TUBEIMOSIDE-1, A TRITERPENOID SAPONIN: AN UPDATE ON ITS PHARMACOLOGICAL EFFECTS

It is known that humans have been using natural products for medicinal use for ages. Tubeimoside-1 (TBMS1) is a triterpenoid saponin first isolated in China from Bolbostemma paniculatum (Maxim) Franquet, Cucurbitaceae. This review provides a deep overview on TBMS1 and extensively summarizes its pharmacological functions. As result, TBMS1 has drawn great interest in medicinal field due to its multiple pharmacological functions such as anticancer, anti-inflammatory, antitumor, antidiabetic, anti-human immunodeficiency viruses, and neuroprotective properties. Further, TBMS1 plays an important role in a wide range of pharmacological processes. Although possessing important functions, further experimentations are required to broaden the scope of its application

Resurgence of Ebola virus in 2021 in Guinea suggests a new paradigm for outbreaks

These authors contributed equally: Alpha K. Keita, Fara R. Koundouno, Martin Faye, Ariane Düx, Julia Hinzmann.International audienc

A study on the reduction of antibiotic use by introducing organic acids in broiler chicken feed in the district of Abidjan - Ivory Coast

The use of organic acids in the diet of animals is potentially beneficial for maintaining intestinal hemostasis and controlling the growth of pathogenic bacteria. The objective of this study was to experiment with organic acids as additives to antibiotics used by farmers. A total of 490 broilers were studied in this study and were divided into 5 lots of 98 subjects. The experimental core consisted of Fysal, Fysal-Selko, Selko, Patheryl (reference antibiotic) and Control. The experimental products were introduced in the drinking water (Selko pH) and in the feed (Fysal MP). A high feed consumption was noticed in the Fysal lot with 80.44±44g/chicken followed respectively by the Pteryl lots with 79.48 ± 42.25g/chicken, Fysal-Selko with 79.34 ± 43.62g/chicken, Selko with 77.27 ± 41.39g/chicken and finally Control with 76.01 ± 39.41g/chicken. The weight gain was high in the Fysal lot with 1770 ± 623.38g followed respectively by the Fysal-Selko lots with 1709 ± 606.05g, Pteryl with 1619 ± 577.70g, Selko with 1607 ± 567.90g against the Control lot with 1550 ± 544.41g. A mortality rate of 3.06% was recorded only in the Selko lot. Economically, the lots (Fysal, Fysal-Selko and Selko) that consumed the feed and water containing organic acids recorded higher profits compared to the Control and Pteryl batches. The organic acids such as Fysal MP and Selko pH could be used as alternatives to antibiotics in poultry farming. Keywords: Broiler, growth performance, organic acids, antibiotic

Evaluation of the antiparasitic properties of Allium sativum L. (Alliaceae) in the treatment of intestinal coccidiosis in broilers

The objective of this study was to evaluate the phytotherapeutic efficacy of Allium sativum L. (garlic) as alternative compounds to antibiotics used by farmers in the treatment of coccidiosis in poultry. In this study, 20 chickens divided into 4 batches received only garlic powder in their feed. The results obtained after a natural infestation revealed a weight loss in all subjects before administration of the different products. Following treatment, a considerable decrease in coccidia eggs in the chickens receiving the highest concentrations of the products. The weight gain was more or less high in the treated batches except in the control batches. In conclusion, this study generated biological results. These data support that garlic could be used as alternatives to antibiotics in poultry and many other livestock operations. Although they have important functions, further experiments are needed to elucidate the biological mechanisms behind their use in animals. Keywords : Garlic, intestinal coccidia, broiler

Seroprevalence and Risk Factors of Toxoplasmosis in Cats and Women Undergoing Prenatal Consultation in Coyah, Guinea

The objective of this study is to describe the epidemiological situation of toxoplasmosis in cats and women undergoing prenatal consultation in the city of Coyah (Guinea). During the study, 100 cat sera and 100 sera from women in prenatal consultation were analyzed with a Toxo-Screen DA (Modified Antigen Agglutination Test) kit. The results indicated prevalences of 73%±8.7 in antenatal women and 51%±9.8 in cats. There was no association found between the variables and Toxoplasma gondii seroprevalence in prenatal females and cats. Keywords: Cat; women in prenatal consultation; Toxoplasma gondii; Coyah; Guinea