Tremorogeni učinci ekstrakata plijesni izoliranih iz prašine drveta u štakora

Among workers in the Swedish wood industry acute alveolitis, known as “woodtrimmer\u27s disease” has been recognized for some time. One of the signs in the acute phase of the disease is transitory tremor. The etiology of the disease is still not clearly understood, but it is assumed to be associated with wood dust containing fungal spores. One of the dominant fungal strains isolated from wood at the saw-mills was found to be Aspergillus fumigatus. As it is known that Aspergillus fumigatus has the ability to produce tremorgenic mycotoxins, the moulds from the working environment were isolated, cultivated and tested for the ability to produce mycotoxins, to estimate a possible relation between fungal spores and tremorgenic effects. Extracts of moulds were prepared and tested on rats after oral administration. The ability to induce tremors in rats was found in six out of nine extracts tested. A very good agreement was found between the results of the chemical analysis of extracts and those of the study in vivo. The results imply that woodtrimmer\u27s disease may at least partly, be mycotoxicosis.U Švedskoj, u radnika zaposlenih u drvnoj industriji, javlja se akutni alveolitis poznat i pod nazivom Woodtrimmer\u27s disease, popraćen prolaznim tremorom. Pojava je nepoznate etiologije ali se povezuje s izloženošću drvenoj prašini u kojoj se nalaze spore različitih plijesni. Aspergillus fumigatus je plijesan koja se najčešće izolira u sušarama drveta. Iz radne sredine izolirane su plijesni Aspergillus flavusa te je nakon kultivacije testirana njihova sposobnost stvaranja tremorogenih mikotoksina analitičkim metodama i u pokusima na štakorima. Ekstrakti plijesni aplicirani su pokusnim životinjama oralno. Šest od devet ekstrakata izazvalo je pojavu tremora u tretiranih životinja. Nađena je vrlo dobra korelacija rezultata kemijskih analiza i rezultata dobivenih u pokusima in vivo. Podaci upućuju na moguću vezu između Woodtrimmer\u27s disease i izloženosti radnika tremorogenim mikotoksinima

An overview of the current status of CMB observations

In this paper we briefly review the current status of the Cosmic Microwave Background (CMB) observations, summarising the latest results obtained from CMB experiments, both in intensity and polarization, and the constraints imposed on the cosmological parameters. We also present a summary of current and future CMB experiments, with a special focus on the quest for the CMB B-mode polarization.Comment: Latest CMB results have been included. References added. To appear in "Highlights of Spanish Astrophysics V", Proceedings of the VIII Scientific Meeting of the Spanish Astronomical Society (SEA) held in Santander, 7-11 July, 200

Highly-parallelized simulation of a pixelated LArTPC on a GPU

The rapid development of general-purpose computing on graphics processing units (GPGPU) is allowing the implementation of highly-parallelized Monte Carlo simulation chains for particle physics experiments. This technique is particularly suitable for the simulation of a pixelated charge readout for time projection chambers, given the large number of channels that this technology employs. Here we present the first implementation of a full microphysical simulator of a liquid argon time projection chamber (LArTPC) equipped with light readout and pixelated charge readout, developed for the DUNE Near Detector. The software is implemented with an end-to-end set of GPU-optimized algorithms. The algorithms have been written in Python and translated into CUDA kernels using Numba, a just-in-time compiler for a subset of Python and NumPy instructions. The GPU implementation achieves a speed up of four orders of magnitude compared with the equivalent CPU version. The simulation of the current induced on 10^3 pixels takes around 1 ms on the GPU, compared with approximately 10 s on the CPU. The results of the simulation are compared against data from a pixel-readout LArTPC prototype

Als de tijd verstrijkt. Fasering, groei en veroudering in universiteitsgeneeskunde van de late middeleeuwen

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E. Huizenga,Een wereld van kennis. Bloemlezing uit de Middelnederlandse artesliteratuur Hilversum:Verloren ,2002 90-6550-679-9

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Binnen en buiten - arts en chirurg. De verdeling van het lichaam, medische praktijk en status in de late Middeleeuwen

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Die sanguwijn vele meer mint… Mooie mensen in de middeleeuwen

Item does not contain fulltextRadboud Universiteit NijmegenStudiedag De mooie middeleeuwe

The rhetoric of academic medicine

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