Impacts of Large-Scale Circulation on Convection: A 2-D Cloud Resolving Model Study

Studies of impacts of large-scale circulation on convection, and the roles of convection in heat and water balances over tropical region are fundamentally important for understanding global climate changes. Heat and water budgets over warm pool (SST=29.5 C) and cold pool (SST=26 C) were analyzed based on simulations of the two-dimensional cloud resolving model. Here the sensitivity of heat and water budgets to different sizes of warm and cold pools is examined

BiOX (X = Cl, Br, I) photocatalysts prepared using NaBiO 3 as the Bi source: Characterization and catalytic performance

The Bismuth oxyhalides, crystalline BiOX (X = Cl, Br, I) were prepared via a facile method, using NaBiO 3 and HX aqueous solutions as the raw materials for the first time. The systematic microstructure and optical property characterizations of the BiOX photocatalysts demonstrated the reliability of this new and facile preparation approach. The photocatalytic activity on the degradation of typical phenolic endocrine disrupting chemicals over BiOX and P25 were evaluated under Xenon-light irradiation and the initial photocatalytic mechanism was discussed based on the band edge potential analysis. © 2009.postprin

A modified protocol for the detection of three different mRNAs with a new-generation in situ hybridization chain reaction on frozen sections

A new multiple fluorescence in situ hybridization method based on hybridization chain reaction was recently reported, enabling simultaneous mapping of multiple target mRNAs within intact zebrafish and mouse embryos. With this approach, DNA probes complementary to target mRNAs trigger chain reactions in which metastable fluorophore-labeled DNA hairpins self-assemble into fluorescent amplification polymers. The formation of the specific polymers enhances greatly the sensitivity of multiple fluorescence in situ hybridization. In this study we describe the optimal parameters (hybridization chain reaction time and temperature, hairpin and salt concentration) for multiple fluorescence in situ hybridization via amplification of hybridization chain reaction for frozen tissue sections. The combined use of fluorescence in situ hybridization and immunofluorescence, together with other control experiments (sense probe, neutralization and competition, RNase treatment, and anti-sense probe without initiator) confirmed the high specificity of the fluorescence in situ hybridization used in this study. Two sets of three different mRNAs for oxytocin, vasopressin and somatostatin or oxytocin, vasopressin and thyrotropin releasing hormone were successfully visualized via this new method. We believe that this modified protocol for multiple fluorescence in situ hybridization via hybridization chain reaction would allow researchers to visualize multiple target nucleic acids in the future

Association of Resistance Exercise, Independent of and Combined With Aerobic Exercise, With the Incidence of Metabolic Syndrome.

OBJECTIVE: To determine the association of resistance exercise, independent of and combined with aerobic exercise, with the risk of development of metabolic syndrome (MetS). PATIENTS AND METHODS: The study cohort included adults (mean ± SD age, 46±9.5 years) who received comprehensive medical examinations at the Cooper Clinic in Dallas, Texas, between January 1, 1987, and December, 31, 2006. Exercise was assessed by self-reported frequency and minutes per week of resistance and aerobic exercise and meeting the US Physical Activity Guidelines (resistance exercise ≥2 d/wk; aerobic exercise ≥500 metabolic equivalent min/wk) at baseline. The incidence of MetS was based on the National Cholesterol Education Program Adult Treatment Panel III criteria. We used Cox regression to generate hazard ratios (HRs) and 95% CIs. RESULTS: Among 7418 participants, 1147 (15%) had development of MetS during a median follow-up of 4 years (maximum, 19 years; minimum, 0.1 year). Meeting the resistance exercise guidelines was associated with a 17% lower risk of MetS (HR, 0.83; 95% CI, 0.73-0.96; P=.009) after adjusting for potential confounders and aerobic exercise. Further, less than 1 hour of weekly resistance exercise was associated with 29% lower risk of development of MetS (HR, 0.71; 95% CI, 0.56-0.89; P=.003) compared with no resistance exercise. However, larger amounts of resistance exercise did not provide further benefits. Individuals meeting both recommended resistance and aerobic exercise guidelines had a 25% lower risk of development of MetS (HR, 0.75; 95% CI, 0.63-0.89; P<.001) compared with meeting neither guideline. CONCLUSION: Participating in resistance exercise, even less than 1 hour per week, was associated with a lower risk of development of MetS, independent of aerobic exercise. Health professionals should recommend that patients perform resistance exercise along with aerobic exercise to reduce MetS

Atmospheric reactive nitrogen concentrations at ten sites with contrasting land use in an arid region of central Asia

