Scaling Laws and Effective Dimension in Lattice SU(2) Yang-Mills Theory with a Compactified Extra Dimension

Monte Carlo simulations are performed in a five-dimensional lattice SU(2) Yang-Mills theory with a compactified extra dimension, and scaling laws are studied. Our simulations indicate that as the compactification radius $R$ decreases, the confining phase spreads more and more to the weak coupling regime, and the effective dimension of the theory changes gradually from five to four. Our simulations also indicate that the limit $a_4 to 0$ with $R/a_4$ kept fixed exists both in the confining and deconfining phases if $R/a_4$ is small enough, where $a_4$ is the lattice spacing in the four-dimensional direction. We argue that the color degrees of freedom in QCD are confined only for $R < R_{\rm max}$, where a rough estimate shows that $1/R_{\rm max}$ lies in the TeV range. Comments on deconstructing extra dimensions are given.Comment: 15 pages, TeX, 5 figure

Were New Labour’s cultural policies neo-liberal?

This article assesses the cultural policies of ‘New Labour’, the UK Labour government of 1997–2010. It takes neo-liberalism as its starting point, asking to what extent Labour’s cultural policies can be validly and usefully characterised as neo-liberal. It explores this issue across three dimensions: corporate sponsorship and cuts in public subsidy; the running of public sector cultural institutions as though they were private businesses; and a shift in prevailing rationales for cultural policy, away from cultural justifications, and towards economic and social goals. Neo-liberalism is shown to be a significant but rather crude tool for evaluating and explaining New Labour’s cultural policies. At worse, it falsely implies that New Labour did not differ from Conservative approaches to cultural policy, downplays the effect of sociocultural factors on policy-making, and fails to differentiate varying periods and directions of policy. It does, however, usefully draw attention to the public policy environment in which Labour operated, in particular the damaging effects of focusing, to an excessive degree, on economic conceptions of the good in a way that does not recognise the limitations of markets as a way of organising production, circulation and consumption

Cardiometabolic Pregnancy Complications in Association With Autism-Related Traits as Measured by the Social Responsiveness Scale in ECHO

Prior work has examined associations between cardiometabolic pregnancy complications and autism spectrum disorder (ASD) but not how these complications may relate to social communication traits more broadly. We addressed this question within the Environmental Inf luences on Child Health Outcomes program, with 6,778 participants from 40 cohorts conducted from 1998–2021 with information on ASD-related traits via the Social Responsiveness Scale. Four metabolic pregnancy complications were examined individually, and combined, in association with Social Responsiveness Scale scores, using crude and adjusted linear regression as well as quantile regression analyses. We also examined associations stratified by ASD diagnosis, and potential mediation by preterm birth and low birth weight, and modification by child sex and enriched risk of ASD. Increases in ASD-related traits were associated with obesity (β = 4.64, 95% confidence interval: 3.27, 6.01) and gestational diabetes (β = 5.21, 95% confidence interval: 2.41, 8.02), specifically, but not with hypertension or preeclampsia. Results among children without ASD were similar to main analyses, but weaker among ASD cases. There was not strong evidence for mediation or modification. Results suggest that common cardiometabolic pregnancy complications may inf luence child ASD-related traits, not only above a diagnostic threshold relevant to ASD but also across the population

An investigation into electrochemical interactions between platinum group minerals and xanthate: Voltammetric study

In the flotation of platinum group minerals (PGMs) containing significant amounts of tellurides and arsenides it is generally assumed that these minerals will respond in the same way as sulphides to collectors such as xanthates which are typically used in sulphide flotation. This paper presents the results of a fundamental study which has been conducted to provide a greater insight into the comparative interactions between synthetic moncheite (PtTe2) and cooperite (PtS) with sodium ethyl xanthate (SEX). Cyclic voltammetry has been used to investigate these interactions in the absence and presence of sodium ethyl xanthate (SEX) in aerated and de-aerated solutions. Reduction potentials of the SEX/dixanthogen couple have been measured and compared to published data. Reduction potentials of possible reactions of the minerals have been predicted from thermodynamic calculations and used to attempt to interpret the potentials measured in the cyclic voltammetry investigations. Results have shown differences in the oxidation behaviour of the minerals as well as in the SEX interaction with the minerals. The effect of pH was investigated in the case of the Pt minerals and fractional surface coverages were calculated with a view to ultimately correlate these results with flotation behaviour. Proposals are made with respect to the various reactions occurring under the conditions studied

An investigation into the electrochemical interactions between platinum group minerals and sodium ethyl xanthate and sodium diethyl dithiophosphate collectors: Mixed potential study

In the flotation of platinum group minerals (PGMs) occurring in the Platreef ore body, it is often assumed that the interactions between thiol collectors and tellurides of Pt and Pd are similar to those occurring with the equivalent sulphides. In order to gain a greater insight into this assumption a rest(mixed) potential study was conducted to investigate the interactions occurring between two thiol collectors, viz. sodium ethyl xanthate (SEX) and sodium diethyl dithiophosphate (SEDTP), and selected PGMs, viz. moncheite (PtTe2), merenskyite (PdTe2), cooperite (PtS) and vysotskite (PdS) as well as pure platinum and palladium. The results have shown that all these minerals reacted with the collectors in question but that the rest potential of the Pt minerals are more anodic than those of the Pd minerals. Moreover when SEX was used, dixanthogen is more likely to form on PtS than PtTe2 but the reverse is the case for PdTe2 and PdS. In the case of SEDTP it was found that the dithiolate (SEDTP2) did not form on any of the mineral surfaces. The results were compared to those already reported in a previous investigation of the same systems using cyclic voltammetry. The information obtained in these two investigations complement each other and may provide a more fundamental understanding of the role of these collectors in recovering the respective minerals

