36 research outputs found
Clinical trial of the anti-PD-L1 antibody BMS-936559 in HIV-1 infected participants on suppressive antiretroviral therapy
Background. Reversing immune exhaustion with an anti-PD-L1 antibody may improve human immunodeficiency virus type 1 (HIV-1)-specific immunity and increase clearance of HIV-1-expressing cells. Methods. We conducted a phase I, randomized, double-blind, placebo-controlled, dose-escalating study of BMS-936559, including HIV-1-infected adults aged >18 to 350 cells/μL and detectable plasma HIV-1 RNA by single-copy assay. Data on single infusions of BMS-936559 (0.3 mg/kg) versus placebo are described. The primary outcomes were safety defined as any grade 3 or greater or immune-related adverse event (AE) and the change in HIV-1 Gag-specific CD8+ T cell responses from baseline to day 28 after infusion. Results. Eight men enrolled: 6 received 0.3 mg/kg of BMS-936559, and 2 received placebo infusions. There were no BMS- 936559-related grade 3 or greater AEs. In 1 participant, asymptomatic hypophysitis (a protocol-defined immune-related AE) was identified 266 days after BMS-936559 infusion; it resolved over time. The mean percentage of HIV-1 Gag-specific CD8+ T cells expressing interferon γ increased from baseline (0.09%) through day 28 (0.20%; P = .14), driven by substantial increases in 2 participants who received BMS-936559. Conclusions. In this first evaluation of an immunologic checkpoint inhibitor in healthy HIV-1-infected persons, single lowdose BMS-936559 infusions appeared to enhance HIV-1-specific immunity in a subset of participants
D* Production in Deep Inelastic Scattering at HERA
This paper presents measurements of D^{*\pm} production in deep inelastic
scattering from collisions between 27.5 GeV positrons and 820 GeV protons. The
data have been taken with the ZEUS detector at HERA. The decay channel
(+ c.c.) has been used in the study. The
cross section for inclusive D^{*\pm} production with
and is 5.3 \pms 1.0 \pms 0.8 nb in the kinematic region
{ GeV and }. Differential cross
sections as functions of p_T(D^{*\pm}), and are
compared with next-to-leading order QCD calculations based on the photon-gluon
fusion production mechanism. After an extrapolation of the cross section to the
full kinematic region in p_T(D^{*\pm}) and (D^{*\pm}), the charm
contribution to the proton structure function is
determined for Bjorken between 2 10 and 5 10.Comment: 17 pages including 4 figure
Observation of Scaling Violations in Scaled Momentum Distributions at HERA
Charged particle production has been measured in deep inelastic scattering
(DIS) events over a large range of and using the ZEUS detector. The
evolution of the scaled momentum, , with in the range 10 to 1280
, has been investigated in the current fragmentation region of the Breit
frame. The results show clear evidence, in a single experiment, for scaling
violations in scaled momenta as a function of .Comment: 21 pages including 4 figures, to be published in Physics Letters B.
Two references adde
Atividade inseticida do óleo essencial de pimenta longa (Piper hispidinervum C. DC.) sobre lagarta-do-cartucho do milho Spodoptera frugiperda (J. E. Smith, 1797) (Lepidoptera: Noctuidae)
Heterogeneous zooplankton distribution in a ship's ballast tanks
We examined the vertical distribution of zooplankton in a ship's ballast water. Some crustacean taxa were more abundant at 0.5 m and 2 m than at 6 m depths. Non-random distributions affect population size estimations and are an important consideration for invasion risk assessment
Association of Human Papillomavirus Type 16 E7 and HLA Class I Antigen Expression in Cervical Premalignant and Malignant Lesions
Supplementation of Avizyme 1502 to Corn-Soybean Meal-Wheat Diets Fed to Turkey Tom Poults: The First Fifty-Six Days of Age
Lake vostok behaves like a ‘captured lake’ and may be near to creating an antarctic jökulhlaup
Recommendations for the collection and synthesis of Antarctic Ice Sheet mass balance data
Recent unexpected changes in the Antarctic Ice Sheet, including ice sheet thinning, ice shelf collapse and changes in ice velocities, along with the recent realization that as much as one third of ice shelf mass loss is due to bottom melt, place a new urgency on understanding the processes involved in these changes. Technological advances, including very new or forthcoming satellite-based (e.g. ICESat, CryoSat) remote sensing missions, will improve our ability to make meaningful determinations of changes in Antarctic Ice Sheet mass balance.
This paper is the result of a workshop held to develop a strategy for international collaboration aimed at the collection and synthesis of Antarctic Ice Sheet mass balance data, and at understanding the processes involved so that we might predict future change. Nine sets of recommendations are made, concerning the most important and sensitive measurements, temporal ranges and study areas. A final tenth recommendation calls for increased synthesis of ice sheet data and communication between the field measurement, satellite observation and modelling communities