824 research outputs found
Efficiency, Efficacy, and Power in the Implementation of a Medication Adherence Aid.
Nonadherence to medication regimens is common, with approximately 50% of patients not taking their medications as prescribed. The Universal Medication Schedule (UMS) is a set of standardized, evidence-based, and patient-centered instructions for pill-form medications that has demonstrated improvements in adherence by promoting patient comprehension. An urban, publicly funded, integrated health care system attempted to adopt UMS labeling but had limited success at its largest pilot site, which was a safety-net health care system's outpatient pharmacy. To assess barriers to implementation, we engaged pharmacists at this site in group interviews. We thematically analyzed transcripts by integrating sociological work on standardization with grounded theory methodologies. In addition to lacking technological infrastructure, tensions among efficiency, efficacy, and effectiveness, and tension between individual/biomedical versus population health perspectives emerged as barriers to implementation. Additionally, we discovered that hierarchies of professional power impeded uptake. For successful implementation of evidence-based practices for vulnerable populations in resource-poor settings, efforts must anticipate and reconcile the tensions among conflicting demands, professional hierarchies, and divergent orientations to patient care. [HLRP: Health Literacy Research and Practice. 2018;2(3):e128-e131.]
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The Office of Combination Products: Its Roots, Its Creation, and Its Role
The Office of Combination Products (OCP), within the Food and Drug Administration (FDA), was created formally by statute in December, 2002. Upon its creation, the Office became broadly responsible for overseeing the regulation of combination products, or products that involve components that would normally be regulated under different FDA Centers. But the statutory creation of this Office in one day represented the culmination of nearly sixty-five years of both technological advancement in the products submitted to the FDA and amassed experience within the FDA and its administrative predecessors for managing those products in the name of the public safety. To understand the need for this Office and its primary goals of timely, effective and clear regulation of these groundbreaking technologies, the history of the FDA with respect to the advent of these combination products must be examined chronologically. Drafts of statutes, administrative proposals offered for public comment, and lengthy debates from Capitol Hill all illustrate the journey that led inevitably to the OCP as a final destination. Nearly twenty-four months have passed since the OCP was created, so an analysis of its initial progress through an explanation of the changes it has effected is necessary. Both combination product manufacturers and FDA jurisdiction officers have benefited from industry guidances, enhanced inter-Center communication, and a wealth of expertise provided by FDA employees eager to streamline the regulatory pathways to be navigated. Thus, the next three years within the OCP would seem to promise similar success for product manufacturers, the FDA and the American public
Acoustic observations of vertical and horizontal swimming velocities of a diel migrator
A strong sound scattering layer which underwent diel vertical migration was observed over 176 days using a bottom-mounted 600 kHz ADCP at a depth of approximately 285 m on the upper continental slope. Average observed descent times of the scatterers were within 12 minutes of sunrise and average ascent times were within 13 minutes of sunset. Average ascent speeds progressively increased away from the bed and approached 6 cm/s. Average descent speeds similarly reached a maximum of ∼6 cm/s. Horizontal velocities of the scatterers during vertical migration were found to be smaller than ambient velocities (by up to 3 cm/s), and it is inferred that the migrators were swimming horizontally against the flow. Horizontal velocities of the scatterers during time intervals when the layer was near the seafloor were found to be southwest (up to 3 cm/s), and onshelf (up to 1.7 cm/s) relative to the flow above the layer. Swimming velocities were independent of alongshelf flow direction, counter to the hypothesis that the scatterers sought to maintain their position by swimming against the flow
Obesity and the food environment: income and ethnicity differences among people with diabetes: the Diabetes Study of Northern California (DISTANCE).
ObjectiveIt is unknown whether any association between neighborhood food environment and obesity varies according to individual income and/or race/ethnicity. The objectives of this study were to test whether there was an association between food environments and obesity among adults with diabetes and whether this relationship differed according to individual income or race/ethnicity.Research design and methodsSubjects (n = 16,057) were participants in the Diabetes Study of Northern California survey. Kernel density estimation was used to create a food environment score for each individual's residence address that reflected the mix of healthful and unhealthful food vendors nearby. Logistic regression models estimated the association between the modeled food environment and obesity, controlling for confounders, and testing for interactions between food environment and race/ethnicity and income.ResultsThe authors found that more healthful food environments were associated with lower obesity in the highest income groups (incomes 301-600% and >600% of U.S. poverty line) among whites, Latinos, and Asians. The association was negative, but smaller and not statistically significant, among high-income blacks. On the contrary, a more healthful food environment was associated with higher obesity among participants in the lowest-income group (<100% poverty threshold), which was statistically significant for black participants in this income category.ConclusionsThese findings suggest that the availability of healthful food environments may have different health implications when financial resources are severely constrained
Maximum-likelihood absorption tomography
Maximum-likelihood methods are applied to the problem of absorption
tomography. The reconstruction is done with the help of an iterative algorithm.
We show how the statistics of the illuminating beam can be incorporated into
the reconstruction. The proposed reconstruction method can be considered as a
useful alternative in the extreme cases where the standard ill-posed
direct-inversion methods fail.Comment: 7 pages, 5 figure
Association of smoking and nicotine dependence with pre-diabetes in young and healthy adults.
INTRODUCTION: Several studies have shown an increased risk of type 2 diabetes among smokers. Therefore, the aim of this analysis was to assess the relationship between smoking, cumulative smoking exposure and nicotine dependence with pre-diabetes.
