447 research outputs found
Canonical Quantization Inside the Schwarzschild Black Hole
We propose a scheme for quantizing a scalar field over the Schwarzschild
manifold including the interior of the horizon. On the exterior, the timelike
Killing vector and on the horizon the isometry corresponding to restricted
Lorentz boosts can be used to enforce the spectral condition. For the interior
we appeal to the need for CPT invariance to construct an explicitly positive
definite operator which allows identification of positive and negative
frequencies. This operator is the translation operator corresponding to the
inexorable propagation to smaller radii as expected from the classical metric.
We also propose an expression for the propagator in the interior and express it
as a mode sum.Comment: 8 pages, LaTex. Title altered. One reference added. A few typos esp.
eq.(7),(38) corrected. To appear in Class.Q.Gra
Low maternal vitamin B12 status is associated with lower cord blood HDL cholesterol in white Caucasians living in the UK
Background and Aims:
Studies in South Asian population show that low maternal vitamin B12 associates with insulin resistance and small for gestational age in the offspring. Low vitamin B12 status is attributed to vegetarianism in these populations. It is not known whether low B12 status is associated with metabolic risk of the offspring in whites, where the childhood metabolic disorders are increasing rapidly. Here, we studied whether maternal B12 levels associate with metabolic risk of the offspring at birth.
Methods:
This is a cross-sectional study of 91 mother-infant pairs (n = 182), of white Caucasian origin living in the UK. Blood samples were collected from white pregnant women at delivery and their newborns (cord blood). Serum vitamin B12, folate, homocysteine as well as the relevant metabolic risk factors were measured.
Results:
The prevalence of low serum vitamin B12 (<191 ng/L) and folate (<4.6 μg/L) were 40% and 11%, respectively. Maternal B12 was inversely associated with offspring’s Homeostasis Model Assessment 2-Insulin Resistance (HOMA-IR), triglycerides, homocysteine and positively with HDL-cholesterol after adjusting for age and BMI. In regression analysis, after adjusting for likely confounders, maternal B12 is independently associated with neonatal HDL-cholesterol and homocysteine but not triglycerides or HOMA-IR.
Conclusions:
Our study shows that low B12 status is common in white women and is independently associated with adverse cord blood cholesterol
The Quantum Gravitationally Induced Stress Tensor
We derive non-perturbative relations between the expectation value of the
invariant element in a homogeneous and isotropic state and the quantum
gravitationally induced pressure and energy density. By exploiting previously
obtained bounds for the maximum possible growth of perturbative corrections to
a locally de Sitter background we show that the two loop result dominates all
higher orders. We also show that the quantum gravitational slowing of inflation
becomes non-perturbatively strong earlier than previously expected.Comment: 13 pages, LaTeX 2 epsilo
Clinical Activity and Quality of Life Indices Are Valid Across Ulcerative Colitis But Not Crohn’s Disease Phenotypes
Background
Clinical activity and quality of life (QOL) indices assess disease activity in Crohn’s disease (CD) and ulcerative colitis (UC). However, a paucity of data exists on the validity of these indices according to disease characteristics.
Aims
To examine the correlation between QOL and clinical activity indices and endoscopic disease activity according to disease characteristics.
Methods
We used a prospective registry to identify CD and UC patients ≥18 years old with available information on Short Inflammatory Bowel Disease Questionnaire scores (SIBDQ), Harvey–Bradshaw Index (HBI) and simple endoscopic scores for CD (SES-CD), and Simple Clinical Colitis Activity Index (SCCAI) and Mayo endoscopic score for UC. We used Spearman rank correlations to calculate correlations between indices and Fisher transformation to compare correlations across disease characteristics.
Results
Among 282 CD patients, we observed poor correlation between clinical activity and QOL indices to SES-CD with no differences in correlation according to disease characteristics. Conversely, among 226 UC patients, clinical activity and QOL had good correlation to Mayo endoscopic score (r = 0.55 and −0.56, respectively) with better correlations observed with left-sided versus extensive colitis (r = 0.73 vs. 0.45, p = 0.005) and shorter duration of disease (r = 0.61 vs. 0.37, p = 0.04).
