Perceived discrimination and mental health outcomes in college students: the mediating role of preventive health behaviors and social support

Perceived discrimination has been linked to adverse mental health outcomes, increased risk-taking behaviors, and poor engagement in health promoting behaviors. College students may be especially susceptible to negative mental health outcomes associated with discrimination due to the unique stressors faced by young adults (e.g., prolonged transition to adulthood, onset of mental health disorders, changes in social support). The current study examined the mediating and moderating roles of health behaviors and social support on the association between perceived discrimination and mental health outcomes (e.g., anxiety, depression, suicidality) in college students. A total of 709 college students (42.8% White; 72.2% female; 30.2% first-generation) from a large urban university completed online questionnaires including: the Everyday Discrimination Scale (EDS), Hopkins Symptom Checklist (HSCL-25), Suicidal Behavior Questionnaire-14 (SBQ-14), Health Behaviors Checklist (HBCL), and Interpersonal Support Evaluation List (ISEL-College Version). To examine study aims, moderation and parallel mediation analyses were conducted in PROCESS SPSS macro version 4.0. Results indicated that preventive health behaviors and social support partially mediated the association between discrimination and mental health outcomes. Findings additionally suggested that first- and continuing-generation students may experience different impacts on health behavior associated with discrimination. Our findings lend support to the generalizability of certain elements of the discrimination-health model in college students reporting on a wider variety of discrimination experiences. Further examination of the discrimination-health model in first- and continuing-generation students may be warranted to better inform the ways that discrimination may uniquely impact health behavior in these populations

Spin Amplification for Magnetic Sensors Employing Crystal Defects

Recently there have been several theoretical and experimental studies of the prospects for magnetic field sensors based on crystal defects, especially nitrogen vacancy (NV) centres in diamond. Such systems could potentially be incorporated into an AFM-like apparatus in order to map the magnetic properties of a surface at the single spin level. In this Letter we propose an augmented sensor consisting of an NV centre for readout and an `amplifier' spin system that directly senses the local magnetic field. Our calculations show that this hybrid structure has the potential to detect magnetic moments with a sensitivity and spatial resolution far beyond that of a simple NV centre, and indeed this may be the physical limit for sensors of this class

Choosing the lesser of two evils, the better of two goods: Specifying the roles of ventromedial prefrontal cortex and dorsal anterior cingulate in object choice

The ventromedial prefrontal cortex (vmPFC) and dorsal anterior cingulate cortices (ACd) are considered important for reward-based decision making. However, work distinguishing their individual functional contributions has only begun. One aspect of decision making that has received little attention is that making the right choice often translates to making the better choice. Thus, response choice often occurs in situations where both options are desirable (e.g., choosing between mousse au chocolat or crème caramel cheesecake from a menu) or, alternatively, in situations where both options are undesirable. Moreover, response choice is easier when the reinforcements associated with the objects are far apart, rather than close together, in value. We used functional magnetic resonance imaging to delineate the functional roles of the vmPFC and ACd by investigating these two aspects of decision making: (1) decision form (i.e., choosing between two objects to gain the greater reward or the lesser punishment), and (2) between-object reinforcement distance (i.e., the difference in reinforcements associated with the two objects). Blood oxygen level-dependent (BOLD) responses within the ACd and vmPFC were both related to decision form but differentially. Whereas ACd showed greater responses when deciding between objects to gain the lesser punishment, vmPFC showed greater responses when deciding between objects to gain the greater reward. Moreover, vmPFC was sensitive to reinforcement expectations associated with both the chosen and the forgone choice. In contrast, BOLD responses within ACd, but not vmPFC, related to between-object reinforcement distance, increasing as the distance between the reinforcements of the two objects decreased. These data are interpreted with reference to models of ACd and vmPFC functioning

Epidural Analgesia Decreases Narcotic Requirements in Low Level Spina Bifida Patients Undergoing Urologic Laparotomy for Neurogenic Bladder and Bowel

