The energy-constrained quickest path problem

This paper addresses a variant of the quickest path problem in which each arc has an additional parameter associated to it representing the energy consumed during the transmission along the arc while each node is endowed with a limited power to transmit messages. The aim of the energy-constrained quickest path problem is to obtain a quickest path whose nodes are able to support the transmission of a message of a known size. After introducing the problem and proving the main theoretical results, a polynomial algorithm is proposed to solve the problem based on computing shortest paths in a sequence of subnetworks of the original network. In the second part of the paper, the bi-objective variant of this problem is considered in which the objectives are the transmission time and the total energy used. An exact algorithm is proposed to find a complete set of efficient paths. The computational experiments carried out show the performance of both algorithms

On beach cusp formation

A system of shallow water equations and a bed evolution equation are used to examine the evolution of perturbations on an erodible, initially plane beach subject to normal wave incidence. Both a permeable (under Darcy's law) and an impermeable beach are considered. It is found that alongshore-periodic morphological features reminiscent of swash beach cusps form after a number of incident wave periods on both beaches. On the permeable (impermeable) beach these patterns are accretional (erosional). In both cases flow is ‘horn divergent’. Spacings of the cusps are consistent with observations, and are close to those provided by a standing synchronous linear edge wave. An analysis of the processes leading to bed change is presented. Two physical mechanisms are identified: concentration gradient and flow divergence, which are dominant in the lower and upper swash respectively, and their difference over a wave cycle leads to erosion or deposition on an impermeable beach. Infiltration enters this balance in the upper swash. A bed wave of elevation is shown to advance up the beach at the tip of the uprush, with a smaller wave of depression on the backwash. It is found that cusp horns can grow by a positive feedback mechanism stemming from decreased (increased) backwash on positive (negative) bed perturbations.Postprint (published version

Snakebite envenoming.

Snakebite envenoming is a neglected tropical disease that kills >100,000 people and maims >400,000 people every year. Impoverished populations living in the rural tropics are particularly vulnerable; snakebite envenoming perpetuates the cycle of poverty. Snake venoms are complex mixtures of proteins that exert a wide range of toxic actions. The high variability in snake venom composition is responsible for the various clinical manifestations in envenomings, ranging from local tissue damage to potentially life-threatening systemic effects. Intravenous administration of antivenom is the only specific treatment to counteract envenoming. Analgesics, ventilator support, fluid therapy, haemodialysis and antibiotic therapy are also used. Novel therapeutic alternatives based on recombinant antibody technologies and new toxin inhibitors are being explored. Confronting snakebite envenoming at a global level demands the implementation of an integrated intervention strategy involving the WHO, the research community, antivenom manufacturers, regulatory agencies, national and regional health authorities, professional health organizations, international funding agencies, advocacy groups and civil society institutions

Debating the use of Arc therapy and Tomotherapy

Debating the use of Arc Therapy and Tomotherapy Strong evidence base in support of these treatments. Advantages outweigh current standard practice. Widely accepted across the world. Progression is necessary

The application of multiplex fluorimetric sensor for the analysis of flavonoids content in the medicinal herbs family Asteraceae, Lamiaceae, Rosaceae

BACKGROUND: The aim of our research work was to quantify total flavonoid contents in the leaves of 13 plant species family Asteraceae, 8 representatives of family Lamiaceae and 9 plant species belonging to familyRosaceae, using the multiplex fluorimetric sensor. Fluorescence was measured using optical fluorescence apparatus Multiplex(R) 3 (Force-A, France) for non-destructive flavonoids estimation. The content of total flavonoids was estimated by FLAV index (expressed in relative units), that is deduced from flavonoids UV absorbing properties. RESULTS: Among observed plant species, the highest amount of total flavonoids has been found in leaves ofHelianthus multiflorus (1.65 RU) and Echinops ritro (1.27 RU), Rudbeckia fulgida (1.13 RU) belonging to the family Asteraceae. Lowest flavonoid content has been observed in the leaves of marigold (Calendula officinalis) (0.14 RU) also belonging to family Asteraceae. The highest content of flavonoids among experimental plants of family Rosaceae has been estimated in the leaves of Rosa canina (1.18 RU) and among plant species of family Lamiaceae in the leaves of Coleus blumei (0.90 RU). CONCLUSIONS: This research work was done as pre-screening of flavonoids content in the leaves of plant species belonging to family Asteraceae, Lamiaceae and Rosaceae. Results indicated that statistically significant differences (P > 0.05) in flavonoids content were observed not only between families, but also among individual plant species within one family