Deep semi-supervised segmentation with weight-averaged consistency targets

Recently proposed techniques for semi-supervised learning such as Temporal Ensembling and Mean Teacher have achieved state-of-the-art results in many important classification benchmarks. In this work, we expand the Mean Teacher approach to segmentation tasks and show that it can bring important improvements in a realistic small data regime using a publicly available multi-center dataset from the Magnetic Resonance Imaging (MRI) domain. We also devise a method to solve the problems that arise when using traditional data augmentation strategies for segmentation tasks on our new training scheme.Comment: 8 pages, 1 figure, accepted for DLMIA/MICCA

Roles of Education and IQ in Cognitive Reserve in Parkinson's Disease-Mild Cognitive Impairment.

Background/aimsThe role of cognitive reserve in Parkinson's disease (PD)-mild cognitive impairment (MCI) is incompletely understood.MethodsThe relationships between PD-MCI, years of education, and estimated premorbid IQ were examined in 119 consecutive non-demented PD patients using logistic regression models.ResultsHigher education and IQ were associated with reduced odds of PD-MCI in univariate analysis. In multivariable analysis, a higher IQ was associated with a significantly decreased odds of PD-MCI, but education was not.ConclusionThe association of higher IQ and decreased odds of PD-MCI supports a role for cognitive reserve in PD, but further studies are needed to clarify the interaction of IQ and education and the impact of other contributors such as employment and hobbies

Unmet Needs in the Pathogenesis and Treatment of Systemic Lupus Erythematosus

Systemic lupus erythematosus (SLE) is an autoimmune rheumatic disease with a prevalence of approximately 1 in 1000. Over the last 30 years, advances in treatment such as use of corticosteroids and immunosuppressants have improved life expectancy and quality of life for patients with lupus and the key unmet needs have therefore changed. With the reduced mortality from disease activity, development of cardiovascular disease (CVD) has become an increasingly important cause of death in patients with SLE. The increased CVD risk in these patients is partly, but not fully explained by standard risk factors, and abnormalities in the immune response to lipids may play a role. Invariant natural killer T cells, which are triggered specifically by lipid antigens, may protect against progression of subclinical atherosclerosis. However, currently our recommendation is that clinicians should focus on optimal management of standard CVD risk factors such as smoking, blood pressure and lipid levels. Fatigue is one of the most common and most limiting symptoms suffered by patients with SLE. The cause of fatigue is multifactorial and disease activity does not explain this symptom. Consequently, therapies directed towards reducing inflammation and disease activity do not reliably reduce fatigue and new approaches are needed. Currently, we recommend asking about sleep pattern, optimising pain relief and excluding other causes of fatigue such as anaemia and metabolic disturbances. For the subgroup of patients whose disease activity is not fully controlled by standard treatment regimes, a range of different biologic agents have been proposed and subjected to clinical trials. Many of these trials have given disappointing results, though belimumab, which targets B lymphocytes, did meet its primary endpoint. New biologics targeting B cells, T cells or cytokines (especially interferon) are still going through trials raising the hope that novel therapies for patients with refractory SLE may be available soon

Human coping strategies to desertification in Yobe State, Nigeria

This paper examined the coping strategies adopted by the rural population in Yobe State of Nigeria to desertification. Data on methods used to cope with desertification were collected from eighteen development areas of the study area, as well as government agencies. The main objective was to examine how the process of desertification has forced the local population to use various coping strategies. Structured questionnaire was used to collect data. Data analysis employed the use of air photographs of thedevelopment areas obtained from the North East Arid Zone Development Programme (NEAZDP) for the 1990s and 2000s. These aerial photographs were used to validate the presence of sand dune accumulation, bare grounds, depletion of water bodies and vegetation cover. These results were validated at the Regional Centre for Remote Sensing in Jos. The study finings show that the expanding desert is a severe environmental problem. Environmental changes have been significant particularly inreduction of water body, depletion of vegetation cover, shifting sand dunes, increasing bare grounds and loss of biodiversity. A combination of coping strategies such as use of trees as wind breaks, woven stick construction around houses, agro-forestry practices and fadama farming have been used by the local population. The paper suggests the needfor massive tree plantings in the study area and Nigeria in general. The Federal and State Departments of Forestry need to be empowered with adequate revenue for massive reforestation programme. Regulation to discourage dependence on wood for local energy should be put in place, while other sources of energy such as kerosene should be adequately provided

Perceptions and Involvement of Neighbouring Communities of Kainji Lake National Park towards the Parks Conservation Programmes

This study investigated the level of awareness of the neighbouring communities of Kainji Lake National Park about the reasons for the establishment of the park and the laws protecting it. The study also assessed the local residents' perception of the park's programmes, the impacts of the programme on the socio-economic status of the residents and their developmental needs with a view to eliciting their support for the park's programmes. Multi stage sampling techniques involving the use of structured questionnaires and oral interviews were used in obtaining information from the residents in the 21 communities surrounding the park. Results obtained depicted a very high level of awareness about the existence of the park (96.8%), reasons for creating the park (94.3%) and the laws governing the park (91.6%). In spite of the respondents claim that the park project has made them poorer (68.7%), majority of them (66.8%) still felt strongly that the project is a good one and therefore supported its existence. The most desirous of the developmental needs that could elicit the support of the local residents include; electricity, credit facilities, agricultural inputs, water, education and health in that order. The provision of these social and economic needs will no doubt ensure a harmonious coexistence with the support zone communities with the attendant accomplishment of the goals of the National park Project

