The variability of the solar output

A review of solar constant determinations and measurements of its spectral distribution is presented. For the period from 1966 to 1980 a mean value of 1367 Wm-2 was determined. Within the corresponding uncertainty, no significant change of both the integral value and the spectral distribution can be detected. However, short term solar variations and their spectral dependence were deduced from measurements during four hours on June 20, 1980 from 34 km altitude with amplitudes of + or - 500 ppm at 368 nm, of 200 ppm at 500 nm and + or - 150 ppm at 778 nm. Comparison with simultaneous total irradiance data of the Solar Maximum Mission (SMM) shows a high correlation which indicates the solar origin. The power spectrum shows a weak peak at about 3.2 mHz, which corresponds to the frequency of the 5 minutes solar oscillation

Proton-rich nucleosynthesis and nuclear physics

Although the detailed conditions for explosive nucleosynthesis are derived from astrophysical modeling, nuclear physics determines fundamental patterns in abundance yields, not only for equilibrium processes. Focussing on the nu p- and the gamma-process, general nucleosynthesis features within the range of astrophysical models, but (mostly) independent of details in the modelling, are presented. Remaining uncertainties due to uncertain Q-values and reaction rates are discussed

Reaction Rates and Nuclear Properties Relevant for Nucleosynthesis in Massive Stars and Far From Stability

Explosive nuclear burning in astrophysical environments produces unstable nuclei which again can be targets for subsequent reactions. In addition, it involves a large number of stable nuclides which are not fully explored by experiments, yet. Thus, it is necessary to be able to predict reaction cross sections and thermonuclear rates with the aid of theoretical models. Such predictions are also of interest for investigations at radioactive ion beam facilities. An extended library of theoretical cross sections and reaction rates is presented. The problem of alpha+nucleus potentials is addressed and new parametrizations presented. The problem of properly predicting cross sections at low level densities is illustrated by the 62Ni(n,gamma) reaction.Comment: 7 pages, invited talk, to appear in proceedings of CGS11 (Prague), World Scientific (new version: fixed typo in potential parameters; note: they will still be incorrect in the printed version

Non-linear terms in 2D cosmology

In this work we investigate the behavior of two-dimensional (2D) cosmological models, starting with the Jackiw-Teitelboim (JT) theory of gravitation. A geometrical term, non-linear in the scalar curvature $R$, is added to the JT dynamics to test if it could play the role of dark energy in a 2D expanding universe. This formulation makes possible, first, the description of an early (inflationary) 2D universe, when the van der Waals (vdW) equation of state is used to construct the energy-momentum tensor of the gravitational sources. Second, it is found that for later times the non-linear term in $R$ can generate an old 2D universe in accelerated expansion, where an ordinary matter dominated era evolves into a decelerated/accelerated transition, giving to the dark energy effects a geometrical origin. The results emerge through numerical analysis, following the evolution in time of the scale factor, its acceleration, and the energy densities of constituents.Comment: tex file plus figures in two zipped files. To appear in Europhys. Let

The Effects of Long-Term Varenicline Administration on Ethanol and Sucrose Seeking and Self-Administration in Male P Rats

Background Varenicline, a partial agonist at α4β2 and full agonist at α7 nicotinic cholinergic receptors, is FDA-approved for treatment of smoking cessation and has been found to reduce alcohol craving in clinical populations. In rodents, varenicline decreases free-choice ethanol (EtOH) intake with somewhat mixed findings in operant paradigms that utilize a combined appetitive/consummatory response. Methods The present experiment utilized an operant paradigm that procedurally separates appetitive from consummatory responding and a “reward-blocking” approach (i.e., rats were able to consume EtOH during treatment) to better understand the efficacy of varenicline as a treatment for EtOH self-administration and subsequent EtOH seeking. Separate groups of EtOH- and sucrose-reinforced alcohol-preferring, male P rats experienced alternating cycles of vehicle (2-week cycles) and varenicline (0.3, 1.0, and 2.0 mg/kg self-administered in a gelatin preparation) treatment (3-week cycles) prior to daily sessions where a single lever press resulted in 20 minutes of reinforcer access. At the end of each cycle, a single extinction session assessed the seeking response in the absence of drug pretreatment. Results Varenicline dose dependently decreased EtOH intake. Sucrose intake was largely unaffected, with no overall treatment effects and only sporadic days where the medium and high dose differed from vehicle. Neither sucrose nor EtOH seeking was significantly decreased by varenicline, and there were no treatment effects on either lick or lever-press latency. Overall effect sizes were much greater for both drinking and seeking in the EtOH group as compared to the sucrose group. Conclusions Varenicline effectively attenuates EtOH self-administration during treatment, but the experience with EtOH consumption while varenicline is “on board” is not sufficient to alter subsequent EtOH seeking. The overall pattern of findings indicates that varenicline blocks the rewarding properties of EtOH while not substituting for EtOH, that the nonspecific effects on an alternate reinforcer are negligible, and that blood levels of varenicline need to be maintained in order for treatment to remain effective

Preparation of Isolated Blood Capillaries

Blood capillaries have been isolated from various tissue sources yielding suspensions of capillary segments. These have provided opportunities to study the cellular properties of capillary endothelium under conditions uncomplicated by the presence of stromal tissues and in which measured parameters can be attributed to endothelial cells. Fresh capillary isolates have been used directly as experimental systems but the yield of endothelium is quite low. Amplification of endothelial biomass has been accomplished by using freshly isolated capillaries as explants for primary tissue culture. It has not been previously possible, however, to obtain large amounts of capillary endothelium from a single preparation nor have different capillary types been isolated from the same tissue. The rete mirabile of the eel swim bladder is a copious source of capillaries of two types: thick-walled, continuous capillaries heavily invested with pericytes and thin-walled, fenestrated capillaries. These can be isolated in large numbers free of large blood vessels and contaminating stromal tissue. The two types of capillaries can be isolated from each other by perfusing magnetic beads into one type prior to isolation and separating them from the other type in a magnetic field. This provides a system in which the cellular properties of the two types of endothelium can be studied in vitro and, due to a common isolation procedure, direct comparisons can be made

Cryo-EM studies of Drp1 reveal cardiolipin interactions that activate the helical oligomer

Dynamins are mechano-chemical GTPases involved in the remodeling of cellular membranes. In this study, we have investigated the mechanism of dynamin-related protein 1 (Drp1), a key mediator of mitochondrial fission. To date, it is unclear how Drp1 assembles on the mitochondrial outer membrane in response to different lipid signals to induce membrane fission. Here, we present cryo-EM structures of Drp1 helices on nanotubes with distinct lipid compositions to mimic membrane interactions with the fission machinery. These Drp1 polymers assemble exclusively through stalk and G-domain dimerizations, which generates an expanded helical symmetry when compared to other dynamins. Interestingly, we found the characteristic gap between Drp1 and the lipid bilayer was lost when the mitochondrial specific lipid cardiolipin was present, as Drp1 directly interacted with the membrane. Moreover, this interaction leads to a change in the helical structure, which alters G-domain interactions to enhance GTPase activity. These results demonstrate how lipid cues at the mitochondrial outer membrane (MOM) can alter Drp1 structure to activate the fission machinery