Epigenetic mechanisms in oral cancer: new diagnostic and therapeutic strategies

Complexity and heterogeneity are frequently present during the development and progression of carcinogenesis and, in the last 15 years, significant progress made in clinical research underlines the role of some epigenetic mechanisms. The most important characteristics of the epigenetic concept are that these events are reversible, not related to modifications in the structure of DNA and may drive fundamental cell signaling alterations1. Among these systems of communication in normal and pathological conditions, also microbiome and staminal cells2 seem to be important. These new profiles of pathological communication develop novel diagnostic, prognostic and therapeutic tool

CORRELATION BETWEEN CHRONIC MUCOSAL TRAUMA AND ORAL CANCER: A CASE REPORT AND REVIEW OF THE LITERATURE

Abstract – Objective: Squamous cell carcinoma is the most common malignancy in the oral cavity representing the 90% of all oral malignancies that affect oral cavity. Primary risk factors associated with oral cancer are alcohol and tobacco consumption. However, other emerging risk factors have been proposed in Literature, including chronic trauma of the oral mucosa related to dental prostheses and incongruous restorations. Therefore, the aim of this study was to review the literature on the correlation between oral carcinoma and chronic irritative trauma, with the help of a case report and with focus on clinical features and differential diagnosis. Materials and Methods: A literature search on MEDLINE, PubMed, ScienceDirect, Cochrane Database of Systematic Reviews and Wiley InterScience was performed, using the following words: Oral Cancer, chronic Trauma and Denture Trauma in various combinations. Results: The review produced 1356 results, but only 8 articles met the inclusion criteria and were involved in the review. No association has been proven between chronic mucosal trauma and oral cancer. Carcinoma has been shown to develop more frequently in trauma regions, particularly in the tongue. As for the data on the gender and age of affected patients, it emerges that most of the greatest incidence occurs around the sixth and seventh decade of life and men are more affected than women. Conclusions: Due to the heterogeneity of the different studies and the strong presence of other factors such as smoking and alcohol, the role of trauma in carcinogenesis is unclear. Further molecular, epidemiological and case-control studies are needed to define this correlation. It is advisable to carry out more restricted checks in patients at risk with dental prostheses

Integration, productivity and technological spillovers: Evidence for eurozone banking industries

In the context of the current debate on increased integration of eurozone banking markets following the global financial and sovereign debt crises, this paper evaluates the impact of regulatory reform, starting from the inception of the Single Market in 1992, on bank productivity and assesses the cross-border benefits of integration in terms of technological spillovers. We utilise a parametric meta-frontier Divisia index to estimate productivity change and identify technological gaps. We then assess the extent to which productivity converges within and across banking industries as a result of technological spillovers. Our results suggest that productivity growth has occurred for eurozone countries, driven by technological progress, both at the country and the supra-country level, although the latter slows or in some cases reverses since the onset of the crisis. Technological spillovers do exist, and have led to progression toward the best technology. However, convergence is not complete and significant long run differences in productivity persist. Improvements in technology are increasingly concentrated in fewer banking industries

Octet Magnetic Moments with Null Instantons and Semibosonized Nambu-Jona-Lasinio Model

It is shown that the difference between the magnetic moment results in the quark model with null instantons and semibosonized Nambu-Jona-Lasinio model lies in the description of the magnetic moment of the $\Lambda$-hyperon.Comment: RevTex, 6 pages, submitted to Progr.Theor.Phy

Whitening with 980 nm diode laser in a dyschromic devitalized tooth with aesthetic value: long-term success

In our society, the progress of aesthetic standards has led to increasing demands from patients to have white and healthy teeth as an index of beauty and health. The main advantages of the laser bleaching technique include greater safety and control, as well as the prevention of tissue damage, the reduction of application times and greater patient satisfaction. Numerous studies in the literature underline that bleaching with diode laser is a safe. The purpose of this in vivo study was to assess the whitening effect of the 980 nm diode laser in combination with the whitening gel, containing hydrogen peroxide, in the discoloration treatment of a dental element undergone to endodontic therap

