On a zero speed sensitive cellular automaton

Using an unusual, yet natural invariant measure we show that there exists a sensitive cellular automaton whose perturbations propagate at asymptotically null speed for almost all configurations. More specifically, we prove that Lyapunov Exponents measuring pointwise or average linear speeds of the faster perturbations are equal to zero. We show that this implies the nullity of the measurable entropy. The measure m we consider gives the m-expansiveness property to the automaton. It is constructed with respect to a factor dynamical system based on simple "counter dynamics". As a counterpart, we prove that in the case of positively expansive automata, the perturbations move at positive linear speed over all the configurations

Metallochaperones Are Needed for Mycobacterium tuberculosis and Escherichia coli Nicotinamidase-Pyrazinamidase Activity.

Mycobacterium tuberculosis nicotinamidase-pyrazinamidase (PZAse) is a metalloenzyme that catalyzes conversion of nicotinamide-pyrazinamide to nicotinic acid-pyrazinoic acid. This study investigated whether a metallochaperone is required for optimal PZAse activity. M. tuberculosis and Escherichia coli PZAses (PZAse-MT and PZAse-EC, respectively) were inactivated by metal depletion (giving PZAse-MT-Apo and PZAse-EC-Apo). Reactivation with the E. coli metallochaperone ZnuA or Rv2059 (the M. tuberculosis analog) was measured. This was repeated following proteolytic and thermal treatment of ZnuA and Rv2059. The CDC1551 M. tuberculosis reference strain had the Rv2059 coding gene knocked out, and PZA susceptibility and the pyrazinoic acid (POA) efflux rate were measured. ZnuA (200 μM) achieved 65% PZAse-EC-Apo reactivation. Rv2059 (1 μM) and ZnuA (1 μM) achieved 69% and 34.3% PZAse-MT-Apo reactivation, respectively. Proteolytic treatment of ZnuA and Rv2059 and application of three (but not one) thermal shocks to ZnuA significantly reduced the capacity to reactivate PZAse-MT-Apo. An M. tuberculosis Rv2059 knockout strain was Wayne positive and susceptible to PZA and did not have a significantly different POA efflux rate than the reference strain, although a trend toward a lower efflux rate was observed after knockout. The metallochaperone Rv2059 restored the activity of metal-depleted PZAse in vitro Although Rv2059 is important in vitro, it seems to have a smaller effect on PZA susceptibility in vivo. It may be important to mechanisms of action and resistance to pyrazinamide in M. tuberculosis Further studies are needed for confirmation.IMPORTANCE Tuberculosis is an infectious disease caused by the bacterium Mycobacterium tuberculosis and remains one of the major causes of disease and death worldwide. Pyrazinamide is a key drug used in the treatment of tuberculosis, yet its mechanism of action is not fully understood, and testing strains of M. tuberculosis for pyrazinamide resistance is not easy with the tools that are presently available. The significance of the present research is that a metallochaperone-like protein may be crucial to pyrazinamide's mechanisms of action and of resistance. This may support the development of improved tools to detect pyrazinamide resistance, which would have significant implications for the clinical management of patients with tuberculosis: drug regimens that are appropriately tailored to the resistance profile of a patient's individual strain lead to better clinical outcomes, reduced onward transmission of infection, and reduction of the development of resistant strains that are more challenging and expensive to treat

Kinematic dynamo action in a sphere. I. Effects of differential rotation and meridional circulation on solutions with axial dipole symmetry

A sphere containing electrically conducting fluid can generate a magnetic field by dynamo action, provided the flow is sufficiently complicated and vigorous. The dynamo mechanism is thought to sustain magnetic fields in planets and stars. The kinematic dynamo problem tests steady flows for magnetic instability, but rather few dynamos have been found so far because of severe numerical difficulties. Dynamo action might, therefore, be quite unusual, at least for large-scale steady flows. We address this question by testing a two-parameter class of flows for dynamo generation of magnetic fields containing an axial dipole. The class of flows includes two completely different types of known dynamos, one dominated by differential rotation (D) and one with none. We find that 36% of the flows in seven distinct zones in parameter space act as dynamos, while the remaining 64% either fail to generate this type of magnetic field or generate fields that are too small in scale to be resolved by our numerical method. The two previously known dynamo types lie in the same zone, and it is therefore possible to change the flow continuously from one to the other without losing dynamo action. Differential rotation is found to promote large-scale axisymmetric toroidal magnetic fields, while meridional circulation (M) promotes large-scale axisymmetric poloidal fields concentrated at high latitudes near the axis. Magnetic fields resembling that of the Earth are generated by D > 0, corresponding to westward flow at the surface, and M of either sign but not zero. Very few oscillatory solutions are found

Transition between nuclear and quark-gluon descriptions of hadrons and light nuclei

We provide a perspective on studies aimed at observing the transition between hadronic and quark-gluonic descriptions of reactions involving light nuclei. We begin by summarizing the results for relatively simple reactions such as the pion form factor and the neutral pion transition form factor as well as that for the nucleon and end with exclusive photoreactions in our simplest nuclei. A particular focus will be on reactions involving the deuteron. It is noted that a firm understanding of these issues is essential for unraveling important structure information from processes such as deeply virtual Compton scattering as well as deeply virtual meson production. The connection to exotic phenomena such as color transparency will be discussed. A number of outstanding challenges will require new experiments at modern facilities on the horizon as well as further theoretical developments.Comment: 37 pages, 17 figures, submitted to Reports on Progress in Physic

