Hydrogeological study of the monti sibillini north-western sector: a contribution to the official hydrogeologic mapping

This work underlines the importance of experimental data and integrates the hydrogeological mapping methods. The work has analyzed the lithological features of the outcropping rocks and their attitude to be crossed by the meteoric waters. Geologic-structural analysis has allowed to identify elements that can constitute the hydraulic barriers and the hydrogeological complexes that can contain the aquifers. A detailed analysis of base flow was carried out through hydrogeological survey directly performed in the river. The hydrogeological survey has allowed us: 1) to appraise the river's base flow; 2) to identify the punctual and linear springs; 3) to quantify the water resource on average drained; and 4) to determine the discharge regime of springs and rivers. The Conceptual Hydrogeological Model for each individual aquifer have been derived from geologic-structural analysis and hydrogeological studies. The Conceptual Hydrogeological Models allowed us to calculate the Mean Effective Infiltration (Ieff) of every aquifer. The values of Ieff are gathered in classes. All merged information has been used in the preparation of Hydrogeological Complexes and Natural Springs Map. The manifold hydrogeological information cannot be represented in one document only; so the Experimental Hydrogeological Mapping has been prepared as the overlap of different informative levels: Hydrogeological Complexes and Natural Springs Map (principal document), Surface Hydrology Map and Conceptual Hydrogeological Models of several recognized aquifers (complementary elements)

Pulses for healthy and sustainable food systems: The effect of origin on market price

Pulses are widely acknowledged for their high nutritional value due to high protein content, low content in calories, and low glycemic index; they are a good alternative to animal proteins thus offering a considerable number of social, environmental, and health benefits. Despite pulses being widely acknowledged as healthy and sustainable food, in mainly European countries, consumption is growing but still lower than the recommended level, production is unprofitable in comparison to the current market prices level, and a reduction in harvested area has led to a strong dependence on import for pulses supply. Pulses are particularly fitting to the feature of local food because they can be suitably grown in any context, even in the most complex areas, and consumer interest and awareness of food origin has strongly increased in recent years. Lentils were selected as a case study in this paper that aims to define which features are effective on market price and, in particular, the role of origin declaration on label plays in defining the market price and how the origin attributes may enhance market price and farms competitiveness. The methodological tool for this investigation is the hedonic price model, useful to explain the effects of attributes of pulses affecting the market price. Results contribute to a better understanding of the pulse market, emphasizing that the “origin declaration” on label may have a positive effect on market price

Characterisation of hydraulic head changes and aquifer properties in the London Basin using Persistent Scatterer Interferometry ground motion data

In this paper, Persistent Scatterer Interferometry was applied to ERS-1/2 and ENVISAT satellite data covering 1992–2000 and 2002–2010 respectively, to analyse the relationship between ground motion and hydraulic head changes in the London Basin, United Kingdom. The integration of observed groundwater levels provided by the Environment Agency and satellite-derived displacement time series allowed the estimation of the spatio-temporal variations of the Chalk aquifer storage coefficient and compressibility over an area of ∼1360 km2. The average storage coefficient of the aquifer reaches values of 1 × 10−3 and the estimated average aquifer compressibility is 7.7 × 10−10 Pa−1 and 1.2 × 10−9 Pa−1 for the periods 1992–2000 and 2002–2010, respectively. Derived storage coefficient values appear to be correlated with the hydrogeological setting, where confined by the London Clay the storage coefficient is typically an order of magnitude lower than where the chalk is overlain by the Lambeth Group. PSI-derived storage coefficient estimates agree with the values obtained from pumping tests in the same area. A simplified one-dimensional model is applied to simulate the ground motion response to hydraulic heads changes at nine piezometers. The comparison between simulated and satellite-observed ground motion changes reveals good agreement, with errors ranging between 1.4 and 6.9 mm, and being 3.2 mm on average

Magnetic resonance guided focused ultrasound surgery (MRgFUS) of bone metastases: from primary pain palliation to local tumor control

Purpose: To evaluate the clinical performance of MRgFUS in primary pain palliation of painful bone metastases and in local tumor control. Materials and Methods: We enrolled 26 consecutive patients (female/male 12/14; age: 64.7±7.5yrs) with painful bone metastases. Before and 3 months after MRgFUS treatment pain severity and pain interference scores were assessed according to Brief Pain Inventory-Quality of Life (BPI-QoL) criteria and patients underwent both CT and MRI. Local tumor control was evaluated according to lesion size, density and perfusion at CT, dynamic contrast enhancement at MRI (Discovery 750HD, GE; Gd-Bopta, Bracco) and metabolic activity at PET or scintigraphy. Patients were classified as responders or non-responders. Results: No treatment-related adverse events were recorded during the study. As statistically significant difference between baseline and follow-up values for both pain severity and pain interference scores was observed (p<0.05). Increased bone density was observed in 9/26 (34.6%) patients. Non-Perfused Volume values ranged between 20% and 92%. There was no difference in NPV values between responders and non-responders (46.7±24.2% [25 - 90 %] vs. 45±24.9% [20 - 93 %]; p=0.7). In 6 patients (5 prostate and 1 breast primary cancer) there was nearly absence of metabolic activity after treatment (mean SUV=1.2). Conclusion: MRgFUS can be safely and effectively used as the primary treatment for pain palliation in patients with painful bone metastases; moreover our experience demonstrated also a potential role for the MRgFUS in local tumor control

