Then You Fall Off : Youth Experiences and Responses to Transitioning to Homelessness

Introduction: This study aims to broaden our understanding of the experience of homelessness and unstable housing in youth. While quantitative research highlights risk factors associated with experiencing homelessness as a youth, little qualitative research has been conducted to explore the lived experience of this transition to homelessness or unstable housing and how youth respond to becoming homeless. This study utilizes data from youth descriptions of their experiences to understand the context of the transition to homelessness and how youth manage this transition. Methods: A qualitative study with a quantitative component was conducted with a nonprobability sample of homeless youth aged 14-24 recruited from shelters, drop-in centers, and magnet events in a large urban area in the Southwest. Four qualitative researchers used content analysis to assess themes that emerged related to transitions to homelessness. Results: A predominately minority (88%) sample of sheltered (67%) and unsheltered (33%) youth (n=64) described their experience of and responses to transitioning to homelessness. Three main themes emerged relating to transitioning to homelessness; family homelessness, histories of foster care, and non-supportive family processes. Youth described how these experiences manifested and influenced their transition into homelessness. In response to homelessness three dominant themes emerged; self-reliance, hope, and resilience. Discussion: The data highlight the unique issues of homeless youth and how they respond to circumstantial challenges. While homeless youth experience lifetime adversities that lead to homelessness, they respond to these circumstantial challenges with self-reliance, hope, and maintaining resilience. Interventions aiming to facilitate health behaviors and improve self-sufficiency in homeless youth should tap into these positive responses to improve self-care strategies, service utilization, and help homeless youth reduce risk behaviors

The impact of international labor migration anf OFW remittances on poverty in the Philippines

The implications of labor migration and remittances on poverty are becoming a global issue. The Philippines is considered as one of the largest labor-sending countries in the world. There are numerous studies on remittances and migration and how they contribute to poverty reduction. However, the studies particularly done for the Philippines are quite scarce. There are still certain aspects that have not yet been explored. In this paper, we aim to enhance the current and previous studies by examining the impact of migration on poverty using a different theoretical and empirical framework. We also intend to analyze the sole effect of migration on poverty in the Philippines and to utilize three measures of poverty to determine the effects of migration and remittances on the different levels of poverty. Finally, in this study, we only consider the role of Overseas Filipino Workers (OFW). Thus, we use the data on labor migration and remittances on OFWs alone. This paper investigates the impact of labor migration and overseas workers' remittances on poverty reduction in the Philippines using a panel data on the 16 regions in the years 1997, 2000 and 2003. The study identifies and quantifies the individual poverty alleviating effects of the level of labor migration and volume of remittances on the three Foster-Greer-Thorbecke poverty indices - the incidence, depth and severity of poverty in the Philippines. The findings suggest that labor migration and remittance flows exert a negative and significant impact on all three measures of poverty. A 10% increase in per capita remittance and number of labor migrants leads to an approximately 0.4% and 0.2% reduction, respectively, in the proportion of families living below the poverty line

Direct Capture Technologies for Genomics-Guided Discovery of Natural Products

Microbes are important producers of natural products, which have played key roles in understanding biology and treating disease. However, the full potential of microbes to produce natural products has yet to be realized; the overwhelming majority of natural product gene clusters encoded in microbial genomes remain “cryptic”, and have not been expressed or characterized. In contrast to the fast-growing number of genomic sequences and bioinformatic tools, methods to connect these genes to natural product molecules are still limited, creating a bottleneck in genome-mining efforts to discover novel natural products. Here we review developing technologies that leverage the power of homologous recombination to directly capture natural product gene clusters and express them in model hosts for isolation and structural characterization. Although direct capture is still in its early stages of development, it has been successfully utilized in several different classes of natural products. These early successes will be reviewed, and the methods will be compared and contrasted with existing traditional technologies. Lastly, we will discuss the opportunities for the development of direct capture in other organisms, and possibilities to integrate direct capture with emerging genome-editing techniques to accelerate future study of natural products