Purpose Concern of anatomical anomalies and worsening neurologic symptoms has prevented widespread use of epidural catheters in patients with low level spina bifida (LLSB). We hypothesize that thoracic epidural placement in the T9-T10 interspace is safe and decreases narcotic requirements in LLSB patients following major open lower urinary tract reconstruction (LUTR). Materials and Methods We reviewed consecutive LLSB patients who had LUTR and epidurals for post-operative pain control. Controls were LLSB patients who received single shot transversus abdominis plane (TAP) blocks with similar procedures. Complications from epidural placement, including changes in motor and sensory status were recorded. Opioid consumption was calculated utilizing equivalent IV morphine doses. Mean and maximum pain scores on post-operative day (POD) 0-3 were calculated. Results 10 LLSB patients who had lower urinary tract reconstruction and epidurals were matched to 10 LLSB patients who had lower urinary tract reconstruction and transverse abdominis plane blocks. Groups were demographically similar. All had full abdominal sensation and functional levels at or below L3. No epidural complications or changes in neurological status were noted. The epidural group had decreased opioid consumption on POD 0-3 (0.75 mg/kg vs. 1.29 mg/kg, p=0.04). Pain scores were similar or improved in the epidural group. Conclusions Thoracic epidural analgesia appears to be a safe and effective opioid sparing option to assist with post-operative pain management following lower urinary tract reconstruction in LLSB patients

Ensemble based quantum metrology

The field of quantum metrology promises measurement devices that are fundamentally superior to conventional technologies. Specifically, when quantum entanglement is harnessed the precision achieved is supposed to scale more favourably with the resources employed, such as system size and the time required. Here we consider measurement of magnetic field strength using an ensemble of spins, and we identify a third essential resource: the initial system polarisation, i.e. the low entropy of the original state. We find that performance depends crucially on the form of decoherence present; for a plausible dephasing model, we describe a quantum strategy which can indeed beat the standard quantum limit

Charge dynamics and spin blockade in a hybrid double quantum dot in silicon

Electron spin qubits in silicon, whether in quantum dots or in donor atoms, have long been considered attractive qubits for the implementation of a quantum computer due to the semiconductor vacuum character of silicon and its compatibility with the microelectronics industry. While donor electron spins in silicon provide extremely long coherence times and access to the nuclear spin via the hyperfine interaction, quantum dots have the complementary advantages of fast electrical operations, tunability and scalability. Here we present an approach to a novel hybrid double quantum dot by coupling a donor to a lithographically patterned artificial atom. Using gate-based rf reflectometry, we probe the charge stability of this double quantum dot system and the variation of quantum capacitance at the interdot charge transition. Using microwave spectroscopy, we find a tunnel coupling of 2.7 GHz and characterise the charge dynamics, which reveals a charge T2* of 200 ps and a relaxation time T1 of 100 ns. Additionally, we demonstrate spin blockade at the inderdot transition, opening up the possibility to operate this coupled system as a singlet-triplet qubit or to transfer a coherent spin state between the quantum dot and the donor electron and nucleus.Comment: 6 pages, 4 figures, supplementary information (3 pages, 4 figures

Quantum metrology with molecular ensembles

This work was supported by the EPSRC through QIP IRC (Grants No. GR/S82176/01 and No. GR/S15808/01), the National Research Foundation and Ministry of Education, Singapore, the DAAD, and the Royal Society.The field of quantum metrology promisesmeasurement devices that are fundamentally superior to conventional technologies. Specifically, when quantum entanglement is harnessed, the precision achieved is supposed to scale more favorably with the resources employed, such as system size and time required. Here, we consider measurement of magnetic-field strength using an ensemble of spin-active molecules. We identify a third essential resource: the change in ensemble polarization (entropy increase) during the metrology experiment. We find that performance depends crucially on the form of decoherence present; for a plausible dephasing model, we describe a quantum strategy, which can indeed beat the standard strategy.Publisher PDFPeer reviewe

Global Optical Control of a Quantum Spin Chain

Quantum processors which combine the long decoherence times of spin qubits together with fast optical manipulation of excitons have recently been the subject of several proposals. I show here that arbitrary single- and entangling two-qubit gates can be performed in a chain of perpetually coupled spin qubits solely by using laser pulses to excite higher lying states. It is also demonstrated that universal quantum computing is possible even if these pulses are applied {\it globally} to a chain; by employing a repeating pattern of four distinct qubit units the need for individual qubit addressing is removed. Some current experimental qubit systems would lend themselves to implementing this idea.Comment: 5 pages, 3 figure