Management of pregnancy after augmentation cystoplasty.

We report a case of successful pregnancy following augmentation ileocystoplasty in a patient with a neurogenic bladder dysfunction. A review of the literature reveals incidences of premature delivery and renal dysfunction. Careful urological monitoring of such patients should result in a successful pregnancy. Nevertheless, the unique clinical challenges and management options published to date are limited

Dinâmica comparada da substituição das pastagens cultivadas e de sua densidade econômica no arco norte da pecuarização do Brasil.

Avalia comparativamente indicadores de substituição das pastagens cultivadas na Região Amazônica mais sujeitas à reconversão de áreas para pastos (Estados do Acre, Rondônia, Pará e Mato Grosso) com a evolução dos indicadores de sua respectiva densidade econômica, por tamanho de estabelecimento rural. A metodologia utilizada implica a utilização combinada de duas fronteiras, analisadas graficamente: a) uma fronteira da substituição de áreas (de pastagens cultivadas por outros usos do solo) e; b) uma segunda fronteira, que é a variação de relativos da densidade-valor da pecuária, em relação à Área Total Recenseada (ATR). Os resultados não se mostraram uniformes, havendo um ponto em comum para os Estados de Rondônia e Mato Grosso (curva da densidade-valor acima da curva de substituição para os estabelecimentos pequenos a médios), bem como para os Estados do Acre e do Pará, que revelaram uma tendência de a fronteira da densidade-valor se localizar sistematicamente abaixo da fronteira de substituição de áreas. Em termos gerais, pode-se afirmar que, para o espectro relevante da estrutura da produção da pecuária (grandes estabelecimentos), a fronteira da densidade-valor mostrou-se abaixo da fronteira da substituição de áreas. Levando-se em conta os resultados de levantamentos econômicos recentes levados a efeito por alguns autores, que mostram uma rentabilidade bastante favorável das atividades pecuárias na Região Amazônica, os resultados do presente trabalho parecem indicar que os movimentos alocativos mais que proporcionais da área das pastagens cultivadas em relação à densidade-valor, verificados até meados da década de 90 apresentam objetivos múltiplos, que vão além da produção pecuária em si mesma (abertura de áreas para consolidação da própria atividade pecuária, conversão para lavouras, consolidação de ativos patrimoniais, envolvendo a expulsão de populações nativas, etc

Agronomic Evaluation of Forage Grasses under Mature Rubber Plantation

The agronomic performance of seven forage grasses, under a mature rubber plantation, was assessed in a cutting trial carried out at Porto Velho, Rondônia. During the rainy season, the higher dry matter yields were obtained with B. brizantha, P. atratum BRA-9610 and B. humidicola. During the dry season, the grasses more productive were B. brizantha and P. atratum BRA-9610. In both seasons, magnesium and potassium contents did not vary among grasses. During the rainy season, the higher nitrogen and phosphorus contents were obtained with P. regnelli BRA-0159 and, P. guenoarum BRA-3824 and B. humidicola, respectively, while P. atratum BRA-9610 and B. humidicola provided higher contents of calcium. During the dry season, P. regnelli BRA-0159 showed the highest nitrogen content, while B. humidicola and B. brizantha gave the highest phosphorus and calcium contents. In order to obtain greater forage yields with better quality, the grasses more promising for pasture establishment in a silvipastoral systems were B. brizantha, B. humidicola and P. atratum BRA-9610

4EHP and GIGYF1/2 mediate translation-coupled messenger RNA decay

Current models of mRNA turnover indicate that cytoplasmic degradation is coupled with translation. However, our understanding of the molecular events that coordinate ribosome transit with the mRNA decay machinery is still limited. Here, we show that 4EHP-GIGYF1/2 complexes trigger co-translational mRNA decay. Human cells lacking these proteins accumulate mRNAs with prominent ribosome pausing. They include, among others, transcripts encoding secretory and membrane-bound proteins or tubulin subunits. In addition, 4EHP-GIGYF1/2 complexes fail to reduce mRNA levels in the absence of ribosome stalling or upon disruption of their interaction with the cap structure, DDX6, and ZNF598. We further find that co-translational binding of GIGYF1/2 to the mRNA marks transcripts with perturbed elongation to decay. Our studies reveal how a repressor complex linked to neurological disorders minimizes the protein output of a subset of mRNAs

Fontes de crescimento do setor agrícola no Estado do Pará: avaliação pelo método shift-share.

Trabalho editado também em CD-ROM

Structure of the TPR Domain of AIP: Lack of Client Protein Interaction with the C-Terminal alpha-7 Helix of the TPR Domain of AIP Is Sufficient for Pituitary Adenoma Predisposition

PMCID: PMC3534021This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited

A Novel Mutation in the Upstream Open Reading Frame of the CDKN1B Gene Causes a MEN4 Phenotype

PubMed ID: 23555276This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited

Cup Blocks the Precocious Activation of the Orb Autoregulatory Loop

Translational regulation of localized mRNAs is essential for patterning and axes determination in many organisms. In the Drosophila ovary, the germline-specific Orb protein mediates the translational activation of a variety of mRNAs localized in the oocyte. One of the Orb target mRNAs is orb itself, and this autoregulatory activity ensures that Orb proteins specifically accumulate in the developing oocyte. Orb is an RNA-binding protein and is a member of the cytoplasmic polyadenylation element binding (CPEB) protein family. We report here that Cup forms a complex in vivo with Orb. We also show that cup negatively regulates orb and is required to block the precocious activation of the orb positive autoregulatory loop. In cup mutant ovaries, high levels of Orb accumulate in the nurse cells, leading to what appears to be a failure in oocyte specification as a number of oocyte markers inappropriately accumulate in nurse cells. In addition, while orb mRNA is mislocalized and destabilized, a longer poly(A) tail is maintained than in wild type ovaries. Analysis of Orb phosphoisoforms reveals that loss of cup leads to the accumulation of hyperphosphorylated Orb, suggesting that an important function of cup in orb-dependent mRNA localization pathways is to impede Orb activation