Zenithal bistable device: comparison of modeling and experiment

A comparative modeling and experimental study of the zenithal bistable liquid crystal device is presented. A dynamic Landau de Gennes theory of nematic liquid crystals is solved numerically to model the electric field induced latching of the device and the results are compared with experimental measurements and theoretical approximations. The study gives a clear insight into the latching mechanism dynamics and enables the dependence of the device latching on both material parameters and surface shape to be determined. Analytical approximation highlights a route to optimize material selection in terms of latching voltages and the numerical model, which includes an accurate surface representation, recovers the complex surface shape effects. Predictions of device performance are presented as a function of both surface anchoring strength and surface shape and grating pitch. A measurement of the homeotropic anchoring energy has been undertaken by comparing the voltage response as a function of cell gap; we find the homeotropic anchoring energies can be varied in the range 0.5 to 4 (10-44 J m-2)

Evidence for deceleration in the radio jets of GRS1915+105?

There is currently a clear discrepancy in the proper motions measured on different angular scales in the approaching radio jets of the black hole X-ray binary GRS1915+105. Lower velocities were measured with the Very Large Array (VLA) prior to 1996 than were subsequently found from higher-resolution observations made with the Very Long Baseline Array and the Multi-Element Radio Linked Interferometer Network. We initiated an observing campaign to use all three arrays to attempt to track the motion of the jet knots from the 2006 February outburst of the source, giving us unprecedented simultaneous coverage of all angular scales, from milliarcsecond scales out to arcsecond scales. The derived proper motion, which was dominated by the VLA measurements, was found to be 17.0 mas per day, demonstrating that there has been no significant permanent change in the properties of the jets since 1994. We find no conclusive evidence for deceleration of the jet knots, unless this occurs within 70 mas of the core. We discuss possible causes for the varying proper motions recorded in the literature.Comment: Accepted for publication in MNRAS. 13 pages, 10 figure

First e-VLBI observations of GRS 1915+105

We present results from the first successful open call e-VLBI science run, observing the X-ray binary GRS 1915+105. e-VLBI science allows the rapid production of VLBI radio maps, within hours of an observation rather than weeks, facilitating a decision for follow-up observations. A total of 6 telescopes observing at 5 GHz across the European VLBI Network (EVN) were correlated in real time at the Joint Institute for VLBI in Europe (JIVE). Constant data rates of 128 Mbps were transferred from each telescope, giving 4 TB of raw sampled data over the 12 hours of the whole experiment. Throughout this, GRS 1915+105 was observed for a total of 5.5 hours, producing 2.8 GB of visibilities of correlated data. A weak flare occurred during our observations, and we detected a slightly resolved component of 2.7 x 1.2 milliarcsecond with a position angle of 140 (+/-2) degrees. The peak brightness was 10.2 mJy per beam, with a total integrated radio flux of 11.1 mJy.Comment: Accepted for publication in MNRAS 4 pages, 3 figure

Spatial sampling of the thermospheric vertical wind field at auroral latitudes

Results are presented from two nights of bistatic Doppler measurements of neutral thermospheric winds using Fabry!Perot spectrometers at Mawson and Davis stations in Antarctica. A scanning Doppler imager (SDI) at Mawson and a narrow-field Fabry-Perot spectrometer (FPS) at Davis have been used to estimate the vertical wind at three locations along the great circle joining the two stations, in addition to the vertical wind routinely observed above each station. These data were obtained from observations of the 630.0 nm airglow line of atomic oxygen, at a nominal altitude of 240 km. Low!resolution all-sky images produced by the Mawson SDI have been used to relate disturbances in the measured vertical wind field to auroral activity and divergence in the horizontal wind field. Correlated vertical wind responses were observed on a range of horizontal scales from ~150 to 480 km. In general, the behavior of the vertical wind was in agreement with earlier studies, with strong upward winds observed poleward of the optical aurora and sustained, though weak, downward winds observed early in the night. The relation between vertical wind and horizontal divergence was seen to follow the general trend predicted by Burnside et al. (1981), whereby upward vertical winds were associated with positive divergence and vice versa; however, a scale height approximately 3–4 times greater than that modeled by NRLMSISE-00 was required to best fit the data using this relation

Patients’ Experiences of Cancer Diagnosis as a Result of an Emergency Presentation: A Qualitative Study