Atmospheric concentrations of reactive nitrogen (N&lt;sub&gt;r&lt;/sub&gt;) species from 2009 to 2011 are reported for ten sites in Xinjiang, China, an arid region of central Asia. Concentrations of NH&lt;sub&gt;3&lt;/sub&gt;, NO&lt;sub&gt;2&lt;/sub&gt;, particulate ammonium and nitrate (&lt;i&gt;p&lt;/i&gt;NH&lt;sub&gt;4&lt;/sub&gt;&lt;sup&gt;+&lt;/sup&gt; and &lt;i&gt;p&lt;/i&gt;NO&lt;sub&gt;3&lt;/sub&gt;&lt;sup&gt;&amp;minus;&lt;/sup&gt;) showed large spatial and seasonal variation and averaged 7.71, 9.68, 1.81 and 1.13 μg N m&lt;sup&gt;−3&lt;/sup&gt;, and PM&lt;sub&gt;10&lt;/sub&gt; concentrations averaged 249.2 μg m&lt;sup&gt;−3&lt;/sup&gt; across all sites. Lower NH&lt;sub&gt;3&lt;/sub&gt; concentrations and higher NO&lt;sub&gt;2&lt;/sub&gt;, &lt;i&gt;p&lt;/i&gt;NH&lt;sub&gt;4&lt;/sub&gt;&lt;sup&gt;+&lt;/sup&gt; and &lt;i&gt;p&lt;/i&gt;NO&lt;sub&gt;3&lt;/sub&gt;&lt;sup&gt;&amp;minus;&lt;/sup&gt; concentrations were found in winter, reflecting serious air pollution due to domestic heating in winter and other anthropogenic sources such as increased emissions from motor traffic and industry. The increasing order of total concentrations of N&lt;sub&gt;r&lt;/sub&gt; species was alpine grassland; desert, desert-oasis ecotone; desert in an oasis; farmland; suburban and urban ecosystems. Lower ratios of secondary particles (NH&lt;sub&gt;4&lt;/sub&gt;&lt;sup&gt;+&lt;/sup&gt; and NO&lt;sub&gt;3&lt;/sub&gt;&lt;sup&gt;&amp;minus;&lt;/sup&gt;) were found in the desert and desert-oasis ecotone, while urban and suburban areas had higher ratios, which implied that anthropogenic activities have greatly influenced local air quality and must be controlled

A high-resolution inland surface water body dataset for the tundra and boreal forests of North America

Inland surface waters are abundant in the tundra and boreal forests of North America, essential to environments and human societies but vulnerable to climate changes. These high-latitude water bodies differ greatly in their morphological and topological characteristics related to the formation, type, and vulnerability. In this paper, we present a water body dataset for the North American high latitudes (WBD-NAHL). Nearly 6.5 million water bodies were identified, with approximately 6 million (∼90 %) of them smaller than 0.1 km2. The dataset provides area and morphological attributes for every water body. During this study, we developed an automated approach for detecting surface water extent and identifying water bodies in the 10 m resolution Sentinel-2 multispectral satellite data to enhance the capability of delineating small water bodies and their morphological attributes. The approach was applied to the Sentinel-2 data acquired in 2019 to produce the water body dataset for the entire tundra and boreal forests in North America. The dataset provided a more complete representation of the region than existing regional datasets for North America, e.g., Permafrost Region Pond and Lake (PeRL). The total accuracy of the detected water extent by the WBD-NAHL dataset was 96.36 % through comparison to interpreted data for locations randomly sampled across the region. Compared to the 30 m or coarser-resolution water datasets, e.g., JRC GSW yearly water history, HydroLakes, and Global Lakes and Wetlands Database (GLWD), the WBD-NAHL provided an improved ability on delineating water bodies and reported higher accuracies in the size, number, and perimeter attributes of water body by comparing to PeRL and interpreted regional dataset. This dataset is available from the National Tibetan Plateau/Third Pole Environment Data Center (TPDC; http://data.tpdc.ac.cn, last access: 6 June 2022): https://doi.org/10.11888/Hydro.tpdc.271021 (Feng and Sui, 2020).</p

A five-gene signature as a potential predictor of metastasis and survival in colorectal cancer.

To understand the molecular mechanisms of metastasis and prognosis of colorectal cancer (CRC), we isolated single cell-derived progenies (SCPs) from SW480 cells in vitro and compared their metastatic potential in an orthotopic CRC tumour model in vivo. Two groups of SCPs with the capability of high and low metastasis, respectively, were obtained. By analysing the gene expression profiles of high (SCP51), low (SCP58) metastatic SCPs, and their parental cell line (SW480/EGFP), we demonstrated that 143 genes were differentially expressed either between SCP51 and SCP58 or between SCP58 and SW480/EGFP. Gene-annotation enrichment analysis of DAVID revealed 80 genes in the top ten clusters of the analysis (gene enrichment score > 1). Of the 80-gene set, 32 genes are potentially involved in metastasis, as revealed by Geneclip. Five putative metastatic genes (LYN, SDCBP, MAP4K4, DKK1, and MID1) were selected for further validations. Immunohistochemical analysis in a cohort of 181 CRC clinical samples showed that the individual expression of LYN, MAP4K4, and MID1, as well as the five-gene signature, was closely correlated with lymph node metastasis in CRC patients. More importantly, the individual expression of LYN, MAP4K4, SDCBP, and MID1, as well as the five-gene signature, was significantly correlated with overall survival in CRC patients. Thus, our five-gene signature may be able to predict metastasis and survival of CRC in the clinic, and opens new perspectives on the biology of CRC

Measurement of proton electromagnetic form factors in e+e−→ppˉe^+e^- \to p\bar{p} in the energy region 2.00-3.08 GeV

The process of $e^+e^- \rightarrow p\bar{p}$ is studied at 22 center-of-mass energy points ($\sqrt{s}$) from 2.00 to 3.08 GeV, exploiting 688.5~pb$^{-1}$ of data collected with the BESIII detector operating at the BEPCII collider. The Born cross section~($\sigma_{p\bar{p}}$) of $e^+e^- \rightarrow p\bar{p}$ is measured with the energy-scan technique and it is found to be consistent with previously published data, but with much improved accuracy. In addition, the electromagnetic form-factor ratio ($|G_{E}/G_{M}|$) and the value of the effective ($|G_{\rm{eff}}|$), electric ($|G_E|$) and magnetic ($|G_M|$) form factors are measured by studying the helicity angle of the proton at 16 center-of-mass energy points. $|G_{E}/G_{M}|$ and $|G_M|$ are determined with high accuracy, providing uncertainties comparable to data in the space-like region, and $|G_E|$ is measured for the first time. We reach unprecedented accuracy, and precision results in the time-like region provide information to improve our understanding of the proton inner structure and to test theoretical models which depend on non-perturbative Quantum Chromodynamics