Effect of dairy farming system, herd, season, parity, and days in milk on modeling of the coagulation, curd firming, and syneresis of bovine milk

The objectives of this study were to characterize the variation in curd firmness model parameters obtained from coagulating bovine milk samples, and to investigate the effects of the dairy system, season, individual farm, and factors related to individual cows (days in milk and parity). Individual milk samples (n=1,264) were collected during the evening milking of 85 farms representing different environments and farming systems in the northeastern Italian Alps. The dairy herds were classified into 4 farming system categories: traditional system with tied animals (29 herds), modern dairy systems with traditional feeding based on hay and compound feed (30 herds), modern dairy system with total mixed ration (TMR) that included silage as a large proportion of the diet (9 herds), and modern dairy system with silage-free TMR (17 herds). Milk samples were analyzed for milk composition and coagulation properties, and parameters were modeled using curd firmness measures (CFt) collected every 15 s from a lacto-dynamographic analysis of 90min. When compared with traditional milk coagulation properties (MCP), the curd firming measures showed greater variability and yielded a more accurate description of the milk coagulation process: the model converged for 93.1% of the milk samples, allowing estimation of 4 CFt parameters and 2 derived traits [maximum CF (CFmax) and time from rennet addition to CFmax (tmax)] for each sample. The milk samples whose CFt equations did not converge showed longer rennet coagulation times obtained from the model (RCTeq) and higher somatic cell score, and came from less-productive cows. Among the sources of variation tested for the CFt parameters, dairy herd system yielded the greatest differences for the contrast between the traditional farm and the 3 modern farms, with the latter showing earlier coagulation and greater instant syneresis rate constant (kSR). The use of TMR yielded a greater tmax because of a higher instant curd-firming rate constant (kCF). Season of sampling was found to be very important, yielding higher values during winter for all traits except kCF and kSR. All CFt traits were affected by individual cow factors. For parity, milk produced by first-lactation cows showed higher kCF and kSR, but delays in achieving CFmax. With respect to stage of lactation, RCTeq and potential asymptotic CF increased during the middle of lactation and stabilized thereafter, whereas the 2 instant rate constants presented the opposite pattern, with the lowest (kCF) and highest (kSR) values occurring in mid lactation. The new challenge offered by prolonging the test interval and individual modeling of milk technological properties allowed us to study the effects of parameters related to the environment and to individual cows. This novel strategy may be useful for investigating the genetic variability of these new coagulation traits. \ua9 2015 American Dairy Science Associatio

"Evil cats" and "jelly floods": young children’s collective constructions of digital art-making in the early years classroom

Digital technologies have the potential to offer new opportunities for children’s expressive arts practices. While adult expectations surround and shape children’s visual art-making on paper in the early years classroom, such expectations are not so established in relation to digital art-making. So how do children make sense of digital art-making when it is newly introduced into the classroom and adult input is minimal? Drawing on a social semiotic ethnographic perspective, this paper explores this question by examining instances of 4-5 year olds’ spoken dialogue around the computer during a week in which digital art-making was first introduced into the classroom. Analysis focused on interactions where children proposed, reinforced or challenged conceptions of digital art-making. These interactions demonstrated that children’s digital art-making was negotiated and constructed through particular processes. Three such processes are presented here: the use of collective motifs and metaphors; attributing ‘expert’ status; and polarizing conflicts. Understanding these processes offers a starting point for thinking about how a new activity like digital art-making can be integrated into the early years classroom and supported by practitioners

Informatica e pensiero computazionale : una proposta costruttivista per gli insegnanti

L\u2019articolo presenta una proposta formativa che ha per tema la didattica dell\u2019informatica con approccio socio-costruttivista. Tale proposta nasce dall\u2019esperienza sviluppata negli ultimi anni progettando e realizzando workshop nelle scuole, e si basa sull\u2019uso di strategie e strumenti costruttivisti per sviluppare il pensiero computazionale e far scoprire l\u2019informatica come disciplina scientifica. Illustriamo gli obiettivi formativi, i contenuti, la metodologia e le attivit\ue0 proposte e descriviamo gli esiti dello svolgimento di due momenti formativi realizzati secondo questa impostazione: un corso rivolto a studenti di laurea magistrale in informatica interessati all\u2019insegnamento e laboratori per insegnanti senza una specifica formazione informatic

‘Draw, write and tell’. A literature review and methodological development on the ‘draw and write’ research method.

The creative research method ‘draw and write’ has been used in health, social care and education research for several decades. A literature search of studies utilising this method was conducted during the planning stages of a study exploring primary school children’s perceptions of infant feeding. A review of this literature noted a range of benefits of ‘draw and write’ in enabling child participation. However, it also identified that the method has been used inconsistently and found that there are issues for researchers in relation to interpretation of creative work and analysis of data. As a result of this, an improvement on this method, entitled ‘draw, write and tell’, was developed in an attempt to provide a more child-orientated and consistent approach to data collection, interpretation and analysis. This article identifies the issues relating to ‘draw and write’ and describes the development and application of ‘draw, write and tell’ as a case study, noting its limitations and benefit

Natural terpenoids from Ambrosia species are active in vitro and in vivo against human pathogenic trypanosomatids

