Crowd synchrony and quorum sensing in delay-coupled lasers

Crowd synchrony and quorum sensing arise when a large number of dynamical elements communicate with each other via a common information pool. Previous evidence in different fields, including chemistry, biology and civil engineering, has shown that this type of coupling leads to synchronization, when coupling is instantaneous and the number of coupled elements is large enough. Here we consider a situation in which the transmission of information between the system components and the coupling pool is not instantaneous. To that end, we model a system of semiconductor lasers optically coupled to a central laser with a delay. Our results show that, even though the lasers are non-identical due to their distinct optical frequencies, zero-lag synchronization arises. By changing a system parameter, we can switch between two different types of synchronization transition. The dependence of the transition with respect to the delay-coupling parameters is studied.Comment: 4 pages, 4 figure

Expressive Power-Based Resource Allocation for Data Centers

As data-center energy consumption continues to rise, efficient power management is becoming increasingly important. In this work, we examine the use of a novel market mechanism for finding the right balance between power and performance. The market enables a separation between a 'buyer side' that strives to maximize performance and a 'seller side' that strives to minimize power and other costs. A concise and scalable description language is defined for agent preferences that admits a mixedinteger program for computing optimal allocations. Experimental results demonstrate the robustness, flexibility, practicality and scalability of the architecture.Engineering and Applied Science

A Powerful New Quantitative Genetics Platform, Combining Caenorhabditis elegans High-Throughput Fitness Assays with a Large Collection of Recombinant Strains.

The genetic variants underlying complex traits are often elusive even in powerful model organisms such as Caenorhabditis elegans with controlled genetic backgrounds and environmental conditions. Two major contributing factors are: (1) the lack of statistical power from measuring the phenotypes of small numbers of individuals, and (2) the use of phenotyping platforms that do not scale to hundreds of individuals and are prone to noisy measurements. Here, we generated a new resource of 359 recombinant inbred strains that augments the existing C. elegans N2xCB4856 recombinant inbred advanced intercross line population. This new strain collection removes variation in the neuropeptide receptor gene npr-1, known to have large physiological and behavioral effects on C. elegans and mitigates the hybrid strain incompatibility caused by zeel-1 and peel-1, allowing for identification of quantitative trait loci that otherwise would have been masked by those effects. Additionally, we optimized highly scalable and accurate high-throughput assays of fecundity and body size using the COPAS BIOSORT large particle nematode sorter. Using these assays, we identified quantitative trait loci involved in fecundity and growth under normal growth conditions and after exposure to the herbicide paraquat, including independent genetic loci that regulate different stages of larval growth. Our results offer a powerful platform for the discovery of the genetic variants that control differences in responses to drugs, other aqueous compounds, bacterial foods, and pathogenic stresses

Using Synchronization for Prediction of High-Dimensional Chaotic Dynamics

We experimentally observe the nonlinear dynamics of an optoelectronic time-delayed feedback loop designed for chaotic communication using commercial fiber optic links, and we simulate the system using delay differential equations. We show that synchronization of a numerical model to experimental measurements provides a new way to assimilate data and forecast the future of this time-delayed high-dimensional system. For this system, which has a feedback time delay of 22 ns, we show that one can predict the time series for up to several delay periods, when the dynamics is about 15 dimensional.Comment: 10 pages, 4 figure

QGP Susceptibilities from PNJL Model

An improved version of the PNJL model is used to calculate various thermodynamical quantities, {\it viz.}, quark number susceptibility, isospin susceptibility, specific heat, speed of sound and conformal measure. Comparison with Lattice data is found to be encouraging.Comment: 4 pages, 2 figures, poster presented at Quark Matter'0

Spatiotemporal pattern of global forest change over the past 60 years and the forest transition theory

Forest ecosystems play an indispensable role in addressing various pressing sustainability and social-ecological challenges such as climate change and biodiversity loss. However, global forest loss has been, and still is today, an important issue. Here, based on spatially explicit data, we show that over the past 60 years (1960–2019), the global forest area has declined by 81.7 million ha (i.e. 10% more than the size of the entire Borneo island), with forest loss (437.3 million ha) outweighing forest gain (355.6 million ha). With this forest decline and the population increase (4.68 billion) over the period, the global forest per capita has decreased by over 60%, from 1.4 ha in 1960 to 0.5 ha in 2019. The spatiotemporal pattern of forest change supports the forest transition theory, with forest losses occurring primarily in the lower income countries in the tropics and forest gains in the higher income countries in the extratropics. Furthermore, economic growth has a stronger association with net forest gain than with net forest loss. Our results highlight the need to strengthen the support given to lower income countries, especially in the tropics, to help improve their capacity to minimize or end their forest losses. To help address the displacement of forest losses to the lower income countries in the tropics, higher income nations need to reduce their dependence on imported tropical forest products

