Preparing for retirement: the pension arrangements andretirement expectations of those approaching state pension age in England

This paper provides a detailed analysis of individuals inhouseholds in England aged between 50 and the State PensionAge in terms of their private pension arrangements and currentnon-pension assets alongside their expectations of futureeconomic circumstances. Our descriptive findings include thatmembers of defined benefit pensions have higher average levelsof current earnings than members of defined contributionpensions and that median expected private pension income inretirement is highest for current members of defined benefitschemes. We find that on average those who have, or have had,a private pension have greater non-pension wealth than thosewho have never had a private pension. In terms of expectationsof the future we find that it is those who have the fewest assetswho have the least attachment to the labour market and are farless likely to expect any inheritance. Hence we conclude thatinequalities in different dimensions of retirement resources tendto reinforce themselves as opposed to offset each other

State pensions and the well-being of the elderly in the UK

This paper presents the trends seen over the last quarter of the 20thCentury in various indicators of the well-being of the elderlyalongside those seen for the young. Specifically we look at measuresof both the level and distribution of income and expenditure, andself-reported measures of life satisfaction and health. We thenexploit the substantial reforms to the UK pension system over thisperiod to examine the impact of reforms to state pensions on theseoutcomes. We find that increases in the generosity of state pensionshave led to increased incomes of the elderly and reductions inmeasures of both relative and absolute income poverty. We also findthat increased state pensions have led to increased expenditure bythe elderly. It is perhaps not surprising that in the UK the reformsto the generosity of state pensions have affected outcomes amongthe elderly (instead of being fully offset by individuals when theywere younger) given that often very little (pre-retirement) notice wasgiven, and that some of the reforms were of a substantial magnitude. This paper presents the trends seen over the last quarter of the 20thCentury in various indicators of the well-being of the elderlyalongside those seen for the young. Specifically we look at measuresof both the level and distribution of income and expenditure, andself-reported measures of life satisfaction and health. We thenexploit the substantial reforms to the UK pension system over thisperiod to examine the impact of reforms to state pensions on theseoutcomes. We find that increases in the generosity of state pensionshave led to increased incomes of the elderly and reductions inmeasures of both relative and absolute income poverty. We also findthat increased state pensions have led to increased expenditure bythe elderly. It is perhaps not surprising that in the UK the reformsto the generosity of state pensions have affected outcomes amongthe elderly (instead of being fully offset by individuals when theywere younger) given that often very little (pre-retirement) notice wasgiven, and that some of the reforms were of a substantial magnitude

A study of the agonistic behaviour of the long-tailed field mouse (Apodemus sylvaticus) and the bank vole (Clethrionomys glareolus)

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Disease-Associated Mutations Disrupt Functionally Important Regions of Intrinsic Protein Disorder

The effects of disease mutations on protein structure and function have been extensively investigated, and many predictors of the functional impact of single amino acid substitutions are publicly available. The majority of these predictors are based on protein structure and evolutionary conservation, following the assumption that disease mutations predominantly affect folded and conserved protein regions. However, the prevalence of the intrinsically disordered proteins (IDPs) and regions (IDRs) in the human proteome together with their lack of fixed structure and low sequence conservation raise a question about the impact of disease mutations in IDRs. Here, we investigate annotated missense disease mutations and show that 21.7% of them are located within such intrinsically disordered regions. We further demonstrate that 20% of disease mutations in IDRs cause local disorder-to-order transitions, which represents a 1.7–2.7 fold increase compared to annotated polymorphisms and neutral evolutionary substitutions, respectively. Secondary structure predictions show elevated rates of transition from helices and strands into loops and vice versa in the disease mutations dataset. Disease disorder-to-order mutations also influence predicted molecular recognition features (MoRFs) more often than the control mutations. The repertoire of disorder-to-order transition mutations is limited, with five most frequent mutations (R→W, R→C, E→K, R→H, R→Q) collectively accounting for 44% of all deleterious disorder-to-order transitions. As a proof of concept, we performed accelerated molecular dynamics simulations on a deleterious disorder-to-order transition mutation of tumor protein p63 and, in agreement with our predictions, observed an increased α-helical propensity of the region harboring the mutation. Our findings highlight the importance of mutations in IDRs and refine the traditional structure-centric view of disease mutations. The results of this study offer a new perspective on the role of mutations in disease, with implications for improving predictors of the functional impact of missense mutations

Source-to-sink magnetic properties of NE Saharan dust in Eastern Mediterranean marine sediments: review and paleoenvironmental implications

