738 research outputs found
Lymphome intravasculaire : à propos de deux observations autopsiques et revue de la littérature
Intravacular large B-cell lymphoma (LIV) is a rare entity individualized in the WHO classification since 2001Â as a subtype of extranodal diffuse large B-cell lymphoma. We report two autopsic cases of LIV: a 77-year-old woman presenting with fever, dyspnea, antehypophyseal failure and a 54-year-old man presenting with fever, weight-loss, night-sweats and encephalopathy. They died respectively 10Â and 7Â months after the beginning of symptoms, without diagnosis. Neither infectious disease nor lymphomatous proliferation had been identified. From these two cases and our literature review, we insist on the importance of histopathological diagnosis on biopsy for this rare pathology which clinical diagnosis remains difficult
Integral Field Spectroscopy of High-Redshift Star Forming Galaxies with Laser Guided Adaptive Optics: Evidence for Dispersion-Dominated Kinematics
We present early results from an ongoing study of the kinematic structure of
star-forming galaxies at redshift z ~ 2 - 3 using integral-field spectroscopy
of rest-frame optical nebular emission lines in combination with Keck laser
guide star adaptive optics (LGSAO). We show kinematic maps of 3 target galaxies
Q1623-BX453, Q0449-BX93, and DSF2237a-C2 located at redshifts z = 2.1820,
2.0067, and 3.3172 respectively, each of which is well-resolved with a PSF
measuring approximately 0.11 - 0.15 arcsec (~ 900 - 1200 pc at z ~ 2-3) after
cosmetic smoothing. Neither galaxy at z ~ 2 exhibits substantial kinematic
structure on scales >~ 30 km/s; both are instead consistent with largely
dispersion-dominated velocity fields with sigma ~ 80 km/s along any given line
of sight into the galaxy. In contrast, DSF2237a-C2 presents a well-resolved
gradient in velocity over a distance of ~ 4 kpc with peak-to-peak amplitude of
140 km/s. It is unlikely that DSF2237a-C2 represents a dynamically cold
rotating disk of ionized gas as the local velocity dispersion of the galaxy
(sigma = 79 km/s) is comparable to the observed shear. Using extant
multi-wavelength spectroscopy and photometry we relate these kinematic data to
physical properties such as stellar mass, gas fraction, star formation rate,
and outflow kinematics and consider the applicability of current galaxy
formation models.[Abridged]Comment: 19 pages, 10 figures (5 color); accepted for publication in ApJ.
Version with full-resolution figures is available at
http://www.astro.caltech.edu/~drlaw/Papers/OSIRIS_data1.pd
Effect of hypoxia/reoxygenation on the cytokine-induced production of nitric oxide and superoxide anion in cultured osteoarthritic synoviocytes
SummaryObjectiveHypoxia/reoxygenation (H/R) is an important feature in the osteoarthritis (OA) physiopathology. Nitric oxide (NO) is a significant proinflammatory mediator in the inflamed synovium. The purpose of this study was to investigate the effects of H/R on inducible NO synthase (iNOS) activity and expression in OA synoviocytes. In addition we studied the relationship between nitrosative stress and NADPH oxidase (NOX) in such conditions.MethodsHuman cultured synoviocytes from OA patients were treated for 24 h with interleukin 1-β (IL-1β), tumour necrosis factor α (TNF-α) or neither; for the last 6 h, they were submitted to either normoxia or three periods of 1-h of hypoxia followed by 1-h of reoxygenation. NO metabolism (iNOS expression, nitrite and peroxynitrite measurements) was investigated. Furthermore, superoxide anion O2− production, NOX subunit expression and nitrosylation were also assessed.ResultsiNOS expression and nitrite (but not peroxynitrite) production were significantly increased under H/R conditions when compared with to normoxia (P < 0.05). H/R conditions decreased O2− production from ∼0.20 to ∼0.12 nmol min−1 mg proteins−1 (P < 0.05), while NOXs' subunit expression and p47-phox phosphorylation were increased. NOXs and p47-phox were dramatically nitrosylated under H/R conditions (P < 0.05 vs normoxia). Using NOS inhibitors under H/R conditions, p47-phox nitrosylation was prevented and O2− production was restored at normoxic levels (0.21 nmol min−1 mg of proteins−1).ConclusionsOur results provide evidence for an up-regulation of iNOS activity in OA synoviocytes under H/R conditions, associated to a down-regulation of NOX activity through nitrosylation. These findings highlight the importance of radical production to OA pathogenesis, and appraise the metabolic modifications of synovial cells under hypoxia