Cancers diagnosed following visits to emergency departments (ED) or emergency admissions (emergency presentations) are associated with poor survival and may result from preventable diagnostic delay. To improve outcomes for these patients, a better understanding is needed about how emergency presentations arise. This study sought to capture patients' experiences of this diagnostic pathway in the English NHS. Eligible patients were identified in a service evaluation of emerge ncy presentations and invited to participate. Interviews, using an open-ended biographical structure, captured participants' experiences of healthcare services before diagnosis and were analysed thematically, informed by the Walter model of Pathways to Treatment and NICE guidance in n iterative process. Twenty-seven interviews were conducted. Three typologies were identified: A: Rapid investigation and diagnosis, and B: Repeated cycles of healthcare seeking and appraisal without resolution, with two variants where B1 appears consistent with guidance and B2 has evidence that management was not consistent with guidance. Most patients’ (23/27) experiences fitted types B1 and B2. Potentially avoidable breakdowns in diagnostic pathways caused delays when patients were conflicted by escalating symptoms and a benign diagnosis given earlier by doctors. ED was sometimes used as a conduit to rapid testing by primary care clinicians, although this pathway was not always successful. This study draws on patients' experiences of their diagnosis to provide novel insights into how emergency presentations arise. Through these typologies, we show that the typical experience of patients diagnosed through an emergency presentation diverges significantly from normative pathways even when there is no evidence of serious service failures. Consultations were not a conduit to diagnosis when they inhibited patients’ capacity to appraise their own symptoms appropriately and when they resulted in a reluctance to seek further healthcare. The findings also point to potentially avoidable breakdowns in the diagnostic process. In particular, to encourage patients to return to the GP if symptoms escalate, a stronger emphasis is needed on diagnostic uncertainty in discussions between patients and doctors in both primary and secondary care. To improve appropriate access to rapid investigations, systems are needed for primary care to communicate directly with secondary care at the time of referral

A transient relativistic radio jet from Cygnus X-1

We report the first observation of a transient relativistic jet from the canonical black hole candidate, Cygnus X-1, obtained with the Multi-Element Radio-Linked Interferometer Network (MERLIN). The jet was observed in only one of six epochs of MERLIN imaging of the source during a phase of repeated X-ray spectral transitions in 2004 Jan--Feb, and this epoch corresponded to the softest 1.5-12 keV X-ray spectrum. With only a single epoch revealing the jet, we cannot formally constrain its velocity. Nevertheless, several lines of reasoning suggest that the jet was probably launched 0.5-4.0 days before this brightening, corresponding to projected velocities of 0.2c < v_app < 1.6c, and an intrinsic velocity of > 0.3c. We also report the occurrence of a major radio flare from Cyg X-1, reaching a flux density of ~120 mJy at 15 GHz, and yet not associated with any resolvable radio emission, despite a concerted effort with MERLIN. We discuss the resolved jet in terms of the recently proposed 'unified model' for the disc-jet coupling in black hole X-ray binaries, and tentatively identify the 'jet line' for Cyg X-1. The source is consistent with the model in the sense that a steady jet appears to persist initially when the X-ray spectrum starts softening, and that once the spectral softening is complete the core radio emission is suppressed and transient ejecta / shock observed. However, there are some anomalies, and Cyg X-1 clearly does not behave like a normal black hole transient in progressing to the canonical soft / thermal state once the ejection event has happened.Comment: Accepted for publication in MNRA

Exploration of PET and MRI radiomic features for decoding breast cancer phenotypes and prognosis.

Radiomics is an emerging technology for imaging biomarker discovery and disease-specific personalized treatment management. This paper aims to determine the benefit of using multi-modality radiomics data from PET and MR images in the characterization breast cancer phenotype and prognosis. Eighty-four features were extracted from PET and MR images of 113 breast cancer patients. Unsupervised clustering based on PET and MRI radiomic features created three subgroups. These derived subgroups were statistically significantly associated with tumor grade (p = 2.0 × 10-6), tumor overall stage (p = 0.037), breast cancer subtypes (p = 0.0085), and disease recurrence status (p = 0.0053). The PET-derived first-order statistics and gray level co-occurrence matrix (GLCM) textural features were discriminative of breast cancer tumor grade, which was confirmed by the results of L2-regularization logistic regression (with repeated nested cross-validation) with an estimated area under the receiver operating characteristic curve (AUC) of 0.76 (95% confidence interval (CI) = [0.62, 0.83]). The results of ElasticNet logistic regression indicated that PET and MR radiomics distinguished recurrence-free survival, with a mean AUC of 0.75 (95% CI = [0.62, 0.88]) and 0.68 (95% CI = [0.58, 0.81]) for 1 and 2 years, respectively. The MRI-derived GLCM inverse difference moment normalized (IDMN) and the PET-derived GLCM cluster prominence were among the key features in the predictive models for recurrence-free survival. In conclusion, radiomic features from PET and MR images could be helpful in deciphering breast cancer phenotypes and may have potential as imaging biomarkers for prediction of breast cancer recurrence-free survival