RoboPol: First season rotations of optical polarization plane in blazars

We present first results on polarization swings in optical emission of blazars obtained by RoboPol, a monitoring program of an unbiased sample of gamma-ray bright blazars specially designed for effective detection of such events. A possible connection of polarization swing events with periods of high activity in gamma rays is investigated using the dataset obtained during the first season of operation. It was found that the brightest gamma-ray flares tend to be located closer in time to rotation events, which may be an indication of two separate mechanisms responsible for the rotations. Blazars with detected rotations have significantly larger amplitude and faster variations of polarization angle in optical than blazars without rotations. Our simulations show that the full set of observed rotations is not a likely outcome (probability $\le 1.5 \times 10^{-2}$) of a random walk of the polarization vector simulated by a multicell model. Furthermore, it is highly unlikely ($\sim 5 \times 10^{-5}$) that none of our rotations is physically connected with an increase in gamma-ray activity.Comment: 16 pages, 9 figure

Sexually dimorphic RB inactivation underlies mesenchymal glioblastoma prevalence in males

The prevalence of brain tumors in males is common but unexplained. While sex differences in disease are typically mediated through acute sex hormone actions, sex-specific differences in brain tumor rates are comparable at all ages, suggesting that factors other than sex hormones underlie this discrepancy. We found that mesenchymal glioblastoma (Mes-GBM) affects more males as the result of cell-intrinsic sexual dimorphism in astrocyte transformation. We used astrocytes from neurofibromin-deficient (Nf1(–/–)) mice expressing a dominant-negative form of the tumor suppressor p53 (DNp53) and treated them with EGF as a Mes-GBM model. Male Mes-GBM astrocytes exhibited greater growth and colony formation compared with female Mes-GBM astrocytes. Moreover, male Mes-GBM astrocytes underwent greater tumorigenesis in vivo, regardless of recipient mouse sex. Male Mes-GBM astrocytes exhibited greater inactivation of the tumor suppressor RB, higher proliferation rates, and greater induction of a clonogenic, stem-like cell population compared with female Mes-GBM astrocytes. Furthermore, complete inactivation of RB and p53 in Mes-GBM astrocytes resulted in equivalent male and female tumorigenic transformation, indicating that intrinsic differences in RB activation are responsible for the predominance of tumorigenic transformation in male astrocytes. Together, these results indicate that cell-intrinsic sex differences in RB regulation and stem-like cell function may underlie the predominance of GBM in males

Overexpression of the astrocyte glutamate transporter GLT1 exacerbates phrenic motor neuron degeneration, diaphragm compromise, and forelimb motor dysfunction following cervical contusion spinal cord injury.

A major portion of spinal cord injury (SCI) cases affect midcervical levels, the location of the phrenic motor neuron (PhMN) pool that innervates the diaphragm. While initial trauma is uncontrollable, a valuable opportunity exists in the hours to days following SCI for preventing PhMN loss and consequent respiratory dysfunction that occurs during secondary degeneration. One of the primary causes of secondary injury is excitotoxic cell death due to dysregulation of extracellular glutamate homeostasis. GLT1, mainly expressed by astrocytes, is responsible for the vast majority of functional uptake of extracellular glutamate in the CNS, particularly in spinal cord. We found that, in bacterial artificial chromosome-GLT1-enhanced green fluorescent protein reporter mice following unilateral midcervical (C4) contusion SCI, numbers of GLT1-expressing astrocytes in ventral horn and total intraspinal GLT1 protein expression were reduced soon after injury and the decrease persisted for ≥6 weeks. We used intraspinal delivery of adeno-associated virus type 8 (AAV8)-Gfa2 vector to rat cervical spinal cord ventral horn for targeting focal astrocyte GLT1 overexpression in areas of PhMN loss. Intraspinal delivery of AAV8-Gfa2-GLT1 resulted in transduction primarily of GFAP(+) astrocytes that persisted for ≥6 weeks postinjury, as well as increased intraspinal GLT1 protein expression. Surprisingly, we found that astrocyte-targeted GLT1 overexpression increased lesion size, PhMN loss, phrenic nerve axonal degeneration, and diaphragm neuromuscular junction denervation, and resulted in reduced functional diaphragm innervation as assessed by phrenic nerve-diaphragm compound muscle action potential recordings. These results demonstrate that GLT1 overexpression via intraspinal AAV-Gfa2-GLT1 delivery exacerbates neuronal damage and increases respiratory impairment following cervical SCI