4,150 research outputs found
Gender Balance in Construction Material Research: The Analysis of Alkali-Activated Materials by a Bibliometric Study Using Scopus Database
Research in alkali-activated materials (AAMs) is an innovative and dynamic material science topic. This is due to the relevant performances in terms of physico-mechanical properties comparable to traditional construction materials (e.g., ordinary Portland cement). The sustainability of AAMs is often highlighted since they can be developed by using many natural or industrial by-productsâbased precursors. This leads to challenges with the optimization of AAM production due to their different performances, availability, and costs. However, they are flexible and locally adapted materials. The research interest in AAMs has rapidly increased in the early 2000s. In recent years, about 1,000 international articles have been published each year. This study aims at assessing the gender balance of this specific research topic to investigate the relevance of womenâs participation. Author lists of the published articles were analyzed throughout the Scopus database, applying âalkali-activated materialâ and âgeopolymersâ as keywords in the titles, abstracts, and keywords search. The last 10 years (2009â2019) were taken into account. The gender of the most prolific authors was analyzed, and a focus of European authors on this topic was considered, as more than 25% of the research in AAMs have been carried out in Europe. The analysis of 5,900 publications in the last decade shows that there is currently a shift toward men in the gender balance in this specific research, and female authors only covered 22% of the most productive authors worldwide. Considering European authors, a more equal gender distribution is reached, when the first author is considered, with a concentration of women in the range of 36â56%, recorded over 1,396 articles
Optical mapping of neuronal activity during seizures in zebrafish
Mapping neuronal activity during the onset and propagation of epileptic seizures can provide a better understanding of the mechanisms underlying this pathology and improve our approaches to the development of new drugs. Recently, zebrafish has become an important model for studying epilepsy both in basic research and in drug discovery. Here, we employed a transgenic line with pan-neuronal expression of the genetically-encoded calcium indicator GCaMP6s to measure neuronal activity in zebrafish larvae during seizures induced by pentylenetretrazole (PTZ). With this approach, we mapped neuronal activity in different areas of the larval brain, demonstrating the high sensitivity of this method to different levels of alteration, as induced by increasing PTZ concentrations, and the rescuing effect of an anti-epileptic drug. We also present simultaneous measurements of brain and locomotor activity, as well as a high-throughput assay, demonstrating that GCaMP measurements can complement behavioural assays for the detection of subclinical epileptic seizures, thus enabling future investigations on human hypomorphic mutations and more effective drug screening methods. Notably, the methodology described here can be easily applied to the study of many human neuropathologies modelled in zebrafish, allowing a simple and yet detailed investigation of brain activity alterations associated with the pathological phenotype
Molecular characterization of membrane steroid receptors in hormone-sensitive cancers
Cancer is one of the most common causes of death worldwide, and its development is a re-sult of the complex interaction of genetic factors, environmental cues, and aging. Hormone-sensitive cancers depend on the action of one or more hormones for their development and progression. Sex steroids and corticosteroids can regulate different physiological functions, including metabolism, growth, and proliferation, through their interaction with specific nuclear receptors, that can tran-scriptionally regulate target genes via their genomic actions. Therefore, interference with hormonesâ activities, e.g., deregulation of their production and downstream pathways or the exposition to exogenous hormone-active substances such as endocrine-disrupting chemicals (EDCs), can affect the regulation of their correlated pathways and trigger the neoplastic transformation. Although nuclear receptors account for most hormone-related biologic effects and their slow genomic responses are well-studied, less-known membrane receptors are emerging for their ability to mediate steroid hormones effects through the activation of rapid non-genomic responses also involved in the development of hormone-sensitive cancers. This review aims to collect pre-clinical and clinical data on these extranuclear receptors not only to draw attention to their emerging role in cancer development and progression but also to highlight their dual role as tumor microenvironment players and potential candidate drug targets
Low temperature dynamics of kinks on Ising interfaces
The anisotropic motion of an interface driven by its intrinsic curvature or
by an external field is investigated in the context of the kinetic Ising model
in both two and three dimensions. We derive in two dimensions (2d) a continuum
evolution equation for the density of kinks by a time-dependent and nonlocal
mapping to the asymmetric exclusion process. Whereas kinks execute random walks
biased by the external field and pile up vertically on the physical 2d lattice,
then execute hard-core biased random walks on a transformed 1d lattice. Their
density obeys a nonlinear diffusion equation which can be transformed into the
standard expression for the interface velocity v = M[(gamma + gamma'')kappa +
H]$, where M, gamma + gamma'', and kappa are the interface mobility, stiffness,
and curvature, respectively. In 3d, we obtain the velocity of a curved
interface near the orientation from an analysis of the self-similar
evolution of 2d shrinking terraces. We show that this velocity is consistent
