Hand pollination to increase seed-set of red helleborine Cephalanthera rubra in the Chiltern Hills, Buckinghamshire, England

In 2007 and in previous years, as part of ongoing attempts to improve red helleborine Cephalanthera rubra seed-set, hand pollination of florets has been undertaken at a small colony of this species in Buckinghamshire, southern England. Natural pollination rarely occurs (one mature pod recorded in 10 years) at this site. In 2007, hand pollination resulted in the production of four seed pods, of which one withered and died. Upon ripening, the three remaining pods were removed for attempted micropropagation of the seeds. Ongoing conservation management has probably benefited the solitary bee Chelostoma campanularum which now appears fairly plentiful at the site, but despite the presence of this red helleborine flower visitor, natural pollination remains virtually unrecorded at this locality; field observations suggest that C.campanularum is in fact probably not large enough to act as an effective red helleborine pollinator as it can slip in and out of the flowers without removing the pollinia, unlike it larger relative C.fuliginosum, absent from the UK but which is a known pollinator of red helleborine in continental Europe

Spatio-temporal distribution of Anthonomus grandis grandis Boh. in tropical cotton fields.

The boll weevil, Anthonomus grandis grandis Boheman (Coleoptera: Curculionidae), is considered to be the most harmful cotton, Gossypium hirsutum L., pest throughout subtropical, and tropical regions of the western hemisphere.1,2 Boll weevil damages cotton by feeding upon and laying eggs inside its reproductive structures, where hatched larvae feed and pupate,3,4 causing abscission or reduction of fiber quality,3,5,6 and economic losses of up to US$74 million per year.7 Boll weevil chemical control interventions are based on economic thresholds obtained by sampling the plants and for adult boll weevils captured in pheromone-baited traps.3,8,9 In order to develop an accurate monitoring and management program, estimates of population density are essential.10,11 Biotic and abiotic factors affect dynamics and within-field distribution (aggregated, random or uniform patterns) of insect populations.10,12 Knowing a pest's distribution within a field can help to: (1) develop site-specific sampling and control efforts; (2) predict pest movement; (3) improve insecticide-resistance management; (4) conserve biological control agents by precision targeting sprays for the infested areas; and (5) reduce the economic, social and environmental costs associated with pest control.10,11,13 The spatial distribution of boll weevils has been investigated using mean?variance relationships4,14 without considering within-field spatial density distribution, or has been based on pheromone-baited trap captures.15 The most accurate approach is the use of geostatistics because the position of the samples in space is accounted for.16 Recent work reported that geostatistics is of particular interest for pest management because it allows inferences about the minimum inter-sample distance needed to obtain independent estimations and indicates patterns of distribution and colonization of an organism, all of which are crucial for the development of effective sampling programs.11,13 The purpose of this study was to investigate the spatial dynamics of A. grandis grandis on cotton by determining within-field distribution of adults and infested reproductive structures (having feeding and/or oviposition punctures)

3. Bird Conservation

Expert assessors Tatsuya Amano, University of Cambridge, UK Andy Brown, Natural England, UK Fiona Burns, Royal Society for the Protection of Birds, UK Yohay Carmel, Israel Institute of Technology Mick Clout, University of Auckland, New Zealand Geoff Hilton, Wildfowl & Wetlands Trust, UK Nancy Ockendon, University of Cambridge, UK James Pearce-Higgins, British Trust for Ornithology, UK Sugoto Roy, Food and Environment Research Agency, DEFRA, UK Rebecca K. Smith, University of Cambridge, UK Wil..

Ten-year mortality, disease progression, and treatment-related side effects in men with localised prostate cancer from the ProtecT randomised controlled trial according to treatment received

Background The ProtecT trial reported intention-to-treat analysis of men with localised prostate cancer randomly allocated to active monitoring (AM), radical prostatectomy, and external beam radiotherapy. Objective To report outcomes according to treatment received in men in randomised and treatment choice cohorts. Design, setting, and participants This study focuses on secondary care. Men with clinically localised prostate cancer at one of nine UK centres were invited to participate in the treatment trial comparing AM, radical prostatectomy, and radiotherapy. Intervention Two cohorts included 1643 men who agreed to be randomised and 997 who declined randomisation and chose treatment. Outcome measurements and statistical analysis Analysis was carried out to assess mortality, metastasis and progression and health-related quality of life impacts on urinary, bowel, and sexual function using patient-reported outcome measures. Analysis was based on comparisons between groups defined by treatment received for both randomised and treatment choice cohorts in turn, with pooled estimates of intervention effect obtained using meta-analysis. Differences were estimated with adjustment for known prognostic factors using propensity scores. Results and limitations According to treatment received, more men receiving AM died of PCa (AM 1.85%, surgery 0.67%, radiotherapy 0.73%), whilst this difference remained consistent with chance in the randomised cohort (p = 0.08); stronger evidence was found in the exploratory analyses (randomised plus choice cohort) when AM was compared with the combined radical treatment group (p = 0.003). There was also strong evidence that metastasis (AM 5.6%, surgery 2.4%, radiotherapy 2.7%) and disease progression (AM 20.35%, surgery 5.87%, radiotherapy 6.62%) were more common in the AM group. Compared with AM, there were higher risks of sexual dysfunction (95% at 6 mo) and urinary incontinence (55% at 6 mo) after surgery, and of sexual dysfunction (88% at 6 mo) and bowel dysfunction (5% at 6 mo) after radiotherapy. The key limitations are the potential for bias when comparing groups defined by treatment received and changes in the protocol for AM during the lengthy follow-up required in trials of screen-detected PCa. Conclusions Analyses according to treatment received showed increased rates of disease-related events and lower rates of patient-reported harms in men managed by AM compared with men managed by radical treatment, and stronger evidence of greater PCa mortality in the AM group. Patient summary More than 95 out of every 100 men with low or intermediate risk localised prostate cancer do not die of prostate cancer within 10 yr, irrespective of whether treatment is by means of monitoring, surgery, or radiotherapy. Side effects on sexual and bladder function are better after active monitoring, but the risks of spreading of prostate cancer are more common

