Measurement of Electron Trapping in the CESR Storage Ring

The buildup of low-energy electrons has been shown to affect the performance of a wide variety of particle accelerators. Of particular concern is the persistence of the cloud between beam bunch passages, which can impose limitations on the stability of operation at high beam current. We have obtained measurements of long-lived electron clouds trapped in the field of a quadrupole magnet in a positron storage ring, with lifetimes much longer than the revolution period. Based on modeling, we estimate that about 7% of the electrons in the cloud generated by a 20-bunch train of 5.3 GeV positrons with 16-ns spacing and $1.3x10^{11}$ population survive longer than 2.3 $\mu$s in a quadrupole field of gradient 7.4 T/m. We have observed a non-monotonic dependence of the trapping effect on the bunch spacing. The effect of a witness bunch on the measured signal provides direct evidence for the existence of trapped electrons. The witness bunch is also observed to clear the cloud, demonstrating its effectiveness as a mitigation technique.Comment: 6 pages, 9 figures, 28 citation

Production and characterization of monoclonal antibodies to the extracellular domain of PO

Seven monoclonal antibodies were raised against the immunoglobulin-like extracellular domain of PO (POED), the major protein of peripheral nervous system myelin. Mice were immunized with purified recombinant rat PO-ED. After fusion, 7 clones (POI-P07) recognizing either recombinant, rat, mouse, or human PO-ED were selected by ELlS A and were characterized by Western blot, immunohistochemistry, and a competition assay. Antibodies belonged to the IgG or IgM class, and P04-P07, reacted with PO in fresh-frozen and paraffin-embedded sections of human or rat peripheral nerve, but not with myelin proteins of the central nervous system of either species. Epitope specificity of the antibodies was determined by a competition enzyme-linked immunosorbent assay (ELISA) and a direct ELlS A using short synthetic peptides spanning the entire extracellular domain of PO. These assays showed that POl and P02 exhibiting the same reaction pattern in Western blot and immunohistochemistry reacted with different distant epitopes of PO. Furthermore, the monoclonal antibodies P05 and P06 recognized 2 different epitopes in close proximity within the neuritogenic extracellular sequence of PO. This panel of monoclonal antibodies, each binding to a different epitope of the extracellular domain of PO, will be useful for in vitro and in vivo studies designed to explore the role of PO during myelination and in demyelinating diseases of the peripheral nervous system

Nonlinear transport of Bose-Einstein condensates through mesoscopic waveguides

We study the coherent flow of interacting Bose-condensed atoms in mesoscopic waveguide geometries. Analytical and numerical methods, based on the mean-field description of the condensate, are developed to study both stationary as well as time-dependent propagation processes. We apply these methods to the propagation of a condensate through an atomic quantum dot in a waveguide, discuss the nonlinear transmission spectrum and show that resonant transport is generally suppressed due to an interaction-induced bistability phenomenon. Finally, we establish a link between the nonlinear features of the transmission spectrum and the self-consistent quasi-bound states of the quantum dot.Comment: 23 pages, 16 figure

The Influence of Boron (B), Tin (Sn), Copper (Cu), and Manganese (Mn) on the Microstructure of Spheroidal Graphite Irons

Most spheroidal graphite irons (SGIs) have a matrix consisting of ferrite, pearlite, or a mix of the two. To achieve the desired matrix composition, pearlite promoters such as Mn, Cu, or Sn, are added to the molten metal. Among these elements, Sn is the most potent pearlite promoter. However, each has a different impact on the solidification, graphite precipitation, eutectoid transformation, and ultimately the final structure of the material. Research has shown that B promotes ferrite in fully pearlitic grades where Cu and Mn were used to promote pearlite. The present work investigates the effect of B in SGI with additions of Sn, Cu, and Mn, and the effects of varying amounts of the different pearlite promoters on the matrix composition. The results show that Mn alone at levels of approximately 0.9 wt% is not enough to promote a fully pearlitic matrix, while 0.5 wt% Cu combined with 0.67 wt% Mn is sufficient. Likewise, a fully pearlitic microstructure can be obtained by alloying with 0.06 wt% Sn and 0.67 wt% Mn. B was found to promote ferrite in fully pearlitic SGI alloyed with Sn or Cu. However, in the absence of those elements, B promoted pearlite when alloyed with just Mn. Graphite protrusions were observed on the graphite nodule surface only for B-added alloys with Sn and Cu. In these cases, it is believed B promotes ferrite by changing the growth mechanism of graphite after solidification from spherical to lamellar. However, a different graphite morphology is observed when B is added with just Mn. Thermal analysis data is in agreement with the microstructural observations regarding the ferrite promoting effect of B

International Guillain-Barré Syndrome Outcome Study (IGOS): protocol of a prospective observational cohort study on clinical and biological predictors of disease course and outcome in Guillain-Barré syndrome

Guillain-Barré syndrome (GBS) is an acute polyradiculoneuropathy with a highly variable clinical presentation, course, and outcome. The factors that determine the clinical variation of GBS are poorly understood which complicates the care and treatment of individual patients. The protocol of the ongoing International GBS Outcome Study (IGOS), a prospective, observational, multi-centre cohort study that aims to identify the clinical and biological determinants and predictors of disease onset, subtype, course and outcome of GBS is presented here. Patients fulfilling the diagnostic criteria for GBS, regardless of age, disease severity, variant forms, or treatment, can participate if included within two weeks after onset of weakness. Information about demography, preceding infections, clinical features, diagnostic findings, treatment, course and outcome is collected. In addition, cerebrospinal fluid and serial blood samples for serum and DNA is collected at standard time points. The original aim was to include at least 1000 patients with a follow-up of 1-3 years. Data are collected via a web-based data entry system and stored anonymously. IGOS started in May 2012 and by January 2017 included more than 1400 participants from 143 active centres in 19 countries across 5 continents. The IGOS data/biobank is available for research projects conducted by expertise groups focusing on specific topics including epidemiology, diagnostic criteria, clinimetrics, electrophysiology, antecedent events, antibodies, genetics, prognostic modelling, treatment effects and long-term outcome of GBS. The IGOS will help to standardize the international collection of data and biosamples for future research of GBS. ClinicalTrials.gov Identifier: NCT01582763