The effect of caffeic acid phenethyl ester on short-term acute myocardial ischemia

Background: We. previously showed that caffeic acid phenethyl ester (CAPE) attenuated NO production, reduced apoptosis, diminished serum CK and AST activities, and is cardio-protective in rat heart subjected to ischemia/reperfusion (I/R). We now studied the short-term cardio-protective effect of CAPE in an I/R rat heart model

Beneficiation of Himmetoǧlu oil shale by flotation as a solid fuel substitute. Part 1. Materials characteristics and flotation behavior

In this study, the processing of Himmetoǧlu oil shale from Bolu, Turkey, by flotation techniques was investigated for the possibility of achieving a clean solid-fuel substitute. The surface characteristics and mineral content of Himmetoǧlu oil shale were determined using mineralogical, XRD, and FTIR analysis. The flotation response of the sample was tested with several nonionizing collectors and a variety of ionizing collectors belonging to both cationic and anionic groups. The effects of collector dosage and pulp pH on the effectiveness of flotation were also determined. XRD analysis showed that majority of incombustible matter in the sample was carbonate, silicate, and sulfide minerals. FTIR spectrum exhibited significantly strong absorption bands from the organic and oxygen-rich functional groups, revealing the organic-rich and highly humic character of Himmetoǧlu oil shale. Flotation experiments showed that Himmetoǧlu oil shale had a hydrophillic nature and extremely poor flotability because of its humic character. Effective means of ash rejection with an acceptable extent of combustible recovery was achieved by reverse flotation, where mineral matter was selectively removed by amine acetates through reverse flotation. Among the amine acetates used, the most favorable cleaning was obtained in the presence of Flotigam CA at natural pulp pH, where the ash yield of Himmetoǧlu oil shale was reduced from 34.76 to 23.52% with a high combustible recovery of 83.57%. © 2006 American Chemical Society

High dose of caffeine administered to pregnant rats causes histopathological changes in the cornea of newborn pups

Background: Caffeine is frequently used during pregnancy and associated with teratogenic effects, such as low birth weight, hearth and digital defects, cleft palate and abortion with fetal loss. This study investigated histopathologically the effects of caffeine on neonatal rat cornea. Material/Methods: Fifty pregnant Wistar-Albino rats (dams) were randomly divided into five groups, one control and four experimental. Between day 9 and 21 of gestation, group 1 dams (control, n = 10) were exposed to intraperitoneal (i.p.) SF daily until delivery. Group 2 (n = 10), group 3 (n = 10 and group 4 (n = 10) clams were treated with i.p. caffeine at doses of 25, 50 and 100 mg/kg/d, respectively, for the same period. Group 5 dams were given caffeine in distilled water in a gavage at a dose of 50 mg/kg/d during the same period. After normal delivery, the litters were killed at postnatal day 1 or 30 and the eyes were enucleated for corneal histopathologic investigation. Results: Control and group 1 eyes had normal corneal epithelium, regular stromal fibers, descement membrane and monolayer inner corneal endothelium. The remaining experimental litters demonstrated changes, such as vacuolated endothelial cells with proliferation, hyperchromasia, polymorphism, endothelial cell agenesis, increased stromal mitotic activity and focal increase in corneal thickness with widely separated corneal lamellae in the injured area. These changes occurred most often in the litters treated with high doses of caffeine. Conclusions: Excessive gestational caffeine intake has been shown histopathologically to have some teratogenic effects on newborn rat cornea

Therapeutic effect of caffeic acid phenethyl ester on cerulein-induced acute pancreatitis

AIM: To evaluate the therapeutic role of caffeic acid phenethyl ester (CAPE) in a rat model of cerulean-induced acute pancreatitis (AP)

Induced locomotor hyperactivity on ethanol withdrawal syndrome in rats is inhibited by quetiapine.

Our aim is to investigate the effects of two atypical antipsychotics; quetiapine and olanzapine on locomotor activity that is a sign of ethanol withdrawal syndrome in rats. Adult male Wistar rats were subjects. Ethanol (7.2%, v/v) was given to rats by a liquid diet for 30 days. Control rats were pair fed an isocaloric liquid diet containing sucrose as a caloric substitute to ethanol. Quetiapine (10 mg/kg), olanzapine (5 mg/kg) and saline were injected to the rats intraperitoneally 7 days after ethanol withdrawal syndrome and the last one 30 min before ethanol withdrawal testing. After 2nd hour of ethanol withdrawal, rats were observed for 5 min and withdrawal signs that included locomotor hyperactivity were recorded. We have found increased vertical and horizontal locomotor activity in ethanol withdrawal group to control and reduced vertical and horizontal locomotor activity in quetiapine-injected rats. In olanzapine injected rats were seen no reduced locomotor activity. Significant inhibitory effects were produced by quetiapine on the signs of ethanol withdrawal. Our results suggest that acute quetiapine treatment has some beneficial efects on ethanol withdrawal in rats. Thus, this drug may be useful for treatment of ethanol withdrawal syndrome