Seabird Bycatch in Pelagic Longline Fisheries Is Grossly Underestimated when Using Only Haul Data

Hundreds of thousands of seabirds are killed each year as bycatch in longline fisheries. Seabirds are predominantly caught during line setting but bycatch is generally recorded during line hauling, many hours after birds are caught. Bird loss during this interval may lead to inaccurate bycatch information. In this 15 year study, seabird bycatch was recorded during both line setting and line hauling from four fishing regions: Indian Ocean, Southern Ocean, Coral Sea and central Pacific Ocean. Over 43,000 albatrosses, petrels and skuas representing over 25 species were counted during line setting of which almost 6,000 seabirds attempted to take the bait. Bait-taking interactions were placed into one of four categories. (i) The majority (57%) of bait-taking attempts were “unsuccessful” involving seabirds that did not take the bait nor get caught or hooked. (ii) One-third of attempts were “successful” with seabirds removing the bait while not getting caught. (iii) One-hundred and seventy-six seabirds (3% of attempts) were observed being “caught” during line setting, with three albatross species – Laysan (Phoebastria immutabilis), black-footed (P. nigripes) and black-browed (Thalassarche melanophrys)– dominating this category. However, of these, only 85 (48%) seabird carcasses were retrieved during line hauling. Most caught seabirds were hooked through the bill. (iv) The remainder of seabird-bait interactions (7%) was not clearly observed, but likely involved more “caught” seabirds. Bait taking attempts and percentage outcome (e.g. successful, caught) varied between seabird species and was not always related to species abundance around fishing vessels. Using only haul data to calculate seabird bycatch grossly underestimates actual bycatch levels, with the level of seabird bycatch from pelagic longline fishing possibly double what was previously thought

Weak radiative hyperon decays, Hara's theorem and the diquark

Weak radiative hyperon decays are discussed in the diquark-level approach. It is pointed out that in the general diquark formalism one may reproduce the experimentally suggested pattern of asymmetries, while maintaining Hara's theorem in the SU(3) limit. At present, however, no detailed quark-based model of parity-violating diquark-photon coupling exists that would have the necessary properties.Comment: 10 pages, LaTe

About one long-range contribution to K+ -> pi+ l+ l- decays

We investigate the mechanism of K+ -> pi+ l+ l- (l= e, mu) decays in which a virtual photon is emitted either from the incoming K+ or the outgoing pi+. We point out some inconsistencies with and between two previous calculations, discuss the possible experimental inputs, and estimate the branching fractions. This mechanism alone fails to explain the existing experimental data by more than one order-of-magnitude. But it may show itself by its interference with the leading long-range mechanism dominated by the a_1^+ and rho^0 mesons.Comment: 12 pages, RevTeX, epsf.sty, 2 embedded figure

Low temperatures enhance organic nitrate formation: evidence from observations in the 2012 Uintah Basin Winter Ozone Study

Nitrogen dioxide (NO2) and total alkyl nitrates (ΣANs) were measured using thermal dissociation laser-induced fluorescence during the 2012 Uintah Basin Winter Ozone Study (UBWOS) in Utah, USA. The observed NO2 concentration was highest before sunrise and lowest in the late afternoon, suggestive of a persistent local source of NO2 coupled with turbulent mixing out of the boundary layer. In contrast, ΣANs co-varied with solar radiation with a noontime maximum, indicating that local photochemical production combined with rapid mixing and/or deposition was the dominant factor in determining the ΣAN concentrations. We calculate that ΣANs were a large fraction (~60%) of the HOx free radical chain termination and show that the temperature dependence of the alkyl nitrate yields enhances the role of ΣANs in local chemistry during winter by comparison to what would occur in the warmer temperatures of summer

A QCD Sum Rule Approach to the s→dγs\to d\gamma Contribution to the Ω−→Ξ−γ\Omega^-\to \Xi^-\gamma Radiative Decay

QCD sum rules are used to calculate the contribution of short-distance single-quark transition $s\rightarrow d \gamma$, to the amplitudes of the hyperon radiative decay, $\Omega^-\rightarrow \Xi^-\gamma$. We re-evaluate the Wilson coefficient of the effective operator responsible for this transition. We obtain a branching ratio which is comparable to the unitarity limit.Comment: 15 pages, Revtex, 13 figures available as a uuencoded, gz-compressed ps fil

η−η′\eta-\eta^\prime mixing and the next-to-leading-order power correction

The next-to-leading-order $O(1/Q^4)$ power correction for $\eta\gamma$ and $\eta^\prime\gamma$ form factors are evaluated and employed to explore the $\eta-\eta^\prime$ mixing. The parameters of the two mixing angle scheme are extracted from the data for form factors, two photon decay widths and radiative $J/\psi$ decays. The $\chi^2$ analysis gives the result: $f_{\eta_1}=(1.16\pm0.06)f_\pi, f_{\eta_8}=(1.33\pm0.23)f_\pi, \theta_1=-9^\circ\pm 3^\circ, \theta_8=-21.3^\circ\pm 2.3^\circ$, where $f_{\eta_{1(8)}}$ and $\theta_{1(8)}$ are the decay constants and the mixing angles for the singlet (octet) state. In addition, we arrive at a stringent range for $f_{\eta^\prime}^c:-10$ MeV$\le f_{\eta^\prime}^c\le -4$ MeV.Comment: 23 pages, 9 figures, To be publshied in Phys. Rev.