Acting without being in control: Exploring volition in Parkinson's disease with impulsive compulsive behaviours.

BACKGROUND: Several aspects of volitional control of action may be relevant in the pathophysiology of impulsive-compulsive behaviours (ICB) in Parkinson's disease (PD). We aimed to explore multiple aspects of action control, assessing reward-related behaviour, inhibition (externally and internally triggered) and sense of agency in PD patients, with and without ICB compared to healthy subjects. METHODS: Nineteen PD patients with ICB (PD-ICB), 19 PD without ICB (PD-no-ICB) and 19 healthy controls (HC) underwent a battery of tests including: Intentional Binding task which measures sense of agency; Stop Signal Reaction Time (SSRT) measuring capacity for reactive inhibition; the Marble task, assessing intentional inhibition; Balloon Analog Risk Task for reward sensitivity. RESULTS: One-way ANOVA showed significant main effect of group for action binding (p = 0.004, F = 6.27). Post hoc analysis revealed that PD-ICB had significantly stronger action binding than HC (p = 0.004), and PD-no-ICB (p = 0.04). There was no difference between PD-no-ICB and HC. SSRT did not differ between PD groups, whereas a significant difference between PD-no-ICB and HC was detected (p = 0.01). No other differences were found among groups in the other tasks. CONCLUSIONS: PD patients with ICB have abnormal performance on a psychophysical task assessing sense of agency, which might be related to a deficit in action representation at cognitive/experiential level. Yet, they have no deficit on tasks evaluating externally and internally triggered inhibitory control, or in reward-based decision-making. We conclude that impaired sense of agency may be a factor contributing to ICB in PD patients

The Planck Low Frequency Instrument

The Low Frequency Instrument (LFI) of the "Planck Surveyor" ESA mission will perform high-resolution imaging of the Cosmic Microwave Background anisotropies at four frequencies in the 30-100 GHz range. We review the LFI main scientific objectives, the current status of the instrument design and the on-going effort to develop software simulations of the LFI observations. In particular we discuss the design status of the PLANCK telescope, which is critical for reaching adequate effective angular resolution.Comment: 10 pages, Latex (use epsfig.sty); 4 Postscript figures; Astrophys. Lett & Comm, in press. Proc. of the Conference: "The Cosmic Microwave Background and the Planck Mission", Santander, Spain, 22-25 June 199

Planck Low Frequency Instrument: Beam Patterns

The Low Frequency Instrument on board the ESA Planck satellite is coupled to the Planck 1.5 meter off-axis dual reflector telescope by an array of 27 corrugated feed horns operating at 30, 44, 70, and 100 GHz. We briefly present here a detailed study of the optical interface devoted to optimize the angular resolution (10 arcmin at 100 GHz as a goal) and at the same time to minimize all the systematics coming from the sidelobes of the radiation pattern. Through optical simulations, we provide shapes, locations on the sky, angular resolutions, and polarization properties of each beam.Comment: On behalf of the Planck collaboration. 3 pages, 1 figure. Article published in the Proceedings of the 2K1BC Experimental Cosmology at millimetre wavelength

Sex of offspring influences metabolism during early transition period in dairy cows

Abstract. A study using 20 Holstein Friesian cows was conducted to investigate the influence of calf gender on metabolism during the transition period in dairy cattle. Blood samples were collected at three time points: 2–4 days prepartum (time 1), and 1 week and 2 weeks postpartum (time 2 and time 3 respectively). Serum samples obtained were analysed for total proteins, albumin, urea, glucose, non-esterified fatty acids (NEFA) and β-hydroxybutyrate (BHB). Depending on the sex of the offspring, cows were divided into two groups: Group 1 consisted of cows with heifer offspring (n = 12) and Group 2 consisted of cows with bull offspring (n = 8). A two-way repeated measures ANOVA and t tests for unpaired data were used to analyse the pattern of studied parameters and differences between the two groups. The results indicate differences in metabolic parameters between the two groups. These results highlight the importance of considering fetal sex as a factor that influences maternal metabolism during the early transition period in dairy cows

Commentary: Anderson-Fabry Disease: A Rare Cause of Levodopa-Responsive Early Onset Parkinsonism

