musculature, digestive and nervous systems, and secondarily the circulatory and respiratory systems,
while histology distinguishes several cell types and confirms the organ identity. Micro-CT resolves a
discrepancy in the literature regarding the nervous system of crab larvae. The major changes occur in
the metamorphosis to the megalopa stage, specifically the formation of the gastric mill, the shortening
of the abdominal nerve cord, the curving of the abdomen beneath the cephalothorax, and the
development of functional pereiopods, pleopods, and lamellate gills. The combination of micro-CT and
histology provides better results than either one alone.Financial support was provided by the Spanish Ministry of Economy and Competitiveness through the INIA
project (grant number RTA2011-00004-00-00) to G.G. and a pre-doctoral fellowship to D.C. (FPI-INIA)
Tipos sociométricos, categorías conductuales y aptitudes intelectuales en adolescentes
El objetivo de este estudio fue analizar la relación entre tipos sociométricos, categorías conductuales y aptitudes intelectuales en una muestra de 1349 (51.7% varones) adolescentes españoles de 12 a 16 años. La identificación sociométrica de los estudiantes se realizó mediante el Programa Socio y para el análisis de las aptitudes intelectuales se administró el Test de Aptitudes Mentales Primarias (PMA; Thurstone, 1938; TEA, 1996). Las hipótesis del estudio plantean, en primer lugar, que los estudiantes nominados positivamente por sus iguales presentarán puntuaciones significativamente superiores en las diferentes escalas del PMA que los estudiantes nominados negativamente por sus compañeros y, en segundo lugar, que las aptitudes intelectuales serán una variable predictora estadísticamente significativa de los tipos sociométricos y categorías conductuales. Los resultados muestran que los estudiantes nominados positivamente obtuvieron puntuaciones significativamente más altas en las diferentes aptitudes intelectuales que los nominados negativamente. Las aptitudes intelectuales resultaron un predictor significativo de los tipos sociométricos, ya que a medida que aumenta la puntuación en las diferentes aptitudes intelectuales los estudiantes presentaron mayor probabilidad de ser nominados positivamente por sus compañeros
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