Re-occurrence of the CD20 molecule expression subsequent to CD20-negative relapse in diffuse large B-cell lymphoma.

We report the first case of diffuse large B-cell lymphoma (DLBCL) of the stomach displaying CD20-negative relapse after rituximab-containing treatment and the re-appearance of CD20 expression at the second failure. The loss of CD20 expression in B-cell lymphomas relapsing after rituximab is a well-known phenomenon, but its actual impact in DLBCL is difficult to estimate. This paradigmatic case suggests that CD20-expression reappearance after purging of CD20-positive clones with rituximab might be an underestimated occurrence in B-cell lymphomas. Accordingly, every relapse, whenever possible, should be histologically assessed with diagnostic and immunophenotyping purposes

Utilizacion de recursos genéticos en produccion animal en el Uruguay con especial referencia a ovinos

En el Uruguay la producción agropecuaria constituye una actividad de suma importancia por la magnitud de su participación en las exportaciones, la generación de empleo, y por servir como fuente de materia prima para la agroindustria nacional. En el 2013, los principales productos de exportación fueron la soja y la carne vacuna, mientras que la carne ovina y la lana se ubicaron entre los primeros diez

Partial maxillary osteotomy following an unsuccessful forced eruption of an impacted maxillary canine: 10 year follow-up. Review and case report

The maxillary canines are amongst the most frequently impacted teeth, second only to the third molars. Several conservative orthodontic and surgical techniques are available to position the teeth properly in the dental arch, even in severe cases. However, when an extraction is necessary, it often leaves a critical alveolar defect of difficult management. The authors present the technique of Partial Maxillary Osteotomy, in which a dento-alveolar segment is moved mesially, hence closing the remaining space, allowing for the formation of healthy periodontium and resulting in an adequate functional and aesthetic outcome. A case report is presented with a 10 year follow-up, proving the technique's stability in the long term

A practical algorithmic approach to mature aggressive B cell lymphoma diagnosis in the double/triple hit era. Selecting cases, matching clinical benefit. A position paper from the Italian Group of Haematopathology (G.I.E.)

An accurate diagnosis of clinically distinct subgroups of aggressive mature B cell lymphomas is crucial for the choice of proper treatment. Presently, precise recognition of these disorders relies on the combination of morphological, immunophenotypical, and cytogenetic/molecular features. The diagnostic workup in such situations implies the application of costly and time-consuming analyses, which are not always required, since an intensified treatment option is reasonably reserved to fit patients. The Italian Group of Haematopathology proposes herein a practical algorithm for the diagnosis of aggressive mature B cell lymphomas based on a stepwise approach, aimed to select cases deserving molecular analysis, in order to optimize time and resources still assuring the optimal management for any patient

Permutation of Sparse Matrices to a Specific Lower BTF using Graph Decompositions

A new partitioning algorithm that permutes sparse matrices to a specific block lower-triangular form (BlTF) complying with special features required for instrumentation problems is presented. The proposal consists in the decomposition of the occurrence matrix in two stages, using methodologies based on graph theory. First of all, Hopcroft-Karp´s algorithm is employed to match the vertices, this classification being carried out by means of a modification of Dulmage-Mendelsohn´s technique, which was devised by the authors. The second step is the application of Tarjan´s algorithm to the square blocks obtained as a result of the first stage.Sociedad Argentina de Informática e Investigación Operativ

The ISIS Project: Indications for Future Near-Earth Plasma Studies through Future Galileo Satellites

The Earth’s plasmasphere variability is a consequence of the Sun’s forcing, determining our planet’s space weather. Plasmaspheric dynamics could be entirely caught only by studying together global and local proxies of the state of this extended system. The ISIS project (Inter-Satellite & In Situ plasmaspheric monitoring and modelling) aimed to design a system for the continuous monitoring of the Earth’s plasmasphere based on the future Galileo satellites. The efforts and expertise of ISC-CNR (Institute for Complex Systems of the National Research Council of Italy), INGV (Istituto Nazionale di Geofisica e Vulcanologia) and TAS-I (Thales Alenia Space - Italy) were put together in this work of assessment. ISIS Team proposed new experimental facilities of the Galileo satellites, designed to realize inter-satellite and in situ measurements to monitor global and local quantities; in particular, a scalable system of Langmuir probes was suggested, while the TEC along all possible inter-satellite ray paths throughout the plasmasphere could be monitored via phase- and group-delay analysis of inter-satellite radio signals

Excessive antigen reactivity may underlie the clinical aggressiveness of chronic lymphocytic leukemia stereotyped subset #8

Subset #8 is a distinctive subset of patients with chronic lymphocytic leukemia (CLL) defined by the expression of stereotyped IGHV4-39/IGKV1(D)-39 B-cell receptors. Subset #8 patients experience aggressive disease and exhibit the highest risk for Richter transformation among all CLL. In order to obtain biological insight into this behavior, we profiled the antigen reactivity and signaling capacity of subset #8 vs other clinically aggressive stereotyped subsets, namely subsets #1 and #2. Twenty-seven monoclonal antibodies (mAbs) from subsets #1, #2, and #8 CLL clones were prepared as recombinant human immunoglobulin G1 and used as primary antibodies in enzyme-linked immuno-sorbent assays against representatives of the major classes of established antigenic targets for CLL. Subset #8 CLL mAbs exhibited broad polyreactivity as they bound to all antigens tested, in clear contrast with the mAbs from the other subsets. Antigen challenge of primary CLL cells indicated that the promiscuous antigen-binding activity of subset #8 mAbs could lead to significant cell activation, again in contrast to the less responsive CLL cells from subsets #1 and #2. These features constitute a distinctive profile for CLL subset #8, supporting the existence of distinct mechanisms of aggressiveness in different immunogenetic subsets of CLL