Simultaneous production of raw starch degrading highly thermostable a-amylase and lactic acid by Lactobacillus fermentum 04BBA19

The widely used thermostable amylases were produced long time ago from Bacillus genus. Although, lactic acid bacteria (LAB) fermentation presents several advantages including the reduction of growth of pathogenic microorganisms, no study has yet reported thermostable amylases from lactic acid bacteria. An amylolytic LAB, Lactobacillus fermentum (04BBA19) isolated from starchy wastes of a soil sample from the western region of Cameroon was studied for amylase and lactic acid production. The bacterium exhibited maximal amylase and lactic acid production at temperature of 45°C, and within pH range of 4.0 to 6.5. Upon the optimization of various environmental and cultural conditions the yield of amylase and lactic acid reached 732.3±0.4 U/ml and 53.2±0.7 g/L respectively in fermented broth after 48 h of culture. The enzyme was identified as α-amylase, with a very high thermostability revealed by the retention of 100% of original activity after pre-incubation for 30 min at 80°C. The stability was improved significantly with the addition of 0.1% (w/v) CaCl2.2H2O; the half life of the enzyme in these conditions was 6 h at 80°C. Owing to its aptitude to exhibit a simultaneous production of thermostable amylase and lactic acid, L. fermentum (04BBA19) appeared as a potential candidate for the making of high density gruel from starchy material.Key words: Lactic acid bacteria, thermostable a-amylase, lactic acid, fermentation, high density gruel

Dictionary Learning and Sparse Coding-based Denoising for High-Resolution Task Functional Connectivity MRI Analysis

We propose a novel denoising framework for task functional Magnetic Resonance Imaging (tfMRI) data to delineate the high-resolution spatial pattern of the brain functional connectivity via dictionary learning and sparse coding (DLSC). In order to address the limitations of the unsupervised DLSC-based fMRI studies, we utilize the prior knowledge of task paradigm in the learning step to train a data-driven dictionary and to model the sparse representation. We apply the proposed DLSC-based method to Human Connectome Project (HCP) motor tfMRI dataset. Studies on the functional connectivity of cerebrocerebellar circuits in somatomotor networks show that the DLSC-based denoising framework can significantly improve the prominent connectivity patterns, in comparison to the temporal non-local means (tNLM)-based denoising method as well as the case without denoising, which is consistent and neuroscientifically meaningful within motor area. The promising results show that the proposed method can provide an important foundation for the high-resolution functional connectivity analysis, and provide a better approach for fMRI preprocessing.Comment: 8 pages, 3 figures, MLMI201

Persistence in epidemic metapopulations: quantifying the rescue effects for measles, mumps, rubella and whooping cough

Metapopulation rescue effects are thought to be key to the persistence of many acute immunizing infections. Yet the enhancement of persistence through spatial coupling has not been previously quantified. Here we estimate the metapopulation rescue effects for four childhood infections using global WHO reported incidence data by comparing persistence on island countries vs all other countries, while controlling for key variables such as vaccine cover, birth rates and economic development. The relative risk of extinction on islands is significantly higher, and approximately double the risk of extinction in mainland countries. Furthermore, as may be expected, infections with longer infectious periods tend to have the strongest metapopulation rescue effects. Our results quantitate the notion that demography and local community size controls disease persistence

Direct and indirect effects of rotavirus vaccination: Comparing predictions from transmission dynamic models

Early observations from countries that have introduced rotavirus vaccination suggest that there may be indirect protection for unvaccinated individuals, but it is unclear whether these benefits will extend to the long term. Transmission dynamic models have attempted to quantify the indirect protection that might be expected from rotavirus vaccination in developed countries, but results have varied. To better understand the magnitude and sources of variability in model projections, we undertook a comparative analysis of transmission dynamic models for rotavirus. We fit five models to reported rotavirus gastroenteritis (RVGE) data from England and Wales, and evaluated outcomes for short- and long-term vaccination effects. All of our models reproduced the important features of rotavirus epidemics in England and Wales. Models predicted that during the initial year after vaccine introduction, incidence of severe RVGE would be reduced 1.8-2.9 times more than expected from the direct effects of the vaccine alone (28-50% at 90% coverage), but over a 5-year period following vaccine introduction severe RVGE would be reduced only by 1.1-1.7 times more than expected from the direct effects (54-90% at 90% coverage). Projections for the long-term reduction of severe RVGE ranged from a 55% reduction at full coverage to elimination with at least 80% coverage. Our models predicted short-term reductions in the incidence of RVGE that exceeded estimates of the direct effects, consistent with observations from the United States and other countries. Some of the models predicted that the short-term indirect benefits may be offset by a partial shifting of the burden of RVGE to older unvaccinated individuals. Nonetheless, even when such a shift occurs, the overall reduction in severe RVGE is considerable. Discrepancies among model predictions reflect uncertainties about age variation in the risk and reporting of RVGE, and the duration of natural and vaccine-induced immunity, highlighting important questions for future research