We present a review of the magnetic properties of NE Saharan dust that was conducted, following a source-to-sink approach, to unravel the paleoclimatic significance of environmental magnetic records from Eastern Mediterranean marine sediments. Our synthesis indicates that pedogenic hematite, which formed during past wetter Green Sahara periods (GSPs), is the most common magnetic mineral in Eastern Mediterranean marine sediments as a result of its eolian transportation, along with smaller amounts of lithogenic hematite, from the NE Sahara. Coupled with the limited impact of reductive sedimentary diagenesis on hematite abundances in Eastern Mediterranean Sea sediments, this indicates that hematite concentrations provide reliable quantitative estimates of NE Saharan dust supply. Our results indicate that variations in NE Saharan dust supply record an on-off mechanism in which a key control on eolian input is provided by the monsoon-driven spread and retreat of savannah vegetation through the Sahara. Magnetite/maghemite is also a common magnetic mineral in NE Saharan dust, and also formed mainly pedogenically during GSPs but in much smaller amounts compared to hematite. Limited production of magnetite/maghemite in the source area during GSPs, along with the later imprint of diagenetic processes, indicates that magnetite/maghemite abundances cannot be used to estimate dust inputs from the NE Sahara. Goethite cannot be used either to estimate variations in NE Saharan dust supply, because its occurrence in Eastern Mediterranean marine sediments also appears to be linked to fluvial inputs. Our results reinforce the view that a source-to-sink approach should be routinely conducted in environmental magnetic studies to understand the complex combination of processes involved in the production, transportation, sedimentation, and diagenetic evolution of magnetic minerals in sedimentary environments. © 2015 Larrasoaña, Roberts, Liu, Lyons, Oldfield, Rohling and Heslop.A Rand D H gratefully acknowledge support from Australian Research Council grant DP110105419 , and ER acknowledges support from 2012 Australia Laureate Fellowship FL120100050.Peer reviewe

The efficacy of luminol in detecting bloodstains that have been washed with sodium percarbonate and exposed to environmental conditions

Blood evidence has a highly valuable role to play in crime investigation and crime reconstruction both in terms of DNA evidence and bloodstain pattern analysis (BPA). This paper presents the results of experiments that were designed to investigate the persistence and detectability of blood on clothing when exposed to different conditions and when washed in conjunction with sodium percarbonate (also known as active oxygen). Previous studies have demonstrated that the removal of traces of blood from denim and carpet is improved by the addition of sodium percarbonate, when compared with washing with detergent alone. In exploring this issue further, this study confirms that the efficacy of sodium percarbonate in removing bloodstains depends on the temperature of the wash cycle, the type of detergent used, drying time of blood and exposure of bloodstains to environmental conditions. The implications for the interpretation or blood evidence are considered, while the importance of continuing to develop an evidence base for the interpretation of blood evidence is emphasized

A cumulative risk model of child physical maltreatment potential: findings from a community-based study

"Published online before print November 20, 2015"Previous studies have identified the predictive risk factors of child physical maltreatment (CPM). However, a significant number of these studies assessed risk factors in isolation. The cumulative risk hypothesis postulates that health problems are caused by the accumulation of risk factors, independently of the presence or absence of specific risk indicators. Few studies examined the effect of cumulative risk on CPM potential. This study aimed to test two concurrent models of cumulative risk of CPM potential by investigating whether CPM potential was better predicted by a threshold cumulative risk model or a linear cumulative risk model. Data from the National Representative Study of Psychosocial Context of Child Abuse and Neglect in Portugal were used. Parents of school-age children (N = 796) answered to self-report measures regarding sociodemographic variables, history of child maltreatment, psychological distress, and CPM potential. A cumulative risk index was computed, comprising 10 dichotomized risk factors. Evidence for a threshold cumulative effect was found. Additional bivariate logistic regressions revealed that the odds for high-potential CPM were dramatically higher for those parents with six or more risk factors when compared with parents with any one risk factor. By testing and confirming a threshold cumulative effect on CPM potential, it was possible to find a "trigger point" from which a dramatic increase in child physical maltreatment potential occurs.This study was supported by the Portuguese Foundation of Science and Technology through a research grant to the second author (POCTI/PSI/14276/1998

PandA: Unsupervised Learning of Parts and Appearances in the Feature Maps of GANs

Recent advances in the understanding of Generative Adversarial Networks (GANs) have led to remarkable progress in visual editing and synthesis tasks, capitalizing on the rich semantics that are embedded in the latent spaces of pre-trained GANs. However, existing methods are often tailored to specific GAN architectures and are limited to either discovering global semantic directions that do not facilitate localized control, or require some form of supervision through manually provided regions or segmentation masks. In this light, we present an architecture-agnostic approach that jointly discovers factors representing spatial parts and their appearances in an entirely unsupervised fashion. These factors are obtained by applying a semi-nonnegative tensor factorization on the feature maps, which in turn enables context-aware local image editing with pixel-level control. In addition, we show that the discovered appearance factors correspond to saliency maps that localize concepts of interest, without using any labels. Experiments on a wide range of GAN architectures and datasets show that, in comparison to the state of the art, our method is far more efficient in terms of training time and, most importantly, provides much more accurate localized control