The care and feeding of slime

The care and feeding of slim

Molecular Distribution, 13C-Isotope, and Enantiomeric Compositions of Carbonaceous Chondrite Monocarboxylic Acids

The watersoluble organic compounds in carbonaceous chondrite meteorites constitute a record of the synthetic reactions occurring at the birth of the solar system and those taking place during parent body alteration and may have been important for the later origins and development of life on Earth. In this present work, we have developed a novel methodology for the simultaneous analysis of the molecular distribution, compoundspecific 13C, and enantiomeric compositions of aliphatic monocarboxylic acids (MCA) extracted from the hotwater extracts of 16 carbonaceous chondrites from CM, CR, CO, CV, and CK groups. We observed high concentrations of meteoritic MCAs, with total carbon weight percentages which in some cases approached those of carbonates and insoluble organic matter. Moreover, we found that the concentration of MCAs in CR chondrites is higher than in the other meteorite groups, with acetic acid exhibiting the highest concentration in all samples. The abundance of MCAs decreased with increasing molecular weight and with increasing aqueous and/or thermal alteration experienced by the meteorite sample. The 13C isotopic values of MCAs ranged from 52 to +27, and aside from an inverse relationship between 13C value and carbon straightchain length for C3C6 MCAs in Murchison, the 13Cisotopic values did not correlate with the number of carbon atoms per molecule. We also observed racemic compositions of 2methylbutanoic acid in CM and CR chondrites. We used this novel analytical protocol and collective data to shed new light on the prebiotic origins of chondritic MCAs

Laser-like X-ray Sources Based on Optical Reflection from Relativistic Electron Mirror

A novel scheme is proposed to generate uniform relativistic electron layers for coherent Thomson backscattering. A few-cycle laser pulse is used to produce the electron layer from an ultra-thin solid foil. The key element of the new scheme is an additional foil that reflects the drive laser pulse, but lets the electrons pass almost unperturbed. It is shown by analytic theory and by 2D-PIC simulation that the electrons, after interacting with both drive and reflected laser pulse, form a very uniform flyer freely cruising with high relativistic gamma-factor exactly in drive laser direction (no transverse momentum). It backscatters probe light with a full Doppler shift factor of 4*gamma^2. The reflectivity and its decay due to layer expansion is discussed.Comment: 5 pages, 3 figures, submitted, invited talk on the workshop of Frontiers in Intense Laser-Matter Interaction Theory, MPQ, March 1-3, 2010

Prior events predict cerebrovascular and coronary outcomes in the PROGRESS trial

<p><b>Background and Purpose:</b> The relationship between baseline and recurrent vascular events may be important in the targeting of secondary prevention strategies. We examined the relationship between initial event and various types of further vascular outcomes and associated effects of blood pressure (BP)–lowering.</p> <p><b>Methods:</b> Subsidiary analyses of the Perindopril Protection Against Recurrent Stroke Study (PROGRESS) trial, a randomized, placebo-controlled trial that established the benefits of BP–lowering in 6105 patients (mean age 64 years, 30% female) with cerebrovascular disease, randomly assigned to either active treatment (perindopril for all, plus indapamide in those with neither an indication for, nor a contraindication to, a diuretic) or placebo(s).</p> <p><b>Results:</b> Stroke subtypes and coronary events were associated with 1.5- to 6.6-fold greater risk of recurrence of the same event (hazard ratios, 1.51 to 6.64; P=0.1 for large artery infarction, P<0.0001 for other events). However, 46% to 92% of further vascular outcomes were not of the same type. Active treatment produced comparable reductions in the risk of vascular outcomes among patients with a broad range of vascular events at entry (relative risk reduction, 25%; P<0.0001 for ischemic stroke; 42%, P=0.0006 for hemorrhagic stroke; 17%, P=0.3 for coronary events; P homogeneity=0.4).</p> <p><b>Conclusions:</b> Patients with previous vascular events are at high risk of recurrences of the same event. However, because they are also at risk of other vascular outcomes, a broad range of secondary prevention strategies is necessary for their treatment. BP–lowering is likely to be one of the most effective and generalizable strategies across a variety of major vascular events including stroke and myocardial infarction.</p&gt

Electrical behavior of GaAs–AlAs heterostructures

We report an experimental study of the electrical behavior of GaAs–AlAs–GaAs heterostructures grown by metal–organic chemical vapor deposition. The structures consisted of a layer of AlAs several thousand angstroms thick sandwiched between layers of GaAs which were a few microns thick. The top layer of GaAs was doped degenerately n-type with Se, while the bottom layer was nondegenerately doped. Capacitance–voltage (C–V) and curent–voltage (I–V) curves were obtained as a function of temperature, illumination, and rate of data acquisition. Deep-level transient spectroscopy (DLTS) measurements were also made. The C–V showed hysteresis near zero bias with the capacitance being larger when the voltage was swept from reverse to forward bias in the dark. The C–V displayed a light sensitive peak near zero bias. With illumination, the capacitance was greater, and no hysteresis was observed. We explain these phenomena as being due to deep levels near the AlAs–GaAs interface; DLTS has confirmed this. I–V curves taken in darkness also showed hysteresis. We take this as further evidence of deep levels. Additionally, capacitance failed to level off in reverse bias, indicating a lack of inversion in the samples

Deep swarm: Nested particle swarm optimization

A new generation of particle swarm optimization (PSO) has been developed that automatically evolves optimal or near-optimal values for parameters of the PSO algorithm such as population size and neighborhood size, and, if used, parameters of associated neural network(s), such as number of hidden processing elements (PEs). Called Deep Swarm, it is a nested version of PSO, and comprises swarms within a swarm

Induction of tyrosinase by B-lactose in Neurospora crassa

Induction of tyrosinase by lactose in Neurospora crass