Funding: Image acquisition and image analysis for this study was funded by the Alzheimer's Research Trust (now Alzheimer's Research UK). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Acknowledgments The authors would like to thank the participants of the Aberdeen 1936 Birth Cohort (ABC36), without whom this research would not have been possible.Peer reviewedPublisher PD

A Forsdahl

A Seidler

A Singhal

AD Murray

Alison D. Murray

B Dubois

B Galobardes

C Power

CB Wright

Christopher J. McNeil

CL Hart

DJ Barker

GD Smith

H Soderlund

IB Meier

Lawrence J. Whalley

LJ Whalley

LM de Lau

MD Gliksman

MP Allin

O Grimaud

O Naess

P Scheltens

PJ Gianaros

PM Bentler

Roger T. Staff

RT Staff

S Benisty

S Debette

S Salarirad

SD Shenkin

Sima Salarirad

Sonia Brucki

SP Wamala

T Delamothe

PLoS ONE

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Early Life Socioeconomic Circumstance and Late Life Brain Hyperintensities – A Population Based Cohort Study

Funding: Image acquisition and image analysis for this study was funded by the Alzheimer's Research Trust (now Alzheimer's Research UK). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Acknowledgments The authors would like to thank the participants of the Aberdeen 1936 Birth Cohort (ABC36), without whom this research would not have been possible.Peer reviewe

Murray, Alison D

McNeil, Christopher J

Salarirad, Sima

Whalley, Lawrence J

Staff, Roger T

Aberdeen University Research

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Early Life Socioeconomic Circumstance and Late Life Brain Hyperintensities : A Population Based Cohort Study

There have been many reports confirming the association between lower childhood socioeconomic circumstance and cardiovascular disease but evidence for links with cerebrovascular disease is contradictory. Hyperintensities on brain magnetic resonance imaging are associated with vascular risk factors, cognitive decline, dementia and death. However, the relationship between childhood socioeconomic circumstance and these lesions is unclear.To test the hypothesis that childhood socioeconomic circumstance is associated with late life hyperintensity burden and that neither adult socioeconomic circumstance nor change in socioeconomic circumstance during life influence this effect.Cohort studyCommunity227 community dwelling members of the 1936 Aberdeen Birth Cohort aged 68 years, who were free from dementia.Relationship between early life socioeconomic circumstance (paternal occupation) and abundance of late life brain hyperintensities.<0.05). In models that include hypertension, the magnitude of the effect of childhood socioeconomic circumstance is similar to and independent from that of hypertension.Childhood socioeconomic circumstance predicts the burden of brain white matter hyperintensities aged 68 years. The mechanism underlying this effect is unknown, but may act through fetal and/or early life programming of cerebrovascular disease. Future work to understand this vulnerability will inform strategies to reduce dementia and stroke

Murray Alison D.

McNeil Christopher J.

Salarirad Sima

Whalley Lawrence J.

Staff Roger T.

Public Library of Science (PLOS)

ContextThere have been many reports confirming the association between lower childhood socioeconomic circumstance and cardiovascular disease but evidence for links with cerebrovascular disease is contradictory. Hyperintensities on brain magnetic resonance imaging are associated with vascular risk factors, cognitive decline, dementia and death. However, the relationship between childhood socioeconomic circumstance and these lesions is unclear.ObjectiveTo test the hypothesis that childhood socioeconomic circumstance is associated with late life hyperintensity burden and that neither adult socioeconomic circumstance nor change in socioeconomic circumstance during life influence this effect.DesignCohort study.SettingCommunity.Participants227 community dwelling members of the 1936 Aberdeen Birth Cohort aged 68 years, who were free from dementia.Main outcome measuresRelationship between early life socioeconomic circumstance (paternal occupation) and abundance of late life brain hyperintensities.ResultsWe find significant negative correlations between childhood socioeconomic circumstance and white matter hyperintensities (ρ = -0.18, PConclusionsChildhood socioeconomic circumstance predicts the burden of brain white matter hyperintensities aged 68 years. The mechanism underlying this effect is unknown, but may act through fetal and/or early life programming of cerebrovascular disease. Future work to understand this vulnerability will inform strategies to reduce dementia and stroke

Alison D Murray

Christopher J McNeil

Lawrence J Whalley

Roger T Staff

Directory of Open Access Journals

Early life socioeconomic circumstance and late life brain hyperintensities--a population based cohort study.

http://dx.doi.org/10.1371/journal.pone.0088969

Early Life Socioeconomic Circumstance and Late Life Brain Hyperintensities : A Population Based Cohort Study

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