141 research outputs found
Adsorption of Oligo- and Polypeptides as Model Polyelectrolytes
The adsorption of oligo- and polylysines on silver iodide and
polystyrene latex has been measured as a function of concentration,
pH and ionic strength w. At low pH, polylysine adsorbs in
a flat conformation. Loops start to develop if the pH is increased
or if w is raised. The electrolyte effect persists up to very high \u27
concentrations. The principles and some results of a new polyelectrolyte
adsorption theory are outlined. It explains the experimentally
observed features at least semiquantitatively. The segment
density profile of a polyelectrolyt adsorbate does not resemble that
of an uncharged macromolecule. It depends on the charge on the
chain and on w and under certain conditions it contains a region
of negative adsorption
Improved diagnosis of Trichomonas vaginalis infection by PCR using vaginal swabs and urine specimens compared to diagnosis by wet mount microscopy, culture, and fluorescent staining
Four vaginal cotton swab specimens were obtained from each of 804 women
visiting the outpatient sexually transmitted disease clinic of the Erasmus
University Medical Center Rotterdam, Rotterdam, The Netherlands, for
validation of various forms of Trichomonas vaginalis diagnostic
procedures. One swab specimen was immediately examined by wet mount
microscopy, a second swab was placed in Kupferberg's Trichosel medium for
cultivation, and two swabs were placed in phosphate-buffered saline (PBS),
pH 7.2. The resulting PBS suspension was used for direct staining with
acridine orange and fluorescence microscopy, inoculation of modified
Diamond's culture medium, and a PCR specific for T. vaginalis. A total of
70 samples positive in one or more of the tests were identified: 31 (3.8%)
infections were detected by wet mount microscopy, and 36 (4.4%) were
Rapid emergence of ciprofloxacin-resistant enterobacteriaceae containing multiple gentamicin resistance-associated integrons in a Dutch hospital
In a hematology unit in the Netherlands, the incidence of
ciprofloxacin-resistant Enterobacter cloacae and Escherichia coli
increased from from 1996 to 1999. Clonal spread of single genotypes of
both ciprofloxacin-resistant E. coli and Enterobacter cloacae from patient
to patient was documented by pulsed-field gel electrophoresis and random
amplification of polymorphic DNA. In addition, genetically heterogeneous
strains were isolated regularly. Integrons associated with gentamicin
resistance were detected in Enterobacter cloacae and E. coli strains.
Integron-containing E. coli were detected in all hematology wards. In
contrast, in Enterobacter cloacae strains two integron types were
encou
Evolution of the gulf of Cadiz margin and southwest Portugal contourite depositional system : Tectonic, sedimentary and paleoceanographic implications from IODP expedition 339
Acknowledgments This research used samples and data collected through the Integrated Ocean Drilling Program (IODP). The research was partially supported through the CTM 2008-06399-C04/MAR, CTM 2012-39599-C03, CGL2011-26493, CTM2012-38248, SA263U14, IGCP-619, INQUA 1204 and FWF P25831-N29 Projects. Some data were collected with 94-1090-C03-03 (FADO) and MAR-98-0209 (TASYO) Projects. Research was conducted in the framework of the Continental Margins Research Group of the Royal Holloway University of London, People and the Program (Marie Curie Actions) of the European Union's Seventh Framework Program FP7/2007-2013/ under REA Grant Agreement No. 290201 MEDGATE’. We are very grateful to REPSeOL, TGS–NOPEC, and the CSIC-Institut Jaume Almera (http://geodb.ictja.csic.es) for allowing us to use an unpublished seismic data from the Gulf of Cadiz. We thank J. Aguire (UGR, Spain) for comments and suggestions concerning the Pliocene and Quaternary outcrops, B. van den Berg (USAL) for organizing a thought-provoking field-trip to Cadiz, Spain in November, 2014, M. Ángel Caja, L. García Diego, and J. Tritlla (REPSOL) for provenance and diagenetic analysis of early Pliocene sandstones and debrites, and L.J. Lourens (Utrecht University) for providing us the eccentricity and 200-Kys glacio-eustatic sea-level curves included in the Figure 16. Both Prof. D.A.V. Stow (Heriot-Watt Univ., UK) and F.J. Hernández-Molina (RHUL, UK), as the main co-proponents of the IODP Proposal 644 and the co-chiefs of the IODP Exp. 339, thanks to IODP, Exp. IODP 339 Scientists; JR crew and technicians, as well as all people, institutions and companies involved in making IODP a success since 2003. Finally, we also thank the editor, Gert J. De Lange and the reviewers T. Mulder (Bourdeaux Univ.); D. Van Rooij (Ghent Univ) and J. Duarte (Monash Univ.) for their very positive and helpful feedback and discussions in publishing this research.Peer reviewedPublisher PD
Pharmacogenomic associations of adverse drug reactions in asthma:systematic review and research prioritisation
We would like to thank the NIHR Collaboration for Leadership in Applied Health Research and Care North West Coast (CLAHRC) for funding Amanda McKenna’s internship, and Charlotte Kings MPhil, and the members of the PiCA consortia for their help in completing the survey. U. Potočnik, K. Repnik and V. Berce were supported by SysPharmPedia grant, co-financed by Ministry of Education, Science and Sport of the Republic of Slovenia Author information These authors contributed equally: Charlotte King, Amanda McKenna These authors jointly supervised this work: Ian Sinha, Daniel B. HawcuttPeer reviewedPublisher PD
ANALYSIS OF LIFE INSURANCE INVESTMENT COMPOSITION
Economic recession and global mettle down have brought the question of insurance
company investment to the forefront. Growing attention has shifted to the pattern of investments by the
insurance and question of how to evaluate such investments. The aim of this research is to evaluate
investment compositions which are made by life insurance companies in Indonesia, as well as to know the
effects on the performance of Insurance companies
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