Knockdown Resistance to DDT and Pyrethroids in the House Fly (Diptera: Muscidae): From Genetic Trait to Molecular Mechanism

Knockdown resistance to DDT and pyrethrins was the 1st insecticide resistance trait involving reduced target site sensitivity to be identified and isolated genetically. Almost 5 decades later, knockdown resistance continues to threaten the continued effectiveness of pyrethroid insecticides in the control of numerous agricultural pests and vectors of human disease. In this review we summarize progress in the characterization of knockdown resistance in the house fly, Musca domestica L., culminating in the identification of the specific sodium channel gene mutations that cause the reduced neuronal sensitivity to DDT and pyrethroids in knockdown-resistant insect

Data Gaps in Evidence-Based Research on Small Water Enterprises in Developing Countries

This paper assess the literature on small water enterprises -- water delivery operations that predominantly provide water at the community level. A research agenda is recommended to advance knowledge on effective SWE service

Press Reporting on El Salvador and Nicaragua in Leading Canadian and American Newspapers

Literature dealing with western news coverage of the Third World points to an unevenness in that coverage. Events that are sensational or violent, especially if they impact on the West, are those most likely to find their way into news reports (Markham, 1961; Hester, 74). This article, based on a study of news coverage of Central America in the fall of 1983, substantiates this generalization, as one hundred and fifty - six out of a total of two hundred and fourteen items dealing with the entire region in four leading Canadian and American newspapers (72.9%), focused on the violence torn countries of El Salvador and Nicaragua. With respect to the remaining items, twelve percent focused on the region in general (often in terms of the implications of the violence in El Salvador and Nicaragua), while only seven percent dealt with Guatemala, 3.7% with Honduras, 3.3% with Costa Rica, and 0.6% with Panama. If violence, both external and internal, is the magnet which attracts western press attention to countries of the Third World, we have little difficulty in locating the primary sites of that violence within the Central American isthmus. </jats:p

Computer-aided diagnosis for (123I)FP-CIT imaging: impact on clinical reporting

BACKGROUND: For (123I)FP-CIT imaging, a number of algorithms have shown high performance in distinguishing normal patient images from those with disease, but none have yet been tested as part of reporting workflows. This study aims to evaluate the impact on reporters' performance of a computer-aided diagnosis (CADx) tool developed from established machine learning technology. Three experienced (123I)FP-CIT reporters (two radiologists and one clinical scientist) were asked to visually score 155 reconstructed clinical and research images on a 5-point diagnostic confidence scale (read 1). Once completed, the process was then repeated (read 2). Immediately after submitting each image score for a second time, the CADx system output was displayed to reporters alongside the image data. With this information available, the reporters submitted a score for the third time (read 3). Comparisons between reads 1 and 2 provided evidence of intra-operator reliability, and differences between reads 2 and 3 showed the impact of the CADx. RESULTS: The performance of all reporters demonstrated a degree of variability when analysing images through visual analysis alone. However, inclusion of CADx improved consistency between reporters, for both clinical and research data. The introduction of CADx increased the accuracy of the radiologists when reporting (unfamiliar) research images but had less impact on the clinical scientist and caused no significant change in accuracy for the clinical data. CONCLUSIONS: The outcomes for this study indicate the value of CADx as a diagnostic aid in the clinic and encourage future development for more refined incorporation into clinical practice

Hay Additive Review: Where We\u27ve Been, Where We\u27re Going

The losses from harvest to feed bunk are undoubtedly greater with hay than any other crop grown by the American farmer. The economic implications of reducing losses through improved harvest technologies is staggering when one considers the 75-85 million tons of alfalfa harvested out of the total 140-145 million tons of hay produced annually in the United States

Adverse prognostic and predictive significance of low DNA-dependent protein kinase catalytic subunit (DNA-PKcs) expression in early-stage breast cancers

Background: DNA-dependent protein kinase catalytic subunit (DNA-PKcs), a serine threonine kinase belonging to the PIKK family (phosphoinositide 3-kinase-like-family of protein kinase), is a critical component of the non-homologous end joining (NHEJ) pathway required for the repair of DNA double strand breaks. DNA-PKcs may be involved in breast cancer pathogenesis. Methods: We evaluated clinicopathological significance of DNA-PKcs protein expression in 1161 tumours and DNA-PKcs mRNA expression in 1950 tumours. We correlated DNA-PKcs to other markers of aggressive phenotypes, DNA repair, apoptosis and cell cycle regulation. Results: Low DNA-PKcs protein expression was associated with higher tumour grade, higher mitotic index, tumour de-differentiation and tumour type (ps<0.05). Absence of BRCA1, low XRCC1/SMUG1/APE1/Polβ were also more likely in low DNA-PKcs expressing tumours (ps<0.05). Low DNA-PKcs protein expression was significantly associated with worse breast cancer specific survival (BCCS) in univariate and multivariate analysis (ps<0.01). At the mRNA level, low DNA-PKcs was associated with PAM50.Her2 and PAM50.LumA molecular phenotypes (ps<0.01) and poor BCSS. In patients with ER positive tumours who received endocrine therapy, low DNA-PKcs (protein and mRNA) was associated with poor survival. In ER negative patients, low DNA-PKcs mRNA remains significantly associated with adverse outcome. Conclusions: Our study suggests that low DNA-PKcs expression may have prognostic and predictive significance in breast cancers

Early Life Socioeconomic Circumstance and Late Life Brain Hyperintensities : A Population Based Cohort Study

Funding: Image acquisition and image analysis for this study was funded by the Alzheimer's Research Trust (now Alzheimer's Research UK). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Acknowledgments The authors would like to thank the participants of the Aberdeen 1936 Birth Cohort (ABC36), without whom this research would not have been possible.Peer reviewedPublisher PD

Innovating in a crisis : Canadian media actors assess the state of convergence

Our content analysis conducted in 2007 revealed little evidence of convergence practices in television networks and newspapers owned by Canwest Global, CTVglobemedia, and Quebecor. In 2009 and early 2010, we interviewed executives and journalists of the media groups studied, as well as other stakeholders, to assess the current situation and speculate about the future of convergence in Canada. Respondents generally acknowledged that TV/print newsroom integration had not succeeded and that future convergence efforts would focus on delivering content online and developing a viable economic model for news production. Respondents offered diverse perceptions of conventional media’s ability to reinvent and sustain themselves as the principal news sources for Canadians. Emerging models include the development of a corporate news service, specialization in certain topic areas, and crossmedia collaboration.Notre analyse de contenu réalisée en 2007 n’a révélé aucune preuve substantielle de convergence entre les nouvelles télévisées et les journaux appartenant aux groupes Canwest Global, CTVglobemedia et Quebecor. Nous avons réalisé une série d’entretiens auprès de gestionnaires et journalistes des médias étudiés, de même que d’autres acteurs du milieu, en 2009 et 2010, afin de recueillir leur évaluation de la situation actuelle et leur vision de l’avenir de la convergence médiatique. De l’avis général des participants, l’intégration des nouvelles télévisuelles et de la presse écrite ne s’était pas réalisée et les initiatives futures s’orienteront surtout vers l’offre en ligne et la rentabilisation des contenus d’information. Ils ont émis des points de vue variés quant à la capacité des médias conventionnels de se réinventer et se maintenir en tant que sources principales d’information pour les Canadiens. Parmi les modèles émergents identifiés : le développement d’agences de presse corporatives, la spécialisation thématique et la collaboration entre médias