The night-sky at the Calar Alto Observatory II: The sky at the near infrared
We present here the characterization of the night sky-brightness at the
near-infrared, the telescope seeing, and the fraction of useful time at the
Calar Alto observatory. For this study we have collected a large dataset
comprising 7311 near-infrared images taken regularly along the last four years
for the ALHAMBRA survey (J, H and Ks-bands), together with a more reduced
dataset of additional near-infrared images taken for the current study. In
addition we collected the information derived by the meteorological station at
the observatory during the last 10 years, together with the results from the
cloud sensor for the last ~2 years. We analyze the dependency of the
near-infrared night sky-brightness with the airmass and the seasons, studying
its origins and proposing a zenithal correction. A strong correlation is found
between the night sky-brightness in the Ks-band and the air temperature, with a
gradient of ~ -0.08 mag per 1 C degree. The typical (darkest) night
sky-brightness in the J, H and Ks-band are 15.95 mag (16.95 mag), 13.99 mag
(14.98 mag) and 12.39 mag (13.55 mag), respectively. These values show that
Calar Alto is as dark in the near-infrared as most of the other astronomical
astronomical sites in the world that we could compare with. Only Mauna Kea is
clearly darker in the Ks-band. The typical telescope seeing at the 3.5m is
~1.0" when converted to the V-band, being only slightly larger than the
atmospheric seeing measured at the same time by the seeing monitor, ~0.9".
Finally we estimate the fraction of useful time based on the relative humidity,
gust wind speed and presence of clouds. This fraction, ~72%, is very similar to
the one derived in Paper I, based on the fraction of time when the extinction
monitor is working.Comment: 15 pages, 6 figures, accepted to be published in PAS
A Multiplicity Census of Young Stars in Chamaeleon I
We present the results of a multiplicity survey of 126 stars spanning ~0.1-3
solar masses in the ~2-Myr-old Chamaeleon I star-forming region, based on
adaptive optics imaging with the ESO Very Large Telescope. Our observations
have revealed 30 binaries and 6 triples, of which 19 and 4, respectively, are
new discoveries. The overall multiplicity fraction we find for Cha I (~30%) is
similar to those reported for other dispersed young associations, but
significantly higher than seen in denser clusters and the field, for comparable
samples. Both the frequency and the maximum separation of Cha I binaries
decline with decreasing mass, while the mass ratios approach unity; conversely,
tighter pairs are more likely to be equal mass. We confirm that brown dwarf
companions to stars are rare, even at young ages at wide separations. Based on
follow-up spectroscopy of two low-mass substellar companion candidates, we
conclude that both are likely background stars. The overall multiplicity
fraction in Cha I is in rough agreement with numerical simulations of cloud
collapse and fragmentation, but its observed mass dependence is less steep than
predicted. The paucity of higher-order multiples, in particular, provides a
stringent constraint on the simulations, and seems to indicate a low level of
turbulence in the prestellar cores in Cha I.Comment: Accepted for publication in Ap
The CFEPS Kuiper Belt Survey: Strategy and Pre-survey Results
We present the data acquisition strategy and characterization procedures for
the Canada-France Ecliptic Plane Survey (CFEPS), a sub-component of the
Canada-France-Hawaii Telescope Legacy Survey. The survey began in early 2003
and as of summer 2005 has covered 430 square degrees of sky within a few
degrees of the ecliptic. Moving objects beyond the orbit of Uranus are detected
to a magnitude limit of =23 -- 24 (depending on the image quality). To
track as large a sample as possible and avoid introducing followup bias, we
have developed a multi-epoch observing strategy that is spread over several
years. We present the evolution of the uncertainties in ephemeris position and
orbital elements as the objects progress through the epochs. We then present a
small 10-object sample that was tracked in this manner as part of a preliminary
survey starting a year before the main CFEPS project.
