Targeted screening strategies to detect Trypanosoma cruzi infection in children

Background: Millions of people are infected with Trypanosoma cruzi, the causative agent of Chagas disease in Latin America. Anti-trypanosomal drug therapy can cure infected individuals, but treatment efficacy is highest early in infection. Vector control campaigns disrupt transmission of T. cruzi, but without timely diagnosis, children infected prior to vector control often miss the window of opportunity for effective chemotherapy. Methods and Findings: We performed a serological survey in children 2-18 years old living in a peri-urban community of Arequipa, Peru, and linked the results to entomological, spatial and census data gathered during a vector control campaign. 23 of 433 (5.3% [95% Cl 3.4-7.9]) children were confirmed seropositive for T. cruzi infection by two methods. Spatial analysis revealed that households with infected children were very tightly clustered within looser clusters of households with parasite-infected vectors. Bayesian hierarchical mixed models, which controlled for clustering of infection, showed that a child's risk of being seropositive increased by 20% per year of age and 4% per vector captured within the child's house. Receiver operator characteristic (ROC) plots of best-fit models suggest that more than 83% of infected children could be identified while testing only 22% of eligible children. Conclusions: We found evidence of spatially-focal vector-borne T. cruzi transmission in peri-urban Arequipa. Ongoing vector control campaigns, in addition to preventing further parasite transmission, facilitate the collection of data essential to identifying children at high risk of T. cruzi infection. Targeted screening strategies could make integration of diagnosis and treatment of children into Chagas disease control programs feasible in lower-resource settings

Population, Land Use and Deforestation in the Pan Amazon Basin: a Comparison of Brazil, Bolivia, Colombia, Ecuador, Perú and Venezuela

This paper discusses the linkages between population change, land use, and deforestation in the Amazon regions of Brazil, Bolivia, Colombia, Ecuador, Perú, and Venezuela. We begin with a brief discussion of theories of population–environment linkages, and then focus on the case of deforestation in the PanAmazon. The core of the paper reviews available data on deforestation, population growth, migration and land use in order to see how well land cover change reflects demographic and agricultural change. The data indicate that population dynamics and net migration exhibit to deforestation in some states of the basin but not others. We then discuss other explanatory factors for deforestation, and find a close correspondence between land use and deforestation, which suggests that land use is loosely tied to demographic dynamics and mediates the influence of population on deforestation. We also consider national political economic contexts of Amazon change in the six countries, and find contrasting contexts, which also helps to explain the limited demographic-deforestation correspondence. The paper closes by noting general conclusions based on the data, topics in need of further research and recent policy proposals.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/42720/1/10668_2003_Article_6977.pd

Euclid preparation. TBD. The effect of linear redshift-space distortions in photometric galaxy clustering and its cross-correlation with cosmic shear

International audienceCosmological surveys planned for the current decade will provide us with unparalleled observations of the distribution of galaxies on cosmic scales, by means of which we can probe the underlying large-scale structure (LSS) of the Universe. This will allow us to test the concordance cosmological model and its extensions. However, precision pushes us to high levels of accuracy in the theoretical modelling of the LSS observables, in order not to introduce biases in the estimation of cosmological parameters. In particular, effects such as redshift-space distortions (RSD) can become relevant in the computation of harmonic-space power spectra even for the clustering of the photometrically selected galaxies, as it has been previously shown in literature studies. In this work, we investigate the contribution of linear RSD, as formulated in the Limber approximation by arXiv:1902.07226, in forecast cosmological analyses with the photometric galaxy sample of the Euclid survey, in order to assess their impact and quantify the bias on the measurement of cosmological parameters that neglecting such an effect would cause. We perform this task by producing mock power spectra for photometric galaxy clustering and weak lensing, as expected to be obtained from the Euclid survey. We then use a Markov chain Monte Carlo approach to obtain the posterior distributions of cosmological parameters from such simulated observations. We find that neglecting the linear RSD leads to significant biases both when using galaxy correlations alone and when these are combined with cosmic shear, in the so-called 3$\times$2pt approach. Such biases can be as large as $5\,\sigma$-equivalent when assuming an underlying $\Lambda$CDM cosmology. When extending the cosmological model to include the equation-of-state parameters of dark energy, we find that the extension parameters can be shifted by more than $1\,\sigma$

Euclid preparation: XXVIII. Modelling of the weak lensing angular power spectrum

International audienceThis work considers which higher-order effects in modelling the cosmic shear angular power spectra must be taken into account for Euclid. We identify which terms are of concern, and quantify their individual and cumulative impact on cosmological parameter inference from Euclid. We compute the values of these higher-order effects using analytic expressions, and calculate the impact on cosmological parameter estimation using the Fisher matrix formalism. We review 24 effects and find the following potentially need to be accounted for: the reduced shear approximation, magnification bias, source-lens clustering, source obscuration, local Universe effects, and the flat Universe assumption. Upon computing these explicitly, and calculating their cosmological parameter biases, using a maximum multipole of $\ell=5000$, we find that the magnification bias, source-lens clustering, source obscuration, and local Universe terms individually produce significant ($\,>0.25\sigma$) cosmological biases in one or more parameters, and accordingly must be accounted for. In total, over all effects, we find biases in $\Omega_{\rm m}$, $\Omega_{\rm b}$, $h$, and $\sigma_{8}$ of $0.73\sigma$, $0.28\sigma$, $0.25\sigma$, and $-0.79\sigma$, respectively, for flat $\Lambda$CDM. For the $w_0w_a$CDM case, we find biases in $\Omega_{\rm m}$, $\Omega_{\rm b}$, $h$, $n_{\rm s}$, $\sigma_{8}$, and $w_a$ of $1.49\sigma$, $0.35\sigma$, $-1.36\sigma$, $1.31\sigma$, $-0.84\sigma$, and $-0.35\sigma$, respectively; which are increased relative to the $\Lambda$CDM due to additional degeneracies as a function of redshift and scale

Euclid preparation. TBD. The effect of linear redshift-space distortions in photometric galaxy clustering and its cross-correlation with cosmic shear

International audienceCosmological surveys planned for the current decade will provide us with unparalleled observations of the distribution of galaxies on cosmic scales, by means of which we can probe the underlying large-scale structure (LSS) of the Universe. This will allow us to test the concordance cosmological model and its extensions. However, precision pushes us to high levels of accuracy in the theoretical modelling of the LSS observables, in order not to introduce biases in the estimation of cosmological parameters. In particular, effects such as redshift-space distortions (RSD) can become relevant in the computation of harmonic-space power spectra even for the clustering of the photometrically selected galaxies, as it has been previously shown in literature studies. In this work, we investigate the contribution of linear RSD, as formulated in the Limber approximation by arXiv:1902.07226, in forecast cosmological analyses with the photometric galaxy sample of the Euclid survey, in order to assess their impact and quantify the bias on the measurement of cosmological parameters that neglecting such an effect would cause. We perform this task by producing mock power spectra for photometric galaxy clustering and weak lensing, as expected to be obtained from the Euclid survey. We then use a Markov chain Monte Carlo approach to obtain the posterior distributions of cosmological parameters from such simulated observations. We find that neglecting the linear RSD leads to significant biases both when using galaxy correlations alone and when these are combined with cosmic shear, in the so-called 3$\times$2pt approach. Such biases can be as large as $5\,\sigma$-equivalent when assuming an underlying $\Lambda$CDM cosmology. When extending the cosmological model to include the equation-of-state parameters of dark energy, we find that the extension parameters can be shifted by more than $1\,\sigma$