Clinical Applications of Prostaglandins in Dogs and Cats

In the biological sciences today there are few substances that generate as much interest as prostaglandins. They have found widespread use in veterinary medicine, yet are only approved by the FDA for specific uses in cattle and horses. However, practical applications in the dog and cat have been reported by clinicians and have been evaluated in clinical research projects

The fate of sediment, wood and organic carbon eroded during an extreme flood, Colorado Front Range, USA

Identifying and quantifying the dominant processes of erosion and tracking the fate of sediment, wood, and carbon eroded during floods is important for understanding channel response to floods, downstream sediment and carbon loading, and the influence of extreme events on landscapes and the terrestrial carbon cycle. We quantify sediment, wood, and organic carbon (OC) from source to local sink following an extreme flood in the tectonically quiescent, semi-arid Colorado (USA) Front Range. Erosion of >500,000 m3 or as much as ~115 yr of weathering products occurred through landsliding and channel erosion during September 2013 flooding. More than half of the eroded sediment was deposited at the inlet and delta of a water supply reservoir, resulting in the equivalent of 100 yr of reservoir sedimentation and 2% loss in water storage capacity. The flood discharged 28 Mg C/km2, producing an event OC flux equivalent to humid, tectonically active areas. Post-flood remobilization resulted in a further ~100 yr of reservoir sedimentation plus export of an additional 1.3 Mg C/km2 of wood, demonstrating the ongoing impact of the flood on reservoir capacity and carbon cycling. Pronounced channel widening during the flood created accommodation space for 40% of flood sediment and storage of wood and eroded carbon. We conclude that confined channels, normally dismissed as transport reaches, can store and export substantial amounts of flood constituents

THE STUDY OF RELATEDNESS AND GENETIC DIVERSITY IN CRANES

The U.S. Fish and Wildlife Service (Service) is responsible for recovery of endangered species in the wild and, when necessary, maintenance in captivity. These programs provide an immediate measure of insurance against extinction. A prerequisite inherent in all of these programs is the preservation of enough genetic diversity to maintain a viable population and to maintain the capacity of the population to respond to change. Measures of genetic diversity examine polymorphic genes that are not influenced by selection pressures. Examples of these techniques and those used to determine relatedness are discussed. Studies of genetic diversity, electrophoresis of blood proteins, relatedness, blood typing, and restriction fragment length polymorphisms which are being used by the Patuxent Wildlife Research Center are discussed in detail

Stably accessing octave-spanning microresonator frequency combs in the soliton regime

Microresonator frequency combs can be an enabling technology for optical frequency synthesis and timekeeping in low size, weight, and power architectures. Such systems require comb operation in low-noise, phase-coherent states such as solitons, with broad spectral bandwidths (e.g., octave-spanning) for self-referencing to detect the carrier-envelope offset frequency. However, stably accessing such states is complicated by thermo-optic dispersion. For example, in the Si3N4 platform, precisely dispersion-engineered structures can support broadband operation, but microsecond thermal time constants have necessitated fast pump power or frequency control to stabilize the solitons. In contrast, here we consider how broadband soliton states can be accessed with simple pump laser frequency tuning, at a rate much slower than the thermal dynamics. We demonstrate octave-spanning soliton frequency combs in Si3N4 microresonators, including the generation of a multi-soliton state with a pump power near 40 mW and a single-soliton state with a pump power near 120 mW. We also develop a simplified two-step analysis to explain how these states are accessed in a thermally stable way without fast control of the pump laser, and outline the required thermal properties for such operation. Our model agrees with experimental results as well as numerical simulations based on a Lugiato-Lefever equation that incorporates thermo-optic dispersion. Moreover, it also explains an experimental observation that a member of an adjacent mode family on the red-detuned side of the pump mode can mitigate the thermal requirements for accessing soliton states

A Kerr-microresonator optical clockwork

Kerr microresonators generate interesting and useful fundamental states of electromagnetic radiation through nonlinear interactions of continuous-wave (CW) laser light. Using photonic-integration techniques, functional devices with low noise, small size, low-power consumption, scalable fabrication, and heterogeneous combinations of photonics and electronics can be realized. Kerr solitons, which stably circulate in a Kerr microresonator, have emerged as a source of coherent, ultrafast pulse trains and ultra-broadband optical-frequency combs. Using the f-2f technique, Kerr combs support carrier-envelope-offset phase stabilization for optical synthesis and metrology. In this paper, we introduce a Kerr-microresonator optical clockwork based on optical-frequency division (OFD), which is a powerful technique to transfer the fractional-frequency stability of an optical clock to a lower frequency electronic clock signal. The clockwork presented here is based on a silicon-nitride (Si$_3$N$_4$) microresonator that supports an optical-frequency comb composed of soliton pulses at 1 THz repetition rate. By electro-optic phase modulation of the entire Si$_3$N$_4$ comb, we arbitrarily generate additional CW modes between the Si$_3$N$_4$ comb modes; operationally, this reduces the pulse train repetition frequency and can be used to implement OFD to the microwave domain. Our experiments characterize the residual frequency noise of this Kerr-microresonator clockwork to one part in $10^{17}$, which opens the possibility of using Kerr combs with high performance optical clocks. In addition, the photonic integration and 1 THz resolution of the Si$_3$N$_4$ frequency comb makes it appealing for broadband, low-resolution liquid-phase absorption spectroscopy, which we demonstrate with near infrared measurements of water, lipids, and organic solvents

Tailoring microcombs with inverse-designed, meta-dispersion microresonators

Nonlinear-wave mixing in optical microresonators offers new perspectives to generate compact optical-frequency microcombs, which enable an ever-growing number of applications. Microcombs exhibit a spectral profile that is primarily determined by their microresonator's dispersion; an example is the $\operatorname{sech}^2$ spectrum of dissipative Kerr solitons under anomalous group-velocity dispersion. Here, we introduce an inverse-design approach to spectrally shape microcombs, by optimizing an arbitrary meta-dispersion in a resonator. By incorporating the system's governing equation into a genetic algorithm, we are able to efficiently identify a dispersion profile that produces a microcomb closely matching a user-defined target spectrum, such as spectrally-flat combs or near-Gaussian pulses. We show a concrete implementation of these intricate optimized dispersion profiles, using selective bidirectional-mode hybridization in photonic-crystal resonators. Moreover, we fabricate and explore several microcomb generators with such flexible `meta' dispersion control. Their dispersion is not only controlled by the waveguide composing the resonator, but also by a corrugation inside the resonator, which geometrically controls the spectral distribution of the bidirectional coupling in the resonator. This approach provides programmable mode-by-mode frequency splitting and thus greatly increases the design space for controlling the nonlinear dynamics of optical states such as Kerr solitons.Comment: 16 pages, includes S