Conclusions
Our data suggest good correlation between SCCAI and endoscopic disease activity in UC, particularly in left-sided disease. Poor correlations between HBI or SIBDQ and SES-CD appear to be consistent across different disease phenotypes.American Gastroenterological Associatio
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Early life environment and natural history of inflammatory bowel diseases
Background: Early life exposures may modify risk of inflammatory bowel diseases (IBD; Crohn’s disease (CD), ulcerative colitis (UC)). However, the relationship between early life exposures and natural history of IBD has not been previously examined. Methods: This single center study included patients with CD or UC recruited in a prospective IBD registry. Enrolled patients completed a detailed environmental questionnaire that assessed various early life environmental exposures. Our primary outcome was requirement for disease-related surgery in CD and UC. Logistic regression models defined independent effect of early life exposures, adjusting for potential confounders. Results: Our study included 333 CD and 270 UC patients. Just over half were female with a median age at diagnosis of 25 years. One-third of the cohort had history of bowel surgery (31%) and nearly half had used at least one biologic agent (47%). Among those with CD, being breastfed was associated with reduced risk of CD-related surgery (34% vs. 55%), while childhood cigarette smoke exposure was associated with increased risk. On multivariate analysis, history of being breastfed (odds ratio (OR) 0.21, 95% confidence interval [CI] 0.09–0.46) and cigarette smoke exposure as a child (OR 2.17, 95% CI 1.10–4.29) remained independently associated with surgery. None of the early life variables influenced disease phenotype or outcome in UC. Conclusion: A history of being breastfed was associated with a decreased risk while childhood cigarette smoke exposure was associated with an increased risk of surgery in patients with CD. Further investigation to examine biological mechanisms is warranted. Electronic supplementary material The online version of this article (doi:10.1186/s12876-014-0216-8) contains supplementary material, which is available to authorized users
Birthweight and risk markers for type 2 diabetes and cardiovascular disease in childhood: the Child Heart and Health Study in England (CHASE).
AIMS/HYPOTHESIS: Lower birthweight (a marker of fetal undernutrition) is associated with higher risks of type 2 diabetes and cardiovascular disease (CVD) and could explain ethnic differences in these diseases. We examined associations between birthweight and risk markers for diabetes and CVD in UK-resident white European, South Asian and black African-Caribbean children.
METHODS: In a cross-sectional study of risk markers for diabetes and CVD in 9- to 10-year-old children of different ethnic origins, birthweight was obtained from health records and/or parental recall. Associations between birthweight and risk markers were estimated using multilevel linear regression to account for clustering in children from the same school.
RESULTS: Key data were available for 3,744 (66%) singleton study participants. In analyses adjusted for age, sex and ethnicity, birthweight was inversely associated with serum urate and positively associated with systolic BP. After additional height adjustment, lower birthweight (per 100 g) was associated with higher serum urate (0.52%; 95% CI 0.38, 0.66), fasting serum insulin (0.41%; 95% CI 0.08, 0.74), HbA1c (0.04%; 95% CI 0.00, 0.08), plasma glucose (0.06%; 95% CI 0.02, 0.10) and serum triacylglycerol (0.30%; 95% CI 0.09, 0.51) but not with BP or blood cholesterol. Birthweight was lower among children of South Asian (231 g lower; 95% CI 183, 280) and black African-Caribbean origin (81 g lower; 95% CI 30, 132). However, adjustment for birthweight had no effect on ethnic differences in risk markers.
CONCLUSIONS/INTERPRETATION: Birthweight was inversely associated with urate and with insulin and glycaemia after adjustment for current height. Lower birthweight does not appear to explain emerging ethnic difference in risk markers for diabetes
Working Group Report: Neutrino and Astroparticle Physics
This is the report of neutrino and astroparticle physics working group at
WHEPP-8. We present the discussions carried out during the workshop on selected
topics in the above fields and also indicate progress made subsequently. The
neutrino physics subgroup studied the possibilites of constraining neutrino
masses, mixing and CPT violation in lepton sector from future experiments.
Neutrino mass models in the context of abelian horizontal symmetries, warped
extra dimensions and in presence of triplet Higgs were studied. Effect of
threshold corrections on radiative magnification of mixing angles was
investigated. The astroparticle physics subgroup focused on how various
particle physics inputs affect the CMBR fluctuation spectrum, and on brane
cosmology. This report also contains an introduction on how to use the publicly
available code CMBFAST to calculate the CMBR fluctuations.Comment: Prepared for the 8th Workshop on High-Energy Physics Phenomenology
(WHEPP-8), IIT Mumbai, India, 5-16 Jan 200
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A Nutrigenetic approach to examine the relationship between vitamin B12 status and cardio-metabolic traits in multiple ethnic groups – findings from the GeNuIne Collaboration
Low vitamin B12 concentrations have been shown to be risk factors for metabolic traits in numerous observational studies; however, the relationship has remained inconsistent. It is possible that certain genotypes jointly contribute to obesity and vitamin B12 deficiency, and these may be modulated by dietary factors. The main objective of this review article was to summarize the effect of gene-nutrient interactions on vitamin B12 concentrations and cardio-metabolic disease risk factors using population-based studies from different ethnic groups from the GeNuIne (Gene-Nutrient Interactions) Collaboration. Interactions between vitamin B12-related SNPs and protein energy intake (%) on waist circumference (Pinteration=0.002) and body fat percentage (Pinteraction=0.034), were observed in Sri Lankan and Indonesian populations, respectively. In the study in Brazilian adolescents, the metabolic and vitamin B12 related SNPs showed a significant interaction with carbohydrate and protein intakes on oxidised low density lipoprotein cholesterol and homocysteine concentrations, respectively. In the Asian Indian population, an association between obesity-related SNPs and vitamin B12 concentrations (P = 0.018) was observed. In summary, these studies in multiple ethnic groups show that the association between genetically low vitamin B12 concentrations and metabolic outcomes may be modified by dietary intake. Further studies utilising larger sample sizes are needed to confirm or refute our findings
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