Tidal controls on the lithospheric thickness and topography of Io from magmatic segregation and volcanism modelling

Tidal heating is expected to impart significant, non-spherically-symmetric structure to Jupiter's volcanic moon Io. A signature of spatially variable tidal heating is generally sought in observations of surface heat fluxes or volcanic activity, an exploration complicated by the transient nature of volcanic events. The thickness of the lithosphere is expected to change over much longer timescales, and so may provide a robust link between surface observations and the tidal heating distribution. To predict long-wavelength lithospheric thickness variations, we couple three-dimensional tidal heating calculations to a suite of one-dimensional models of magmatic segregation and volcanic eruption. We find that the lithospheric thickness could either be correlated with the radially integrated heating rate, or weakly anti-correlated. Lithospheric thickness is correlated with radially integrated heating rate if magmatic intrusions form at a constant rate in the lithosphere, but is weakly anti-correlated if intrusions form at a rate proportional to the flux through volcanic conduits. Utilising a simple isostasy model we show how variations in lithospheric thickness can predict long-wavelength topography. The relationship between lithospheric thickness and topography depends on the difference in chemical density between the lithosphere and mantle. Assuming that this difference is small, we find that long-wavelength topography anti-correlates with lithospheric thickness. These results will allow future observations to critically evaluate models for Io's lithospheric structure, and enable their use in constraining the distribution of tidal heating.Comment: Published in Icaru

An investigation of dendritic delay in octopus cells of the mammalian cochlear nucleus

Octopus cells, located in the mammalian auditory brainstem, receive their excitatory synaptic input exclusively from auditory nerve fibers (ANFs). They respond with accurately timed spikes but are broadly tuned for sound frequency. Since the representation of information in the auditory nerve is well understood, it is possible to pose a number of questions about the relationship between the intrinsic electrophysiology, dendritic morphology, synaptic connectivity, and the ultimate functional role of octopus cells in the brainstem. This study employed a multi-compartmental Hodgkin-Huxley model to determine whether dendritic delay in octopus cells improves synaptic input coincidence detection in octopus cells by compensating for the cochlear traveling wave delay. The propagation time of post-synaptic potentials from synapse to soma was investigated. We found that the total dendritic delay was approximately 0.275 ms. It was observed that low-threshold potassium channels in the dendrites reduce the amplitude dependence of the dendritic delay of post-synaptic potentials. As our hypothesis predicted, the model was most sensitive to acoustic onset events, such as the glottal pulses in speech when the synaptic inputs were arranged such that the model's dendritic delay compensated for the cochlear traveling wave delay across the ANFs. The range of sound frequency input from ANFs was also investigated. The results suggested that input to octopus cells is dominated by high frequency ANFs

Antibiotic additives alter the static and viscoelastic properties of bone cements

Introduction: In arthroplasty antibiotics are added to bone cements to prevent deep infection. The static properties of plain and antibiotic laden cements have been extensively described in the literature [1]. Commercially available cements must perform above the minimum values set by ISO 5833:2002 [2]. However, no upper or lower limits are set for the viscoelastic properties of the cements, despite this being a recognised factor affecting the cement-implant performance [3]. The ability of acrylic bone cement to creep and stress relax in conjunction with forceclosed stems in hip arthroplasty affords protection of the vital bone-cement interface. With this design subsidence of the stem within the cement mantle over time does not lead to clinical failure [4]. Conversely, the clinical performance of shapeclosed stem designs can be negatively affected by cements demonstrating excessive creep. This study investigated the effect of antibiotic additives on the static and viscoelastic properties of PMMA cement. Materials and Methods: The mechanical and viscoelastic properties of Simplex P, Simplex Antibiotic and Simplex Tobramycin (Stryker, Limerick, IE) were investigated. This family of cements was chosen as they are characterised by the same polymeric base, that of Simplex P, the plain formulation, but contain different antibiotic additives. In particular Simplex Antibiotic contains 0.5g Erythromycin and 3 million I.U. Colistin, while in Simplex Tobramycin the only additive is 0.5g of Tobramycin. The static properties of the cements (compressive strength, bending strength and bending modulus) were assessed following ISO 5833:2002 [2], while stress relaxation and creep were assessed under quasi static conditions in a four pointbending configuration. The creep experiments were carried out using a custom made apparatus with the specimens positioned in a distilled water bath at 37 o

Biogenic carbonate mercury and marine temperature records reveal global influence of Late Cretaceous Deccan Traps

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/155784/1/Meyer_et_al_2019_Biogenic_carbonate_mercury.pd

