9,504 research outputs found
Ultrasonic propagation in gases at high temperatures
Ultrasonic pulse method /1 to 3 MHz/ measures both sound speed and absorption in monatomic and polyatomic gases in a temperature range of 300 to 20000 degrees K at atmospheric pressure. Helium, nitrogen, oxygen, and argon are investigated
Interrater and intrarater reliability of arthroscopic measurements of articular cartilage defects in the knee
Ecological factors controlling biodiversity in the British countryside (ECOFACT). Module 6 - The causes of change in biodiversity. Interim report
The motivating operation and negatively reinforced problem behavior. A systematic review.
The concept of motivational operations exerts an increasing influence on the understanding and assessment of problem behavior in people with intellectual and developmental disability. In this systematic review of 59 methodologically robust studies of the influence of motivational operations in negative reinforcement paradigms in this population, we identify themes related to situational and biological variables that have implications for assessment, intervention, and further research. There is now good evidence that motivational operations of differing origins influence negatively reinforced problem behavior, and that these might be subject to manipulation to facilitate favorable outcomes. There is also good evidence that some biological variables warrant consideration in assessment procedures as they predispose the person's behavior to be influenced by specific motivational operations. The implications for assessment and intervention are made explicit with reference to variables that are open to manipulation or that require further research and conceptualization within causal models
Identity of acyl group conformations in the active sites of papain and cathepsin B by resonance Raman spectroscopy.
Resonance Raman spectroscopic data provide conclusive evidence for the existence of an acyl-enzyme intermediate during the reaction of a thionoester substrate, N-methyloxycarbonylphenylalanylglycine methyl thionoester (CH3OC(=O)-Phe-NHCH2C(=S) OCH3), with cathepsin B from porcine spleen. The resonance Raman spectrum of CH3OC(=O)-Phe-NHCH2C(=S)S-cathepsin B, where the thiol S is from the active-site cysteine residue, is compared to that of the corresponding papain acyl-enzyme. Within the limits of experimental error (+/-2 cm-1 for peak positions), there are no detectable spectral differences. Since the resonance Raman spectrum is sensitive to the torsional angles in the glycinic bonds and the cysteine linkages, the conformations are identical in those parts of the acyl-enzymes where chemical transformation occurs. A conformational analysis of the model compound CH3OC(=O)-Phe-NHCH2C(=S)SC2H5 demonstrates that the dithioacyl group in both dithioacyl-enzymes is present as a single population of a form known as conformer B. Conformer B is characterized by a small torsional angle about the glycinic NHCH2-CS(thiol) bond such that the nitrogen and S (thiol) atoms are in close contact. This conformer is widespread among the dithioacyl intermediates of plant cysteine proteinases, and it is apparent that the same chemistry is retained in a mammalian cysteine proteinase. Steady-state kinetic parameters are also reported for CH3OC(=O)-Phe-NHCH2C(=S)OCH3 reacting with papain and cathepsin B. The similarity of the Kcat values, 0.53 and 1.15 s-1, for papain and cathepsin B, respectively, provides further evidence for a conserved deacylation process
OGLE-2016-BLG-1190Lb: The First Spitzer Bulge Planet Lies Near the Planet/Brown-dwarf Boundary
We report the discovery of OGLE-2016-BLG-1190Lb, which is likely to be the first Spitzermicrolensing planet in the Galactic bulge/bar, an assignation that can be confirmed by two epochs of high-resolution imaging of the combined source–lens baseline object. The planet's mass, M_p = 13.4 ± 0.9 M_J , places it right at the deuterium-burning limit, i.e., the conventional boundary between "planets" and "brown dwarfs." Its existence raises the question of whether such objects are really "planets" (formed within the disks of their hosts) or "failed stars" (low-mass objects formed by gas fragmentation). This question may ultimately be addressed by comparing disk and bulge/bar planets, which is a goal of the Spitzer microlens program. The host is a G dwarf, M_(host) = 0.89 ± 0.07 M⊙, and the planet has a semimajor axis a ~ 2.0 au. We use Kepler K2 Campaign 9 microlensing data to break the lens-mass degeneracy that generically impacts parallax solutions from Earth–Spitzerobservations alone, which is the first successful application of this approach. The microlensing data, derived primarily from near-continuous, ultradense survey observations from OGLE, MOA, and three KMTNet telescopes, contain more orbital information than for any previous microlensing planet, but not quite enough to accurately specify the full orbit. However, these data do permit the first rigorous test of microlensing orbital-motion measurements, which are typically derived from data taken over <1% of an orbital period
The proposed Caroline ESA M3 mission to a Main Belt Comet
We describe Caroline, a mission proposal submitted to the European Space Agency in 2010 in response to the Cosmic Visions M3 call for medium-sized missions. Caroline would have travelled to a Main Belt Comet (MBC), characterizing the object during a flyby, and capturing dust from its tenuous coma for return to Earth. MBCs are suspected to be transition objects straddling the traditional boundary between volatile–poor rocky asteroids and volatile–rich comets. The weak cometary activity exhibited by these objects indicates the presence of water ice, and may represent the primary type of object that delivered water to the early Earth. The Caroline mission would have employed aerogel as a medium for the capture of dust grains, as successfully used by the NASA Stardust mission to Comet 81P/Wild 2. We describe the proposed mission design, primary elements of the spacecraft, and provide an overview of the science instruments and their measurement goals. Caroline was ultimately not selected by the European Space Agency during the M3 call; we briefly reflect on the pros and cons of the mission as proposed, and how current and future mission MBC mission proposals such as Castalia could best be approached
Gravity vs radiation model: on the importance of scale and heterogeneity in commuting flows
We test the recently introduced radiation model against the gravity model for
the system composed of England and Wales, both for commuting patterns and for
public transportation flows. The analysis is performed both at macroscopic
scales, i.e. at the national scale, and at microscopic scales, i.e. at the city
level. It is shown that the thermodynamic limit assumption for the original
radiation model significantly underestimates the commuting flows for large
cities. We then generalize the radiation model, introducing the correct
normalisation factor for finite systems. We show that even if the gravity model
has a better overall performance the parameter-free radiation model gives
competitive results, especially for large scales.Comment: in press Phys. Rev. E, 201
Proper Motions of Young Stellar Outflows in the Mid-infrared with Spitzer (IRAC). I. The NGC 1333 Region
We use two 4.5 μm Spitzer (IRAC) maps of the NGC 1333 region taken over a ~7 yr interval to determine proper motions of its associated outflows. This is a first successful attempt at obtaining proper motions of stellars' outflow from Spitzer observations. For the outflow formed by the Herbig-Haro objects HH7, 8, and 10, we find proper motions of ~9-13 km s–1, which are consistent with previously determined optical proper motions of these objects. We determine proper motions for a total of eight outflows, ranging from ~10 to 100 km s–1. The derived proper motions show that out of these eight outflows, three have tangential velocities ≤20 km s–1. This result shows that a large fraction of the observed outflows have low intrinsic velocities and that the low proper motions are not merely a projection effect
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