Aesthetic bite for the management of temporomandibular disorders: A case series review

Background: Oral appliances (OA) are the most widely used treatment approach for temporomandibular disorders (TMDs): They are designed to relieve or prevent degenerative forces on the joint, the articular disk, and dentition. Classical OAs, however, are cumbersome and esthetically unpleasing: A more esthetic and functional appliance might improve treatment efficacy and shorten treatment time. Aim: The aim of this case series is to introduce an esthetical device for the management of TMD. Methodology: Three adults between 43 and 60 years old with a diagnosis of intra-articular TMD were included and were instructed to apply the device throughout the day and night. The patients were recruited at the same private dental clinic and each one signed an informed consent for both treatment and inclusion in the study. We evaluated and compared four clinical parameters (mandibular excursion, mandibular opening pattern, muscular and articular pain, and TMJ noises) between time 0 (T0) and 1, 2, 3, 6, and 12 months of using the device following the protocol of diagnostic criteria for temporomandibular joint disorders (DC/TMD). A magnetic resonance imaging exam was conducted to investigate tissue changes between T0 and 3 and 12 months of therapy. Conclusions: For all four parameters, we observed considerable improvements in all patients, who noticed the positive effects of the therapy themselves. The results suggest that this esthetic device was an effective treatment to manage TMD in the described cases, also increasing patients’ quality of life. However, studies on a larger scale are required to prove the effectiveness of this device. Clinical Significance: This case series aims to highlight the potentiality of an esthetic device used for the management of TMDs. This is because a more esthetically pleasant and comfortable device increases the time of usage, thus improving the positive effects of the device on the TMD

correction on the stability of manganese tris β diketonate complexes as redox mediators in dsscs

Correction for 'On the stability of manganese tris(β-diketonate) complexes as redox mediators in DSSCs' by Stefano Carli et al., Phys. Chem. Chem. Phys., 2016, 18, 5949–5956

Clinical and molecular characterization of patients affected by Beckwith-Wiedemann spectrum conceived through assisted reproduction techniques

The prevalence of Beckwith-Wiedemann spectrum (BWSp) is tenfold increased in children conceived through assisted reproductive techniques (ART). More than 90% of ART-BWSp patients reported so far display imprinting center 2 loss-of-methylations (IC2-LoM), versus 50% of naturally conceived BWSp patients. We describe a cohort of 74 ART-BWSp patients comparing their features with a cohort of naturally conceived BWSp patients, with the ART-BWSp patients previously described in literature, and with the general population of children born from ART. We found that the distribution of UPD(11)pat was not significantly different in ART and naturally conceived patients. We observed 68.9% of IC2-LoM and 16.2% of mosaic UPD(11)pat in our ART cohort, that strongly differ from the figure reported in other cohorts so far. Since UPD(11)pat likely results from post-fertilization recombination events, our findings allows to hypothesize that more complex molecular mechanisms, besides methylation disturbances, may underlie BWSp increased risk in ART pregnancies. Moreover, comparing the clinical features of ART and non-ART BWSp patients, we found that ART-BWSp patients might have a milder phenotype. Finally, our data show a progressive increase in the prevalence of BWSp over time, paralleling that of ART usage in the last decades

The detector control unit of the fine guidance sensor instrument on-board the ARIEL mission: design status

ARIEL is an ESA mission whose scientific goal is to investigate exoplanetary atmospheres. The payload is composed by two instruments: AIRS (ARIEL IR Spectrometer) and FGS (Fine Guidance System). The FGS detection chain is composed by two HgCdTe detectors and by the cold Front End Electronics (SIDECAR), kept at cryogenic temperatures, interfacing with the F-DCU (FGS Detector Control Unit) boards that we will describe thoroughly in this paper. The F-DCU are situated in the warm side of the payload in a box called FCU (FGS Control Unit) and contribute to the FGS VIS/NIR imaging and NIR spectroscopy. The F-DCU performs several tasks: drives the detectors, processes science data and housekeeping telemetries, manages the commands exchange between the FGS/DPU (Data Processing Unit) and the SIDECARs and provides high quality voltages to the detectors. This paper reports the F-DCU status, describing its architecture, the operation and the activities, past and future necessary for its development