Among the natural compounds, terpenoids play an important role in the drug discovery process for tropical diseases. The aim of the present work was to isolate antiprotozoal compounds from Ambrosia elatior and A. scabra. The sesquiterpene lactone (STL) cumanin was isolated from A. elatior whereas two other STLs, psilostachyin and cordilin, and one sterol glycoside, daucosterol, were isolated from A. scabra. Cumanin and cordilin were active against Trypanosoma cruzi epimastigotes showing 50% inhibition concentrations (IC50) values of 12 µM and 26 µM, respectively. Moreover, these compounds are active against bloodstrean trypomastigotes, regardless of the T. cruzi strain tested. Psilostachyin and cumanin were also active against amastigote forms with IC50 values of 21 µM and 8 µM, respectively. By contrast, daucosterol showed moderate activity on epimastigotes and trypomastigotes and was inactive against amastigote forms. We also found that cumanin and psilostachyin exhibited an additive effect in their trypanocidal activity when these two drugs were tested together. Cumanin has leishmanicidal activity with growth inhibition values greater than 80% at a concentration of 5 µg/ml (19 µM), against both L. braziliensis and L. amazonensis promastigotes. In an in vivo model of T. cruzi infection, cumanin was more active than benznidazole, producing an 8-fold reduction in parasitemia levels during the acute phase of the infection compared with the control group, and more importantly, a reduction in mortality with 66% of the animals surviving, in comparison with 100% mortality in the control group. Cumanin also showed nontoxic effects at the doses assayed in vivo, as determined using markers of hepatic damage.Fil: Sülsen, Valeria P.. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco (i); ArgentinaFil: Cazorla, Silvia Ines. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral "Profesor R. A. Margni"; ArgentinaFil: Frank, Fernanda Maria. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral "Profesor R. A. Margni"; ArgentinaFil: Laurella, Laura C.. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco (i); ArgentinaFil: Muschietti, Liliana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco (i); ArgentinaFil: Catalan, Cesar Atilio Nazareno. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tucumán. Instituto de Quimica del Noroeste; ArgentinaFil: Martino, Virginia Susana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco (i); ArgentinaFil: Malchiodi, Emilio Luis. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral "Profesor R. A. Margni"; Argentin

Sign-changing tower of bubbles for a sinh-Poisson equation with asymmetric exponents

Motivated by the statistical mechanics description of stationary 2D-turbulence, for a sinh-Poisson type equation with asymmetric nonlinearity, we construct a concentrating solution sequence in the form of a tower of singular Liouville bubbles, each of which has a different degeneracy exponent. The asymmetry parameter $\gamma\in(0,1]$ corresponds to the ratio between the intensity of the negatively rotating vortices and the intensity of the positively rotating vortices. Our solutions correspond to a superposition of highly concentrated vortex configurations of alternating orientation; they extend in a nontrivial way some known results for $\gamma=1$. Thus, by analyzing the case $\gamma\neq1$ we emphasize specific properties of the physically relevant parameter $\gamma$ in the vortex concentration phenomena

La formazione degli insegnanti della classe 42/A – Informatica: l'esperienza dell'Università degli Studi di Milano

In Italia la formazione universitaria all'insegnamento nella scuola se- condaria ha una tradizione piuttosto recente: alle scuole di specializ- zazione attive negli anni 1999-2008 dovrebbero \u2013 secondo quanto pre- visto dal Decreto Ministeriale del 10 settembre 2010, n. 249 \u2013 sostituirsi lauree magistrali innestate sulla corrispondente formazione discipli- nare triennale; nel transitorio sono stati attivati corsi annuali riservati a laureati di secondo livello selezionati tramite esami (Tirocinio forma- tivo attivo, TFA) o titolari di un'esperienza professionale di insegna- mento di almeno 3 anni (Percorsi abilitanti speciali, PAS). Questo ca- pitolo descrive l'esperienza dell'Universit\ue0 degli Studi di Milano nel progettare e gestire i corsi 42/A TFA e PAS, nel triennio 2012-2015

How Challenging are Bebras Tasks? : An IRT Analysis Based on the Performance of Italian Students

This paper analyses the results of the 2014 edition of the Italian Bebras/Kangourou contest, exploiting the Item Response Theory statistical methodology in order to infer the difficulty of each of the proposed tasks starting from the scores attained by the participants. Such kind of analysis, enabling the organizers of the contest to check whether or not the difficulty perceived by pupils was substantially different from that estimated by those who proposed the tasks, is important as a feedback in order to gain knowledge to be used both in ranking participants and in organizing future editions of the contest. We show how the proposed analysis essentially highlights that the 63% of tasks was perceived at the same level of difficulty estimated by those who proposed them, but a 37% of tasks were either easier or more difficult than expected

The pedagogy and principles of teaching therapeutic practice with children and young people.

Technical approaches suggesting that systematically produced, generalized, and scientific knowledge are the most solid foundations for practice present significant challenges for the social work profession, in which the decisions faced often are not technical but rather moral, requiring the application of ethically based and intuitive skills. Meanwhile, the command, control, and measurement of outcomes in social work practice also present significant conundrums for the delivery of relational person-centered social work and social care. With a focus too often on efficiency rather than on effectiveness, this managerialistic approach frequently fails to acknowledge the complexity inherent in the act of caring. In this context and framework, teaching therapeutic practice with children draws a balance between traditional systematic teaching methods and use of creative media including art, play, and music. This article outlines the positive contribution to professional social work practice that the teaching of therapeutic approaches to child care can make

Data-Driven Induction of Shadowed Sets Based on Grade of Fuzziness

We propose a procedure devoted to the induction of a shadowed set through the post-processing of a fuzzy set, which in turn is learned from labeled data. More precisely, the fuzzy set is inferred using a modified support vector clustering algorithm, enriched in order to optimize the fuzziness grade. Finally, the fuzzy set is transformed into a shadowed set through application of an optimal alpha-cut. The procedure is tested on synthetic and real-world datasets