Shareholder Engagement and Chevron’s Policy 520 on Human Rights: The Role Played by the United States Jesuit Conference’s “National Jesuit Committee on Investment Responsibility”

Purpose To demonstrate how the Society of Jesus (Jesuits) in the United States through the “National Jesuit Committee on Investment Responsibility” played a significant role as a socially conscious institutional and religious investor in influencing Chevron’s Human Rights Policy 520 and to analyze the factors that contributed to a successful shareholder engagement with the company. Methodology/approach Case study based on firsthand information. Findings Our conclusion offers support for Allen et al.’s (2012) conclusion of legitimacy (credibility) being the dominant force in a successful engagement. We found that coalition-building is a significant moderating variable in increasing shareholder salience. This finding contradicts the study by Gifford (2010). Originality/value of chapter The chapter is based on the actual process of shareholder engagement with Chevron Corporation that led to the human rights policy and is written mainly based on firsthand information

Being an English academic:a social domains account

This paper considers the differential placements of social actors in the contemporary English university, as practices consistent with neoliberal ideologies become increasingly influential. It uses Layder's theory of ‘social domains’ and the first-hand experiences of the author to explore how the options available–to students, those on precarious conditions of employment, and those occupying more influential roles in the institution–change in relation to alterations in structured social relations. Examples are provided of interventions by people opposed to both the rhetoric and the reality of developments in the sector, and reasons for their limited effectiveness are also discussed

ANTHROPOMETRIC AND PHYSICAL FITNESS PROFILES OF YOUTH ATHLETES

Mason Thieu1, Quincy R. Johnson1,Yang Yang1, Dayton Sealey2, Clay Frels2, Dimitrije Cabarkapa1, & Andrew C. Fry1, FACSM 1University of Kansas, Lawrence, Kansas; 2Department of Kinesiology and Sport Science, University of Nebraska at Kearney, Kearney, Nebraska Youth sports participation, competitiveness, and training intensity continues to increase. However, more information is needed regarding the anthropometric and physical fitness profile of today’s youth athletes. Common strategies for profiling anthropometric and physical fitness characteristics of athletes across their lifespan include the sit and reach (SR), functional movement screen (FMS), isometric mid-thigh pull (IMTP), and the countermovement jump (CMJ) tests. PURPOSE: This study aimed to assess SR, FMS, IMTP, and CMJ performance of youth athletes. METHODS: Youth athletes participating in a community-based strength and conditioning program (male; n=15, age=10.7±0.9, height=157.7±9.2cm, weight=53.2±14.3kg, female; n=6, age=10.2±0.4, height=146.9±8.7cm, weight=40.4±8.2kg) participated in this study. Each athlete performed a SR test, FMS test, two maximum effort IMTPs, and two maximum effort CMJs. Mann-Whitney U Tests (p\u3c0.05) were performed using sex as the grouping variable. RESULTS: Among the variables analyzed, significant differences were found in SR performance (p=0.026), FMS total score (p=0.018), IMTP peak force (p=0.006), and CMJ peak propulsive power (p=0.016) between sexes. The mean ± SD is reported in Table 1. CONCLUSION: Significant differences in anthropometric and physical fitness were observed between male and female youth athletes. While sex differences in anthropometrics have been well reported, the present study provides novel insights on physical fitness data measuring muscular strength and power for youth athletes. These findings can be utilized by coaches, physical educators, strength and conditioning professionals, and sport scientists to better understand the youth athlete population and contribute to their long-term development of athletic qualities

The N-terminus of hTERT contains a DNA-binding domain and is required for telomerase activity and cellular immortalization

Telomerase defers the onset of telomere damage-induced signaling and cellular senescence by adding DNA onto chromosome ends. The ability of telomerase to elongate single-stranded telomeric DNA depends on the reverse transcriptase domain of TERT, and also relies on protein:DNA contacts outside the active site. We purified the N-terminus of human TERT (hTEN) from Escherichia coli, and found that it binds DNA with a preference for telomeric sequence of a certain length and register. hTEN interacted with the C-terminus of hTERT in trans to reconstitute enzymatic activity in vitro. Mutational analysis of hTEN revealed that amino acids Y18 and Q169 were required for telomerase activity in vitro, but not for the interaction with telomere DNA or the C-terminus. These mutants did not reconstitute telomerase activity in cells, maintain telomere length, or extend cellular lifespan. In addition, we found that T116/T117/S118, while dispensable in vitro, were required for cellular immortalization. Thus, the interactions of hTEN with telomere DNA and the C-terminus of hTERT are functionally separable from the role of hTEN in telomere elongation activity in vitro and in vivo, suggesting other roles for the protein and nucleic acid interactions of hTEN within, and possibly outside, the telomerase catalytic core

A blood-based metabolomics test to distinguish relapsing–remitting and secondary progressive multiple sclerosis: addressing practical considerations for clinical application