This case had young onset parkinsonism beginning at age 45 mainly affecting the right side with foot dystonia and limb pain as an early and prominent feature.1 There was a family history of renal disease in one sister, stroke like episodes and dementia in another sister, and ischemic cardiac disease in the father. Single-photon emission computed tomography of the dopamine transporter showed bilateral reduced uptake and there was a good levodopa response and later development non-motor fluctuations. Although a number of parkinsonian conditions particularly genetic forms of young onset parkinsonism are in the differential, the patient also showed signs of renal (microalbuminuria) and cardiac (left ventricular hypertrophy) dysfunction which further narrowed the differential to conditions such as mitochondrial disease and neuronal inclusion body disease (though brain MRI did not show characteristic white matter changes). Given the severity of pain and renal involvement, Anderson-Fabry was considered as the most likely diagnosis. This x-linked lysosomal storage disease is caused by absent or minimal enzymatic activity of α-galactosidase and usually affects males in whom its fully penetrant but has been described rarely also to affect women.2 It is important to recognize this condition given the availability of treatment with enzyme replacement therapy (agalsidase alfa). The list of genetic parkinsonian conditions is increasing.2 Involvement of non-neurologic organ systems in patient or family members may offer clues to diagnosis. Anderson-Fabry disease specifically must be kept in mind in anyone with young onset parkinsoni

The use of thermography on the slaughter-line for the assessment of pork and raw ham quality

The left and right hams of forty heavy pig carcasses were thermographed to evaluate whether surface temperature differences were related to meat and ham quality. Thermal imaging analysis showed no differences in average surface temperature among classes of pH or of L* colour co-ordinate nor among classes of ham defects such as veining and red skin. However, hams with a lower fat cover displayed a significantly warmer average temperature surface. Infrared thermography seems to be a practical and non-invasive method to detect hamswith a fat cover below the minimum requested to be submitted to the dry-curing process

Assembly and Annotation of Red Spruce (Picea rubens) Chloroplast Genome, Identification of Simple Sequence Repeats, and Phylogenetic Analysis in Picea

We have sequenced the chloroplast genome of red spruce (Picea rubens) for the first time using the single-end, short-reads (44 bp) Illumina sequences, assembled and functionally annotated it, and identified simple sequence repeats (SSRs). The contigs were assembled using SOAPdenovo2 following the retrieval of chloroplast genome sequences using the black spruce (Picea mariana) chloroplast genome as the reference. The assembled genome length was 122,115 bp (gaps included). Comparatively, the P. rubens chloroplast genome reported here may be considered a near-complete draft. Global genome alignment and phylogenetic analysis based on the whole chloroplast genome sequences of Picea rubens and 10 other Picea species revealed high sequence synteny and conservation among 11 Picea species and phylogenetic relationships consistent with their known classical interrelationships and published molecular phylogeny. The P. rubens chloroplast genome sequence showed the highest similarity with that of P. mariana and the lowest with that of P. sitchensis. We have annotated 107 genes including 69 protein-coding genes, 28 tRNAs, 4 rRNAs, few pseudogenes, identified 42 SSRs, and successfully designed primers for 26 SSRs. Mononucleotide A/T repeats were the most common followed by dinucleotide AT repeats. A similar pattern of microsatellite repeats occurrence was found in the chloroplast genomes of 11 Picea species

Localization and Coherence in Nonintegrable Systems

We study the irreversible dynamics of nonlinear, nonintegrable Hamiltonian oscillator chains approaching their statistical asympotic states. In systems constrained by more than one conserved quantity, the partitioning of the conserved quantities leads naturally to localized and coherent structures. If the phase space is compact, the final equilibrium state is governed by entropy maximization and the final coherent structures are stable lumps. In systems where the phase space is not compact, the coherent structures can be collapses represented in phase space by a heteroclinic connection to infinity.Comment: 41 pages, 15 figure

Imaging the first light: experimental challenges and future perspectives in the observation of the Cosmic Microwave Background Anisotropy

Measurements of the cosmic microwave background (CMB) allow high precision observation of the Last Scattering Surface at redshift $z\sim$1100. After the success of the NASA satellite COBE, that in 1992 provided the first detection of the CMB anisotropy, results from many ground-based and balloon-borne experiments have showed a remarkable consistency between different results and provided quantitative estimates of fundamental cosmological properties. During 2003 the team of the NASA WMAP satellite has released the first improved full-sky maps of the CMB since COBE, leading to a deeper insight into the origin and evolution of the Universe. The ESA satellite Planck, scheduled for launch in 2007, is designed to provide the ultimate measurement of the CMB temperature anisotropy over the full sky, with an accuracy that will be limited only by astrophysical foregrounds, and robust detection of polarisation anisotropy. In this paper we review the experimental challenges in high precision CMB experiments and discuss the future perspectives opened by second and third generation space missions like WMAP and Planck.Comment: To be published in "Recent Research Developments in Astronomy & Astrophysics Astrophysiscs" - Vol I