with the one predicted from the 3d tensorial generalization of the law for
anisotropic curvature-driven motion. In this generalization, both the interface
stiffness tensor and the curvature tensor are singular at the
orientation. However, their product, which determines the interface velocity,
is smooth. In addition, we illustrate how this kink-based kinetic description
provides a useful framework for studying more complex situations by modeling
the effect of immobile dilute impurities.Comment: 11 pages, 10 figure
Methylene blue adsorption on thermo plasma expanded graphite in a multilayer column system
The removal of dyes from wastewater is an important topic in environmental applications. Methylene blue (MB) is one of the most worrisome compounds, as it is widespread and used in many industrial activities. Adsorption represents an effective technique for the removal of this contaminant. Thermo plasma expanded graphite (TPEG) is an industrial material characterized by a fibrous morphology, a very low density and overlapped graphene layers. TPEG has a higher specific surface compared to conventional thermo-expanded graphite and it can establish effective attractive forces with charged pollutants. These properties make TPEG a very promising adsorbent material. In the present work, TPEG was tested in an innovative multilayer column system to treat MB contaminated solutions. Several batch experiments were carried out by varying pH, initial MB concentration and temperature. The optimal adsorption performance was assessed at pH 11, around which the TPEG assumed the maximum negative charge. Based on these results, the adsorption mechanism appeared to be related mainly to electrostatic interactions. At room temperature, the greatest amount of MB adsorbed on TPEG was detected by treating solutions with an initial concentration of 30 mgMB/L. The temperature increase from 20 to 40 °C caused an enhanced adsorption capacity when concentrations higher than 10 mgMB/L were treated. The adsorption trends were accurately described by a pseudo-second order kinetic law and the adsorption isotherms at 20 and 40 °C were found to follow both the features of Freundlich and Langmuir models. The adsorption capacity was estimated to reach threshold values around 95 mgMB/gTPEG and 265 mgMB/gTPEG at 20 and 40°C, respectively. The Gibbs energy change (ÎG°) was calculated to about â7.80 kJ/mol, which proved that the process is spontaneous from a thermodynamic point of view. Finally, it was verified that TPEG can be efficiently reused 5 times after a simple chemical regeneration phase with HCl
Development of ultra-light pixelated ladders for an ILC vertex detector
The development of ultra-light pixelated ladders is motivated by the
requirements of the ILD vertex detector at ILC. This paper summarizes three
projects related to system integration. The PLUME project tackles the issue of
assembling double-sided ladders. The SERWIETE project deals with a more
innovative concept and consists in making single-sided unsupported ladders
embedded in an extra thin plastic enveloppe. AIDA, the last project, aims at
building a framework reproducing the experimental running conditions where sets
of ladders could be tested
CALDER - Neutrinoless double-beta decay identification in TeO bolometers with kinetic inductance detectors
Next-generation experiments searching for neutrinoless double-beta decay must
be sensitive to a Majorana neutrino mass as low as 10 meV. CUORE, an array of
988 TeO bolometers being commissioned at Laboratori Nazionali del Gran
Sasso in Italy, features an expected sensitivity of 50-130 meV at 90% C.L, that
can be improved by removing the background from radioactivity. This is
possible if, in coincidence with the heat release in a bolometer, the Cherenkov
light emitted by the signal is detected. The amount of light detected
is so far limited to only 100 eV, requiring low-noise cryogenic light
detectors. The CALDER project (Cryogenic wide-Area Light Detectors with
Excellent Resolution) aims at developing a small prototype experiment
consisting of TeO bolometers coupled to new light detectors based on
kinetic inductance detectors. The R&D is focused on the light detectors that
could be implemented in a next-generation neutrinoless double-beta decay
experiment.Comment: 8 pages, 3 figures, added reference to first result
Diffusive behavior for randomly kicked Newtonian particles in a spatially periodic medium
We prove a central limit theorem for the momentum distribution of a particle
undergoing an unbiased spatially periodic random forcing at exponentially
distributed times without friction. The start is a linear Boltzmann equation
for the phase space density, where the average energy of the particle grows
linearly in time. Rescaling time, the momentum converges to a Brownian motion,
and the position is its time-integral showing superdiffusive scaling with time
. The analysis has two parts: (1) to show that the particle spends
most of its time at high energy, where the spatial environment is practically
invisible; (2) to treat the low energy incursions where the motion is dominated
by the deterministic force, with potential drift but where symmetry arguments
cancel the ballistic behavior.Comment: 55 pages. Some typos corrected from previous versio
Dynamics of Shock Probes in Driven Diffusive Systems
We study the dynamics of shock-tracking probe particles in driven diffusive
systems and also in equilibrium systems. In a driven system, they induce a
diverging timescale that marks the crossover between a passive scalar regime at
early times and a diffusive regime at late times; a scaling form characterises
this crossover. Introduction of probes into an equilibrium system gives rise to
a system-wide density gradient, and the presence of even a single probe can be
felt across the entire system.Comment: Accepted in Journal of Statistical Mechanics: Theory and Experimen
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