In a hematology unit in the Netherlands, the incidence of
ciprofloxacin-resistant Enterobacter cloacae and Escherichia coli
increased from from 1996 to 1999. Clonal spread of single genotypes of
both ciprofloxacin-resistant E. coli and Enterobacter cloacae from patient
to patient was documented by pulsed-field gel electrophoresis and random
amplification of polymorphic DNA. In addition, genetically heterogeneous
strains were isolated regularly. Integrons associated with gentamicin
resistance were detected in Enterobacter cloacae and E. coli strains.
Integron-containing E. coli were detected in all hematology wards. In
contrast, in Enterobacter cloacae strains two integron types were
encou