We describe the CFEPS survey simulator, to be released in 2006, which allows
theoretical models of the Kuiper Belt to be compared with the survey
discoveries since CFEPS has a well-documented pointing history with
characterized detection efficiencies as a function of magnitude and rate of
motion on the sky. Using the pre-survey objects we illustrate the usage of the
simulator in modeling the classical Kuiper Belt.Comment: to be submitted to Icaru
An Upper Bound on the Flux Ratio of rho CrB's Companion at 1.6um
We use high resolution infrared spectroscopy to investigate the 2001 report
by Gatewood and colleagues that rho CrB's candidate extrasolar planet companion
is really a low-mass star with mass 0.14+-0.05 Msun. We do not detect evidence
of such a companion; the upper bounds on the (companion/primary) flux ratio at
1.6 microns are less than 0.0024 and 0.005 at the 90 and 99% confidence levels,
respectively. Using the H-band mass-luminosity relationship calculated by
Baraffe and colleagues, the corresponding upper limits on the companion mass
are 0.11 and 0.15 Msun. Our results indicate that the infrared spectroscopic
technique can detect companions in binaries with flux ratios as low as 0.01 to
0.02.Comment: 22 pages, 10 figures, accepted for publication in the Astronomical
Journa
A multiwavelength approach to the SFR estimation in galaxies at intermediate redshifts
We use a sample of 7 starburst galaxies at intermediate redshifts (z ~ 0.4
and z ~ 0.8) with observations ranging from the observed ultraviolet to 1.4
GHz, to compare the star formation rate (SFR) estimators which are used in the
different wavelength regimes. We find that extinction corrected Halpha
underestimates the SFR, and the degree of this underestimation increases with
the infrared luminosity of the galaxies. Galaxies with very different levels of
dust extinction as measured with SFR(IR)/SFR(Halpha, uncorrected for
extinction) present a similar attenuation A[Halpha], as if the Balmer lines
probed a different region of the galaxy than the one responsible for the bulk
of the IR luminosity for large SFRs. In addition, SFR estimates derived from
[OII]3727 match very well those inferred from Halpha after applying the
metallicity correction derived from local galaxies. SFRs estimated from the UV
luminosities show a dichotomic behavior, similar to that previously reported by
other authors in galaxies at z <~ 0.4. Here we extend this result up to z ~
0.8. Finally, one of the studied objects is a luminous compact galaxy (LCG)
that may be suffering similar dust-enshrouded star formation episodes. These
results highlight the relevance of quantifying the actual L(IR) of LCGs, as
well as that of a much larger and generic sample of luminous infrared galaxies,
which will be possible after the launch of SIRTF.Comment: Accepted for publication in The Astrophysical Journa
Management of imatinib-resistant CML patients
Imatinib has had marked impact on outcomes in chronic myelogenous leukemia (CML) patients for all stages of the disease and is endorsed by international treatment guidelines as the first line option. Although imatinib is highly effective and well tolerated, the development of resistance represents a clinical challenge. Since the most frequently identified mechanism of acquired imatinib resistance is bcr-abl kinase domain point mutations, periodic hematologic, cytogenetic, and molecular monitoring is critical throughout imatinib therapy. Once cytogenetic remission is achieved, residual disease can be monitored by bcr-abl transcript levels as assayed by reverse transcription polymerase chain reaction (RT-PCR). Detection of bcr-abl mutants prior to and during imatinib therapy can aid in risk stratification as well as in determining therapeutic strategies. Thus, mutation screening is indicated in patients lacking or losing hematologic response. Moreover, search for mutations should also be performed when a 3-log reduction of bcr-abl transcripts is not achieved or there is a reproducible increase of transcript levels. In patients harboring mutations which confer imatinib resistance, novel second line tyrosine kinase inhibitors have demonstrated encouraging efficacy with low toxicity. Only the T315I bcr-abl mutant has proved totally resistant to all clinically available bcr-abl inhibitors. Strategies to further increase the rates of complete molecular remissions represent the next frontier in the targeted therapy of CML patients
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