The transition from relapsing–remitting multiple sclerosis (RRMS) to secondary progressive MS (SPMS) represents a huge clinical challenge. We previously demonstrated that serum metabolomics could distinguish RRMS from SPMS with high diagnostic accuracy. As differing sample-handling protocols can affect the blood metabolite profile, it is vital to understand which factors may influence the accuracy of this metabolomics-based test in a clinical setting. Herein, we aim to further validate the high accuracy of this metabolomics test and to determine if this is maintained in a ‘real-life’ clinical environment. Blood from 31 RRMS and 28 SPMS patients was subjected to different sample-handling protocols representing variations encountered in clinics. The effect of freeze–thaw cycles (0 or 1) and time to erythrocyte removal (30, 120, or 240 min) on the accuracy of the test was investigated. For test development, samples from the optimised protocol (30 min standing time, 0 freeze–thaw) were used, resulting in high diagnostic accuracy (mean ± SD, 91.0 ± 3.0%). This test remained able to discriminate RRMS and SPMS samples that had experienced additional freeze–thaw, and increased standing times of 120 and 240 min with accuracies ranging from 85.5 to 88.0%, because the top discriminatory metabolite biomarkers from the optimised protocol remained discriminatory between RRMS and SPMS despite these sample-handling variations. In conclusion, while strict sample-handling is essential for the development of metabolomics-based blood tests, the results confirmed that the RRMS vs. SPMS test is resistant to sample-handling variations and can distinguish these two MS stages in the clinics

Mangroves enhance the biomass of coral reef fish communities in the Caribbean

Mangrove forests are one of the world's most threatened tropical ecosystems with global loss exceeding 35% (ref. 1). Juvenile coral reef fish often inhabit mangroves, but the importance of these nurseries to reef fish population dynamics has not been quantified. Indeed, mangroves might be expected to have negligible influence on reef fish communities: juvenile fish can inhabit alternative habitats and fish populations may be regulated by other limiting factors such as larval supply or fishing. Here we show that mangroves are unexpectedly important, serving as an intermediate nursery habitat that may increase the survivorship of young fish. Mangroves in the Caribbean strongly influence the community structure of fish on neighbouring coral reefs. In addition, the biomass of several commercially important species is more than doubled when adult habitat is connected to mangroves. The largest herbivorous fish in the Atlantic, Scarus guacamaia, has a functional dependency on mangroves and has suffered local extinction after mangrove removal. Current rates of mangrove deforestation are likely to have severe deleterious consequences for the ecosystem function, fisheries productivity and resilience of reefs. Conservation efforts should protect connected corridors of mangroves, seagrass beds and coral reefs

Delineation of individual human chromosomes in metaphase and interphase cells by in situ suppression hybridization using recombinant DNA libraries

A method of in situ hybridization for visualizing individual human chromosomes from pter to qter, both in metaphase spreads and interphase nuclei, is reported. DNA inserts from a single chromosomal library are labeled with biotin and partially preannealed with a titrated amount of total human genomic DNA prior to hybridization with cellular or chromosomal preparations. The cross-hybridization of repetitive sequences to nontargeted chromosomes can be markedly suppressed under appropriate preannealing conditions. The remaining single-stranded DNA is hybridized to specimens of interest and detected with fluorescent or enzymelabeled avidin conjugates following post-hybridization washes. DNA inserts from recombinant libraries for chromosomes 1, 4, 7, 8, 13, 14, 18, 20, 21, 22, and X were assessed for their ability to decorate specifically their cognate chromosome; most libraries proved to be highly specific. Quantitative densitometric analyses indicated that the ratio of specific to nonspecific hybridization signal under optimal preannealing conditions was at least 8:1. Interphase nuclei showed a cohesive territorial organization of chromosomal domains, and laserscanning confocal fluorescence microscopy was used to aid the 3-D visualization of these domains. This method should be useful for both karyotypic studies and for the analysis of chromosome topography in interphase cells

On the relevance of the mathematics curriculum to young people

In this paper we draw upon focus group data from a large study of learner trajectories through 14-19 mathematics education to think about the notion of relevance in the mathematics curriculum. Drawing on data from three socially distanced sites we explore how different emphases on what might be termed practical, process and/or professional forms of relevance affect the experiences and aspirations of learners of mathematics. We consider whether an emphasis on practical relevance in schools serving relatively disadvantaged communities might aid the reproduction of students’ social position. This leads us to suggest that a fourth category of curriculum relevance – political relevance – is largely missing from classrooms

Slow violence and toxic geographies : ‘out of sight’ to whom?

Toxic pollution is a form of violence. This article explores the gradual brutalities that communities surrounded by petrochemical infrastructure endure over time. Contributing to political geographies of violence and environmental justice, this paper puts the concept of ‘slow violence’ into critical comparison with work on ‘structural violence’. In doing so, the paper makes two key contributions: First, it emphasizes the intimate connections between structural and slow forms of harm, arguing that structural inequality can mutate into noxious instances of slow violence. Second, the paper pushes back against framings of toxic landscapes as entirely invisible to the people they impact. Instead of accepting the standard definition of slow violence as ‘out of sight’, we have to instead ask the question: ‘out of sight to whom?’ In asking this question, and taking seriously the knowledge claims of communities who inhabit toxic spaces, we can begin to unravel the political structures that sustain the uneven geographies of pollution. Based on long-term ethnographic research in a postcolonial region of Louisiana, nicknamed ‘Cancer Alley’, this paper reveals how people gradually ‘witness’ the impacts of slow violence in their everyday lives. Finally, drawing on the notion of ‘epistemic violence’, the paper suggests that slow violence does not persist due to a lack of arresting stories about pollution, but because these stories do not count, thus rendering certain populations and geographies vulnerable to sacrifice