Changing Nonhuman Impulsive Choice

Preference for smaller-sooner over larger-later rewards characterizes one type of impulsivity—impulsive choice. Impulsive choice is related to a number of maladaptive behaviors including substance abuse, pathological gambling, and poor health behaviors. As such, interventions designed to reduce impulsive choice may have therapeutic benefits. The purpose of this dissertation was to explore two methods to change nonhuman impulsive choice. In doing so, we hope to provide a baseline that future research can use to assess variables that are less amenable to human research (e.g., drug self-administration following reductions in impulsive choice). In Chapter 2, we failed to reduce nonhuman impulsive choice using working-memory training, a finding both inconsistent and consistent with the extant human literature. Chapters 3-5 sought to better understand a training regimen that generates large between-group differences in nonhuman impulsive choice—delay- and immediacy-exposure training. The results from Chapters 3 and 4 suggest that prolonged exposure to delayed food rewards produces large and long-lasting reductions in impulsive choice. Chapter 5 showed that the delay-exposure training effect can be obtained in fewer sessions than has previously been employed. A better understanding of the effects of delay-exposure training on nonhuman impulsive choice may have implications for the design and implementation of a human analog

Impulsive choice predicts poor working memory in male rats.

A number of maladaptive behaviors and poor health outcomes (e.g., substance abuse, obesity) correlate with impulsive choice, which describes the tendency to prefer smaller, immediate rewards in lieu of larger, delayed rewards. Working memory deficits are often reported in those diagnosed with the same maladaptive behaviors. Human studies suggest that impulsive choice is associated with working memory ability but, to date, only one study has explored the association between working memory and impulsive choice in rats and no relation was reported. The current study reevaluated the association between working memory and impulsive choice in 19 male Long-Evans rats. Psychophysical adjusting procedures were used to quantify working memory (titrating-delay match-to-position procedure) and impulsive choice (adjusting delay procedure). Rats were partitioned into low- and high-impulsive groups based on performance in the impulsive choice task. Low-impulsive rats performed significantly better in the working memory assessment. Across all rats, impulsive choice was negatively correlated with working memory performance. These findings support the hypothesis that prefrontal cortex function, specifically, working memory, is related to impulsive choice. Future research might profitably examine the experimental variables designed to influence working memory to evaluate the effects of these variables on impulsive choice and maladaptive behaviors with which it is correlated

Adjusted delays and retention intervals.

<p><i>Panels A–B.</i> The solid data paths represent average adjusted delays over the final 20 sessions of the adjusting-delay task for HiI and LoI rats, respectively. <i>Panel C.</i> Terminal mean adjusted delays (MADs) for HiI and LoI rats. <i>Panels D–E.</i> Each colored data path denotes a different subject's changing retention interval over the course of the TDMTP task for HiI rats and LoI rats, respectively. The dashed black data paths show the mean retention interval for each group. <i>Panel F.</i> Average peak retention intervals for HiI and LoI rats. * indicates significance at p<.05; ** indicates significance at p<.01. Error bars depict <i>SEM</i>.</p

Schematic representation of experimental conditions across age.

<p>Age varied slightly across sessions due to mastery-based criteria in training.</p

Impulsive Choice and Pre-Exposure to Delays: IV. Effects of Delay- and Immediacy-Exposure Training Relative to Maturational Changes in Impulsivity

Impulsive choice describes preference for smaller, sooner rewards over larger, later rewards. Excessive delay discounting (i.e., rapid devaluation of delayed rewards) underlies some impulsive choices, and is observed in many maladaptive behaviors (e.g., substance abuse, gambling). Interventions designed to reduce delay discounting may provide therapeutic gains. One such intervention provides rats with extended training with delayed reinforcers. When compared to a group given extended training with immediate reinforcers, delay-exposed rats make significantly fewer impulsive choices. To what extent is this difference due to delay-exposure training shifting preference toward self-control or immediacy-exposure training (the putative control group) shifting preference toward impulsivity? The current study compared the effects of delay- and immediacy-exposure training to a no-training control group and evaluated within-subject changes in impulsive choice across 51 male Wistar rats. Delay-exposed rats made significantly fewer impulsive choices than immediacy-exposed and control rats. Between-group differences in impulsive choice were not observed in the latter two groups. While delay-exposed rats showed large, significant pre- to posttraining reductions in impulsive choice, immediacy-exposed and control rats showed small reductions in impulsive choice. These results suggest that extended training with delayed reinforcers reduces impulsive choice, and that extended training with immediate reinforcers does not increase impulsive choice