Majocchi’s Granuloma by Trichophytum rubrum in a kidney transplant patient - A case report

Introduction: Trichophytum rubrum is a filamentous fungus, with worldwide distribution, that usually causes superficial infections of skin and nails, namely tinea pedis, tinea corporis, tinea cruris and onychomycosis. Rarely, severe dermatophytosis can occur, presenting as deep dermatophytosis, Majocchi’s Granuloma or extensive dermatophytosis. Objectives and Methods: Case report of Majocchi’s Granuloma in a kidney transplant patient. Results: A case of a 55-year-old woman who underwent a kidney transplant 7 months before, under immunosuppressive therapy with tacrolimus and mycophenolate mofetil. She attended a Dermatology consultation to clarify skin lesions that appeared 6 months earlier. The skin exam revealed hard and painful plaque lesions on both legs, with an ulcer on the left leg lesion, violaceous papular lesions on the dorsum of the left foot and toes and a hard consistency nodule on the left leg. Some of the toe nails presented dystrophy or onycholysis. The patient denied any previous trauma or contact with plants or soil. Biopsies of lesions of the left leg and foot dorsum where sent for histology and mycological culture and toe nails for mycological culture. The histological examinations showed, in the reticular dermis and reaching the hypodermis, suppurative granulomas with multinucleated giant cells and areas of necrosis. PAS (Periodic Acid- Schiff) and GMS (Grocott’s Methenamine Silver) staining revealed multiple spores and septate hypha within the granulomas but not in the stratum corneum. No remnants of hair follicles where found. Culture of skin biopsies were positive for Tricophytum rubrum but nails´ culture was negative. Identification was further confirmed by sequencing of ITS region of ribosomal DNA (GenBank accession number MK967277). Oral Itraconazole 100mg bid and topic Sertoconazole where initiated. The patient was observed one month after and reported general malaise, tiredness, exertional dyspnea, whitish stools and increased abdominal volume. The physician chose to discontinue itraconazole and initiate oral terbinafine 250mg id. After two months on oral terbinafine, there was regression of the legs´ and left foot lesions with ulcer healing and disappearance of the left leg nodule. Conclusion: Diagnosis of deeper dermatophytosis is difficult, in part because there is no specific clinical presentation and, in many cases, it is even polymorphic. However, especially in patients with immunodeficiency, this hypothesis should be weighed. Confirmation is achieved by finding hyphae compatible with dermatophytes in the dermis and a positive culture for a dermatophyte. Treatment should include systemic antifungal agents, to which topical medication may be associated. Multiple therapeutic regimens have been proposed, but randomized trials or large case series are lacking. Antifungal therapy should be continued until the lesions are completely resolved. Surgical treatment has been reported as an option for highly localized lesions.info:eu-repo/semantics/publishedVersio

Comparison of indoor and outdoor fungi and particles in poultry units

A descriptive study was developed in order to compare indoor and outdoor air contamination caused by fungi and particles in seven poultry units. Twenty eight air samples of 25 litters were collected through the impaction method on malt extract agar. Air sampling and particles concentration measurement were done in the interior and also outside premises of the poultries’ pavilions. Regarding the fungal load in the air, indoor concentration of mold was higher than outside air in six poultry units. Twenty eight species / genera of fungi were identified indoor, being Scopulariopsis brevicaulis (40.5%) the most commonly isolated species and Rhizopus sp. (30.0%) the most commonly isolated genus. Concerning outdoor, eighteen species/genera of fungi were isolated, being Scopulariopsis brevicaulis (62.6%) also the most isolated. All the poultry farms analyzed presented indoor fungi different from the ones identified outdoors. Regarding particles’ contamination, PM2.5, PM5.0 and PM10 had a statistically significant difference (Mann-Whitney U test) between the inside and outside of the pavilions, with the inside more contaminated (p=.006; p=.005; p=.005, respectively). The analyzed poultry units are potential reservoirs of substantial amounts of fungi and particles and could therefore free them in the atmospheric air. The developed study showed that indoor air was more contaminated than outdoors, and this can result in emission of potentially pathogenic fungi and particles via aerosols from poultry units to the environment, which may post a considerable risk to public health and contribute to environmental pollution

Variação estacional de preços para o figo comercializado na CEASA/RS.