Use of remote digital surveys to generate exposure models of residential structures in Chile

This article describes a methodology used to build detailed exposure models of residential structures in three cities of Chile using remote digital surveys. The models provide the location of the structures classified into 18 different structural typologies. Two tools were used simultaneously to build the models: Google StreetView, and GEM’s Inventory Data Capture Tool. The method is described, a summary of the results of the exposure models is presented, and the detailed results of the local models are compared with a previously developed national exposure model for the whole country. The proposed methodology to develop exposure models proved to be useful, simple, and low cost, and can be replicated elsewhere with proper StreetView coverage. The methodology is accurate to count structures, despite presenting certain difficulties to classify the surveyed buildings into different structural typologies. The developed exposure models represent an important input for risk calculations, thus improving technical capabilities for seismic risk management of the country

Response of mycorrhizal grapevine to Armillaria mellea inoculation: disease development and polyamines.

A study was conducted with the vine rootstock Richter 110 (Vitis berlandieri Planch. x Vitis rupestris L.) in order to assess whether the colonisation by the arbuscular mycorrhizal fungus (AMF) Glomus intraradices (BEG 72) can delay the disease development in plants inoculated with the root-rot fungus Armillaria mellea (Vahl:Fr) Kummer, and to elucidate if the levels of polyamines (PAs) are modified in response to G. intraradices, A. mellea or by the dual infection. Four treatments were considered: control and G. intraradices-inoculated plants infected or not with A. mellea. Plant growth, mycorrhizal colonisation and disease development were monitored throughout the experiment. High performance liquid chromatography (HPLC) in combination with fluorescence spectrophotometry was used to separate and quantify free root and leaf polyamines. The slower development of pathogenic symptoms and the higher plant biomass of mycorrhizal plants inoculated with A. mellea indicate an increase of tolerance due to the AMF inoculation. The variations in free PA levels detected at the beginning of the pathogenic infection suggest that PAs may have a potential role in the signalling mechanisms of the tolerance of mycorrhizal plants against A. mellea

El régimen natural de caudales: una diversidad imprescindible, una diversidad predecible

During last years the scientific community has realized flow regime importance as a connexion and explaining element of the fluvial ecosystem. Related to this paradigm, flow regime alteration analysis is necessary for the evaluation of environmental integrity. The objective is to show a new tool for characterizing stream flow regimes, quantifiying hydrologic impacts caused by dam construction. To reach this objective, this paper proposes: 1) to establish reference conditions and 2) evaluation of hydrological alteration: with 24 alteration indexes of alteration to measure the altered regime distortion against the natural. They have been applied to Vado reservoir situated in the upper reach of Jarama river which is integrated in Madrid water supply system.En los últimos años la comunidad científica ha puesto de manifiesto la importancia del régimen de caudales como elemento vertebrador del ecosistema fluvial, estableciendo el denominado «paradigma del régimen natural de caudales». A la luz de este paradigma, cualquier valoración de la integridad de un ecosistema fluvial debe incluir necesariamente un análisis objetivo de la alteración de su régimen de caudales. De hecho, la Directiva Marco del Agua establece el régimen hidrológico como uno de los elementos a considerar en la caracterización del estado ecológico de nuestros ríos. La metodología que se presenta en este trabajo permite: 1) definir el estatus hidrológico de referencia y 2) valorar la alteración del régimen de caudales, mediante 24 índices que evalúan la distorsión que en términos hidrológicos supone un determinado régimen frente al natural. Por último, se exponen los resultados de la aplicación de esta metodología al embalse de El Vado, ubicado en la cabecera del río Jarama e integrante del sistema de abastecimiento de agua a Madrid

Assessing the Need and Receptivity for an Integrated Healthy Sexual and Dating Relationships Intervention for Community College Students