A proposal for compiling quantitative hydrogeological maps

An innovative approach to hydrogeological mapping based on quantitative analysis is shown in this paper. It gives some cartographical solutions for an immediate evaluation of the groundwater resources and their spatial distribution. All relevant aquifers, springs and their regime, geological and structural setting and their hydraulic role should be shown in several understandable and clear hydrogeological maps where all hydrogeological information is reported in detail in the “Hydrogeological experimental Map” composed by a. “Hydrogeological Complexes and Natural Springs Map”, b. “Surface Hydrology Map”, c. “Conceptual Hydrogeological Model” and d. “Hydrogeological sections”. The cartographical solutions adopted for representing all these documents are proposed in this paper. Some graphical solutions have been proposed for improving the Italian official guidelines of hydrogeological mapping at scale 1:50.000, explain the legends symbols and illustrate the structure of a hydrogeological GIS database. An application of this approach has been carried out in north-western sector of Sibillini Mts. (Marche, Italy)

Taeniid cestodes in a wolf pack living in a highly anthropic hilly agro-ecosystem

The Italian wolf population in human-modified landscapes has increased greatly in the last few decades. Anthropisation increases the risk of transmission of many zoonotic infections and in this context, control of taeniid cestode species needs to be addressed from a One Health perspective. Predator-prey interactions are at the root of taeniid cestode transmission, and the wolf plays a key role in the maintenance and transmission of taeniids. To date, all available data on the taeniids of wolves in Italy refer to populations living in a wild habitat. Between 2018 and 2019, we investigated taeniids in a wolf pack living in a highly anthropic hilly agro-ecosystem. Thirty-eight faecal samples were collected and analysed, 4 of which were also genetically characterised for individual wolves and belonged to three different animals. Samples collected were analysed microscopically and by molecular analysis in order to identify the taeniid species. Taeniid eggs were detected in 34.2% (13/38) of samples. Within samples positive to taeniid eggs only Echinococcus granulosus s.s. and Taenia hydatigena were identified in 26.3% and 10.5% of the samples, respectively. On microscopic examination, Capillaria spp., Ancylostomatidae and Toxocara canis eggs, Crenosoma vulpis larvae, and coccidian oocysts were also found. The combination of low biodiversity of taeniid species with a high occurrence of E. granulosus s.s. recorded in this study could be the consequence of a deeper link occurring between wolves and livestock in human-modified landscapes than in wild settings

The sensitivity of a specific denitrification rate under the dissolved oxygen pressure

The biological denitrification process is extensively discussed in scientific literature. The process requires anoxic conditions, but the influence of residual dissolved oxygen (DO) on the efficiency is not yet adequately documented. The present research aims to fill this gap by highlighting the effects of DO on the specific denitrification rate (SDNR) and consequently on the efficiency of the process. SDNR at a temperature of 20◦C (SDNR20◦C) is the parameter normally used for the sizing of the denitrification reactor in biological-activated sludge processes. A sensitivity analysis of SNDR20◦C to DO variations is developed. For this purpose, two of the main empirical models illustrated in the scientific literature are taken into consideration, with the addition of a deterministic third model proposed by the authors and validated by recent experimentations on several full-scale plants. In the first two models, SDNR20◦C is expressed as a function of the only variable food:microrganism ratio in denitrification (F:MDEN), while in the third one, the dependence on DO is made explicit. The sensitivity analysis highlights all the significant dependence of SDNR20◦C on DO characterized by a logarithmic decrease with a very pronounced gradient in correspondence with low DO concentrations. Moreover, the analysis demonstrates the relatively small influence of F:MDEN on the SDNR20◦C and on the correlation between SDNR20◦C and DO. The results confirm the great importance of minimizing DO and limiting, as much as possible, the transport of oxygen in the denitrification reactor through the incoming flows and mainly the mixed liquor recycle. Solutions to achieve this result in full-scale plants are reported

Primary tumor sidedness and benefit from FOLFOXIRI plus bevacizumab as initial therapy for metastatic colorectal cancer. Retrospective analysis of the TRIBE trial by GONO

Right-sided metastatic colorectal cancer (mCRC) patients have poor prognosis and achieve limited benefit from first-line doublets plus a targeted agent. In this unplanned analysis of the TRIBE study, we investigated the prognostic and predictive impact of primary tumor sidedness in mCRC patients and the differential impact of the intensification of the chemotherapy in subgroups defined according to both primary tumor sidedness and RAS and BRAF mutational status

Skyrmion Lattice in a Chiral Magnet

Skyrmions represent topologically stable field configurations with particle-like properties. We used neutron scattering to observe the spontaneous formation of a two-dimensional lattice of skyrmion lines, a type of magnetic vortices, in the chiral itinerant-electron magnet MnSi. The skyrmion lattice stabilizes at the border between paramagnetism and long-range helimagnetic order perpendicular to a small applied magnetic field regardless of the direction of the magnetic field relative to the atomic lattice. Our study experimentally establishes magnetic materials lacking inversion symmetry as an arena for new forms of crystalline order composed of topologically stable spin states