Analisou-se a variação estacional de preços do figo maduro comercializado no atacado, junto a CEASA/RS, em uma série temporal de 10 anos. Empregou-se a metodologia das médias geométricas móveis sobre os preços médios mensais

Trace fossils from the Upper Cretaceous Capacete Formation, Sanfranciscana Basin, Central Brazil

The Upper Cretaceous Capacete Formation, from the intracratonic Sanfranciscana Basin, central Brazil, consists of epiclastic sediments with a significant aeolian contribution. This unit has been traditionally interpreted as deposited by alluvial fans distally grading to braided rivers in an arid- to semiarid climate within the central part of southwestern Gondwana. Locally, some expositions with wide lateral extension show architectural ele-ments indicative of deposition in meandering rivers, such as floodplain fines (FF) interbedded with crevasse splay (CR), lateral-accretion macroforms (LA), and channels (CH). Bioturbation within the meandering fluvial deposits is commonly associated with the floodplain element, mainly occurring in fine-grained sandstone and mudstone. The lateral-accretion elements and channel deposits are barren of trace fossils. Sandstone with climbing ripples (Sr) from the element CR show low bioturbation of meniscate trace fossils assigned to Taenidium, Beaconites, and Scoyenia ichnogenera. Simple vertical and horizontal burrows identified as Skolithos and Palaeophycus occur associated with Taenidium and Camborygma in sandstone facies (Sr, St and Sh), as well as rhizoliths, representing the Scoyenia ichnofacies. The predominance of trace fossils related to the FF and CR architectural elements attests to the colonization mostly by insects in episodic and vegetated flood plains of the meandering river system from the Capacete Formation. Thus, despite the primarily arid to semiarid conditions interpreted for the inner parts of the newly formed South American continent during the Upper Cretaceous, our new data support deposition under humid conditions in some intervals of the Capacete Formation from the Sanfranciscana Basin

Effect of type of food and culture density on growth and lipid composition of Seriola dumerili juveniles

The aim of this study was to determine the effect of three different types of food and two stocking densities on growth, survival and lipid composition of muscle and liver of Seriola dumerili juveniles. Juvenile of S. dumerili were randomly distributed in groups of 15 fish/tank (low stocking density, LD) and groups of 25 fish/tank (high stocking density, HD) and fed with three different types of food: commercial pellets for Sparidae (SP), commercial pellets for S. dumerili (SE) and frozen Mackerel (MA). Samples of muscle and liver were taken for lipid analysis at the end of trial (86 days). Fish fed with SP showed growth significantly lower than the groups fed with SE and MA for both stocking densities. Higher survival rates was observed in fish fed diet SE and MA held at LD. Lipid composition analyses revealed important differences between fish fed with different diets but no difference between groups with different stocking density were detected. Total lipid content in muscle and liver from fish fed with SE was very much higher than in fish fed with SP and MA, which was reflected in higher tryglicerides and lower cholesterol contents. The fatty acid composition of tissues clearly reflected the composition of the diet supplied. The groups fed with MA presented the highest proportion of docosahexaenoic acid (DHA), arachidonic acid (ARA) and the lower amounts of eicosapentaenoic acid (EPA). In contrast, fish fed with SE presented the lower amounts of ARA and DHA and higher content in 18:2n-6 specifically in the liver. In consequence, fish fed with MA presented a higher DHA/EPA ratio and a lower EPA/AA ratio in both tissues while the opposite was observed in group SE. These preliminary results indicate that SE diet allows get better performance than SP diet obtaining growth and survival rates comparable to fish fed with MA, although with a higher lipid deposition in tissues

A mastite em ovinos de corte afeta os ganhos de peso dos cordeiros?.

O Brasil possui um rebanho ovino de aproximadamente quinze milhões de animais que apresenta tendência de crescimento devido à elevação da demanda e consequente valorização da carne, o que torna a ovinocultura de corte uma atividade lucrativa. A preocupação com a mastite aumentou em relação a rebanhos destinados à produção de carne, pelo descarte prematuro das ovelhas com anormalidades de úbere e a redução do ganho de peso diário (GPD) das crias. A forma subclínica da doença pode acarretar menor taxa de crescimento e maior mortalidade dos cordeiros, pela redução da concentração de imunoglobulinas no soro e da produção de leite. Este trabalho teve como objetivo comparar os GPDs de animais oriundos de mães sadias com GPDs de crias de mães doentes em dois rebanhos localizados no Estado de São Paulo

Contact-induced spin polarization in carbon nanotubes

Motivated by the possibility of combining spintronics with molecular structures, we investigate the conditions for the appearance of spin-polarization in low-dimensional tubular systems by contacting them to a magnetic substrate. We derive a set of general expressions describing the charge transfer between the tube and the substrate and the relative energy costs. The mean-field solution of the general expressions provides an insightful formula for the induced spin-polarization. Using a tight-binding model for the electronic structure we are able to estimate the magnitude and the stability of the induced moment. This indicates that a significant magnetic moment in carbon nanotubes can be observed.Comment: To appear in Phys. Rev. B (2003

Interaction between lactose and cadmium chloride in aqueous solutions as seen by diffusion coefficients measurements

Diffusion coefficients of an aqueous system containing cadmium chloride 0.100 mol · dm−3 and lactose at different concentrations at 25 °C have been measured, using a conductimetric cell and an automatic apparatus to follow diffusion. The cell relies on an open-ended capillary method and a conductimetric technique is used to follow the diffusion process by measuring the resistance of a solution inside the capillaries, at recorded times. From these results and by ab initio calculations, it was possible to obtain a better understanding of the effect of lactose on transport of cadmium chloride in aqueous solutions