Axon Myelin Transfer of a Non-Enveloped Virus

We showed previously that Theiler's virus, a neurotropic non-enveloped picornavirus of mouse, traffics from the axon of infected neurons into the surrounding myelin. When this traffic is interrupted, as in the shiverer mouse which bears a mutation in the myelin basic protein gene, the virus is unable to persist in the central nervous system. In the present work, we used the Wlds mutant mouse, a strain in which axonal degeneration is considerably slowed down, to show that axon to myelin traffic takes place in the absence of axon degeneration. Our results suggest the existence of a mechanism of transfer of axonal cytoplasm into the myelin which Theiler's virus might exploit to ensure its persistence

The correlation between reading and mathematics ability at age twelve has a substantial genetic component

Dissecting how genetic and environmental influences impact on learning is helpful for maximizing numeracy and literacy. Here we show, using twin and genome-wide analysis, that there is a substantial genetic component to children’s ability in reading and mathematics, and estimate that around one half of the observed correlation in these traits is due to shared genetic effects (so-called Generalist Genes). Thus, our results highlight the potential role of the learning environment in contributing to differences in a child’s cognitive abilities at age twelve

Lateralization of mesial temporal lobe epilepsy with chronic ambulatory electrocorticography

OBJECTIVE: Patients with suspected mesial temporal lobe (MTL) epilepsy typically undergo inpatient video-electroencephalography (EEG) monitoring with scalp and/or intracranial electrodes for 1 to 2 weeks to localize and lateralize the seizure focus or foci. Chronic ambulatory electrocorticography (ECoG) in patients with MTL epilepsy may provide additional information about seizure lateralization. This analysis describes data obtained from chronic ambulatory ECoG in patients with suspected bilateral MTL epilepsy in order to assess the time required to determine the seizure lateralization and whether this information could influence treatment decisions. METHODS: Ambulatory ECoG was reviewed in patients with suspected bilateral MTL epilepsy who were among a larger cohort with intractable epilepsy participating in a randomized controlled trial of responsive neurostimulation. Subjects were implanted with bilateral MTL leads and a cranially implanted neurostimulator programmed to detect abnormal interictal and ictal ECoG activity. ECoG data stored by the neurostimulator were reviewed to determine the lateralization of electrographic seizures and the interval of time until independent bilateral MTL electrographic seizures were recorded. RESULTS: Eighty-two subjects were implanted with bilateral MTL leads and followed for 4.7 years on average (median 4.9 years). Independent bilateral MTL electrographic seizures were recorded in 84%. The average time to record bilateral electrographic seizures in the ambulatory setting was 41.6 days (median 13 days, range 0-376 days). Sixteen percent had only unilateral electrographic seizures after an average of 4.6 years of recording. SIGNIFICANCE: About one third of the subjects implanted with bilateral MTL electrodes required >1 month of chronic ambulatory ECoG before the first contralateral MTL electrographic seizure was recorded. Some patients with suspected bilateral MTL seizures had only unilateral electrographic seizures. Chronic ambulatory ECoG in patients with suspected bilateral MTL seizures provides data in a naturalistic setting, may complement data from inpatient video-EEG monitoring, and can contribute to treatment decisions

Simplified Models for LHC New Physics Searches

This document proposes a collection of simplified models relevant to the design of new-physics searches at the LHC and the characterization of their results. Both ATLAS and CMS have already presented some results in terms of simplified models, and we encourage them to continue and expand this effort, which supplements both signature-based results and benchmark model interpretations. A simplified model is defined by an effective Lagrangian describing the interactions of a small number of new particles. Simplified models can equally well be described by a small number of masses and cross-sections. These parameters are directly related to collider physics observables, making simplified models a particularly effective framework for evaluating searches and a useful starting point for characterizing positive signals of new physics. This document serves as an official summary of the results from the "Topologies for Early LHC Searches" workshop, held at SLAC in September of 2010, the purpose of which was to develop a set of representative models that can be used to cover all relevant phase space in experimental searches. Particular emphasis is placed on searches relevant for the first ~50-500 pb-1 of data and those motivated by supersymmetric models. This note largely summarizes material posted at http://lhcnewphysics.org/, which includes simplified model definitions, Monte Carlo material, and supporting contacts within the theory community. We also comment on future developments that may be useful as more data is gathered and analyzed by the experiments.Comment: 40 pages, 2 figures. This document is the official summary of results from "Topologies for Early LHC Searches" workshop (SLAC, September 2010). Supplementary material can be found at http://lhcnewphysics.or