Is increased time to diagnosis and treatment in symptomatic cancer associated with poorer outcomes?:Systematic review

background: It is unclear whether more timely cancer diagnosis brings favourable outcomes, with much of the previous evidence, in some cancers, being equivocal. We set out to determine whether there is an association between time to diagnosis, treatment and clinical outcomes, across all cancers for symptomatic presentations. methods: Systematic review of the literature and narrative synthesis. results: We included 177 articles reporting 209 studies. These studies varied in study design, the time intervals assessed and the outcomes reported. Study quality was variable, with a small number of higher-quality studies. Heterogeneity precluded definitive findings. The cancers with more reports of an association between shorter times to diagnosis and more favourable outcomes were breast, colorectal, head and neck, testicular and melanoma. conclusions: This is the first review encompassing many cancer types, and we have demonstrated those cancers in which more evidence of an association between shorter times to diagnosis and more favourable outcomes exists, and where it is lacking. We believe that it is reasonable to assume that efforts to expedite the diagnosis of symptomatic cancer are likely to have benefits for patients in terms of improved survival, earlier-stage diagnosis and improved quality of life, although these benefits vary between cancers

ESTERASE-D ANALYSIS in FAMILIAL RETINOMA and RETINOBLASTOMA

ESCOLA PAULISTA MED SCH,BIOCHEM GENET LAB,CP 20372,BR-04023 São Paulo,SP,BRAZILESCOLA PAULISTA MED SCH,BIOCHEM GENET LAB,CP 20372,BR-04023 São Paulo,SP,BRAZILWeb of Scienc

BILATERAL RETINOBLASTOMA ASSOCIATED WITH 13Q- MOSAICISM - POSSIBLE MANIFESTATION of A GERMINAL MUTATION

ESCOLA PAULISTA MED,DISCIPLINA GENET,CAIXA POSTAL 20363,BR-04034 São Paulo,SP,BRAZILESCOLA PAULISTA MED,DISCIPLINA GENET,CAIXA POSTAL 20363,BR-04034 São Paulo,SP,BRAZILWeb of Scienc

ESTERASE-D ASSAY in BRAZILIAN RETINOBLASTOMA FAMILIES

ESCOLA PAULISTA MED SCH,DEPT MORPHOL,BIOCHEM GENET LAB,BR-04023 São Paulo,SP,BRAZILHOSP AC CARMARGO FUNDACAO ANTONIO PRUDENTE,DEPT OPHTHALMOL,São Paulo,SP,BRAZILESCOLA PAULISTA MED SCH,DEPT MORPHOL,BIOCHEM GENET LAB,BR-04023 São Paulo,SP,BRAZILWeb of Scienc

Fordyce nodules in a buccal membrane graft to the ocular surface

Purpose: To present a case of epibulbar Fordyce nodules, with a referral diagnosis of primary tumor.Methods: Case report.Results: A 38-year-old woman was referred for ocular oncology consultation because of a conjunctival lesion in the right eye. She had had a buccal mucous graft to treat recurrent pterygium 18 years earlier. the lesion consisted of multiple small, yellow granules over a pink, thickened mucosa from the 12 to 3 o'clock meridians. Excisional biopsy revealed multiple subepithelial sebaceous glands consistent with Fordyce nodules.Conclusions: Fordyce nodules are a possible late benign complication of buccal mucous grafts.Universidade Federal de São Paulo, Paulista Sch Med, Dept Ophthalmol, BR-04024002 São Paulo, BrazilUniversidade Federal de São Paulo, Paulista Sch Med, Dept Ophthalmol, BR-04024002 São Paulo, BrazilWeb of Scienc

SISTER CHROMATID EXCHANGE FREQUENCY in A RETINOBLASTOMA MOSAIC PATIENT WITH DEL(13)

HOSP AC CAMARGO,FDN ANTONIO PRUDENTE,SERV OFTALMOL,São Paulo,BRAZILWeb of Scienc

Relationship between histopathological features of chemotherapy treated retinoblastorna and P-glycoprotein expression

Background: P-glycoprotein (P-gp) has been identified as a possible mediator of chemoresistance in retinoblastoma. the aim of this study was to determine the expression of P-gp in retinoblastoma treated with chemotherapy prior to enucleation.Methods: Seventeen enucleated specimens of retinoblastoma from 16 patients were studied. Nine had been treated with chemotherapy alone, and eight had been treated with chemotherapy and other forms of local treatment. Tumour differentiation as well as choroidal and optic nerve invasion were assessed. P-gp immunohistochemical staining was performed and evaluated as negative, low or high.Results: Histopathological assessment of the cases showed that 14 of 17 eyes (82.3%) had viable retinoblastoma cells. Nine retinoblastomas were considered regressed with a well-differentiated component, five regressed retinoblastomas had viable cells with poor differentiation and three retinoblastomas had regressed leaving no viable cells. Sixteen of 17 retinoblastomas were P-gp positive. in the one case with optic nerve invasion and the three cases with massive choroidal invasion, P-gp expression was found in invading retinoblastoma cells.Conclusion: Almost all retinoblastomas expressed P-gp. High levels of P-gp expression might play a role in chemotherapy resistance of retinoblastoma or, conversely, chemotherapy might induce P-gp expression. These results might have an impact on management of bilateral retinoblastoma.Universidade Federal de São Paulo, Dept Ophthalmol, São Paulo, BrazilMcGill Univ, Henry C Witelson Ocular Pathol Lab, Dept Ophthalmol, Montreal, PQ, CanadaUniversidade Federal de São Paulo, Dept Ophthalmol, São Paulo, BrazilWeb of Scienc