Effect of solid propellant rocket exhaust impingement on spacecraft materials Final report, 18 Mar. 1966 - 21 Feb. 1969

Solid propellant rocket exhaust impingement effect on spacecraft material

Catalysts on Demand: Selective Oxidations by Laboratory-Evolved Cytochrome P450 BM3

Efficient catalysts for selective oxidation of C-H bonds using atmospheric oxygen are highly desirable to decrease the economic and environmental costs associated with conventional oxidation processes. We have used methods of directed evolution to generate variants of bacterial cytochrome P450 BM3 that catalyze hydroxylation and epoxidation of a wide range of nonnative substrates. This fatty acid hydroxylase was converted to a propane monooxygenase (PMO) capable of hydroxylating propane at rates comparable to that of BM3 on its natural substrates. Variants along the PMO evolutionary lineage showed broadened substrate scope; these became the starting points for evolution of a wide array of enzymes that can hydroxylate and derivatize organic scaffolds. This work demonstrates how a single member of enzyme family is readily converted by evolution into a whole family of catalysts for organic synthesis

Supersonic turbulent boundary-layer flows with mass injection through slots and/or porous walls

An implicit finite-difference method was used to solve the compressible boundary-layer equations, and to study the effects of mass transfer through porous plates, slots, and a combination of the two. The effects of the external pressure field were also included by using a global pressure interaction scheme. Two different eddy viscosity models were used for the slot and slot-porous combination cases: one was a two-layer model with inner and outer laws, and the other was a multi-layer model with as many as five separate layers. Results of the present method were compared with experimental data at a Mach number of 2.8. Comparisons of the skin friction reduction and Mach number profiles gave good to excellent agreement. Pressure interaction had little effect on the slot injection skin friction but increased the skin friction of the porous and slot-porous combination markedly

Computer user's guide for a chemically reacting viscous shock-layer program

A description is given of the computer code for predicting viscous shock-layer flows over nonanalytic blunt bodies (Program VISLNABB) for hypersonic, low Reynolds number flows. Four specific and one general body geometries are considered. In addition to sphere-cones, cylinder wedges and geometries defined in tabular form, options for hyperboloids and paraboloids are included. Details of the theory and results are included in a separate engineering report. The program, subroutines, variables in common, and input and output data are described. Listings of the program code, output data for a sample case, and the input data for this sample case are included

The influence of ship motion of manual control skills

The effects of ship motion on a range of typical manual control skills were examined on the Warren Spring ship motion simulator driven in heave, pitch, and roll by signals taken from the frigate HMS Avenger at 13 m/s (25 knots) into a force 4 wind. The motion produced a vertical r.m.s. acceleration of 0.024g, mostly between 0.1 and 0.3 Hz, with comparatively little pitch or roll. A task involving unsupported arm movements was seriously affected by the motion; a pursuit tracking task showed a reliable decrement although it was still performed reasonably well (pressure and free moving tracking controls were affected equally by the motion); a digit keying task requiring ballistic hand movements was unaffected. There was no evidence that these effects were caused by sea sickness. The differing response to motion of the different tasks, from virtual destruction to no effect, suggests that a major benefit could come from an attempt to design the man/control interface onboard ship around motion resistant tasks

Rearward-facing steps in laminar supersonic flows with and without suction

An experimental investigation of heat-transfer and pressure distributions within regions of laminar separated flows produced by two-dimensional rearward-facing steps has been carried out at freestream Mach numbers of around 4 in the range of step height-to-boundary layer thickness varying from 0.1 to 2.4. With no suction from the separated area, the ratio of the maximum post-step heat transfer to the attached-flow values was less than unity. The maximum heating-rate region was located far downstream of the reattachment plate stagnation point. Mass suction from the separated area increased the local heating rates, this effect was however relatively weak for purely laminar flow conditions and the competing effect of the step height clearly predominated. At step heights comparable with boundary-layer thickness, even removing the entire approaching boundary layer was not sufficient to raise the post-step heating rates above the flat-plate values

A multiphase model describing vascular tumour growth

In this paper we present a new model framework for studying vascular tumour growth, in which the blood vessel density is explicitly considered. Our continuum model comprises conservation of mass and momentum equations for the volume fractions of tumour cells, extracellular material and blood vessels. We include the physical mechanisms that we believe to be dominant, namely birth and death of tumour cells, supply and removal of extracellular fluid via the blood and lymph drainage vessels, angiogenesis and blood vessel occlusion. We suppose that the tumour cells move in order to relieve the increase in mechanical stress caused by their proliferation. We show how to reduce the model to a system of coupled partial differential equations for the volume fraction of tumour cells and blood vessels and the phase averaged velocity of the mixture. We consider possible parameter regimes of the resulting model. We solve the equations numerically in these cases, and discuss the resulting behaviour. The model is able to reproduce tumour structure that is found `in vivo' in certain cases. Our framework can be easily modified to incorporate the effect of other phases, or to include the effect of drugs

Hypersonic ionizing air viscous shock-layer flows over nonanalytic blunt bodies

The equations which govern the viscous shock-layer flow are presented and the method by which the equations are solved is discussed. The predictions of the present finite-difference method are compared with other numerical predictions as well as with experimental data. The principal emphasis is placed on predictions of the viscous flowfield for the windward plane of symmetry of the space shuttle orbiter and other axisymmetric bodies which approximate the shuttle orbiter geometry. Experimental data on two slender sphere-cones at hypersonic conditions are also considered. The present predictions agreed well with experimental data and with the past predictions. Substantial differences were found between present predictions and more approximate methods

Simultaneous muscle force and displacement transducer

A myocardial transducer for simultaneously measuring force and displacement within a very small area of myocardium is disclosed. The transducer comprised of an elongated body forked at one end to form an inverted Y shaped beam with each branch of the beam constituting a low compliant tine for penetrating the myocardium to a predetermined depth. Bonded to one of the low compliance tines is a small piezoresistive element for converting a force acting on the beam into an electrical signal. A third high compliant tine of the transducer, which measures displacement of the myocardium in a direction in line with the two low compliant tines, is of a length that just pierces the surface membrane. A small piezoresistive element is bonded to the third tine at its upper end where its bending is greatest. Displacement of the myocardium causes a deformation in curvature of the third tine, and the second small piezoresistive element bonded to the surface of its curved end converts its deformation into an electrical signal