METHODS: We performed a cross-sectional analysis of healthy adults aged 25-41 in the Principality of Liechtenstein. Individuals with known diabetes, Body Mass Index (BMI) >35 kg/m² and prevalent cardiovascular disease were excluded. Smoking behaviour was assessed by self-report. Pre-diabetes was defined as glycosylated haemoglobin between 5.7% and 6.4%. Multivariable logistic regression models were done.
RESULTS: Of the 2142 participants (median age 37 years), 499 (23.3%) had pre-diabetes. There were 1,168 (55%) never smokers, 503 (23%) past smokers and 471 (22%) current smokers, with a prevalence of pre-diabetes of 21.2%, 20.9% and 31.2%, respectively (p <0.0001). In multivariable regression models, current smokers had an odds ratio (OR) of pre-diabetes of 1.82 (95% confidential interval (CI) 1.39; 2.38, p <0.0001). Individuals with a smoking exposure of <5, 5-10 and >10 pack-years had an OR (95% CI) for pre-diabetes of 1.34 (0.90; 2.00), 1.80 (1.07; 3.01) and 2.51 (1.80; 3.59) (p linear trend <0.0001) compared with never smokers. A Fagerström score of 2, 3-5 and >5 among current smokers was associated with an OR (95% CI) for pre-diabetes of 1.27 (0.89; 1.82), 2.15 (1.48; 3.13) and 3.35 (1.73; 6.48) (p linear trend <0.0001).
DISCUSSION: Smoking is strongly associated with pre-diabetes in young adults with a low burden of smoking exposure. Nicotine dependence could be a potential mechanism of this relationship
Comparison of optical probes and X-ray tomography for bubble characterization in fluidized bed methanation reactors
The performance of many fluidized bed reactors strongly depends on the bubble behavior since they influence the mass transfer to the dense phase where the catalyst is present. An example is the methanation in a fluidized bed that allows for conversion of unsaturated hydrocarbons in the gasification gas without catalyst deactivation [1]. The BFB reactor is a very challenging step in the process chain to produce SNG out of biomass as feedstock since next to the bubble behavior a lot of other parameters like temperature, pressure, particle size, attrition of the catalyst, internals, bed height and reactor diameter etc. affect the overall performance. The focus of this research work lies on the determination of the bubble properties which are an important factor to model a bubbling fluidized methanation reactor in order to predict and optimize its performance and to support its scale-up [2]. Tomographic methods such as X-ray measurements are often used to characterize bubbles in a fluidized bed. Compared to intrusive measurement, e.g. optical probing, this method possesses the advantage of measuring bubbles throughout the entire cross section. However, X-ray measurements cannot be applied to all installation, especially not in large scale plants. For these purpose, we have developed optical probes that can be employed to investigate the fluidization state in a hot pilot scale reactor. A main drawback of the optical measurements lies in their locally limited detection of the hydrodynamic pattern since they are only able to measure at one point in the reactor. Therefore, conclusions on the bubble behavior of the whole cross section based on optical measurements are not easy to derive. To compare the influence of the measurement method on the measured bubble properties, in the scope of this study, an artificial optical signal is created out of the existing X-ray measurement data set for a cold flow model of the pilot scale methanation reactor. The obtained bubble properties of both methods (i.e. evaluation of the derived artificial optical probe signal and image reconstruction based on the original X-ray tomographic data) are compared with regard to the hold-up, bubble rise velocity and the bubble size (for the X-ray method) or chord length (for the optical evaluation method), respectively. The process to obtain an artificial optical signal is depicted in Figure 1. The comparison shows that for the evaluation of optical probe data, statistical effects have to be considered carefully. The detected mean chord length of the optical method does not represent the mean bubble size determined by the X-ray method. Moreover, also a difference in the bubble rise velocity was detected for some fluidization states. This knowledge may be the basis for the derivation of a statistically sound method to calculate different hydrodynamic properties in fluidized bed reactors based on optical probe measurements.
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The association of health literacy with adherence in older 2 adults, and its role in interventions: a systematic meta-review
Background: Low health literacy is a common problem among older adults. It is often suggested to be associated with poor adherence. This suggested association implies a need for effective adherence interventions in low health literate people. However, previous reviews show mixed results on the association between low health literacy and poor adherence. A systematic meta-review of systematic reviews was conducted to study the association between health literacy and adherence in adults above the age of 50. Evidence for the effectiveness of adherence interventions among adults in this older age group with low health literacy was also explored. Methods: Eight electronic databases (MEDLINE, ERIC, EMBASE, PsycINFO, CINAHL, DARE, the Cochrane Library, and Web of Knowledge) were searched using a variety of keywords regarding health literacy and adherence. Additionally, references of identified articles were checked. Systematic reviews were included if they assessed the association between health literacy and adherence or evaluated the effectiveness of interventions to improve adherence in adults with low health literacy. The AMSTAR tool was used to assess the quality of the included reviews. The selection procedure, data-extraction, and quality assessment were performed by two independent reviewers. Seventeen reviews were selected for inclusion. Results: Reviews varied widely in quality. Both reviews of high and low quality found only weak or mixed associations between health literacy and adherence among older adults. Reviews report on seven studies that assess the effectiveness of adherence interventions among low health literate older adults. The results suggest that some adherence interventions are effective for this group. The interventions described in the reviews focused mainly on education and on lowering the health literacy demands of adherence instructions. No conclusions could be drawn about which type of intervention could be most beneficial for this population. Conclusions: Evidence on the association between health literacy and adherence in older adults is relatively weak. Adherence interventions are potentially effective for the vulnerable population of older adults with low levels of health literacy, but the evidence on this topic is limited. Further research is needed on the association between health literacy and general health behavior, and on the effectiveness of interventions
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