Background: In emerging adulthood, youth often become involved in more serious romantic relationships. However, many lack the skills to avoid an unplanned pregnancy or sexually transmitted infection (STI), and to ensure a healthy dating relationship. Community college students serve nearly half of all undergraduate students in the United States; yet, community colleges typically lack resources for sexual health promotion. Purpose: To assess the need and receptivity for a web-based integrated healthy sexual and dating relationships intervention among community college students. Methods: In summer 2016, we partnered with three community colleges in South Central Texas to conduct an online survey of students’ sexual behaviors and dating relationships, and usability testing of activities from an integrated, web-based healthy sexual and dating relationship intervention. Results: Online survey participants (n=271) were 70% female, 38% Hispanic, 24% White, 17% Black, and 16% Asian; 20% self-identified as sexual minority; mean age was 20.8 years (SD = 2.05). Participants reported high rates of sexual risk behavior including sex without a condom or an effective birth control method, low use of long-acting reversible contraception, frequent use of emergency contraception, and low use of dual protection to prevent pregnancy and sexually transmitted infections. Two-thirds reported experiencing any type of dating violence perpetration or victimization in the past year. Usability testing participants (n=14) were 86% female, 42% Hispanic, 50% Asian/Pacific Islander, 14% Black, and 7% White; 71% were sexually experienced; mean age was 20.7 years (SD = 1.64). The web-based activities were highly rated in terms of usability parameters, and positively impacted short-term psychosocial outcomes related to condom use, accessing contraceptive health services, and constructive interpersonal conflict resolution. Conclusion: Findings underscore the high need and receptivity for an integrated healthy sexual and dating relationship web-based intervention among community college students, an understudied subgroup of youth in emerging adulthood

ROCKETSHIP: a flexible and modular software tool for the planning, processing and analysis of dynamic MRI studies

Background: Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is a promising technique to characterize pathology and evaluate treatment response. However, analysis of DCE-MRI data is complex and benefits from concurrent analysis of multiple kinetic models and parameters. Few software tools are currently available that specifically focuses on DCE-MRI analysis with multiple kinetic models. Here, we developed ROCKETSHIP, an open-source, flexible and modular software for DCE-MRI analysis. ROCKETSHIP incorporates analyses with multiple kinetic models, including data-driven nested model analysis. Results: ROCKETSHIP was implemented using the MATLAB programming language. Robustness of the software to provide reliable fits using multiple kinetic models is demonstrated using simulated data. Simulations also demonstrate the utility of the data-driven nested model analysis. Applicability of ROCKETSHIP for both preclinical and clinical studies is shown using DCE-MRI studies of the human brain and a murine tumor model. Conclusion: A DCE-MRI software suite was implemented and tested using simulations. Its applicability to both preclinical and clinical datasets is shown. ROCKETSHIP was designed to be easily accessible for the beginner, but flexible enough for changes or additions to be made by the advanced user as well. The availability of a flexible analysis tool will aid future studies using DCE-MRI

Nanostructure of cellulose microfibrils in spruce wood

The structure of cellulose microfibrils in wood is not known in detail, despite the abundance of cellulose in woody biomass and its importance for biology, energy, and engineering. The structure of the microfibrils of spruce wood cellulose was investigated using a range of spectroscopic methods coupled to small-angle neutron and wide-angle X-ray scattering. The scattering data were consistent with 24-chain microfibrils and favored a “rectangular” model with both hydrophobic and hydrophilic surfaces exposed. Disorder in chain packing and hydrogen bonding was shown to increase outwards from the microfibril center. The extent of disorder blurred the distinction between the I alpha and I beta allomorphs. Chains at the surface were distinct in conformation, with high levels of conformational disorder at C-6, less intramolecular hydrogen bonding and more outward-directed hydrogen bonding. Axial disorder could be explained in terms of twisting of the microfibrils, with implications for their biosynthesis

Variability in the establishment of an external reference point for central venous pressure measurement in children