Hand arm vibration generated by a rotary pick-up for table olives harvesting

The manual harvest of olives is one of the most expensive operations in the table olives production, but the use of the electric hand-guided machines triples the productivity.  The development of these new machines leads to changes in the harvesting methodologies and in the operator’s working behavior.  These items may also affect the hand-arm vibration (HAV) transmitted to the operators during the work.  Aim of this study is to evaluate the hand-arm vibration transmitted to the operator using an experimental electric labor saving machine with rotary combs with teeth of different dimensions covered by silicon to minimize the damage to the drupes.  Moreover, the olives removal forces have been analyzed to understand if the force necessary to detach the drupes is correlated to the vibration levels transmitted to the operator’s hand arm.  With this type of hand held olive harvester, it has been found that higher is the fruit removal force, higher are the measured vibration levels.   Keywords: HAV, portable olive shakers, rotary pick-up, table olive

Oral microbiota, health, and cancer: the dual face of the same coin in the field of the host-microbe interactome

In recent years, within the extensive research regarding human microbiota and chronic diseases, new medical and laboratory technologies have played a crucial role in understanding more complex biological pathways between human cells and microbes. On the other hand, molecular and cellular diversity and their involvement in health responses to changing host conditions have only recently been understood, through the development of brand-new laboratory tools based on ‘omics approaches. The continuous insertion of already conceptualized, new experimental large datasets and raw data onto bibliographic platforms means that they are now accessible for subsequent elaboration by other researchers. This aspect has allowed the creation of an interactive mesh of proteins, genes, and small molecules, usually called, interactome or interactomics

Formation mechanisms and phase stability of solid-state grown cspbi3 perovskites

CsPbI3 inorganic perovskite is synthesized by a solvent-free, solid-state reaction, and its structural and optical properties can be deeply investigated using a multi-technique approach. X-ray Diffraction (XRD) and Raman measurements, optical absorption, steady-time and time-resolved luminescence, as well as High-Resolution Transmission Electron Microscopy (HRTEM) imaging, were exploited to understand phase evolution as a function of synthesis time length. Nanoparticles with multiple, well-defined crystalline domains of different crystalline phases were observed, usually surrounded by a thin, amorphous/out-of-axis shell. By increasing the synthesis time length, in addition to the pure α phase, which was rapidly converted into the δ phase at room temperature, a secondary phase, Cs4PbI6, was observed, together with the 715 nm-emitting γ phase

Synchrotron radiation photoionization mass spectrometry of laser ablated species

The present paper describes an experimental apparatus suitable to create and study free clusters by combining laser ablation and synchrotron radiation. First tests on sulfur samples, S, showed the production, through laser ablation, of neutral Sn clusters (n = 1–8). These clusters were ionized using synchrotron radiation at photon energies from 160 eV to 175 eV, across the S 2p core edge. The feasibility of such combined ablation–synchrotron radiation experiments is demonstrated, opening new possibilities on the investigation of free clusters and radical

Baryon Magnetic Moments and Proton Spin: A Model with Collective Quark Rotation

We analyse the baryon magnetic moments in a model that relates them to the parton spins $\Delta u$, $\Delta d$, $\Delta s$, and includes a contribution from orbital angular momentum. The specific assumption is the existence of a 3-quark correlation (such as a flux string) that rotates with angular momentum $\langle L_z \rangle$ around the proton spin axis. A fit to the baryon magnetic moments, constrained by the measured values of the axial vector coupling constants $a^{(3)}=F+D$, $a^{(8)}=3F-D$, yields $\langle S_z \rangle = 0.08 \pm 0.13$, $\langle L_z \rangle = 0.39 \pm 0.09$, where the error is a theoretical estimate. A second fit, under slightly different assumptions, gives $\langle L_z \rangle = 0.37 \pm 0.09$, with no constraint on $\langle S_z \rangle$. The model provides a consistent description of axial vector couplings, magnetic moments and the quark polarization $\langle S_z \rangle$ measured in deep inelastic scattering. The fits suggest that a significant part of the angular momentum of the proton may reside in a collective rotation of the constituent quarks.Comment: 16 pages, 3 ps-figures, uses RevTeX. Abstract, Sec. II, III and IV have been expande