What Works in Conservation 2018

This book provides an assessment of the effectiveness of 1277 conservation interventions based on summarized scientific evidence. The 2018 edition contains new chapters covering practical global conservation of primates, peatlands, shrublands and heathlands, management of captive animals as well as an extended chapter on control of freshwater invasive species. Other chapters cover global conservation of amphibians, bats, birds and forests, conservation of European farmland biodiversity and some aspects of enhancing natural pest control, enhancing soil fertility and control of freshwater invasive species. It contains key results from the summarized evidence for each conservation intervention and an assessment of the effectiveness of each by international expert panels. The accompanying website www.conservationevidence.com describes each of the studies individually, and provides full references

Functional and quality of life outcomes of localised prostate cancer treatments (prostate testing for cancer and treatment [ProtecT] study)

Objective To investigate the functional and quality of life (QoL) outcomes of treatments for localised prostate cancer and inform treatment decision-making. Patients and Methods Men aged 50–69 years diagnosed with localised prostate cancer by prostate-specific antigen testing and biopsies at nine UK centres in the Prostate Testing for Cancer and Treatment (ProtecT) trial were randomised to, or chose one of, three treatments. Of 2565 participants, 1135 men received active monitoring (AM), 750 a radical prostatectomy (RP), 603 external-beam radiotherapy (EBRT) with concurrent androgen-deprivation therapy (ADT) and 77 low-dose-rate brachytherapy (BT, not a randomised treatment). Patient-reported outcome measures (PROMs) completed annually for 6 years were analysed by initial treatment and censored for subsequent treatments. Mixed effects models were adjusted for baseline characteristics using propensity scores. Results Treatment-received analyses revealed different impacts of treatments over 6 years. Men remaining on AM experienced gradual declines in sexual and urinary function with age (e.g., increases in erectile dysfunction from 35% of men at baseline to 53% at 6 years and nocturia similarly from 20% to 38%). Radical treatment impacts were immediate and continued over 6 years. After RP, 95% of men reported erectile dysfunction persisting for 85% at 6 years, and after EBRT this was reported by 69% and 74%, respectively (P < 0.001 compared with AM). After RP, 36% of men reported urinary leakage requiring at least 1 pad/day, persisting for 20% at 6 years, compared with no change in men receiving EBRT or AM (P < 0.001). Worse bowel function and bother (e.g., bloody stools 6% at 6 years and faecal incontinence 10%) was experienced by men after EBRT than after RP or AM (P < 0.001) with lesser effects after BT. No treatment affected mental or physical QoL. Conclusion Treatment decision-making for localised prostate cancer can be informed by these 6-year functional and QoL outcomes

“Just too busy living in the moment and surviving”: barriers to accessing health care for structurally vulnerable populations at end-of-life

Background: Despite access to quality care at the end-of-life (EOL) being considered a human right, it is not equitable, with many facing significant barriers. Most research examines access to EOL care for homogenous ‘normative’ populations, and as a result, the experiences of those with differing social positioning remain unheard. For example, populations experiencing structural vulnerability, who are situated along the lower rungs of social hierarchies of power (e.g., poor, homeless) will have unique EOL care needs and face unique barriers when accessing care. However, little research examines these barriers for people experiencing life-limiting illnesses and structural vulnerabilities. The purpose of this study was to identify barriers to accessing care among structurally vulnerable people at EOL. Methods: Ethnography informed by the critical theoretical perspectives of equity and social justice was employed. This research drew on 30 months of ethnographic data collection (i.e., observations, interviews) with structurally vulnerable people, their support persons, and service providers. Three hundred hours of observation were conducted in homes, shelters, transitional housing units, community-based service centres, on the street, and at health care appointments. The constant comparative method was used with data collection and analysis occurring concurrently. Results: Five significant barriers to accessing care at EOL were identified, namely: (1) The survival imperative; (2) The normalization of dying; (3) The problem of identification; (4) Professional risk and safety management; and (5) The cracks of a ‘silo-ed’ care system. Together, findings unveil inequities in accessing care at EOL and emphasize how those who do not fit the ‘normative’ palliative-patient population type, for whom palliative care programs and policies are currently built, face significant access barriers. Conclusions: Findings contribute a nuanced understanding of the needs of and barriers experienced by those who are both structurally vulnerable and facing a life-limiting illness. Such insights make visible gaps in service provision and provide information for service providers, and policy decision-makers alike, on ways to enhance the equitable provision of EOL care for all populations.Medicine, Faculty ofOther UBCNon UBCReviewedFacult

The birds of Palas, North-West Frontier Province, Pakistan

Volume: 15Start Page: 77End Page: 8