OBJECTIVE: To investigate the variability in the establishment of the midaxillary line as external reference point (ERP), by different healthcare workers, for the measurement of central venous pressure in children. METHODS: Descriptive and correlational study carried out in a pediatric intensive care unit of a teaching hospital. During the establishment of the midaxillary line as ERP for central venous pressure measurement, five assessments of the same patient made by healthcare workers and one assessment made by a trained evaluator were compared. A total of 120 assessments were made by 44 healthcare workers, 17 (38.6%) by nursing assistants and nursing technicians, 16 (36.3%) by nurses and 11 (25.1%) by physicians, in addition to 24 assessments made by the trained evaluator. The data were analyzed using the chi-square test, ANOVA, Kruskal-Wallis test and t test. Significance level was set at 5%. RESULTS: There was statistically significant difference between the assessments made by healthcare workers and by the evaluator (p < 0.001). The comparison of the variability in the measurements made by healthcare workers revealed that 56 (46.7%) measurements were lower than those obtained by the evaluator (range from -0.5 to -9), 44 (36.7%) were higher (range from 0.5 to 4) and 20 (16.7%) were concordant (zero variability). Professional category did not influence the concordance between the ERPs (p = 0.899), or the variability observed (p = 0.778). However, the measurements made by professionals with greater experience in intensive care tended to differ more sharply from those made by the evaluators. CONCLUSION: The indications of the midaxillary line as ERP presented variations when measured by the healthcare team and by the trained evaluator. Variability was not influenced by professional category, and the more experienced the healthcare worker, the greater the probability for underestimation of the ERP. According to the results of this study, such situations may compromise both the efficacy of this procedure and patient safety.OBJETIVO: Verificar variabilidade na determinação da linha axilar média como ponto externo de referência (PER), por diferentes profissionais de saú de, para a aferição de pressão venosa central em crianças. MÉTODOS: Estudo descritivo e de correlação realizado em uma unidade de cuidados intensivos pediátricos de um hospital universitário. Durante a determinação da linha axilar média como PER para a aferição da pressão venosa central, cinco avaliações realizadas no mesmo paciente por profissionais de saúde e uma realizada por um avaliador treinado foram comparadas. O resultado foi um total de 120 indicações de 44 profissionais de saúde, 17 (38,6%) auxiliares e técnicos de enfermagem, 16 (36,3%) enfermeiros e 11 (25,1%) médicos, além de 24 identificações realizadas por avaliador treinado. Os dados foram analisados utilizando os testes do qui-quadrado, ANOVA, Kruskall-Wallis e teste t, fixando o nível de significância em 5%. RESULTADOS: Houve diferença significante entre as identificações realizadas pelos profissionais de saúde e pelo avaliador (p < 0,001). Comparando a variabilidade das medidas realizadas pelos profissionais, 56 (46,7%) foram menores do que a identificação do avaliador (variação de -0,5 até -9), 44 (36,7%) foram maiores (variação de 0,5 até 4) e 20 (16,7%) foram coincidentes (variação nula). Não se identificou influência da categoria profissional sobre a concordância entre os PER indicados (p = 0,899), tampouco na variabilidade observada (p = 0,778). Observou-se, contudo, que profissionais com maior tempo de experiência em unidades de cuidados intensivos demonstraram uma tendência a maior variabilidade com as medidas dos avaliadores. CONCLUSÃO: Verificou-se variabilidade nas indicações da linha axilar média como PER entre os profissionais e o avaliador treinado. A variabilidade não foi influenciada pela categoria profissional e quanto maior o tempo de experiência do profissional, maior a tendência em subestimar o ponto de referência. Os resultados deste estudo indicaram situações que poderiam comprometer a eficácia do procedimento e a segurança do paciente.Universidade Federal de São Paulo (UNIFESP)Universidade Federal de São Paulo (UNIFESP) Departamento de EnfermagemUNIFESP Departamento de EnfermagemUNIFESP Departamento de PediatriaUNIFESP, Depto. de EnfermagemUNIFESP, Depto. de EnfermagemUNIFESP, Depto. de PediatriaSciEL