Influence of Hydroxyls on Pd Atom Mobility and Clustering on Rutile TiO₂(011)‑2 × 1

Understanding agglomeration of late transition metal atoms, such as Pd, on metal oxide supports, such as TiO₂, is critical for designing heterogeneous catalysts as well as for controlling metal/oxide interfaces in general. One approach for reducing particle sintering is to modify the metal oxide surface with hydroxyls that decrease adatom mobility. We study by scanning tunneling microscopy experiments, density functional theory (DFT) calculations, and Monte Carlo (MC) computer simulations the atomistic processes of Pd sintering on a hydroxyl-modified TiO₂(011)-2 × 1 surface. The formation of small 1–3 atom clusters that are stable at room temperature is achieved on the hydroxylated surface, while much larger clusters are formed under the same conditions on a hydroxyl-free surface. DFT shows that this is a consequence of stronger binding of Pd atoms adjacent to hydroxyls and increased surface diffusion barriers for Pd atoms on the hydroxylated surface. DFT, kinetic MC, and ReaxFF-based NVT-MC simulations show that Pd clusters larger than single Pd monomers can adsorb the hydrogen from the oxide surface and form Pd hydrides. This depletes the surface hydroxyl coverage, thus allowing Pd to more freely diffuse and agglomerate at room temperature. Experimentally, this causes a bimodal cluster size distribution with 1–3 atom clusters prevalent at low Pd coverage, while significantly larger clusters become dominant at higher Pd concentrations. This study demonstrates that hydroxylated oxide surfaces can significantly reduce Pd cluster sizes, thus enabling the preparation of surfaces populated with metal clusters composed of single to few atoms

Combination of variations in inflammation- and endoplasmic reticulum-associated genes as putative biomarker for bevacizumab response in KRAS wild-type colorectal cancer

Chemotherapy combined with the angiogenesis inhibitor bevacizumab (BVZ) is approved as a first-line treatment in metastatic colorectal cancer (mCRC). Limited clinical benefit underpins the need for improved understanding of resistance mechanisms and the elucidation of novel predictive biomarkers. We assessed germline single-nucleotide polymorphisms (SNPs) in 180 mCRC patients (Angiopredict [APD] cohort) treated with combined BVZ + chemotherapy and investigated previously reported predictive SNPs. We further employed a machine learning approach to identify novel associations. In the APD cohort IL8 rs4073 any A carriers, compared to TT carriers, were associated with worse progression-free survival (PFS) (HR = 1.51, 95% CI:1.03–2.22, p-value = 0.037) and TBK1 rs7486100 TT carriers, compared to any A carriers, were associated with worse PFS in KRAS wild-type (wt) patients (HR = 1.94, 95% CI:1.04–3.61, p-value = 0.037), replicating previous findings. Machine learning identified novel associations in genes encoding the inflammasome protein NLRP1 and the ER protein Sarcalumenin (SRL). A negative association between PFS and carriers of any A at NLRP1 rs12150220 and AA for SRL rs13334970 in APD KRAS wild-type patients (HR = 4.44, 95% CI:1.23–16.13, p-value = 0.005), which validated in two independent clinical cohorts involving BVZ, MAVERICC and TRIBE. Our findings highlight a key role for inflammation and ER signalling underpinning BVZ + chemotherapy responsiveness

Loss of Chromosome 18q11.2-q12.1 Is Predictive for Survival in Patients With Metastatic Colorectal Cancer Treated With Bevacizumab

Purpose Patients with metastatic colorectal cancer (mCRC) have limited benefit from the addition of bevacizumab to standard chemotherapy. However, a subset probably benefits substantially, highlighting an unmet clinical need for a biomarker of response to bevacizumab. Previously, we demonstrated that losses of chromosomes 5q34, 17q12, and 18q11.2-q12.1 had a significant correlation with progression-free survival (PFS) in patients with mCRC treated with bevacizumab in the CAIRO2 clinical trial but not in patients who did not receive bevacizumab in the CAIRO trial. This study was designed to validate these findings. Materials and Methods Primary mCRC samples were analyzed from two cohorts of patients who received bevacizumab as first-line treatment; 96 samples from the European multicenter study Angiopredict (APD) and 81 samples from the Italian multicenter study, MOMA. A third cohort of 90 samples from patients with mCRC who did not receive bevacizumab was analyzed. Copy number aberrations of tumor biopsy specimens were measured by shallow whole-genome sequencing and were correlated with PFS, overall survival (OS), and response. Results Loss of chromosome 18q11.2-q12.1 was associated with prolonged PFS most significantly in both the cohorts that received bevacizumab (APD: hazard ratio, 0.54; P = .01; PFS difference, 65 days; MOMA: hazard ratio, 0.55; P = .019; PFS difference, 49 days). A similar association was found for OS and overall response rate in these two cohorts, which became significant when combined with the CAIRO2 cohort. Median PFS in the cohort of patients with mCRC who did not receive bevacizumab and in the CAIRO cohort was similar to that of the APD, MOMA, and CAIRO2 patients without an 18q11.2-q12.1 loss. Conclusion We conclude that the loss of chromosome 18q11.2-q12.1 is consistently predictive for prolonged PFS in patients receiving bevacizumab. The predictive value of this loss is substantiated by a significant gain in OS and overall response rate